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高分子力化学制备力致变色和力致增强聚合物材料

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高分子力化学制备力致变色和力致增强聚合物材料

The formation of autophagosomes at Er-pM contact sites in concert with the actin cytoskeleton and the endocytic machinery

中国化学会第30届学术年会

作者：张欢高飞曹晓东李燕群许元泽翁文桂 roman Boulatov 厦门大学化学化工学院 Department of Chemistry University of Liverpool and Donnan Lab

在高分子链上引入能够在机械力作用发生化学反应的小分子单元(力色团)是制备力响应高分子材料的主要方法。本文报道一类在溶液和本体中同时具有力致变色和力致诱导加成特性的高分子材料。这些高分子中含有螺噻喃力色团(STp,Fig.1)。被... 详细信息

在高分子链上引入能够在机械力作用发生化学反应的小分子单元(力色团)是制备力响应高分子材料的主要方法。本文报道一类在溶液和本体中同时具有力致变色和力致诱导加成特性的高分子材料。这些高分子中含有螺噻喃力色团(STp,Fig.1)。被引入到高分子骨架中的STp能够在机械力作用下发生电开环反应生成绿色的部花菁(TMC);TMC中含有具有高度反应活性的S负离子,能够与活化的双键发生定量的巯基-双键"点击"反应。当含有STp的线性聚酯与双官能团的马来酰亚胺交联剂一起溶液超声时,与通常超声波造成高分子链断裂降解不同,体系产生大量固体沉淀物。表明STp在超声下被活化成TMC并与马来酰亚胺交联剂发生加成,生成交联网络结构,起到力致增强效果。本工作证明可以将破坏性的机械力同时转化成多种有用的功能(力致变色和力致交联),为高级力响应材料的设计提供了更大的空间。

关键词：交联反应力致变色力色团弹性体螺噻喃

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The formation of autophagosomes at ER-PM contact sites in co...

2018全国植物生物学大会

作者： pengwei Wang roman pleskot Jingze Zang Joanna Winkler Jie Wang Klaas Yperman Jinli gong Kun Wang Yajie guan patrick Duckney Christine richardson Michael VANDorpe Jindriska Fiserova Daniel Van Damme patrick J.Hussey Key Laboratory of Horticultural plant Biology (MOE) College of Horticulture and Forestry SciencesHuazhong Agricultural University Department of Biosciences Durham University ghent University Department of Plant Biotechnology and Bioinformatics Department of Biology of the Cell Nucleus Institute of Molecular Genetics CAS

plants evolved their own strategy to form the essential link between the endoplasmic reticulum(Er) and the plasma membrane(pM) through a complex including NET3 C and VAp27(Wang et al 2014,Curr Biol).However,the function of plant Er-pM contact sites has not been fully *** this study,we have identified a function for Er-pM contact sites(EpCS) in plants and that is in the autophagosome biogenesis pathway,in concert with actin cytoskeleton and the Arabidopsis EH ***1 and AtEH2 are components of the endocytic TpLATE complex which is known to be essential for endocytosis in plants(gadeyne et al.,2014,Cell).Both proteins(from now on termed AtEH/pan1) share high sequence similarity with the yeast Arp2/3 complex activator,pan1 *** AtEH/panl proteins localise to the plasma membrane and autophagosomes,and their autophagosome membrane recruitment requires its N-terminal EH domains which interact with *** induction of autophagy,AtEH/pan1 proteins recruit TpC and Ap-2 subunitsand Arp2/3 proteins onto the autophagosome *** expression of AtEH1/pan1 boosts autophagosome formation and suggest independent and redundant pathways for actin mediated autophagy in ***,AtEH/pan1 regulated autophagosomes are found associated with EpCS where AtEH/panl interacts with *** knock-down expression of either AtEH/pan1 or VAp27-1 are more susceptible to nutrient depleted conditions,indicating defective *** conclusion,our results suggest that AtEH/pan1 proteins regulate an autophagosome-dependent degradation pathway which starts at the EpCS through its interaction with VAp27-1 and merges with endocytic pathways.

关键词： Membrane contact sites Autophagy Actin cytoskeleton panlp TpLATE

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母猪胎次对后裔健康有没有影响?

今日养猪业 2008年第3期 38-39,42页

作者： Thomas E．Burkey phillip S. Miller rodger K. Johnson Duane E. reese roman Moreno 温鹏（翻译）不详英国国际猪网

在现代养猪生产系统的推动下，许多新技术应运而生，旨在使繁殖性能和生长性能达到最佳水平。人们采用早期隔离断奶、全进全出以及多点式生产系统来最大限度地发挥被动免疫的作用，以便实现下列目的：降低病原传播，让负责每个生产阶段... 详细信息

在现代养猪生产系统的推动下，许多新技术应运而生，旨在使繁殖性能和生长性能达到最佳水平。人们采用早期隔离断奶、全进全出以及多点式生产系统来最大限度地发挥被动免疫的作用，以便实现下列目的：降低病原传播，让负责每个生产阶段的工作人员分工更加专业，简化后勤保障，最大限度地提高繁殖性能，并最终使养猪生产达到最优化。数据（表1）显示，1胎母猪的后代断奶体重较低，保育期和肥育期平均日增重（ADg）较低，并且保育期和肥育期死亡率较高。

