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Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study

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Stroke & Vascular Neurology 2024年第2期9卷 165-173,I0426,I0427页

作者： romain Didier lucie Garnier Gauthier Duloquin Alexandre Meloux Audrey Sagnard Mathilde Graber Geoffrey Dogon Karim Benali Thibaut Pommier Gabriel laurent Catherine Vergely Yannick Bejot Charles Guenancia Cardiology CHU Dijon BourgogneDijonFrance Dijon Stroke Registry Department of NeurologyUniversity Hospital Centre DijonDijonFrance PEC 2 Universitéde BourgogneDijonFrance Cardiology CHU Saint EtienneSaint EtienneFrance

Background Atrial cardiomyopathy(AC)is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation(AF).A definition based on the presence of electrical abnormality(P-wave terminal force in lead V1(PTFV1)>5000µV×ms),N-Terminal pro-B-type natriuretic peptide(NT pro BNP)>250pg/ml and/or indexed left atrial diameter(lADI)>3cm/m^(2)is currently tested in the ARCADIA(AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke)*** set out to estimate the prevalence of AC as defined in the ARCADIA trial,its determinants and its association with AF detected after stroke(AFDAS).Methods Stepwise screening for silent Atrial Fibrillation After Stroke(SAFAS)study prospectively included 240 ischaemic stroke *** markers were complete for 192 of them and 9 were not included in this analysis because AF had been diagnosed on *** A total of 183 patients were analysed,of whom 57%(104 patients)met the AC criteria(79 NT-proBNP,47 PTFV1,4 lADI).In the multivariate logistic regression,C reactive protein>3mg/l(OR(95%CI)2.60(1.30 to 5.21),p=0.007)and age(OR(95%CI)1.07(1.04 to 1.10),ply associated with *** 6 months of follow-up,AFDAS was detected in 33%of AC patients and in 14%of the remaining ones(p=0.003).However,AC was not independently associated with AFDAS,contrary to left atrial volume index(>34ml/m^(2),OR 2.35(CI 1.09 to 5.06)p=0029).Conclusion AC as defined in ARCADIA is mostly based on NT pro BNP elevation(76%of patients)and is associated with age and ***,AC was not independently associated with AFDAS at *** ARCADIA trial,which compares aspirin to apixaban in patients with embolic strokes of undetermined source with AC markers and must,therefore be analysed in the light of these limitations.

关键词： atrial cardiomyopathy prevention

Tree-ring:a suitable implement for spatial and temporal fire distribution analysis in savanna woodland and dry forest

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Journal of Forestry Research 2015年第2期26卷 435-446页

作者： Franck Sinsin romain GlèlèKaka? Bettina Orthmann Brice Sinsin laboratoire d’Ecologie Appliquée Faculté des Sciences AgronomiquesUniversité d’Abomey-Calavi03 BP 1974 CotonouBénin laboratory of Biomathematics and Forest Estimations Faculté des Sciences AgronomiquesUniversité d’Abomey-Calavi03 BP 1974 CotonouBénin Institute of Biosciences University of Rostock

Based on 120 stem discs collected during3 months of fieldwork along a 12 km route,the history of fires in the Wari Maro Forest（09 1000 N–02 1000E） over the past century in savanna woodland and dry forest was *** major ecological areas are characterized：one highly burnt zone located between two relative less burnt *** analyzing tree rings,246 fire scars were *** scars were caused by 51 fire years,occurring at a mean interval of 2.23 *** 1890 to1965,only 6 years with fires were recorded from sampled *** 1966,no year has passed without *** fire frequency point scale reached 14 *** was the case of Burkea africana,which has been identified as a species tolerant to fire and could be planted to create a natural *** contrast,Anogeissus leiocarpa is highly sensitive to fire,and in a dry forest ecosystem that burns seasonally,it requires a special conservation *** new concepts are described：the rebarking of trees after fire and Mean Kilometer Fire *** first concept was tested with Daniellia oliveri（Rolfe） Hutch ＆ Dalz trees,and the second concept was used to evaluate spatial fire *** demonstrate that savanna woodland and dry forest were subject to a degradation process caused by destructive fires related to vegetation cover clearance and illegal logging.

