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Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

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Oncology Research 2024年第1期32卷 101-125页

作者： roghayeh ghorbani MAHMOUD GHARBAVI ALI SHARAFI ELHAM RISMANI HAMED REZAEEJAM YOUSEF MORTAZAVI BEHROOZ JOHARI Department of Medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjanIran Nanotechnology Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Department of Pharmaceutical Biotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran Molecular Medicine Department Biotechnology Research CenterPasteur Institute of IranPasteur AvenueTehranIran Department of Radiology Technology School of Allied Medical SciencesZanjan University of Medical SciencesZanjanIran

In the present study,we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer *** decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics *** were loaded on the synthesized Se@BSA@Chi-MTX *** physicochemical characteristics of nanostructures were determined by FTIR,DLS,UV-vis,TEM,EDX,in vitro release,and hemolysis ***,the cytotoxicity properties of them with and without X-irradiation were investigated by uptake,MTT,cell cycle,apoptosis,and scratch assays on the LNCaP cell *** results of DLS and TEM showed negative charge(−9 mV)and nanometer size(40 nm)for Se@BSA@Chi-DEC-MTX NPs,*** results of FTIR,UV-vis,and EDX showed the proper interaction of different parts and the correct synthesis of *** results of hemolysis showed the hemocompatibility of this nanoparticle in concentrations less than 6 mg/*** ODNs release from the nanostructures showed a pH-dependent manner,and the release rate was 15%higher in acidic *** targeted Se@BSA@Chi-labeled ODN-MTX NPs were efficiently taken up by LNCaP cells by targeting the prostate-specific membrane antigen(PSMA).The significant synergistic effects of nanostructure(containing MTX drug)treatment along with X-irradiation showed cell growth inhibition,apoptosis induction(~57%),cell cycle arrest(G2/M phase),and migration inhibition(up to 90%)compared to the *** results suggested that the Se@BSA@Chi-DEC-MTX NPs can potentially suppress the cell growth of LNCaP *** nanostructure system can be a promising approach for targeted drug delivery and chemoradiotherapy in prostate cancer treatment.

关键词： Chemoradiotherapy Combination therapy Decoy oligodeoxynucleotides Myc transcription factor Selenium nanoparticle Prostate cancer

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Annual growth of Fagus orientalis is limited by spring drought conditions in Iran’s Golestan Province

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Journal of Forestry Research 2024年第1期35卷 128-142页

作者： Khalil ghorbani Jahangir Mohammadi Laleh Rezaei Ghaleh Department of Water Engineering Faculty of Water and Soil EngineeringGorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Forestry Gorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Water Engineering Faculty of AgricultureUrmia UniversityUrmiaIran

Due to the lack of a uniform and accurate defi-nition of‘drought’,several indicators have been introduced based on different variables and methods,and the efficiency of each of these is determined according to their relationship with *** relationship between two drought indices,SPI(standardized precipitation index)and SPEI(standard-ized precipitation-evapotranspiration index)in different sea-sons was investigated using annual rings of 15 tree samples to determine the effect of drought on the growth of oriental beech(Fagus orientalis Lipsky)in the Hyrcanian forests of northern *** different evapotranspiration calcula-tion methods were evaluated on SPEI efficiency based on Hargreaves-Samani,Thornthwaite,and Penman-Monteith methods using the step-by-step M5 decision tree regression *** results show that SPEI based on the Penman-Monteith in a three-month time scale(spring)had similar temporal changes and a better relationship with annual tree rings(R^(2)=0.81)at a 0.05 significant *** change and a decreasing trend in the time series of annual tree rings are similar to the variation in the SPEI based on the Penman-Monteith *** affecting evapotranspiration,temperature,wind speed,and sunshine hours(used in the Penman-Monteith method),increased but precipitation *** non-linear modeling methods,SPEI based on Penman-Monteith best illustrated climate changes affecting tree growth.

