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E-selectin ligand complexes adopt an extended high-affinity conformation

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Journal of Molecular Cell Biology 2016年第1期8卷 62-72页

作者： Roland C.preston roman p.Jakob Florian p.C.Binder Christoph p.Sager Beat Ernst Timm Maier Institute of Molecular pharmacy Universitat Basel4056 BaselSwitzerland Biozentrum Universitat Basel4056 BaselSwitzerland

E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewisx(sLex).Efficient leukocyte recruitment under vascular flow conditions depends on an increased lifetime of E-selectin/ligand complexes under tensile force in a so-called catch-bond binding ***-crystal structures of a representative fragment of the extracellular E-selectin region with sLex and a glycomimetic antagonist thereof reveal an extended E-selectin conformation,which is identified as a high-affinity binding state of E-selectin by molecular dynamics ***-angle X-ray scattering experiments demonstrate a direct link between ligand binding and E-selectin conformational transition under static conditions in *** permits tracing a series of concerted structural changes connecting ligand binding to conformational stretching as the structural basis of E-selectin catch-bond-mediated leukocyte *** detailed molecular view of the binding site paves the way for the design of a new generation of selectin *** is of special interest,since their therapeutic potentialwas recently demonstrated with the pan-selectin antagonists GMI-1070(Rivipansel).

关键词： inﬂammation leukocyte adhesion E-selectin glycomimetic antagonist sialyl Lewisx conformational change

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新的皂用杀菌剂

日用化学品科学 1987年第1期 42-44页

作者： Daniel p.roman 陈桔阿

本文论述一种杰出的皮肤抗菌化合物——3,4,4’-三氯化碳酸替苯胺 (TCC)。早在1957年Beaver等发表了TCC及其有关化合物的合成,同时,初步报道了它们的体外活性。TCC是经氯化的二苯脲,其结构如下:

关键词：微球菌皮肤解剖部位细菌数抑菌浓度 TCC 百分数抑菌剂受检人员体外活性

Influence of Geological Factor on Indoor Radon Concentrations in Dwelling of Queretaro,Mexico

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Open Journal of Geology 2014年第12期4卷 627-635页

作者： Rocio García Martínez Anatoliy Kotsarenko roman pérez Enriquez Jose Antonio López Cruz Abeyro Svetlana Koshevaya Jesús Efrén Ospina Norena Centro de Ciencias de la Atmósfera Universidad Nacional Autónoma de MéxicoCiudad UniversitariaMéxico CityMéxico Universidad Autónoma del Carmen(UNACAR) Facultad de IngenieríaCiudad del CarmenMéxico Centro de Geociencias Universidad Nacional Autónoma de MéxicoCampus JuriquillaQuerétaroMéxico CIICAp Autonomous University of State Morelos(UAEM)CuernavacaMéxico programa de Investigación de Cambio Climático Universidad Nacional Autónoma de MéxicoCiudad UniversitariaMéxico CityMéxico

In this study, radon-222 concentrations were measured within 34 houses distributed in the northern, southern, and central areas of the city of Querétaro in 2007. The objective of this study was to establish the spatial distribution of radon with respect to geological faults and its relation to certain environmental variables. For each sampling site, the radon-222 concentration was analyzed as a function of various climate variables, relative humidity, temperature, and atmospheric pressure, in addition to the ventilation of the house and distance of each site from any geological faults in the area. A multivariate statistical technique was used to analyze these variables based on two components. For component 1, the relative humidity and temperature had the greatest weight, 0.677 and 0.492, respectively, while for component 2, the greatest weights corresponded to radon and the temperature with 0.693 and 0.609, respectively. The average radon concentration across the entire sampling period was 38.92 Bq/m3, the minimum detected value was 6.01 Bq/m3?for site 91GAG0607, and the maximum detected value was 225.95 Bq/m3?for site 91CAM20907. This last value is outside the standards permitted by the Environmental protection Agency of the United Stated, which is 148 Bq/m3?for indoor environments. With respect to geological faults and their relationship to radon-222, the concentrations for the sampling sites had no relationship to the closeness or distance to these faults.

