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电影文学 2005年第10期 61-62页

作者： romain

最好是和"群魔"在—起伯格曼:我在小岛上走来走去,一整天不跟任何人讲话,这是经常会发生的事。我非常迷恋这里,因为我可以享受安静。伯格曼比其他任何人,更能影响全世界对于瑞典人内心世界的认知和理解。在各大电影节上,每一部新的瑞典... 详细信息

最好是和"群魔"在—起伯格曼:我在小岛上走来走去,一整天不跟任何人讲话,这是经常会发生的事。我非常迷恋这里,因为我可以享受安静。伯格曼比其他任何人,更能影响全世界对于瑞典人内心世界的认知和理解。在各大电影节上,每一部新的瑞典影片都要经过伯格曼的筛选。通过这些影片,一代又一代的外国电影制作者和爱好者都准确地知道瑞典人是什么样子。而瑞典人却认为自己不应该被禁锢于那些忧郁和沉闷的影像之中。尽管如此,他们仍毫无保留地深爱着《芬妮与亚历山大》。对于伯格曼。

关键词：电影节瑞典人戏剧亚历山大演员影片莎士比亚内心世界外国电影大师

Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics

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Cellular & Molecular Immunology 2021年第6期18卷 1581-1583页

作者： Yunhao Zhai Javier Celis-Gutierrez Guillaume Voisinne Daiki Mori Laura Girard Odile Burlet-Schiltz Anne Gonzalez de Peredo romain Roncagalli Bernard Malissen Centre d’Immunologie de Marseille-Luminy Aix Marseille UniversitéINSERMCNRS13288MarseilleFrance Centre d’Immunophénomique Aix Marseille UniversitéINSERMCNRSMarseilleFrance Institut de Pharmacologie et de Biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089ToulouseFrance

Deciphering how T-cell antigen receptor signals are modulated by coinhibitors is a fundamental goal in immunology and of considerable clinical interest because blocking coinhibitory signals via therapeutic antibodies have become a standard cancer immunotherapeutic *** of the attention devoted to T-cell immunoglobulin and mucin domain-3(TIM3;also known as HAVCR2 or CD366)molecules stems from their expression on exhausted T cells in settings of chronic viral infection and ***,T cells expressing high levels of both PD-1 and TIM3 coinhibitors appear more dysfunctional than those expressing PD-1 *** therapies intending to block both PD-1 and TIM3 are thus actively being explored in the cancer treatment *** interaction with Galectin-9(GAL-9)and carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM-1),the tyrosines found in the TIM3 cytoplasmic tail are phosphorylated.1 Because these conserved tyrosines do not form a recognizable inhibitory signaling motif,the mechanism by which TIM3 transmits inhibitory signals has not been ***,TIM3 also has costimulatory activity in T cells.2,3 Published biochemical studies attempting to unveil the mode of action of TIM3 have relied on approaches addressing one candidate effector at a time with limited quantitative insight,and most used transformed *** mice expressing an affinity Twin-Strep-tag(OST)at the TIM3-protein C-terminus(TIM3OST mice)(Figs.1a and S1a)and affinity purification coupled with mass spectrometry(AP-MS),we herein defined the composition and dynamics of the signaling protein complex(signalosome)used by TIM3 in primary effector T *** results provide a more complete model of TIM3 signaling and explain its paradoxical coinhibitory and costimulatory functions.

关键词： TIM3 expressing devoted

Helpfulness of the combination of acetic acid and FICE in the detection of Barrett's epithelium and Barrett's associated neoplasias

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World Journal of Gastroenterology 2012年第16期18卷 1921-1925页

作者： Marine Camus romain Coriat Sarah Leblanc Catherine Brezault Benoit Terris Elise Pommaret Marianne Gaudric Ariane Chryssostalis Frederic Prat Stanislas Chaussade Gastroenterology and Endoscopy Unit Cochin HospitalAssistance Publique-Hpitaux de ParisUniversité Paris DescartesSorbone Paris Cité75014 ParisFrance Pathology Department Cochin HospitalAssistance Publique-Hpitaux de ParisUniversité Paris DescartesSorbone Paris Cité75014 ParisFrance

