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A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface

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International Journal of oral Science 2024年第2期16卷 225-237页

作者： William Macalester Asme Boussahel Rafael o.Moreno-Tortolero Mark R.Shannon Nicola West Darryl Hill Adam Perriman School of Cellular and Molecular Medicine Biomedical Sciences BuildingUniversity of BristolUniversity WalkBristolUnited Kingdom Bristol Centre for Functional Nanomaterials HH Wills Physics LaboratoryUniversity of BristolTyndall AvenueBristolUnited Kingdom Centre for Protolife Research School of ChemistryUniversity of BristolCantocks CloseBristolUnited Kingdom Max Planck-Bristol Centre for Minimal Biology School of ChemistryUniversity of BristolBristolUnited Kingdom Periodontology Bristol Dental SchoolUniversity of BristolLower Maudlin StreetBristolUnited Kingdom

Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral ***,the oral cavity presents a unique and challenging environment for in vivo bone tissue engineering,exhibiting both hard and soft periodontal tissue as well as acting as key biocenosis for many distinct microbial communities that interact with both the external environment and internal body systems,which will impact on cell fate and subsequent treatment ***,we design and bioprint a facile 3D in vitro model of a human dentine interface to probe the effect of the dentine surface on human mesenchymal stem cells(hMSCs)encapsulated in a microporous hydrogel *** demonstrate that the dentine substrate induces osteogenic differentiation of encapsulated hMSCs,and that both dentine andβ-tricalcium phosphate substrates stimulate extracellular matrix production and maturation at the gel-media interface,which is distal to the gel-substrate *** findings demonstrate the potential for long-range effects on stem cells by mineralized surfaces during bone tissue engineering and provide a framework for the rapid development of 3D dentine-bone interface models.

关键词： interface den surface

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Sociodemographic determinants associated with breastfeeding in term infants with low birth weight in Latin American countries

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World Journal of Clinical Pediatrics 2024年第1期13卷 141-149页

作者： Carlos Javier Avendaño-Vásquez Magda Liliana Villamizar-osorio Claudia Jazmin Niño-Peñaranda Judith Medellín-olaya Nadia Carolina Reina-Gamba School of Nursing Antonio Nariño UniversityBogotá111511Colombia School of Nursing Universidad Cooperativa de ColombiaBucaramanga 102536Colombia School of Nursing Universidad Nacional de ColombiaColombia 111511Colombia

BACKGRoUND A progressive decrease in exclusive breastfeeding(BF)is observed in Latin America and the Caribbean compared with global *** possibility of being breastfed and continuing BF for>6 months is lower in low birth weight than in healthy-weight *** To identify factors associated with BF maintenance and promotion,with particular attention to low-and middle-income countries,by studying geographic,socioeconomic,and individual or neonatal health *** A scoping review was conducted in 2018 using the conceptual model of social determinants of health published by the Commission on Equity and Health Inequalities in the United *** extracted data with common characteristics were synthesized and categorized into two main themes:(1)Sociodemographic factors and proximal determinants involved in the initiation and maintenance of BF in low-birth-weight term infants in Latin America;and(2)individual characteristics related to the self-efficacy capacity for BF maintenance and adherence in low-birth-weight term *** This study identified maternal age,educational level,maternal economic capacity,social stratum,exposure to BF substitutes,access to BF information,and quality of health services as mediators for maintaining *** Individual self-efficacy factors that enable BF adherence in at-risk populations should be analyzed for better health outcomes.

关键词： Breastfeeding Low birth weight Latin America Self-efficacy Social determinants of health

Generation of lossy mode resonances(LMR)using perovskite nanofilms

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opto-Electronic Advances 2024年第2期7卷 33-40页

作者： Dayron Armas Ignacio R.Matias M.Carmen Lopez-Gonzalez Carlos Ruiz Zamarreño Pablo Zubiate Ignacio del Villar Beatriz romero Electrical Electronic and Communications Engineering DepartmentPublic University of NavarraPamplona 31006Spain Institute of Smart Cities(ISC) Public University of NavarraPamplona 31006Spain Experimental Science and Technology School Rey Juan Carlos UniversityMostoles 28933Spain

The results presented here show for the first time the experimental demonstration of the fabrication of lossy mode resonance(LMR) devices based on perovskite coatings deposited on planar waveguides. Perovskite thin films have been obtained by means of the spin coating technique and their presence was confirmed by ellipsometry, scanning electron microscopy, and X-ray diffraction testing. The LMRs can be generated in a wide wavelength range and the experimental results agree with the theoretical simulations. overall, this study highlights the potential of perovskite thin films for the development of novel LMR-based devices that can be used for environmental monitoring, industrial sensing, and gas detection, among other applications.