关键词： Indoor Radon Geology Building Characteristics and Seasonal Variations

What can a heavy U(1)B-L Z'boson do to the muon(g-2)u anomaly and to a new Higgs boson mass?

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Chinese physics C 2021年第1期45卷 32-46页

作者： Antonio p.Morais roman pasechnik J.pedro Rodrigues Departamenlo de Fisica da Universidade de Aveiro and CIDMA Campus de Santiago 3810-183 AveiroPortugal Department of Astronomy and Theoretical physics Lund UniversitySE 223-62 LundSweden Nuclear physics Institute ASCR 25068 RezCzech Republic Departamento de Fisica CFMUniversidade Federal de Santa CatarinaC.P.476CEP 88.040-900FlorianopolisSCBrazil

The minimal U(1)B_L extension of the Standard Model(B-L-SM)offers an explanation for neutrino mass generatio n via a seesaw mechanism;it also offers two new physics states,namely an extra Higgs bos on and a new Z'gauge *** emerge nee of a second Higgs particle as well as a new Z'gauge boson,both lin ked to the breaking of a local U(1)B_L symmetry,makes the B-L-SM rather constrained by direct searches in Large Hadron Collider(LHC)*** investigate the phenomenological status of the B-L-SM by confr on ting the new physics predictions with the LHC and electroweak precision *** into account the current bounds from direct LHC searches,we demonstrate that the prediction for the muon(g-2)u anomaly in the B-L-SM yields at most a contribution of approximately 8.9×10^-12,which represents a tension of 3.28 standard deviations,with the current 1σuncertainty,by means of a Z'boson if its mass is in the range of 6.3 to 6.5 TeV,within the reach of future LHC *** means that the B-L-SM,with heavy yet allowed Z‘bos on mass range,in practice,does not resolve the tension between the observed anomaly in the muon(g-2)u and the theoretical prediction in the Standard *** a heavy Z'boson also implies that the minimal value for the new Higgs mass is of the order of 400 GeV.

关键词： beyond Standard Model Higgs physics gauge extensions of the Standard Model Z'boson

Chiral Autoamplification Meets Dynamic Chirality Control to Suggest Nonautocatalytic Chemical Model of prebiotic Chirality Amplification

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Research 2019年第1期2019卷 318-326页

作者： Evgenii p.Talsi Anna A.Bryliakova roman V.Ottenbacher Tatyana V.Rybalova Konstantin p.Bryliakov Novosibirsk State University Pirogova 2Novosibirsk 630090Russia Boreskov Institute of Catalysis Pr.Lavrentieva 5Novosibirsk 630090Russia Vorozhtsov Novosibirsk Institute of Organic Chemistry Pr.Lavrentieva 9Novosibirsk 630090Russia

Oxidative kinetic resolution of 1-phenylethanol in the presence of manganese complexes,bearing conformationally nonrigid achiral bis-amine-bis-pyridine ligands,in the absence of any exogenous chiral additives,is *** only driving force for the chiral discrimination is the small initial enantiomeric imbalance of the scalemic(nonracemic)substrate:the latter dynamically controls the chirality of the catalyst,serving itself as the chiral *** effect,the ee of 1-phenylethanol increases monotonously over the reaction *** dynamic control of catalyst chirality by the substrate has been unprecedented;a consistent kinetic model for this process is *** reported catalyzed substrate self-enantioenrichment mechanism is discussed in relation to the problem of prebiotic chirality amplification.

关键词： chiral Chiral catalyst

地中海膳食可降低24h动态血压、空腹血糖及血脂:1年随机临床试验

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中华高血压杂志 2014年第7期22卷 699-699页

作者： Doménech M roman p Lapetra J García de la Corte FJ Sala-Vila A de la Torre R Corella D Salas-Salvadó J Ruiz-Gutiérrez V Lamuela-Raventós RM Toledo E Estruch R Coca A Ros E 赵狄

地中海膳食（MedDiets）添加橄榄油或坚果，较对照组低脂膳食可减少心血管事件，特别是脑卒中，但其心血管保护机制尚不清楚。研究人员进行随机、平行设计、对照试验研究，评估长达1年添加橄榄油或坚果的地中海膳食对24h动态血压、血糖... 详细信息