AIM:To investigate the mucosal morphology in Barrett's oesophagus by chromo and magnifying ***:A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid pulverisation combined with virtual chromoendoscopy using Fujinon intelligent chromoendoscopy(FICE) for semiological characterization of the mucosal morphology in Barrett's oesophagus and its neoplastic *** endoscopy using high definition whitelight,2% acid acetic pulverisation and FICE with high definition videoendoscopy were performed in 20 patients including 18 patients who presented with aspects of Barrett's oesophagus at endoscopy *** patients used as controls had normal endoscopy and histological ***,videos were watched blind from histological results by three trained FICE technique ***:The videos of patients with high-grade dysplasia showed an irregular mucosal pattern in 14% using high definition white light endoscopy and in 100% using acid acetic-FICE *** did not identify irregular vascular patterns using high definition white light endoscopy,while acid acetic-FICE combined visualised one in 86% of ***:Combined acetic acid and FICE is a promising method for screening high-grade dysplasia and early cancer in Barrett's oesophagus.

关键词： Acetic acid Barrett's metaplasia Chromoendoscopy Fujinon intelligent chromoendoscopy

地质观测、地震剖面和重力测量的综合方法在前陆褶皱冲断带的应用：以天山北麓呼图壁河剖面为例

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地球物理学报 2014年第1期57卷 75-87页

作者：陈科 GUMIAUX Charles AUGIER romain 陈岩梅岩辉林伟王清晨中国地质调查局油气资源调查中心北京100029 奥尔良大学地球科学系法国奥尔良45071 中国科学院地质与地球物理研究所北京100029

褶皱逆冲带的几何学研究是造山带研究的热点,但是无论是传统构造地质学方法还是地球物理学方法都在研究褶皱逆冲带几何特征时存在多解性.为了制约这种多解性,本文以天山北麓的呼图壁河剖面为列,介绍一种地质与地球物理相结合的研究方法... 详细信息

褶皱逆冲带的几何学研究是造山带研究的热点,但是无论是传统构造地质学方法还是地球物理学方法都在研究褶皱逆冲带几何特征时存在多解性.为了制约这种多解性,本文以天山北麓的呼图壁河剖面为列,介绍一种地质与地球物理相结合的研究方法.该方法首先沿呼图壁河剖面进行详细的地表观测,获取地表的构造地质数据形成初步的地质模型,其次结合地表构造和钻井分层数据,对收集到的石油地震剖面进行重新解释.然而,地震反射数据只分布在盆地内部,在盆山结合带缺失或者不清晰,因此对该剖面进行了重力测量并计算出布格重力异常.结合盆地各沉积地层和基底密度值,用重力正演方法模拟呼图壁河剖面的密度结构.研究结果显示沿呼图壁河剖面并不存在天山北缘断裂,盆地的沉积盖层可以从准噶尔盆地连续过度到天山内部并不整合覆盖在天山古生代基底之上.这一结果与西段金钩河剖面的天山基底逆冲到准噶尔盆地显然不同,说明了天山北缘盆山结合带构造的多样性.利用平衡剖面技术,恢复的呼图壁河平衡剖面缩短量约为4.8km,对比前人研究,说明了天山北缘的缩短量沿东西方向存在显著的不均一性.本研究也说明这种构造地质与地震及非震地球物理相结合的方法可以广泛地被应用于褶皱逆冲带.

关键词：天山褶皱逆冲带构造观测地震剖面重力测量多学科综合

Deep learning methods for biotic and abiotic stresses detection and classification in fruits and vegetables:State of the art and perspectives

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Artificial Intelligence in Agriculture 2023年第3期9卷 46-60页

作者： Sèton Calmette Ariane Houetohossou Vinasetan Ratheil Houndji Castro Gbêmêmali Hounmenou Rachidatou Sikirou romain Lucas Glele Kakaï Laboratoire de Biomathématiques et d'Estimations Forestières Faculty of Agronomic SciencesUniversity of Abomey-Calavi04 BP 1525CotonouBenin Institut de Formation et de Recherche en Informatique University of Abomey-Calavi01 BP 526CotonouBenin Laboratoire de Défense des Cultures Centre de Recherches Agricoles d'AgonkanmeyInstitut National des Recherches Agricoles du Bénin(INRAB)01 BP 884CotonouBenin

