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PACK-CXL *** therapy for bacterial,fungal,and mixed infectious keratitis:a prospective randomized phase 3 trial

Eye and Vision 2024年第1期10卷 10-20页

作者： Farhad Hafezi Mohammed Hosny rohit shetty Boris Knyazer Shihao Chen Qinmei Wang Hassan Hashemi Emilio A.Torres‑Netto 无 Center for Applied Biotechnology and Molecular Medicine(CABMM) University of ZurichZurichSwitzerland ELZA Institute DietikonSwitzerland. Faculty of Medicine University of GenevaGenevaSwitzerland Department of Ophthalmology Medical University of WenzhouWenzhouChina USC Roski Eye Institute University of Southern California Los AngelesLos AngelesUSA Department of Ophthalmology University of CairoCairoEgypt Narayana Nethralaya Eye Hospital and the Postgraduate Institute of Ophthal‑mology BangaloreIndia Department of Ophthalmology Soroka University Medical CenterBen-Gurion University of the NegevBeershebaIsrael Noor Ophthalmology Research Center Noor Eye HospitalTehranIran University Hospital Zurich ZurichSwitzerland. the PACK-CXL Working Group

Background:Infectious keratitis is a major cause of global *** tested whether standalone photoactivated chromophore corneal cross-linking(PACK-CXL)may be an efective frst-line treatment in early to moderate infectious keratitis,compared with standard antimicrobial ***:This is a randomized,controlled,multinational phase 3 clinical *** in fve centers in Egypt,India,Iran,Israel,and China,aged≥18 years,with infectious keratitis of presumed bacterial,fungal,or mixed origin,were randomly assigned(1:1)to PACK-CXL,or antimicrobial *** measures included healing,defned as time to re-epithelialization of the corneal epithelial defect in the absence of infammatory activity in the anterior chamber and clearance of stromal *** success was defned as the complete resolution of signs of ***:Between July 21,2016,and March 4,2020,participants were randomly assigned to receive PACK-CXL(n=18)or antimicrobial therapy per American Academy of Ophthalmology(AAO)guidelines(n=21).No participants were lost to *** eyes were excluded from the epithelialization time analysis due to treatment failure:two in the antimicrobial therapy group,and two in the PACK-CXL *** rates were 88.9%(16/18 patients)in the PACK-CXL group and 90.5%(19/21 patients)in the medication *** was no signifcant diference in time to complete corneal re-epithelialization(P=0.828)between both treatment ***:PACK-CXL may be an alternative to antimicrobial drugs for frst-line and standalone treatment of early to moderate infectious keratitis of bacterial or fungal origin.

关键词： Photoactivated chromophore Corneal cross-linking Infectious keratitis Corneal melting PACK-CXL

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Correlation between tear fluid and serum vitamin D levels

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Eye and Vision 2016年第1期3卷 178-182页

作者： Swaminathan Sethu rohit shetty Kalyani Deshpande Natasha Pahuja Nandini Chinnappaiah Aarti Agarwal Anupam Sharma Arkasubhra Ghosh GROW Research Laboratory Narayana Nethralaya Foundation#258/A Hosur RoadNarayana Health CityBommasandra560099 BangaloreIndia Cornea and Refractive Surgery Division Narayana NethralayaBangaloreIndia

Background:Vitamin D deficiency is associated with a range of systemic diseases including ocular *** objective of this study is to measure tear vitamin D levels and investigate the correlation between serum and tear vitamin D ***:A total of 48 healthy volunteers without any systemic and ocular disease were recruited for this observational cohort *** was collected using clot activator coated Vacutainer®Plus *** fluid was collected using Schirmer’s *** and tear total 25-hydroxyvitamin D levels were measured by competitive chemiluminescent ELISA and the correlation between the levels were ***:The measured serum 25-hydroxyvitamin D level ranged between 3.3 and 27.5 ng/ml(Mean±SEM,9.4±0.7 ng/ml;Median 8.4 ng/ml).Significantly(p<0.0001)higher level of 25-hydroxyvitamin D was detected in the tears(Mean±SEM,17.0±1.6 ng/ml;Range 3.2–45.8 ng/ml;Median,16.3 ng/ml)compared to *** average of~2 fold(Mean±SEM,1.9±0.2;Range 0.4–5.8;Median,1.7)higher 25-hydroxyvitamin D was observed in tears compared to serum in the *** addition,a positive correlation was observed between serum and tear 25-hydroxyvitamin D levels(r=0.5595;p<0.0001).Conclusions:A higher level of 25-hydroxyvitamin D was observed in the tear fluid compared to that of the *** would be beneficial to consider tear vitamin D levels to study its role with reference to ocular surface diseases.