关键词： Climate change Drought index Hyrcanian forests SPEI'Annual growth rings Fagus orientalis

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Modelling rapid non-destructive test using light weight deflectometer on granular soils across different degrees of saturation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2732-2748页

作者： Javad ghorbani Arooran Sounthararajah Troyee Tanu Dutta Jayantha Kodikara ARC Smart Pavements Hub Dept.of Civil EngineeringMonash UniversityVIC3800Australia

This study introduces an advanced finite element model for the light weight deflectometer(LWD),which integrates contact mechanics with fully coupled *** simulating LWD tests on granular soils at various saturation levels,the model accurately reflects the dependence of the LWD modulus on dry density,water content,and effective *** model addresses and overcomes the limitations of previous finite element models for this specific ***,this research presents the first experimentally validated fully coupled contact impact ***,the research provides a comparative assessment of elastoplastic and nonlinear elastic models and contrasts an enriched node-tosegment method(developed in this study)with the more precise mortar technique for contact *** comparisons reveal unique advantages and challenges for each ***,the study underscores the importance of careful application of the LWD modulus,emphasising the need for sophisticated tools to interpret soil behaviour accurately.

关键词： Granular soils Plasticity Finite element analysis Contact mechanics Modulus Degree of saturation

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Event segmentation in ADHD:neglect of social information and deviant theta activity point to a mechanism underlying ADHD

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General Psychiatry 2024年第3期37卷 431-439页

作者： Astrid Prochnow Xianzhen Zhou Foroogh ghorbani Veit Roessner Bernhard Hommel Christian Beste Cognitive Neurophysiology Department of Child and Adolescent PsychiatryFaculty of MedicineTU DresdenDresdenGermany Faculty of Psychology Shandong Normal UniversityJinanShandongChina

Background Attention-deficit/hyperactivity disorder(ADHD)is one of the most frequently diagnosed psychiatric conditions in children and *** the symptoms appear to be well described,no coherent conceptual mechanistic framework integrates their occurrence and variance and the associated problems that people with ADHD *** The current study proposes that altered event segmentation processes provide a novel mechanistic framework for understanding deficits in *** Adolescents with ADHD and neurotypically developing(NT)peers watched a short movie and were then asked to indicate the boundaries between meaningful segments of the *** recorded electroencephalography(EEG)data were analysed for differences in frequency band activity and effective connectivity between brain *** Compared with their NT peers,the ADHD group showed less dependence of their segmentation behaviour on social information,indicating that they did not consider social information to the same extent as their unaffected *** divergence was accompanied by differences in EEG theta band activity and a different effective connectivity network architecture at the source ***,NT adolescents primarily showed error signalling in and between the left and right fusiform gyri related to social information processing,which was not the case in the ADHD *** the ADHD group,the inferior frontal cortex associated with attentional sampling served as a hub instead,indicating problems in the deployment of attentional *** This study shows that adolescents with ADHD perceive events differently from their NT peers,in association with a different brain network architecture that reflects less adaptation to the situation and problems in attentional sampling of environmental *** results call for a novel conceptual view of ADHD,based on event segmentation theory.

关键词： instead meaningful primarily

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Exploring the relationship between ambient sulfur dioxide and semen quality parameters:A systematic review and meta-analysis

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Asian pacific Journal of Reproduction 2024年第1期13卷 12-21页

作者： Seyed Sobhan Bahreiny Mojtaba Aghaei Mohammad Reza Dabbagh Hamid ghorbani Moslem Javidan Reza Mohammadpour Fard Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Medical Basic Sciences Research Institute Physiology Research CenterDepartment of PhysiologySchool of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Biology Faculty of ScienceShahid Chamran University of AhvazAhvazIran Department of Immunology Faculty of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

Objective:To investigate the relationship between ambient sulfur dioxide(SO2)exposure and semen quality ***:A systematic literature search was conducted to identify relevant studies investigating the association between SO2 exposure and semen quality *** search encompassed the timeframe from January 2000 to May 2023 and included electronic databases such as Web of Science,Google Scholar,PubMed,Cochrane,and *** effect estimates with 95%confidence intervals(CI)were calculated using percent changes(PC).The meta-analysis included seven studies with 6711 participants and 15087 semen ***:The results revealed a significant negative association between ambient SO2 exposure and certain semen quality *** particular,SO2 exposure was associated with a significant decrease in progressive motility(PC=0.032;95%CI:-0.063 to-0.001;P=0.044)and sperm concentration(PC=-0.020;95%CI:-0.036 to-0.005;P=0.012).However,no statistically significant associations were observed for total sperm count(PC=-0.038;95%CI:-0.079 to 0.003;P=0.070),seminal fluid volume(PC=-0.009;95%CI:-0.048 to-0.030;P=0.662)and sperm motility(PC=-0.17;95%CI:-0.363 to 0.022;P=0.830).In addition,the results of the subgroup analysis revealed specific variables that were associated with the decrease in relevant sperm ***:This systematic review and meta-analysis provides compelling evidence supporting a consistent negative association between exposure to ambient SO2 and semen quality parameters.

