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An in vitro demonstration of a passive,acoustic metamaterial as a temperature sensor with mK resolution for implantable applications

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Microsystems & Nanoengineering 2024年第1期10卷 41-54页

作者： Lucrezia Maini Vicente Genovés roman Furrer Nikola Cesarovic Christofer Hierold Cosmin roman Micro-and Nanosystems Department of Mechanical and Process EngineeringETH ZurichTannenstrasse 38092 ZurichSwitzerland. Translational Cardiovascular Technology Department of Health Science and TechnologyETH ZurichLeopold-Ruzicka-Weg 48093 ZurichSwitzerland. Transport at Nanoscale Interfaces Swiss Federal Laboratories for Materials Science and TechnologyEMPAÜberlandstrasse 1298600 DübendorfSwitzerland Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charite(DHZC)13353 BerlinGermany

Wireless medical sensors typically utilize electromagnetic coupling or ultrasound for energy transfer and sensor *** transfer and management is a complex aspect that often limits the applicability of implantable sensor *** this work,we report a new passive temperature sensing scheme based on an acoustic metamaterial made of silicon embedded in a polydimethylsiloxane *** to other approaches,this concept is implemented without additional electrical components in situ or the need for a customized receiving unit.A standard ultrasonic transducer is used for this demonstration to directly excite and collect the reflected *** metamaterial resonates at a frequency close to a typical medical value(5 MHz)and exhibits a high-quality *** the design features of the metamaterial with the high-temperature sensitivity of the polydimethylsiloxane matrix,we achieve a temperature resolution of 30 *** value is below the current standard resolution required in infrared thermometry for monitoring postoperative complications(0.1 K).We fabricated,simulated,in vitro tested,and compared three acoustic sensor designs in the 29-43℃(~302-316 K)temperature *** this concept,we demonstrate how our passive metamaterial sensor can open the way toward new zero-power smart medical implant concepts based on acoustic interrogation.

关键词： passive resolution utilize

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SoundMeGood: A Trust Model Supporting preliminary Trust Establishment Between Mutually Unknown Entities

SoundMeGood: A Trust Model Supporting Preliminary Trust Esta...

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作者： roman pánek pavel Tyl Institute of Computer Science of the Czech Republic Technical University of Liberec

The paper proposes a SoundMeGood trust model being able to establish a preliminary trust level among unknown users in a distributed environment. Computation of preliminary level of trust is based on similarities among users based on various components of their profiles. As a metric used for similarity computation has been used and experimentally evaluated DTW* algorithm.

关键词： Trust Social Network Trust Management System Distributed Systems.

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Microglia out of place—mapping macrophages across the developing human body

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Cellular & Molecular Immunology 2024年第3期21卷 210-212页

作者： roman Sankowski Marco prinz Institute of Neuropathology Faculty of MedicineUniversity of FreiburgFreiburgGermany Signalling Research Centres BIOsS and CIBSs University of FreiburgFreiburgGermany

Macrophages(MΦs)are versatile cells found in every *** the body,they work tirelessly to maintain *** this end,they are instructed by their respective niches to express organ-specific genes and proteins,resulting in a variety of cell morphologies and highly specialized functions across different tissues[1].A recent study by Wang et *** single-cell RNA sequencing to comprehensively profile human MΦphenotypes across 19 organs between postconception weeks(pCW)4 and 26[2].This study revealed a surprising diversity of these cells and suggests new avenues of research.

关键词： organs instru

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Taxonomy,distribution,and contemporary exposure of terrestrial mammals to floods and human pressure across different areas for biodiversity conservation in China

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Integrative Zoology 2024年第3期19卷 458-467页

作者： roman SHARNUUD Eric I.AMECA MOE Key Laboratory for Biodiversity Science&Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijingChina Climate Change Specialist Group Species Survival CommissionInternational Union for Conservation of NatureGlandSwitzerland

A significant research focus is placed on identifying animal species and areas at future risk to human-induced alterations of the environment and long-term changes in climatic ***,the extent to which exposure to extreme climatic events and intense human pressure can increase the risk of harmful impacts on species remains poorly *** on terrestrial mammals in China,one of the world’s megadiverse countries,we investigated patterns of contemporary exposure to floods and human pressures and determined their taxonomic representation and distribution across three major area-based conservation schemes,namely,national nature reserves(NNRs),priority areas for biodiversity conservation(pABCs),and key biodiversity areas(KBAs).Among the 440 species assessed with moderate or high exposure to floods,327(∼75%)also qualified as moderate or high in exposure to intense human *** species mainly belong to the orders Chiroptera,Eulipotyphla,and ***,there were 305,311,and 311 species with moderate or high exposure to flood and intense human pressure represented across NNRs,pABCs,and KBAs,*** findings support the prioritization of KBAs for expansion of site-based protection efforts such as NNRs in China,considering threats to species from exposure to adverse effects from both extreme climate and human pressure.

