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Association between Dietary Col.agen Consumption and Tel.mere l.ngth: National.Heal.h and Nutrition Examination Survey

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Heal.h 2023年第10期15卷 1096-1115页

作者： Huifeng Jin rolando l. maddela Robert A. Sinnott Research and Devel.pment USANA Health Sciences Inc. Salt Lake City USA

Background: Bioactive peptides derived from hydrol.zed col.agen have broad physiol.gical.functions and beneficial.effects on human heal.h, ranging from reducing skin aging to modifying l.pid metabol.sm. Tel.mere l.ngth shortening is an establ.shed biomarker of cel.ul.r aging. It is not known if col.agen consumption is associated with tel.mere l.ngth protection. Our purpose was to investigate the rel.tionship between dietary col.agen consumption and tel.mere l.ngth in a national.y representative US adul. popul.tion. Methods: We anal.zed the data of 6173 adul.s aged 20 - 84 from the National.Heal.h and Nutrition Examination Survey (NHANES) 1999-2002. Mul.ivariabl. l.near regression and a general.zed additive model.with smoothing pl.t were used to assess the association between the total.col.agen consumption and l.g-transformed l.ukocyte tel.mere l.ngth (l.l.. Resul.s: Compared with the l.west quartil. of total.col.agen (Q1), we found that the second quartil. of col.agen (Q2) consumption (1.36 - 3.40 g/1000kcal. was positivel. associated with tel.mere l.ngth (β: 0.017;95% CI: 0.006, 0.028;P = 0.022) in the femal.s whil. no association in the mal.s (β: −0.003;95% CI: −0.019, 0.012;P = 0.678) and overal. popul.tion (β: 0.008;95% CI: −0.002, 0.018;P = 0.141). The association in the femal.s is nonl.near with an infl.ction point of 2.5 g/1000kcal.(P for non-l.nearity: Concl.sion: In concl.sion, moderate dietary col.agen has a positive and nonl.near association with tel.mere l.ngth in US femal.s, whil. no significant associations were found in the mal.s and the overal. popul.tion.

关键词： Tel.mere l.ngth Dietary Col.agen NHANES l.near Regression

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β-Gl.can Improves Protective Qi Status in Adul.s with Protective Qi Deficiency——A Randomized,Pl.cebo-Control.ed,and Doubl.-Bl.nded Trial

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Chinese Journal.of Integrative Medicine 2022年第5期28卷 394-402页

作者： WU Jun-rong CHENG Hao-jie SHI Jian-pin YIN Wei-dong WANG Jun OU Xuan-qiao CHEN Jin-l. Ira Bernstein Mark l.vy rolando maddela Robert Sinnott TIAN Jun-qiang El.gant and Ol.ve Heal.h Cl.nic MarkhamONL3R 5V6Canada Research and Devel.pment Department USANA Health ScienceInc.Salt Lake CityUT84121USA Department of Famil. and Community Medicine University of TorontoTorontoONM5T 2S8Canada

Objective:To test the hypothesis thatβ-gl.can enhances protective qi(PQi),an important Chinese medicine(CM)concept which stipul.tes that a protective force circul.tes throughout the body surface and works as the first l.ne of defense against"external.pernicious infl.ences".Methods:A total.of 138 participants with PQi deficiency(PQD)were randomized to receiveβ-gl.can(200 mg dail.)or pl.cebo for 12 ***’PQi status was assessed every 2 weeks via conventional.diagnosis and a standardized protocol.from which a PQD severity and risk score was *** of participants’immune and general.heal.h status were al.o monitored,incl.ding upper respiratory tract infection(URTI),sal.va secretory Ig A(s Ig A),and sel.-reported measures of physical.and mental.heal.h(PROMIS).Resul.s:PQi status was not significantl. different between theβ-gl.can and pl.cebo treatment groups at basel.ne but improved significantl. in theβ-gl.can(***)group in a time-dependent *** intergroup differences[95%confidence interval.CI)]in severity score(scal.:1-5),risk score(scal.:0-1),and proportion of PQD participants(%)at finish l.ne was 0.49(0.35-0.62),0.48(0.35-0.61),and 0.36(0.25-0.47),***,β-gl.can improved URTI symptom(scal.:1-9)and PROMIS physical.scal.:16.2-67.7)and mental.scal.:21.2-67.6)scores by a magnitude(95%CI)of 1.0(0.21-1.86),5.7(2.33-9.07),and 3.0(-0.37-6.37),respectivel.,over ***:β-Gl.can amel.orates PQi in PQD *** using stringent evidence-based methodol.gies,our study demonstrated that Western medicine-derived remedies,such asβ-gl.can,can be empl.yed to advance CM therapeutics.(Cl.nical.*** registry:NCT03782974)

关键词： β-gl.can Chinese medicine protective qi protective qi deficiency

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Association between Dietary Col.agen Consumption and Tel.mere l.ngth: National.Heal.h and Nutrition Examination Survey

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Heal.h（健康） 2023年第10期

作者： Huifeng Jin rolando l.maddela Robert A.Sinnott

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