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Synchrotron microtomography reveals insights into the degradation kinetics of bio-degradable coronary magnesium scaffolds

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Bioactive Materials 2024年第2期32卷 1-11页

作者： roman menze Bernhard Hesse Maciej Kusmierczuk Duote Chen Timm Weitkamp Stephanie Bettink Bruno Scheller MeKo Manufacturing e.K. Im Kirchenfelde 12-1431157SarstedtGermany Xploraytion GmbH Bismarckstr.10-1210625BerlinGermany Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190Saint-AubinFrance InnoRa GmbH Robert-Koch-Platz 410115BerlinGermany Universität des Saarlandes Campus Homburg66421HomburgGermany

Bioresorbable magnesium scaffolds are a promising future treatment option for coronary artery stenosis,especially for young *** to the degradation of these scaffolds(<1 year),long-term device-related clinical events could be reduced compared to treatments with conventional drug eluting *** clinical trials indicate a return of vasomotion after one year,which may be associated with improved long-term clinical ***,even after decades of development,the degradation process,ideal degradation time and biological response in vivo are still not fully *** present study investigates the in vivo degradation of magnesium scaffolds in the coronary arteries of pigs influenced by different strut thicknesses and the presence of antiproliferative *** to high 3D image contrast of synchrotron-based micro-CT with phase contrast(SR-μCT),a qualitative and quantitative evaluation of the degradation morphology of magnesium scaffolds was *** the segmentation of theμCT images a convolutional network architecture(U-net)was exploited,demonstrating the huge potential of merging high resolution SR-μCT with deep learning(DL)supported data *** total,30 scaffolds,made of the rare earth alloy Resoloy^(®),with different strut designs were implanted into the coronary arteries of 10 domestic pigs for 28 days using drug-coated or uncoated angioplasty balloons for *** degradation morphology was analyzed using scanning electron microscopy,energy dispersive x-ray spectroscopy and SR-μ*** data from these methods were then related to data from angiography,optical coherence tomography and histology.A thinner strut size(95 vs.130μm)and the presence of paclitaxel indicated a slower degradation rate at 28 d in vivo,which positively influences the late lumen loss(0.5 and 0.6 mm vs.1.0 and 1.1 mm)and recoil values(0 and 1.7%vs.6.1 and 22%).

关键词： Resoloy Magnesium scaffold DCB Paclitaxel Degradation Inflammation Artificial intelligence

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