关键词： Vitamin D 25-hydroxyvitamin D 1,25-dihydroxyvitamin D Tears Serum

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Tear biomarkers for keratoconus

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Eye and Vision 2016年第1期3卷 147-153页

作者： Krishnatej Nishtala Natasha Pahuja rohit shetty Rudy M.M.A.Nuijts Arkasubhra Ghosh Cornea Department Narayana NethralayaBangaloreIndia GROW Research Laboratory Narayana Nethralaya FoundationBangaloreIndia Cornea Clinic Department of OphthalmologyMaastricht University Medical CenterMaastrichtNetherlands

Keratoconus is a progressive corneal thinning,ectatic condition,which affects *** advances in corneal topography measurements has helped advance proper diagnosis of this condition and increased research and clinical interests in the disease *** progress has been achieved in understanding the progression of the disease and tear fluid has played a major role in the *** review discusses the importance of tear fluid as a source of biomarker for keratoconus and how advances in technology have helped map the complexity of tears and thereby molecular readouts of the *** knowledge of the tear proteome,lipidome and metabolome opened up new avenues to study keratoconus and to identify probable prognostic or diagnostic biomarkers for the disease.A multidimensional approach of analyzing tear fluid of patients layering on proteomics,lipidomics and metabolomics is necessary in effectively decoding keratoconus and thereby identifying targets for its treatment.

关键词： Keratoconus Tears Biomarkers Proteins Metabolites

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The impact of dysfunctional tear films and optical aberrations on chronic migraine

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Eye and Vision 2017年第1期4卷 18-21页

作者： rohit shetty Kalyani Deshpande Chaitra Jayadev Kareeshma Wadia Pooja Mehta Rushad Shroff Harsha L.Rao Department of Ophthalmology Narayana Nethralaya Eye Institute121/CChord Road1“R”BlockRajajinagarBangalore 560010KarnatakaIndia

Background:Migraine is a multifactorial disorder with complex neuronal and vascular mechanisms that encompasses a wide clinical spectrum of symptoms,including ocular *** eye disease and dysfunction of ocular somatosensory pathways have been implicated in the *** current study investigates the association between a dysfunctional tear film and ocular aberrations with ***:Sixty eyes of 30 patients with migraine and 60 eyes of 30 controls were *** eye evaluation included Schirmer’s test,tear film break-up time,corneal esthesiometry and lipid layer analysis using Lipiview^(®)*** aberrations were measured using Optical Path Difference before performing the dry eye *** intraocular light scatter was quantified using the objective scatter index(OSI)of the optical quality analysis *** parameters were compared between the migraine and the control group using independent sample *** analysis was performed using commercial software.A p value of≤0.05 was considered statistically ***:There were 19 females and 11 males in each *** significant difference was found between the two groups with respect to total aberrations(p=0.049),higher order aberrations(p=0.009),coma(p=0.03),spherical aberrations(p=0.018),Lipiview interferometric coloric units(p<0.001)and OSI(p<0.001).Trefoil(p=0.26)and TBUT(p=0.398)were not significantly different between both ***:Ocular aberrations are higher in patients with migraine as compared with *** film abnormalities add to the aberrations in otherwise asymptomatic patients and may also be associated with migraineous *** the ocular surface to obtain a healthy tear film might introduce a potential modifiable factor in the prevention of migraneous attacks.

关键词： Migraine Dry eye Aberrations

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Retinal structural-vascular-functional relationship using optical coherence tomography and optical coherence tomography -angiography in myopia

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Eye and Vision 2019年第1期6卷 51-62页

作者： Ramesh Venkatesh Shivani Sinha Deepika Gangadharaiah Santosh G.K.Gadde Ashwin Mohan rohit shetty Naresh Kumar Yadav Department of Retina and Vitreous Narayana Nethralaya#121/C1st R BlockChord RoadRajaji NagarBengaluru 560010India. Department of Cornea and Refractive surgery Narayana Nethralaya#121/C1st R BlockChord RoadRajaji NagarBengaluru 560010India

