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Single organ hepatic artery vasculitis as an unusual cause of epigastric pain:A case report

World Journal of Clinical Cases 2022年第26期10卷 9384-9389页

作者： rojin kaviani Jessica Farrell Natasha Dehghan Sarvee Moosavi Internal Medicine University of British ColumbiaVancouver V5Z 1M9British ColumbiaCanada Division of Radiology Providence Health CareVancouver V5T 3N4British ColumbiaCanada Division of Rheumatology Providence Health CareVancouver V5T 3N4British ColumbiaCanada Division of Gastroenterology University of British ColumbiaVancouver V6Z 2K5British ColumbiaCanada

BACKGROUND Single-organ vasculitis(SOV)is characterized by inflammation of a blood vessel,affecting one organ,such as the skin,genitourinary system,or the aorta without systemic *** SOV is rare,with hepatic artery involvement reported only in two prior published ***,we presented a case of isolated hepatic artery vasculitis presenting after Pfizer-BioNTech mRNA corona virus disease 2019(COVID-19)*** SUMMARY A 50-year-old woman with hypertension presented to our Emergency Department with recurrent diffuse abdominal pain that localized to the epigastrium and emesis without diarrhea that began eight days after the second dose of the PfizerBioNTech COVID-19 *** work revealed an elevated C-reactive protein(CRP)of 19 mg/L(normal<4.8 mg/L),alkaline phosphatase 150 U/L(normal 25-105 U/L),gamma-glutamyl transferase(GGT)45 U/L(normal<43 U/L)and elevated immunoglobulins(Ig)G 18.4 g/L(normal 7-16 g/L)and IgA 4.4 g/L(normal 0.7-4 g/L).An abdominal computed tomography revealed findings in keeping with hepatic artery vasculitis.A detailed review of her history and examination did not reveal infectious or systemic autoimmune causes of her *** extensive autoimmune panel was ***-19polymerase chain reaction nasopharyngeal swab,human immunodeficiency virus,viral hepatitis and Heliobacter pylori serology were *** six months,the patient’s symptoms,and blood work spontaneously *** High clinical suspicion of SOV is required for diagnosis in patients with acute abdominal pain and dyspepsia.

关键词： Single organ vasculitis Hepatic artery gastrointestinal vasculitis COVID-19 vaccine Hepatic artery vasculitis Case report

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Complication of lengthening and the role of post-operative care, physical and psychological rehabilitation among fibula hemimelia

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World Journal of Clinical Cases 2022年第24期10卷 8482-8489页

作者： Maryam Salimi rojin Sarallah Salar Javanshir Seyed Peyman Mirghaderi Amirhossein Salimi Shokoufeh Khanzadeh Department of Orthopaedic Surgery Shiraz University of Medical SciencesShiraz 71936-13311Iran Department of Medicine Islamic Azad University Medical Branch of TehranTehran 713843809Iran Students'Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Department of Medicine Shahid Sadoughi University of Medical SciencesYazd ***Iran Student Research Committee Tabriz Sadoughi University of Medical SciencesTabriz 716534908Iran

There is a clear clinical need for efficient physiotherapy and rehabilitation programs during and after bone lengthening and reconstruction for gaining the optimal effect and also prevention or treatment of lengthening side *** tract infection is the most prevalent side effect during lengthening which could be prevented and treated initially via proper wound *** contractures are typically a consequence of the generated tension on the distracted *** can be managed by physiotherapy initially and surgically in later severe ***,it is essential to avoid muscle contracture development,which is the demonstration of the imbalanced muscle appeals on the joint to inhibit the following *** knee is the furthermost affected joint by the aforementioned problem due to the inherent lack of ligamentous and bony *** stiffness is the other possible unfavorable effect of *** happens because of extensive muscle contractures or may possibly be attributed to rigidity of the joint following the amplified pressure on the joint surface during the process of *** and occupational therapy including endurance and strength exercise as well as stretching play an important role during the rehabilitation periods for the prevention and also the treatment of muscle contracture and the following deformity and also joint ***,the effect of mental and physical rehabilitation programs should not be overlooked.

