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Insights on the structural characteristics of NDM-1: The journey so far

Advances in Biological Chemistry 2012年第4期2卷 323-334页

作者： Avneet Saini rohit Bansal Department of Biophysics Panjab University Chandigarh India

New Delhi metallo-β-lactamase (NDM-1) has created a medical storm ever since it was first reported;as it is active on virtually all clinically used β-lactam antibiotics. NDM-1 rampancy worldwide is now considered a nightmare scenario, particularly due to its rapid dissemination. An underlying theme in the majority of recent studies is structural characterization as knowledge of the three-dimensional structure of NDM-1 shall help find connections between its structure and function. Moreover, structural details are even critical in order to reveal the resistance mecha- nism to β-lactam antibiotics. In this perspective, we review structural characteristics of NDM-1 that have been delineated since its first report. We anticipate that these structure-function connections made by its characterization shall further serve as future guidelines for elucidating pathways towards de novo design of functional inhibitors.

关键词： NDM-1 Metallo-β-Lactamase Superbug β-Lactam Extended-Spectrum β-Lactamases

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Correlation between tear fluid and serum vitamin D levels

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Eye and Vision 2016年第1期3卷 178-182页

作者： Swaminathan Sethu rohit Shetty Kalyani Deshpande Natasha Pahuja Nandini Chinnappaiah Aarti Agarwal Anupam Sharma Arkasubhra Ghosh GROW Research Laboratory Narayana Nethralaya Foundation#258/A Hosur RoadNarayana Health CityBommasandra560099 BangaloreIndia Cornea and Refractive Surgery Division Narayana NethralayaBangaloreIndia

Background:Vitamin D deficiency is associated with a range of systemic diseases including ocular *** objective of this study is to measure tear vitamin D levels and investigate the correlation between serum and tear vitamin D ***:A total of 48 healthy volunteers without any systemic and ocular disease were recruited for this observational cohort *** was collected using clot activator coated Vacutainer®Plus *** fluid was collected using Schirmer’s *** and tear total 25-hydroxyvitamin D levels were measured by competitive chemiluminescent ELISA and the correlation between the levels were ***:The measured serum 25-hydroxyvitamin D level ranged between 3.3 and 27.5 ng/ml(Mean±SEM,9.4±0.7 ng/ml;Median 8.4 ng/ml).Significantly(p<0.0001)higher level of 25-hydroxyvitamin D was detected in the tears(Mean±SEM,17.0±1.6 ng/ml;Range 3.2–45.8 ng/ml;Median,16.3 ng/ml)compared to *** average of~2 fold(Mean±SEM,1.9±0.2;Range 0.4–5.8;Median,1.7)higher 25-hydroxyvitamin D was observed in tears compared to serum in the *** addition,a positive correlation was observed between serum and tear 25-hydroxyvitamin D levels(r=0.5595;p<0.0001).Conclusions:A higher level of 25-hydroxyvitamin D was observed in the tear fluid compared to that of the *** would be beneficial to consider tear vitamin D levels to study its role with reference to ocular surface diseases.

关键词： Vitamin D 25-hydroxyvitamin D 1,25-dihydroxyvitamin D Tears Serum

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Recent progress in emerging BiPO_(4)-based photocatalysts:Synthesis,properties,modification strategies,and photocatalytic applications

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Journal of Materials Science & Technology 2022年第13期108卷 208-225页

作者： rohit Kumar Pankaj Raizada Aftab Aslam Parwaz Khan Van-Huy Nguyen Quyet Van Le Suresh Ghotekar Rangabhashiyam Selvasembian Vimal Gandhi Archana Singh Pardeep Singh School of Advanced Chemical Sciences Shoolini UniversitySolan(Himachal Pradesh)-173212India Center of Excellence for Advanced Materials Research King Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia Chemistry Department Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia Faculty of Biotechnology Binh Duong UniversityThu Dau MotVietnam. Department of Materials Science and Engineering Korea University145Anam-ro Seongbuk-guSeoul 02841South Korea Department of Chemistry Smt.Devkiba Mohansinhji Chauhan College of Commerce and ScienceSilvassa 396230University of MumbaiDadra and Nagar Haveli(UT)India Department of Chemistry S.N.ArtsD.J.M.Commerce and B.N.S.Science CollegeSangamner 422605Savitribai Phule Pune UniversityMaharashtraIndia Department of Biotechnology School of Chemical and BiotechnologySASTRA Deemed UniversityThanjavur-613401TamilnaduIndia Department of Chemical Engineering Faculty of TechnologyDharmsinh Desai UniversityNadiad-387001GujaratIndia Advanced Materials and Processes Research Institute Hoshangabad RoadBhopal 462026India

In this perspective,we have highlighted the current literature and explained the synthesis,structure,morphology,modification strategies,and photocatalytic applications of emerging BiPO_(4)-based *** BiPO_(4)is a large bandgap photocatalyst,it uses UV light for the excitation of electrons,and also,the recombination of charge carriers is an issue in BiPO_(4).Various novel modification strategies of BiPO_(4)photocatalysts *** modifications,heterojunction formation,phase-junctions,surface plasmon resonance,Schottky junction have been successfully proposed and *** modifications enhance the light absorption and inhibit the recombination of charge carriers BiPO_(4)***,future aspects for further research on BiPO_(4)-based photocatalysts are also *** expects that BiPO_(4)-based photocatalysts represent a promising strategy for developing practical photocatalysts for energy and environmental remediation applications.

关键词： Photocatalysis Modification strategies Environmental remediation BiPO_(4)photocatalyst

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Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model

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World Journal of Clinical Oncology 2018年第8期9卷 188-199页

作者： Himani Garg rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey Talwar Research Foundation Neb Sarai Amity Institute of Virology and Immunology Amity University Uttar Pradesh

AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast *** Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer *** Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen *** Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches.

关键词： Immunotherapy Survivin Luteinizing hormone-releasing hormone fusion protein Combination immunotherapy Breast cancer

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A comprehensive review of approaches to detect fatigue using machine learning techniques

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Chronic Diseases and Translational Medicine 2022年第1期8卷 26-35页

作者： rohit Hooda Vedant Joshi Manan Shah Gandhinagar Institute of Technology Gujarat Technological UniversityGandhinagarGujaratIndia LJ Institute of Engineering and Technology Gujarat Technological UniversityAhmedabadGujaratIndia Department of Chemical Engineering School of TechnologyPandit Deendayal Energy UniversityGandhinagarGujaratIndia

In the past decades,there have been numerous advancements in the field of *** has led to many scientific breakthroughs in the field of medical *** this,rapidly transforming world we are having a difficult time and the problem of fatigue is becoming ***,this study aimed to understand what is fatigue,its repercussions,and techniques to detect it using machine learning(ML)*** paper introduces,discusses methods and recent advancements in the field of fatigue ***,we categorized the methods that can be used to detect fatigue into four diverse groups,that is,mathematical models,rule-based implementation,ML,and deep *** study presents,compares,and contrasts various algorithms to find the most promising approach that can be used for the detection of ***,the paper discusses the possible areas for improvement.

关键词： deep learning driver monitoring fatigue detection healthcare machine learning

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