Deep Learning(DL),a type of Machine Learning,has gained significant interest in many fields,including *** paper aims to shed light on deep learning techniques used in agriculture for abiotic and biotic stress detection in fruits and vegetables,their benefits,and the challenges faced by *** papers were collected from Web of Science,Scopus,Google Scholar,Springer,and Directory of Open Access Journals(DOAJ)using combinations of specific keywords such as:’Deep Learning’OR’Artificial Intelligence’in combination with fruit disease’,vegetable disease’,‘fruit stress',OR‘vegetable stress'following PRISMA *** the initial 818 papers identified using the keywords,132 were reviewed after excluding books,reviews,and the *** recovered scientific papers were from 2003 to 2022;93%addressed biotic stress on fruits and *** most common biotic stresses on species are fungal diseases(grey spots,brown spots,black spots,downy mildew,powdery mildew,and anthracnose).Few studies were interested in abiotic stresses(nutrient deficiency,water stress,light intensity,and heavy metal contamination).Deep Learning and Convolutional Neural Networks were the most used keywords,with GoogleNet(18.28%),ResNet50(16.67%),and VGG16(16.67%)as the most used ***-two percent of the data used to compile these models come from the fields,followed by data obtained *** problems due to unbalanced classes and the small size of some databases were also *** provided the research gaps and some perspectives from the reviewed *** research works are required for a deep understanding of the use of machine learning techniques in fruit and vegetable studies:collection of large datasets according to different scenarios on fruit and vegetable diseases,evaluation of the effect of climatic variability on the fruit and vegetable yield using AI methods and more abiotic stress studies.

关键词： Deep learning Prediction Fruits Vegetables Stress Agricultural yield

Microbial markers in colorectal cancer detection and/or prognosis

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World Journal of Gastroenterology 2018年第22期24卷 2327-2347页

作者： romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet Université Clermont Auvergne Research Biologics Sanofi R&D Chirurgie digestive Centre Hospitalier Universitaire Université Clermont Auvergne Institut Universitaire de Technologie de Clermont-Ferrand

Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations.

关键词： Colorectal cancer microbiota F.nucleatum Colibactin-producing E.coli prognostic markers diagnostic markers dysbiosis

Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells: An In-Vitro Model to Predict Cardiac Effects of Drugs

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Journal of Biomedical Science and Engineering 2017年第11期10卷 527-549页

作者： romain Sube Eric A. Ertel Idorsia Pharmaceuticals Ltd. Allschwil Switzerland

Introduction: Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) form spontaneously beating syncytia in-vitro. We evaluated whether hiPSC-CM are a compelling model of human cardiac pharmacology useful for early drug development. Methods: We measured hiPSC-CM beating frequency using Ca-sensitive dyes and a high-throughput screening system. We quantified the effects of 640 drugs with various structures and pharmacologies. Results: When tested at 1 μM, most drugs without direct effects on heart rhythm or with effects at high concentrations do not change frequency, indicating specificity. In contrast, the preparation detects compounds with direct activity on heart rhythm, demonstrating sensitivity. In particular, β-adrenergic agonists increase frequency and the model differentiates β2 from β1 agonists, as well as partial from full agonists. Phosphodiesterase inhibitors have subtype-specific actions and PDE4 is particularly important in controlling frequency. The preparation is sensitive to cardiac ion channel blockers: L-type calcium channel blockers, Class-I and Class-III antiarrhythmics change frequency but drugs acting on KATP channels do not. The assay detects compounds blocking the cardiac rapid delayed-rectifier K channel and is an alternative to the classic “hERG test”. Conclusion: hiPSC-CM are a useful in-vitro cardiac model in drug development since they respond appropriately to drugs that modify heart rate in humans.

关键词： Cardiomyocytes Rhythm iPS Cell Phenotypic Screening Pharmacology

Matched or nonmatched interventions based on the transtheoretical model to promote physical activity.A meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2018年第1期7卷 50-57页

作者： Ahmed Jerome romain Catherine Bortolon Mathieu Gourlan Marion Carayol Emmanuelle Decker Olivier Lareyre Grégory Ninot Julie Boiché Paquito Bernard EA4556 Laboratory Epsylon-Dynamics of Human Abilities and Health Behaviours University of Montpellier Montpellier 34000 France Challenge for the Change of Behaviour (CCB) Group Montpellier 34000 France University of Montreal Hospital Research Centre Montreal Quebec H2X OA9 Canada Unit of Adult Psychiatry La colombiere University Hospital of Montpellier Montpellier 34295 France Prevention Department of institut Regional du Cancer de Montpellier Epidaure Montpellier 34298 France Research Centre of the University Hospital of Quebec Quebec GIR 2J6 Canada Cancer Research Centre University of LavaL Quebec G1R 3S3 Canada School of Psychology University of Laval Quebec G1C OA6 Canada