关键词：母猪健康后裔胎次早期隔离断奶生产系统繁殖性能养猪生产

Automation of choice of instrumental equipment and study of thermo-stressed conditions of metal-cutting instrument

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Journal of Harbin Institute of Technology(New Series) 2000年第S1期7卷 87-87页

作者： Anatoly V.Levchenko roman A.Eshenko Olga I.Skarlykina Khabarovsk State University of Technology RussiaKhabarovsk State University of TechnologyRussiaKhabarovsk State University of TechnologyRussia

This article about possibility of automations of choice of instrumental equipment. In it described problems of choice of equipment, which are decided by means of mathematical model, developed on the base of finite ele... 详细信息

关键词： automatization instrumental equipment mathematical model arrangement instrumental block metal-cutting instrument thermal-stressed condition finite element method

The famous versus the inconvenient-or the dawn and the rise of 3D-culture systems

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World Journal of Stem Cells 2009年第1期1卷 43-48页

作者： Brigitte Altmann Alexander Welle Stefan giselbrecht roman Truckenmüller Eric gottwald Institute for Biological Interfaces Karlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz 1 76344 Eggenstein-LeopoldshafenGermany University of Twente MIRA Insti-tute for Biomedical Technology and Technical Medicine Department of Tissue RegenerationDrienerlolaan 57522 NB EnschedeThe Netherlands

One of the greatest impacts on in vitro cell biology was the introduction of three-dimensional(3D)culture systems more than six decades ago and this era may be called the dawn of 3D-tissue *** the advantages were obvious,this field of research was a "sleeping beauty"until the 1970s when multicellular spheroids were discovered as ideal tumor *** this rebirth,organotypical culture systems became valu-able tools and this trend continues to *** in the beginning,simple approaches,such as aggregation culture techniques,were favored due to their simplicity and convenience,now more sophisticated systems are used and are still being *** of the boosts in the development of new culture techniques arises from elaborate manufacturing and surface modification tech-niques,especially micro and nano system technologies that have either improved dramatically or have evolved very *** the help of these tools,it will soon be possible to generate even more sophisticated and more organotypic-like culture *** 3D per-fused or superfused systems are much more complex to set up and maintain compared to use of petri dishes and culture flasks,the added value of 3D approaches still needs to be demonstrated.

关键词： Three-dimensional cell culture Micro- bioreactors Chips Scaffold perfusion

诊断性试验和策略的证据质量和推荐强度的分级

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中国循证医学杂志 2009年第5期9卷 503-508页

作者： Holger J Schünemann Andrew D Oxman Jan Brozek paul glasziou roman Jaeschke gunn E Vist John W Williams Jr regina Kunz Jonathan Craig Victor M Montori patrick Bossuyt gordon H guyatt 李晓黄程陈耀龙李幼平代表grADE工作组

grADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局，

关键词：诊断性试验证据质量强度 E系统

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东南亚国家出口前景变得不妙

商业周刊（中文版） 2017年第1期 8-8页

作者： David roman

几十年来，出口推动了东南亚的经济增长，然而这个地区的出口前景看起来很黯淡。随着全球增长承压，而且在特朗普领导下的美国有可能更加趋向保护主义，这个依赖出口的地区前景变得不妙。

关键词：东南亚国家出口前景经济增长保护主义特朗普国有

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中心动脉脉压增大与恶性心血管预后独立相关

国际老年医学杂志 2011年第3期32卷 142-142页

作者： roman MJ

既往曾报道，中心动脉脉压（pp）较肱动脉pp与颈动脉增厚和动脉粥样硬化进展更密切，且更能较有效的预测心血管病（CAD）罹发风险。本文特就中心动脉pp在预测继发恶性心血管事件不良预后中的可靠性与肱动脉pp进行了大样本对照分析。

关键词：脉压增大心血管病不良预后心动脉恶性动脉粥样硬化心血管事件动脉增厚

Estimation of Light Commercial Vehicles Dynamics by results of road Tests and Simulation

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通讯和计算机（中英文版） 2014年第5期11卷 412-422页

作者： Anton Tumasov Anatoly groshev roman Musarsky galina Konikova Yury Trusov Sergey Kostin Institute of Transport Systems Nizhny Novgorod State Technical University n.a. R.E. Alekseev (NNSTU) 603950 Russia NizhnyNovgorod Minin str. 24

The chassis of LCV could be used for creating a wide range of vehicles modifications with the similar base (chassis), but really different performance in wide range of maneuvers. The differences could be explained by a variety of design parameters. It means that the design of LCV modifications needs some effective approach that will provide an engineer by necessary data that could help to estimate the performance of new vehicles in particular active safety characteristics. This paper presents the combination of experiment and simulation methods that could be used for estimation of LCV active safety characteristics (first of all cornering stability). The experimental method of estimation of cornering stability is shown, that is based on regulations of the russian Standard gOST r 31507-2012 that presupposes different types of testing: static rollover and dynamic maneuvering on a road (line changing and running into the corner). The multi-body simulation method with using MSC. ADAMS/CAr software was also used in a study. The approval of developed LCV multi-body model was made on a basis of good correlation between simulation results and experimental data. The relationship between LCVs design parameters (axle load distribution, height of the center of gravity, vertical and angular suspension stiffness) and active safety characteristics are received.

关键词：轻型商用车道路试验估计模拟设计参数安全特性仿真方法实验数据