关键词： perovskite thin films slab waveguide lossy mode resonance

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Sickle cell retinopathy and systemic disease

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Annals of Eye Science 2024年第2期9卷 53-61页

作者： oladipupo o.Anibire Daniel ABrill Basil K.Williams Jr Meharry Medical College NashvilleTNUSA Department of ophthalmology University of Cincinnati College of MedicineCincinnatiOHUSA Cincinnati Eye Institute CincinnatiOHUSA Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA

Sickle cell disease(SCD)is a widespread hemoglobinopathy that results in significant patient morbidity and *** occlusion can cause acute pain,acute chest syndrome,and avascular necrosis,while hemolysis and endothelial disruption can cause ischemic stroke,leg ulcers,pulmonary hypertension,and *** ocular and orbital structures can be affected by SCD ischemic events,including orbital bone infarction,ischemic optic neuropathy,retinal artery occlusion,hyphema,secondary glaucoma,sickle cell maculopathy,and sickle cell *** sickle cell retinopathy(PSR)is the most common cause of vision *** PSR can lead to macular ischemia,vitreous hemorrhage,and tractional retinal *** screening exams and multimodal imaging can lead to earlier detection of sickle cell retinopathy and improved patient *** patients undergoing vitreoretinal surgery may require coordination of care with hematologists to avoid ischemic *** hydroxyurea was the only United States Food and Drug Administration approved treatment for several decades,patients with SCD now have several more treatment *** the United States screening all infants for SCD,there can be delays in diagnosis and *** review article aims to provide an overview of sickle disease for the ophthalmologist,and to discuss emerging treatment options and current management of SCD ocular complications.

关键词： Sickle cell anemia sickle cell disease(SCD) sickle cell retinopathy retinal detachment vitreous hemorrhage(VH)

A new look at the first dinosaur discovered in Antarctica: reappraisal of Antarctopelta oliveroi(Ankylosauria: Parankylosauria)

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Advances in Polar Science 2024年

作者： Sergio SoTo ACU?A Alexander o.VARGAS Jonatan KALUZA Consejo Nacional de Investigaciones Científicas y Técnicas (CoNICET) Red Paleontológica U-Chile，Departamento de Biología， Facultad de Ciencias， Universidad de Chile Fundación de Historia Natural Félix de Azara， Universidad Maimónides Escuela de Geología，Facultad de Ciencias， Ingeniería y Tecnología， Universidad Mayor， Providencia

The first dinosaur discovered in the Antarctic continent was the ankylosaur Antarctopelta oliveroi in the 1980s. Nevertheless， since then several hypotheses of phylogenetical relationships have been proposed because these have been depended on how the skeletal remains have been interpreted. The main obstacle for clarifying its phylogenetic position is that many portions of the skeleton remain unknown， in addition to the presence of unknown characters in typical ankylosaurs. Considered an ankylosaurid， nodosaurid， or even a chimaera， a recent proposal based on mostly complete material of a new ankylosaur from Chilean Patagonia provided support for a novel phylogenetic hypothesis: Antarctopelta and other southern ankylosaurs are an early branching clade， the Parankylosauria， whose origin probably dates to the Late Jurassic. In the light of this new view， a redescription of the available skeletal remains is provided together with a new reconstruction of the first Antarctic dinosaur known to the science community.

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Glucagon-like peptide-1 agonists:Role of the gut in hypoglycemia unawareness,and the rationale in type 1 diabetes

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World Journal of Diabetes 2024年第11期15卷 2167-2172页

作者： Hyder o Mirghani Internal Medicine University of TabukTabuk 51941TabukSaudi Arabia

Type 1 diabetes is increasing and the majority of patients have poor glycemic *** advanced technology and nanoparticle use have greatly enhanced insulin delivery and glucose monitoring,weight gain and hypoglycemia remain major challenges and a constant source of concern for patients with type 1 *** 1 diabetes shares some pathophysiology with type 2 diabetes,and an overlap has been *** above observation created great interest in glucagon-like peptide-1 receptor agonists(GLP-1)as adjuvants for type 1 *** trials confirmed the positive influence of GLP-1 agonists onβcell ***,hypoglycemia unawareness and dysregulated glucagon response have been previously reported in patients with recurrent hypoglycemia using GLP-1 *** et al found that the source of glucagon dysregulation due to GLP-1 agonists resides in the *** explanations could be gut nervous system dysregulation or gut microbiota *** review evaluates the potential of GLP-1 agonists in managing type 1 diabetes,particularly focusing on their impact on glycemic control,weight management,and glucagon *** provide a broader insight into the problem of type 1 diabetes mellitus management in the light of recent findings and provide future research directions.

