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Distinct molecular targets of proEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

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Journal of pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan Hung Massimiliano Gaetani Yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding Gene Chi Wai Man Tao Zhang Yi Song Yao Wang Jacqueline pui Wah Chung Tak Hang Chan roman A.Zubarev Chi Chiu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of physiological Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(proEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral proEGCG can be effective in preventing and treating ***,1D and 2D proteome Integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and pX domain containing serine/threonine kinase-like(pXK)as novel binding targets of EGCG and proEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase B(Akt)-mediated angiogenesis,while pXK-proEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HIF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that proEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets proEGCG EGCG Angiogenesis Treatment Endometriosis

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独立游戏开发者:坚守创造梦

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The World of Chinese 2024年第1期 92-98页

作者： roman Kierst Cai Tao 不详

Indie video game developers risk it all for creative and commercial success in an ultracompetitive industry独立游戏开发者:在激烈的行业竞争中坚守创作梦To make his latest video game,Yang Yi had to sell his *** his previous game had its launch delayed by a licensing freeze in China’s game market in 2018,then suffered poor sales after its final release in 2020,Yang and his small team were in a“pretty dire”financial situation,he *** had to take on external software development gigs to stay afloat before they ran out of money completely in 2021.

关键词： money competitive float

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库夫施泰因在童话世界和无垠山野共振

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环球人文地理 2024年第11期 144-152页

作者：十一 ARochau Erika Karl Allen Lugmayer Nikolai Sorokin Olivier pictureserver roman Babakin Stephan Sühling Thomas Gross 摄图网

欧洲最适合隐居的地方在哪里？近日Lonely planet公布的名单中，阿尔卑斯山脚下的库夫施泰因榜上有名。古典音乐环绕小镇，而走进大自然的方式有无数种：夏季徒步，冬季滑雪……库夫施泰因，奥地利西部的一个美丽小镇。得益于德、奥边...

欧洲最适合隐居的地方在哪里？近日Lonely planet公布的名单中，阿尔卑斯山脚下的库夫施泰因榜上有名。古典音乐环绕小镇，而走进大自然的方式有无数种：夏季徒步，冬季滑雪……库夫施泰因，奥地利西部的一个美丽小镇。得益于德、奥边界的地理之势，无论从慕尼黑还是萨尔茨堡出发，都只需乘车约1小时就能到达。小镇夹在阿尔卑斯山的一个河谷，碧绿草坪、原始森林和清澈湖水环绕四周，八个村庄点缀其间，从高空俯瞰，犹如散落的珍珠。

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塔额盆地草原蝗虫空间生态位研究

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环境昆虫学报 2024年第3期46卷 625-634页

作者：宋占云万育欣查绪栋陈冉杨静 roman Jashenko 季荣新疆师范大学生命科学学院新疆特殊环境物种保护与调控生物学实验室中亚区域跨境有害生物联合控制国际研究中心乌鲁木齐830054 哈萨克斯坦科学院动物研究所阿拉木图050038

本文分析塔额盆地草原蝗虫的生态位,旨在为当地的蝗灾监控、治理及生态平衡保护提供理论依据。本研究对塔额盆地冲积平原、山前洪积倾斜平原、山地3种地形的草原蝗虫的空间生态位进行分析,统计得出了蝗虫优势度、群落组成差异、Levins... 详细信息

本文分析塔额盆地草原蝗虫的生态位,旨在为当地的蝗灾监控、治理及生态平衡保护提供理论依据。本研究对塔额盆地冲积平原、山前洪积倾斜平原、山地3种地形的草原蝗虫的空间生态位进行分析,统计得出了蝗虫优势度、群落组成差异、Levins生态位宽度和Shannon生态位宽度、pianka生态位重叠等相关参数。结果表明:3种地形共采集蝗虫6科19种1023头,不同地形优势种、常见种及稀有种均存在差异。山地与山前洪积倾斜平原、冲积平原的蝗虫群落组成差异较大。黑条小车蝗Oedaleus decorus decorus、蓝胫戟纹蝗Dociostaurus tartarus、意大利蝗Calliptamus italicus、红胫戟纹蝗Dociostaurus kraussi kraussi、伪星翅蝗Calliptamus coelesyriensis的生态位较宽且与其他蝗虫存在生态位重叠。塔额盆地草原蝗虫发生种类较多,绝大部分优势种蝗虫对空间资源的利用能力较强、竞争较激烈,对优势危害种加大监测力度,而针对山前洪积倾斜平原中的稀有种类,应加以保护以确保生物多样性。

关键词：塔额盆地生态位宽度生态位重叠草原蝗虫

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Editor's Letter

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The World of Chinese 2024年第2期 1-1页

作者： roman Kierst 不详

What do spicy hot pot,public exercise equipment,and barbecue restaurants have in common?They have all risen to viral internet fame in China and attracted hordes of tourists to previously unknown *** this issue,our cov... 详细信息

关键词： restaurant destination tourism

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Mechanical Complications after Myocardial Infarction: A Comprehensive Review

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World Journal of Cardiovascular Diseases 2024年第1期14卷 43-60页