Background:To examine the retinal structure–vascular-function relationship using optical coherence tomography(OCT)and optical coherence tomography angiography(OCTA)in ***:This was a prospective cross-sectional study comprising 86 eyes of 45 individuals with varying axial lengths and spherical equivalents and no posterior segment *** eyes underwent optical coherence tomography with the Spectralis SD-OCT and OCTA with RTVue-XR Avanti;*** macular retinal layer thicknesses and flow areas and vessel densities were measured on OCT and OCTA,*** correlations were made between the macular layer thicknesses,flow areas and vessel densities with axial length,spherical equivalent and visual ***:The participants’mean ages were 33.34±14.45 years,mean spherical equivalent refractions were−7.17±5.71 D and axial lengths were 25.95±2.41 *** were significant positive correlations of foveal angle(r=0.757,p=0.001),inner retinal(r=0.764,p=0.001)and outer plexiform layer(r=0.771,p=0.001)thickness on OCT and vessel densities in deep capillary plexus(r=0.313,p=0.003)on OCTA with axial length and negative correlations with spherical equivalents and visual *** negative correlations of outer nuclear layer(r=−0.560,p=0.03)and photoreceptor outer segment layer thickness(r=−0.856,p<0.001)were noted on OCT with axial length and positive correlations with spherical equivalents and visual ***:The lateral retinal stretching in myopia could possibly explain the correlation between retinal layer thickness,vascular density and visual acuity in these *** research is required to investigate this.

关键词： Myopia Axial elongation Spherical equivalent OCT Optical coherence tomography angiography Structure Visual acuity

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Quantifying microstructural changes in retinitis pigmentosa using spectral domain – optical coherence tomography

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Eye and Vision 2019年第1期6卷 91-98页

作者： B.Poornachandra Aruj K.Khurana Preethi Sridharan Priyansha Chatterjee Chaitra Jayadev Naresh Kumar Yadav rohit shetty Department of Vitreo Retina Narayana Nethralaya Eye InstituteBangaloreIndia. Department of Ophthalmology Narayana Nethralaya Eye Institute121/CChord Road1“R”BlockRajajinagarBangaloreKarnataka 560010India

Background:Most patients of established retinitis pigmentosa(RP)have subnormal peripheral vision and heavily rely on central vision for their daily *** visual acuity is dependent on photoreceptor survival at the *** of structural changes that precede visual loss is *** aim of this study was to correlate the Spectral Domain-Optical Coherence Tomography(SD-OCT)characteristics with visual acuity in patients with typical ***:This was a retrospective,observational case series of 224 eyes of 113 RP patients conducted a tertiary eye care ***-OCT imaging was done for all *** retinal thickness(CRT),photoreceptor outer segment length(PROS),foveal outer segment pigment epithelial thickness(FOSPET)and ellipsoid zone(EZ)extent were measured.A new variable,FOSPET-PROS ratio(FPR),obtained by dividing FOSPET by PROS is defined and correlated to corrected distance visual acuity(CDVA)in logMAR using linear ***:Out of 113 patients,71 were males and 42 *** age of the patients was 35.4±15.1 *** CDVA was 0.33±0.25 logMAR with no difference between the *** CRT(218.74±83.5μm)and FPR(1.63±0.22)significantly correlated to CDVA with a correlation coefficient of r=−0.139(p=0.048)and r=0.842(p=0.0001),***(mean=71.15±13.8μm)and PROS(mean=44.85±12.5μm)did not show a significant correlation to CDVA,independent of ***:Retinal microstructural changes on SD-OCT,especially the FPR,can be used as a surrogate marker to monitor disease progression in the central retina in degenerative diseases like RP.

关键词： Retinitis Pigmentosa Photoreceptor outer segment length(PROS) Foveal outer segment pigment epithelial thickness(FOSPET) Ellipsoid zone(EZ) FOSPET-PROS ratio(FPR)

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Correction to:The impact of dysfunctional tear films and optical aberrations on chronic migraine

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Eye and Vision 2017年第1期4卷 150-150页

作者： rohit shetty Kalyani Deshpande Chaitra Jayadev Kareeshma Wadia Pooja Mehta Rushad Shroff Harsha LRao Department of Ophthalmology Narayana Nethralaya Eye Institute121/CChord Road1“R”BlockRajajinagarBangaloreKarnataka 560010India

Correction After publication of this article[1]it came to our attention that Table 1 was presented *** correct table can be found below。

关键词： migraine impact chronic

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