关键词： Glucagon-like peptide-1 receptor agonists Glucagon response Hypoglycemia unawareness Gut Type 1 diabetes

Green retrofitting of heritage buildings based on(3Ts)framework:An applied case study

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Frontiers of Architectural Research 2024年第4期13卷 776-798页

作者： Alaa o.Shehata Asmaa M.Hassan Merhan M.Shahda Naglaa A.Megahed Architectural Engineering and Urban Planning Department Faculty of EngineeringPort Said UniversityPort SaidEgypt

Diverse heritage architecture characterizes Port Said in Egypt,reflecting European and Arab *** Canal heritage villas comprise 25%of the total listed heritage buildings in the ***,it is important to retrofit them,aligning with the Sustainable Development Goals(SDGs).By reviewing the previous literature related to the green retrofitting of heritage buildings,the(3Ts)framework can be considered a holistic framework that covers the latest trends due to its three components:targets,tools,and tasks,which help the success of the process through a holistic vision of supporting building information modeling(BIM)technologies and organizing stakeholders’*** paper aims to apply the(3Ts)framework to Suez Canal heritage villas in Port Said,*** applied study is based on how stakeholders perceive their input and decision-making,measuring the climate parameters,proposing several green retrofits,and integrating them into green *** of scenarios is conducted by utilizing the Design Builder simulation ***,the Skelion plugin calculates the photovoltaic system’s(PVs)energy *** results indicated that the total energy savings could reach approximately 12%e74%and nearly 10%e73%Co₂emissions reduction without affecting heritage values.

关键词： Green retrofitting Heritage buildings BIM BES Suez Canal heritage villas Port Said/Egypt

Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder

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World Journal of Psychiatry 2024年第1期14卷 159-178页

作者： Renee J Dufault Katherine M Adler David o Carpenter Steven G Gilbert Raquel A Crider College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGRoUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their *** may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ***-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sample t-tests were conducted to determine any differences in mean diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the

关键词： Epigenomics Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals

Temperature Trends and Accumulation of Chill Hours, Chill Units, and Chill Portions in South Carolina

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Atmospheric and Climate Sciences 2024年第2期14卷 173-190页

作者： José o. Payero Edisto Research and Education Center Clemson University Blackville SC USA Department of Agricultural Sciences Clemson University Clemson SC USA

There is considerable concern about the potential impact of climate change on agriculture, such as the accumulation of chilling hours needed to break the dormancy of many perennial plants, like fruit trees. Therefore, this study aimed to determine if there had been a significant change in air temperatures and chill hours, chill units, and chill portion accumulation in South Carolina over the last two decades. Two decades of daily maximum (Tmax) and minimum (Tmin) air temperature records were obtained from weather stations in thirty-one counties in South Carolina. Hourly temperature data, reconstructed from the daily data, were used to calculate the daily and annual chill hours, chill units, and chill portions accumulation using four different chill models for each location and year. The chill models included the T(t) °C model, the 0°C °C model, the Utah model, and the Dynamic model. For each county, regression analyses were conducted to evaluate the historical trends. Despite year-to-year variability, the tendency was a statistically significant (α = 0.05) increase in air temperature, averaging 0.089°C per year for 20 out of 31 counties in South Carolina. The other 11 counties had no significant change in temperature. The average temperature increase in the 31 counties was 0.072°C per year. The temperature increase resulted in a decrease in annual chill accumulation during the fall to spring, averaging 17.7 chill hours, 8.6 chill hours, 17.0 chill units, and 0.40 chill portions per year calculated with the T(t) °C, 0°C °C, Utah, and Dynamic models, respectively. However, whether this decrease in chill values was statistically significant or not depended on the chill model used. This study did not investigate the cause of the observed historical trends in temperature and chill accumulation. Still, if the trends continue, they could significantly impact the future of the temperate fruit tree industry in the state.

关键词： Chill Hours Chill Units Chill Portions Temperature Fruit Trees Climate Change Dormancy