关键词： Fire ecology Tree-rings Savanna woodland Dry forest Conservation strategies

Vegetation structure,dominance patterns and height growth in an Afromontane forest,Southern Africa

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Journal of Forestry Research 2020年第2期31卷 453-462页

作者： Sylvanus Mensah Anthony Egeru Achille Ephrem Assogbadjo romain GleleKakai laboratoire de Biomathematiques et d’Estimations Forestieres Facultedes Sciences AgronomiquesUniversite d’Abomey-Calavi04 BP 1525 CotonouBenin Regional Universities Forum for Capacity Building in Agriculture Makerere UniversityP.O Box 16811WandegeyaKampalaUganda laboratoire d’Ecologie Appliquee Facultedes Sciences AgronomiquesUniversite d’Abomey-Calavi03 BP 1974 CotonouBenin

Information on forest structure is fundamentally important to track successional vegetation dynamics for efficient forest *** study reports on vegetation characteristics,dominance patterns and species height growth in a northern mistbelt forest type in South *** alpha-diversity indices(species richness and Shannon-Weiner diversity),structural vegetation parameters(tree density and basal area),and species importance value index were *** class distribution and height-diameter allometry were further examined for the overall stand and most important *** densities(472.0±43.5 and 605.3±28.1 trees ha^-1 for C 5 cm to\10 cm and C 10 cm dbh(diameter at breast height)classes,respectively)and basal area values(1.99±0.19 and 48.07±3.46 m^2 ha^-1,respectively)are comparable to other Afromontane forests in East *** overall stand showed an inverted-J shaped distribution pattern which is a typical feature of stand size class distribution in most natural *** ecologically important species also exhibited an inverted-J shaped distribution pattern,suggesting good regeneration and recruitment *** were significant differences in species on height,reflecting species-specific height growth patterns,possibly a result of intrinsic growth potential and competitive *** present study suggests that conservation and management policies,including protection of surrounding land uses against fire,contribute to maintaining a successful recovery of these ***,it should be noted that these forests may be experiencing relatively slow dynamic flux as a result of the overmature state of some trees with several years under relatively strict protection.

关键词： Diversity Population structure Species composition Size class distribution

Multi-dimensional Simulation of Phase Change by a 0D-2D Model Coupling via Stefan Condition

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Communications on Applied Mathematics and Computation 2023年第2期5卷 853-884页

作者： Adrien Drouillet romain le Tellier Raphaël loubère Mathieu Peybernes louis Viot Institut de Mathématiques de Bordeaux Universitéde Bordeaux33405 Talence CedexFrance CEA-DES-IRESNE-DTN CEA Cadarache13108 Saint Paul-lez-DuranceFrance

Considering phase changes associated with a high-temperature molten material cooled down from the outside,this work presents an improvement of the modelling and the numerical simulation of such processes for an application pertaining to the safety of light water nuclear *** a core meltdown accident,the behaviour of the core melt(aka corium)into a steel vessel is of tremendous importance when evaluating the vessel *** correctly the heat fluxes requires the numerical simulation of the interaction between the liquid material and its solid counterpart which forms during the solidification process,but also may melt *** simulate this configuration,encoun-tered in various industrial applications,one considers a bi-phase model constituted by a liquid phase in contact and interaction with its solid *** liquid phase may solidify in presence of low energetic source,while the solid phase may melt due to an intense heat flux from the high-temperature *** the frame of the in-house legacy code,several simplifying assumptions(0D multi-layer discretization,instantaneous heat transfer via a quadratic temperature profile in solids)are made for the modelling of such phase *** the present work,these shortcomings are illustrated and further overcome by solving a 2D heat conduction model in the solid by a mixed Raviart-Thomas finite element method coupled to the liquid phase due to heat and mass exchanges through Stefan *** liquid phase is modeled with a 0D multi-layer *** 0D-liquid and 2D-solid mod-els are coupled by a Stefan like phase change interface *** sanity checks are performed to assess the validity of the approach on 1D and 2D academical configurations for which exact or reference solutions are *** more advanced situations(genu-ine multi-dimensional phase changes and an"industrial-like scenario")are simulated to verify the appropriate behavior of the obtained coupled simulation schem

关键词： Simulation of phase change Fusion Solidification 0D multi-layer model 2D heat conduction model Model coupling