作者： Alexis D. Aparicio-Ortiz María Natalia Alonso-Jimenez Adrian Espejel-Guzman Aldo Cabello-Ganem Javier Serrano-roman Santiago Luna-Alcala Nilda Espinola-Zavaleta Department of Nuclear Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Echocardiography ABC Medical Center Mexico City Mexico

Mechanical complications of myocardial infarction are potentially fatal events that can occur after an acute myocardial infarction. While the introduction of primary percutaneous reperfusion and fibrinolysis has reduced the incidence of these complications to less than 1%. These complications pose significant hemodynamic consequences and necessitate prompt diagnosis. Echocardiography, cardiac magnetic resonance imaging, and computed tomography are valuable tools for establishing an accurate and expedited diagnosis. Consequently, it is imperative to conduct further scientific research to enhance hemodynamic stabilization techniques such as intra-aortic balloon counterpulsation and extracorporeal membrane oxygenation, in addition to exploring new surgical procedures that can reduce mortality resulting from mechanical complications. This article aims to provide a comprehensive review of mechanical complications following myocardial infarction and their correlation with multi-imaging, facilitating a better understanding of these complications.

关键词： Infarction Mechanical Complications Echocardiography Magnetic Resonance

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Video Games

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The World of Chinese 2024年第2期 98-98页

作者： roman Kierst

The Hungry Lamb:Traveling in the Late Ming Dynasty(Zerocreation Games,April 23)Set against the tumultuous backdrop of the!late Ming dynasty,The Hungry Lambis a haunting visual novel that blends dark themes with historical *** take on the role of Liang,a disillusioned bandit-turned-unwilling hero,as he escorts four girls to the supposed safety of Luoyang.

关键词： player visual authentic

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On the Homology of the Dual de Rham Complex

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Acta Mathematica Sinica,English Series 2022年第10期38卷 1666-1676页

作者： roman MIKHAILOV Laboratory of Modern Algebra and Applications St.Petersburg State University14th Line29bSaint Petersburg199178Russia St.petersburg Department of Steklou Mathematical Institute Fontanka 27SaintPetersburg191023Russia

We study the homology of the dual de Rham complex as functors on the category of abelian *** give a description of homology of the dual de Rham complex up to degree 7 for free abelian groups and present a corrected ve... 详细信息

关键词： Dual de Rham complex polynomial functor divided powers derived functors

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Fabry Disease: Update, Focusing on Heart Disease by Multimodal Imaging

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World Journal of Cardiovascular Diseases 2024年第6期14卷 351-362页

作者： Adrian Espejel-Guzman Emily Rodríguez Valente Fernandez-Badillo Javier Serrano-roman Aldo Cabello-Ganem Alexis Daniel Aparicio-Ortiz Alberto Ramon-Rios Mariali palacios-Cruz Nilda Espinola-Zavaleta Department of Nuclear Cardiology. National Institute of Cardiology Ignacio Chavez Mexico City Mexico ABC Medical Center IAP Department of Echocardiography Mexico City Mexico

Fabry disease (FD) is a rare X-linked lysosomal accumulation disorder caused by a deficiency in the enzyme alpha-galactosidase A (Gal A), resulting in excessive storage of glycosphingolipids, particularly globotriaosylceramide (Gb3). This leads to cellular dysfunction in various organs, with cardiovascular compromise being the major cause of morbidity and mortality. This study aimed to provide a comprehensive overview of FD focusing on its genetic, epidemiological, clinical, diagnostic, and therapeutic aspects. This study explored the genetic mutations associated with FD, its epidemiology, clinical phenotypes, cardiac manifestations, diagnostic approaches, and current treatment options. Background: FD is caused by mutations in GLA on the X chromosome, with over 1000 identified variants. Neonatal screening and specific studies have shown an increased incidence of FD. The clinical presentation varies between classic and late phenotypes, with cardiac involvement being a major concern, particularly in late-onset FD. purpose: This study aimed to summarize the current knowledge on FD, emphasizing cardiac involvement, diagnostic modalities, and treatment options. Methods: A literature review of relevant studies on FD, including genetics, epidemiology, clinical presentation, diagnostic methods, and treatment options, was conducted. Results: Cardiac manifestations of FD included left ventricular hypertrophy (LVH), heart failure, arrhythmias, and sudden death. Diagnostic approaches such as electrocardiography, echocardiography, and cardiac magnetic resonance imaging play crucial roles in the early detection and monitoring of cardiac involvement. Enzyme replacement therapy (ERT) and emerging treatments have shown promise in managing FD, although challenges remain. Conclusions: FD remains a challenging condition in cardiology, with under-diagnosis being a concern. Early detection and specific therapy are essential to improve patient outcomes. Echocardiography and cardiac MRI ar

关键词： Fabry Disease Hypertrophic Cardiomyopathy Echocardiography Cardiac Magnetic Resonance Imaging Enzyme Replacement Therapy

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南京天印山医院

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建筑实践 2024年第4期 152-153页

作者：曹伟孙承磊吉英雷 Todd pilgreen roman Wittmer 舒帆东南大学建筑设计研究院有限公司晋思建筑设计事务所

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