地中海膳食（MedDiets）添加橄榄油或坚果，较对照组低脂膳食可减少心血管事件，特别是脑卒中，但其心血管保护机制尚不清楚。研究人员进行随机、平行设计、对照试验研究，评估长达1年添加橄榄油或坚果的地中海膳食对24h动态血压、血糖和血脂的影响。膳食时间随意，

关键词： 24h动态血压随机临床试验低脂膳食空腹血糖地中海血脂心血管事件保护机制

Wilson's disease: prospective developments towards new therapies

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World Journal of Gastroenterology 2017年第30期23卷 5451-5456页

作者： Giusy Ranucci roman polishchuck Raffaele Iorio Department of Translational Medical Science Section of Pediatric University Federico Ⅱ Telethon Institute of Genetics and Medicine

Wilson's disease(WD) is an autosomal recessive disorder of copper metabolism, caused by mutations in the ATp7 B gene. A clear demand for novel WD treatment strategies has emerged. Although therapies using zinc salts and copper chelators can effectively cure WD, these drugs exhibit limitations in a substantial pool of WD patients who develop intolerance and/or severe side effects. Several lines of research have indicated intriguing potential for novel strategies and targets for development of new therapies. Here, we review these new approaches, which comprise correction of ATp7 B mutants and discovery of new compounds that circumvent ATp7B-deficiency, as well as cell and gene therapies. We also discuss whether and when these new therapeutic strategies will be translated into clinical use, according to the key requirements for clinical trials that remain to be met. Finally, we discuss the hope for the current rapidly developing research on molecular mechanisms underlying WD pathogenesis and for the related potential therapeutic targets to provide a solid foundation for the next generation of WD therapies that may lead to an effective, tolerable and safe cure.

关键词： ATp7B Stem cell-derived hepatocyte like cells Methanobactin Heat shock protein 70 p38 JNK Correctors Translational medicine precision medicine

Rapid purification and Identification of Osteopontin from Human Milk by HpLC Coupled to FT-ICR-MS

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Chemical Research in Chinese Universities 2010年第1期26卷 17-22页

作者： SHI Lei YANG Tie-zheng ZUBAREV A. roman College of public Health Jilin University Changchun 130021 P. R. China Affiliated Hospital of Changchun University of Chinese Medicine Changchun 130021 P. R. China Laboratory for Biological and Medical Mass Spectrometry BMC Uppsala University Box 583 75123 Uppsala Sweden

Milk as a key element for infant nutrition represents the only source of feeding for newborns and infants, breast-feeding milk normally contains several bioactive proteins or peptides useful for the development of the immune system that protects infants from diseases. Osteopontin（OpN） plays a distinct role during the processes of lactation, Some studies on OpN isolated and purified from the human milk via HpLC on SCX and Ca columns adopted biological mass spectrometry. After digesting the purified OpN sample with trypsin, the typical correlative polypeptide fragments GDSVVYGLR and QNLLApQTLpSK are identified by FT-ICR-MS. The rapid identification of OpN is assumed to be reasonably well behaving in a standard bottom-up experiment. It shows that nano-spray HpLC combined with FT-ICR-MS and Mascot search can be used as a high efficient method for the identification of purified OpN and its polypeptide fragments. Further study will provide more academic theories of their different modifications and the bioactivity as well.

关键词： Osteopontin(OpN) FT-ICR-MS purification Identification

Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients

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Hepatobiliary & pancreatic Diseases International 2019年第1期18卷 28-37页

作者： Andreas Kroh Diane Uschner Toine Lodewick roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf p Neumann Marcel Binneb?sel Department of General Visceral and Transplant Surgery University Hospital RWTH Aachen Institute of Medical Statistics University Hospital RWTH Aachen Department of Surgery Maastricht University Medical Center Department of Radiology Zuyderland Medical Centre Department of Radiology Maastricht University Medical Centre

Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( p = 0.035) and sarcopenic obese( p = 0.048) patients as well as a trend favoring obese( p = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients.

关键词： Hepatocellular carcinoma Sarcopenia Obesity Sarcopenic obesity Liver resection