关键词： Fibular hemimelia Rehabilitation Reconstruction Lengthening

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Mesoscale fracture behavior of Longmaxi outcrop shale with different bedding angles:Experimental and numerical investigations

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第2期12卷 297-309页

作者： Jianping Zuo Jingfang Lu rojin Ghandriz Jintao Wang Yanhong Li Xiaoyan Zhang Jun Li Hongtao Li School of Mechanics and Civil Engineering China University of Mining and TechnologyBeijing100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyBeijing100083China Department of Mechanical Engineering University of MassachusettsDartmouth02747USA

The mechanical properties and fracturing mechanism of shale containing beddings are critically important in shale gas exploitation and wellbore *** investigate the effects of shale bedding on crack behavior and fracturing mechanism,scanning electron microscope(SEM)with a loading system was employed to carry out three-point bending tests on Longmaxi outcrop *** crack initiation and propagation of Longmaxi shale were observed and recorded by taking photos during *** cracking paths were extracted to calculate the crack length through a MATLAB *** peak load,fracture toughness and fracture energy all increase with the bedding angle from 0°to 90°.The crack length and energy were also found to increase with the bedding angle in the range of 0°-600 and then drop *** fracturing mechanism of shale includes the main crack affected by the bedding angle and disturbed by randomly distributed *** main cracking path was accompanied by several microcrack branches which could form an interconnected crack *** the main crack encounters larger sedimentary particles,it will deflect around the particles and then restore to the initial direction.A numerical technique using extended finite element method(XFEM)coupled with anisotropic cohesive damage criteria was developed,which is able to capture the dependence of crack propagations on bedding angle and sedimentary *** study sheds light on understanding and predicting mesoscale fracture behavior of shale with different bedding angles.

关键词： Longmaxi shale Three-point bending test Fracture toughness Fracture energy Crack propagation Anisotropic cohesive damage Extended finite element method(XFEM)

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Severe acute respiratory syndrome coronavirus 2 infection: Role of interleukin-6 and the inflammatory cascade

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World Journal of Virology 2022年第3期11卷 113-128页

作者： Mohaddeseh Bahmani rojin Chegini Elham Ghanbari Elham Sheykhsaran Parisa Shiri Aghbash HamedEbrahimzadeh Leylabadlo Ehsan Moradian Amir Masoud Kazemzadeh Houjaghan Hossein Bannazadeh Baghi Department of Virology Student Research CommitteeTabriz University of Medical SciencesTabriz 15731Iran Department of Medical Science Metabolic Liver Disease Research CenterIsfahan University of Medical SciencesIsfahan 81745-33871Iran Department of Medical Science Fertility and Infertility Research CenterHealth Technology InstituteKermanshah University of Medical SciencesKermanshah 67159-59167Iran Department of Microbiology Student Research CommitteeTabriz University of Medical SciencesTabriz 15731Iran Immunology Research Center Tabriz University of Medical SciencesTabriz 15731Iran Department of Virology Faculty of MedicineTabriz University of Medical SciencesTabriz 15731Iran Liver and Gastrointestinal Diseases Research Center Tabriz University of Medical SciencesTabriz 15731Iran Department of Medical Science Medical FacultyTabriz University of Medical SciencesTabriz ***Iran Department of Internal Medicine Medical FacultyTehran University of Medical SciencesTehran 14155-6559Iran Department of Virology Infectious and Tropical Diseases Research CenterTabriz University of Medical SciencesTabriz 15731Iran

Since December 2019,a novel coronavirus that represents a serious threat to human lives has *** is still no definite treatment for severe cases of the disease caused by this virus,named coronavirus disease 2019(COVID-19).One of the most considered treatment strategies targets the exaggerated immune regulator,and interleukin(IL)-6 is a crucial pro-inflammatory *** acute respiratory syndrome coronavirus 2(SARSCoV-2)cases show an elevated level of IL-6 related to disease ***-6 activity can be inhibited by the following:IL-6 itself,IL-6 signaling pathways such as Janus kinase and signal transducer and activator of transcription(JAK-STAT),gp130,IL-6R,and downstream activated ILs,such as IL-17 and IL-6 ***,according to these studies and their results,IL-6 blockade with anti-IL-6 or its receptor antibodies such as tocilizumab in COVID-19 is beneficial in severe cases and may reduce the mortality ***-STAT inhibitors block the cytokine storm by inhibiting several crucial pro-inflammatory mediators such as TNF-αand IL-6 and have shown various results in clinical ***-6 induces IL-17 secretion,and IL-17 is involved in the pathogenesis of inflammatory *** trials of anti-IL-17 drugs are currently recruiting,and anti-gp130 antibody is ***,this agent has shown positive effects in inflammatory bowel disease clinical trials and could be tested for *** study aimed to review the role of IL-6 in the cytokine storm and studies regarding IL-6 and blockade of its inflammatory pathways in COVID-19 to determine if any of these agents are beneficial for COVID-19 patients.

关键词： Anti-interleukin-6 COVID-19 Inflammation Interleukin-6 Interleukin-6 receptor SARS-CoV-2

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