Thermogravimetric analysis and kinetic modeling of the co-pyrolysis of a bituminous coal and poplar wood

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Chinese Journal of Chemical Engineering 2023年第6期58卷 53-68页

作者： Wei Wang romain l.maire Ammar Bensakhria Denis luart Department of Mechanical Engineering École de technologie supérieureMontrealQuebec H3C 1K3Canada Universitéde Technologie de Compiègne Centre de recherche de RoyallieuEA 4297-TIMRBP2052960205 CompiègneFrance École Supérieure de Chimie Organique et Minérale 1 Rue du Réseau Jean-Marie Buckmaster60200 CompiègneFrance

The co-pyrolysis of coal and biomass has proven to be a promising route to produce liquid and gaseous fuels as well as specific value-added chemicals while contributing to mitigating CO_(2) *** interactions between the co-processed feedstocks,however,need to be elucidated to support the development of such a thermochemical conversion *** this context,the present work covers the kinetic analysis of the co-pyrolysis of a bituminous coal with poplar *** this research,biomass was blended with coal at two different mass ratios(10%(mass)and 20%(mass)).Thermogravimetric analyses were carried out with pure and blended samples at four heating rates(5,10,15 and 30℃·min^(-1)).A direct comparison of experimental and theoretical results(based on a simple additivity rule)failed to yield a clear-cut conclusion regarding the existence of synergistic *** analyses have therefore been achieved using two model-free methods(the Ozawa-Flynn-Wall and Kissinger-Akahira-Sunose models)to estimate the rate constant parameters related to the pyrolysis process.A significant decrease of the activation energy has thus been observed when adding wood to coal(activation energies associated with the blend containing 20%(mass)of biomass being even lower than those estimated for pure wood at low conversion degrees).This trend was attributed to the possible presence of synergies whose related mechanisms are *** rate constant parameters derived by means of the two tested models were finally used to simulate the evolution of the conversion degree of each sample as a function of the temperature,thus leading to a satisfying agreement between measured and simulated data.

关键词： Co-pyrolysis Coal Wood Kinetics Synergistic effects

Masquelet technique in military practice:specificities and future directions for combat-related bone defect reconstruction

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Military Medical Research 2023年第3期10卷 369-382页

作者： laurent Mathieu romain Mourtialon Marjorie Durand Arnaud de Rousiers Nicolas de l’Escalopier Jean‑Marc Collombet Department of Orthopedic Trauma and Reconstructive SurgeryPercy Military Hospital101 avenue Henri Barbusse92140 ClamartFrance Department of Surgery Ecole du Val‑de‑GrâceFrench Military Health Service Academy1place Alphonse Laveran75005 ParisFrance Military Biomedical Research Institute(IRBA) 1 place Général Valérie André91220 Brétigny‑sur‑OrgeFrance

Because of its simplicity,reliability,and replicability,the Masquelet induced membrane technique(IMT)has become one of the preferred methods for critical bone defect reconstruction in *** it is now used worldwide,few studies have been published about IMT in military *** reconstruction is particularly challenging in this context of care due to extensive soft-tissue injury,early wound infection,and even delayed management in austere *** on our clinical expertise,recent research,and a literature analysis,this narrative review provides an overview of the IMT application to combat-related bone *** presents technical specificities and future developments aiming to optimize IMT outcomes,including for the management of massive multi-tissue defects or bone reconstruction performed in the field with limited resources.

关键词： Bone defect Induced membrane technique Gunshot wound low resources Masquelet technique Military War surgery

Mechanisms of electrochemical magnesium(de)alloying of Mg-Sn and Mg-Pb polymorphs

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Journal of Magnesium and Alloys 2022年第6期10卷 1609-1616页

作者： Clément Pechberty Antoine Klein Bernard Fraisse lorenzo Stievano romain Berthelot ICGM CNRSUniv.MontpellierENSCMMontpellierFrance RS2E CNRSHub de l’EnergieAmiensFrance