关键词： conservation floods human pressure mammals taxonomy

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Methyltransferase-like 3(METTL3)inhibition potentiates anti-tumor immunity:a novel strategy for improving anti-pD1 therapy

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Signal Transduction and Targeted Therapy 2024年第1期9卷 10-11页

作者： Anna Brichkina roman Suezov Magdalena Huber Institute of Systems Immunology Member of the German Center for Lung Research(DZL)Philipps University of Marburg35043 MarburgGermany

In a recent article published in Cancer Discovery,Guirguis et *** that enzymatic inhibitors of the m6 A methyltransferase METTL3 induced a formation of immunostimulatory doublestranded mRNAs(dsRNAs)in cancer cells,which triggered a profound tumor-cell-intrinsic interferon response leading to an enhanced antigen presentation and thereby increased killing of tumor cells by cytotoxic CD8+*** inhibition of METTL3 synergized with anti-pD1 immunotherapy,highlighting its potential for improving cancer treatment.

关键词： pD1 immunity

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Study of relationship between motion of mechanisms in gas operated weapon and its shock absorber

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Defence Technology（防务技术） 2024年第3期33卷 42-54页

作者： Jiri Balla roman Vitek Dung Nguyen Van Zbynek Krist Hung Nguyen Van Department of Weapons and Ammunition University of Defence BrnoCzech Republic Department of Weapons Le Quy Don Technical UniversityHanoiViet Nam Department of Design and Special Engineering Alexander Dubcek University of TrencinSlovakia

The article deals with the motion of the breech block carrier and the weapon casing of an automatic weapon mounted on a flexible carriage and the base of the *** works,which did not consider the dynamic properties of the base of the weapon,did not allow to reconcile the calculated and experimental results of the weapon casing displacement when shooting from firing *** the analysis of the motion of individual parts,the methods of mathematical modelling and firing experiments using a high-speed camera were *** show the best accord with experiment when modelling the system with 4 degrees of *** oscillation of the system regarding the movement of the breech block carrier and the weapon casing was investigated under changed conditions of rate of fire,the use of a muzzle brake and different types of shock *** velocities and displacements of the weapon casing and the breech block carrier at different values of the impulse of the gases to the breech block carrier were determined.

关键词： Shock absorber Gas-operated weapon Force-impulse diagram Recoil system Breech block carrier

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Efficient cold atom source from a single-layer atom chip

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Chinese Optics Letters 2024年第6期22卷 108-113页

作者： petr Skakunenko Darya Bykova Anton Afanasiev Alexey Kalmykov roman Kirtaev Victor Balykin Institute of Spectroscopy Russian Academy of Sciences Moscow Institute of physics and Technology Skolkovo Institute of Science and Technology National Research University Higher School of Economics Emerging Technologies Research Center XPANCEO

We developed a new single-layer atom chip with an additional U-shaped current-carrying *** new U-shaped microwire creates optimized magnetic field distribution,which increases the trapping volume of a magneto-optical trap（MOT） near the *** approach allows one to localize more atoms,while a setup remains relatively simple （single-layer approach） and consumes low current （up to 10 A）. The total number of trapped87Rb atoms in our setup is 5×10～7.

关键词： Bose Einstein condensates Laser beams Laser cooling Optical clocks Quantum noise Rubidium

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Investigation of the effect of hydrocarbons and monoesters in the gelators’composition on the properties of edible oleogel

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Grain & Oil Science and Technology 2024年第2期7卷 96-104页

作者： Yuliya Frolova roman Sobolev Varuzhan Sarkisyan Alla Kochetkova Federal Research Centre of Nutrition Biotechnology and Food Safety2/14 Ustyinsky ProyezdMoscow 109240Russia

Natural wax gelators have different compositions of compounds(hydrocarbons,wax esters,free fatty alcohols,and free fatty acids),which results in oleogels with varying *** maintain a consistent composition,the individual components can be added to the original wax *** content of hydrocarbons and wax esters greatly affects the structuring process of liquid edible oils with *** aim of this study was to evaluate the possibility of modifying the properties of beeswax as a gelling agent by adding hydrocarbons or monoesters to obtain oleogels with specific *** tests were conducted to assess the changes in the oleogel properties,such as color,microstructure,oil-binding capacity,thermal and textural *** research results have shown that the addition of the studied fractions has led to a significant change in all properties of *** initial size of oleogel crystals(7.29±1.80μm)changed after adding fractions,varying from 5.28μm to 12.58μm with hydrocarbons and from 9.95μm to 30.41μm with wax *** addition of 30%–50% hydrocarbons decreased the ability of the oleogels to bind oil and made them less firm compared to samples with 10%-20% *** 10%-20% monoesters increased the firmness of the oleogels,but this indicator decreased when their content was increased to 50%.The obtained data indicate that hydrocarbons and wax esters can be used for targeted correction of the gelling properties of beeswax.

关键词： Oleogel Beeswax Hydrocarbons Wax monoesters Component composition of gelator Textural properties Food

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A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres M.Angélica Michea Ákos Végvári Marion Arce Valentina pérez Marcela Alcota Alicia Morales Rolando Vernal Mauricio Budini roman A.Zubarev Fermín E.González Laboratory of Experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and Molecular pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(GSE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SNCA,CA1,HBB,SLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SNCA,FTH1,HSpB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

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Stripped Down

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The World of Chinese 2024年第1期 110-115页

作者： roman Kierst 不详

How simple,greasy,cheap latiao(literally“spicy strips”)became the people’s snack辣条:何以成为国民零食?It seems that everyone who grew up in China during the 2000s has some memory of *** spicy strips of greasy dough... 详细信息

关键词： everyone money literal

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