Purpose: The aim of this study was to examine whether the efficacy of transtheoretical model(TTM)-based interventions on physical activity(PA)varied according to the following criteria:(1) interventions targeted the actual stages of change(SOCs) or did not;(2) participants were selected according to their SOC or were not; and(3) its theoretical constructs(decisional balance, temptation, self-efficacy, processes of change).Methods: Thirty-three randomized controlled trials assessing TTM-based interventions promoting PA in adults were systematically ***: The between-group heterogeneity statistic(Qb) did not reveal any differential efficacy either in interventions targeting the actual SOC compared with those that did not(Qb = 1.48, p = 0.22) or in interventions selecting participants according to their SOC compared with those that did not(Qb = 0.01, p = 0.91). TTM-based interventions enhanced PA behavior whether they targeted the actual SOC(Cohen's d = 0.36; 95%confidence interval(CI): 0.22–0.49) or not(d = 0.23; 95%CI: 0.09–0.38) and whether they selected their participants according to their SOC(d = 0.33; 95%CI: 0.13–0.53) or not(d = 0.32; 95%CI: 0.19–0.44). The moderators of the efficacy of TTM-based interventions were the number of theoretical constructs used to tailor the intervention(Qb = 8.82, p = 0.003), the use of self-efficacy(Qb = 6.09, p = 0.01), and the processes of change(Qb = 3.51, p = 0.06).Conclusion: TTM-based interventions significantly improved PA behavior, and their efficacy was not moderated by SOC but by the TTM theoretical constructs.

关键词： Exercise Interventions Meta-regression Moderators Processes of change Stages of change Theory-based

Second-line therapy for gemcitabine-pretreated advanced or metastatic pancreatic cancer

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World Journal of Gastroenterology 2012年第12期18卷 1357-1364页

作者： romain Altwegg Marc Ychou Vanessa Guillaumon Simon Thezenas Pierre Senesse Nicolas Flori Thibault Mazard Ludovic Caillo Stéphanie Faure Emmanuelle Samalin Eric Assenat the Oncology and Digestive Endoscopy Department of the CRLC Val d'Aurelle 34000 MontpellierFrance

AIM： To investigate second-line chemotherapy in gemcitabine-pretreated patients with advanced or metastat- ic pancreatic cancer [（frequency, response, outcome, course of carbohydrate antigen 19-9 （CA 19-9）].METHODS： This retrospective study included all patients with advanced or metastatic pancreatic cancer （adenocarcinoma or carcinoma） treated with secondline chemotherapy in our center between 2000 and 2008. All patients received first-line chemotherapy with gemcitabine, and prior surgery or radiotherapy was permitted. We analyzed each chemotherapy protocol for second-line treatment, the number of cycles and the type of combination used. The primary endpoint was overall survival. Secondary endpoints included progression-free survival, response rate, grade 3-4 toxicity, dosage modifications and CA 19-9 course.a second-line therapy among 206 patients who had initially received first-line treatment with a gemcitabi- ne-based regimen. Median number of cycles was 4 （range： 1-12） and the median duration of treatment was 2.6 mo （range： 0.3-7.4）. The overall disease control rate was 40.0%. The median overall survival and progression-free survival from the start of second-line therapy were 5.8 （95% CI： 4.1-6.6） and 3.4 mo （95% CI： 2.4-4.2）, respectively. Toxicity was generally acceptable. Median overall survival of patients with a CA 19-9 level declining by more than 20% was 10.3 mo （95% CI： 4.5-11.6） vs 5.2 mo （95% CI： 4.0-6.4） for others （P = 0.008）.CONCLUSION： A large proportion of patients could benefit from second-line therapy, and CA 19-9 allows efficient treatment monitoring both in first and secondline chemotherapy.

关键词： Second-line Chemotherapy Pancreatic can-cer Gemcitabine Carbohydrate antigen 19-9