Different polymorphs of Mg-Sn and Mg-Pb intermetallic compounds were prepared by high-energy mechanical alloying and then investigated as active material in magnesium batteries. Beside thermodynamically stable Mg_(2)Sn and Mg_(2)Pb crystallizing in the anti-fluorite structure, other polymorphs Mg_(~2)Sn and Mg_(~2)Pb were prepared by increasing the ball-milling time. The first dealloying process is almost complete only for the cubic polymorphs, then similar capacities are observed during the subsequent alloying and dealloying *** to operando X-ray diffraction, the electrochemical mechanism is revealed and shows that the cubic polymorphs Mg_(2)Sn and Mg_(2)Pb tend to preferentially form during the alloying whatever the pristine intermetallic. Weak traces of Mg_(~2)Sn and Mg_(~2)Pb are observed during the alloying, suggesting that these polymorphs act as a by-product and/or an intermediate phases of the electrochemical process. Finally, the compatibility of cubic Mg_(2)Sn and Mg_(2)Pb with Mg(TFSI)_(2)-based electrolyte is confirmed in full cell vs. a positive electrode based on the Chevrel phase Mo6S8, although limited performance is achieved. This fundamental work provides new insights in the behavior of alloy-type negative electrodes for magnesium-ion batteries.

关键词： Magnesium batteries Alloy electrode Mechanochemistry Operando X-ray diffraction

Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy

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World Journal of Gastroenterology 2017年第5期23卷 853-858页

作者： Gaetan-romain Joliat Ismail labgaa Nicolas Demartines Nermin Halkic Department of Visceral Surgery University Hospital CHUV1011 LausanneSwitzerland

AIM To identify a preoperative blood marker predictive of alveolar echinococcosis(AE) recurrence after *** All consecutive patients who underwent operation for liver AE at the lausanne University Hospital(CHUV) between January 1992 and December 2015 were included in this retrospective study. Preoperative laboratory values of leukocytes, mean corpuscular volume(MCV), red blood cell distribution width(RDW), thrombocytes, C-reactive protein(CRP) and albumin were collected and analyzed. Univariate and multivariate Cox regression analyses were performed to determine the risk factors for AE recurrence after liver resection. A receiver operating characteristic(ROC) curve was used to define the best discrimination threshold of the blood marker. Moreover, recurrencefree survival curves were calculated using the KaplanMeier *** The cohort included 68 adult patients(37 females) with median age of 61 years [interquartile range(IQR): 46-71]. Eight of the patients(12%) presented a recurrence over a median follow-up time of 76 mo(IQR: 34-128). Median time to recurrence was 10 mo(IQR: 6-11). Median preoperative leukocyte, MCV, RDW,thrombocyte and CRP levels were similar between recurrent and non-recurrent cases. Median preoperative albumin level was 43 g/l(IQR: 41-45) for nonrecurrent cases and 36 g/l(IQR: 33-42) for recurrent cases(P = 0.005). The area under the ROC curve for preoperative albumin level to predict recurrence was 0.840(95%CI: 0.642-1, P = 0.002). The cutoff albumin level value was 37.5 g/l for sensitivity of 94.5% and specificity of 75%. In multivariate analysis, preoperative albumin and surgical resection margins were independent predictors of AE recurrence(HR = 0.099, P = 0.007 and HR = 0.182, P = 0.045 respectively).CONClUSION low preoperative albumin level was associated with AE recurrence in the present cohort. Thus, preoperative albumin may be a useful biomarker to guide follow-up.

关键词： liver surgery Alveolar echinococcosis Albumin Predictive marker Recurrence

Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer

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World Journal of Gastroenterology 2019年第34期25卷 5082-5096页

作者： Diane lorenzo Vinciane Rebours Frédérique maire Maxime Palazzo Jean-Michel Gonzalez Marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe lévy louis de Mestier Pancreatology Department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 75013France INSERM UMR1149Paris 92110France Departement of Gastroenterology Aix Marseille university-APHM-Hopital NordMarseille 13000France Radiology Department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 92110France Oncology Department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 92110France

Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and ***-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo *** appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic *** can also be used to obtain tissue ***,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to *** cost-effectiveness of screening is also *** new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising.

关键词： Endoscopic ultrasound Familial pancreatic cancer Fine-needle aspiration Intraductal papillary mucinous neoplasm Pancreatic cancer Pancreatic intraepithelial neoplasia Pancreatic cancer screening guidelines