关键词： Semen quality Sulfur dioxide Ambient air pollution Meta-analysis

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Closure to“Discussion on‘Optimum placement and characteristics of velocity-dependent dampers under seismic excitation' by SA Mousavi and AK ghorbani-Tanha”by Izuru Takewaki

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Earthquake Engineering and Engineering Vibration 2013年第4期12卷 681-682页

作者： Seyed Amin Mousavi Amir K.ghorbani-Tanha School of Civil Engineering College of EngineeringUniversity of Tehran

The authors would like to thank the discusser for his considerations and comments. The discusser believes that some of the derived formulations need to be referred to his previously published works and also some relat... 详细信息

关键词： Optimum placement and characteristics of velocity-dependent dampers under seismic excitation by SA Mousavi and AK ghorbani-Tanha Closure to

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Synthesis and characterization of a Pd(0) Schiff base complex anchored on magnetic nanoporous MCM-41 as a novel and recyclable catalyst for the Suzuki and Heck reactions under green conditions

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Chinese Journal of Catalysis 2017年第8期38卷 1413-1422页

作者： Mohsen Nikoorazm Farshid ghorbani Arash ghorbani-Choghamarani Zahra Erfani Department of Chemistry Faculty of Science Ilam University P. O. Box69315516 Ilam Iran Department of Environment Faculty of Natural Resource University of Kurdistan Sanandaj 66177‐15177 Iran

A Pd Schiff base complex was immobilized onto the surface of magnetic MCM‐41(Fe3O4@MCM‐41@Pd(0)‐P2C)as a novel,eco‐friendly,and recyclable heterogeneous nanocatalyst and fully characterized by FT‐IR,VSM,EDS,transmission electron microscopy,scanning electron microscopy,thermogravimetric analyses,ICP‐OES,and X‐ray powder diffraction *** Fe3O4@MCM‐41@Pd(0)‐P2C was investigated as a catalyst for the one‐pot Suzuki and Heck reactions in PEG as a green solvent to provide the target products in excellent *** main advantages of using this catalyst include a short reaction time,green reaction conditions,a simple experimental procedure,non‐use of hazardous organic solvents,low loading of the catalyst,and the ability to use various *** importantly,the catalyst could be easily separated from the reaction mixture with the assistance of an external magnet and could be recovered and reused several times without significant loss of stability and activity.

关键词： MCM‐41 Magnetic nanoparticles Suzuki reaction Heck reaction Polyethylene glycol (PEG) Palladium

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Numerical study of cavitating flow in orifices and its effect on spray characteristics

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Journal of Hydrodynamics 2018年第5期30卷 908-919页

作者： Morteza ghorbani Mechatronics Engineering Program Faculty of Engineering and Natural Science Sabanci University Department of Biomedical Engineering and Health Systems KTH Royal Institute of Technology

The bubbly flow regime inside orifices has significant effects on several applications, and studying its trend along an orifice could be helpful in identifying the flow mechanism in various situations. The flow regime inside an orifice depends on the situation which has been specified for the orifice. Orifice geometry has a considerable effect on bubbly flow in injectors. Meanwhile, spray characteristics are influenced by the fuel flow inside an orifice, which has strong effects on the mixture of fuel-air. In this study, spray characteristics are studied for different values of the orifice angle. The cavitation phenomenon which occurs inside an orifice varies in intensity and patterns at different angles of the orifice and consequently has diverse effects on spray characteristics. The governing equations are solved by the SIMPLE algorithm. The spray flow is modeled by the discrete droplet method（DDM）, the droplet breakup is modeled by the WAVE model, and the primary breakup is modeled by the DIESEL BREAK UP model. In order to generate cavitation phenomenon inside orifices and investigate its effect on spray characteristics, the angle of orifice with respect to the injector body is varied and the problem is studied for different angles of orifice.

关键词： Cavitation iinjector angle microchannel spray

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Synthesis of biaryls using palladium nanoparticles immobilized on peptide nanofibers as catalyst and hydroxybenzotriazole as novel phenylating reagent

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Chinese Journal of Catalysis 2017年第3期38卷 469-474页

作者： Arash ghorbani-Choghamarani Zahra Taherinia 伊拉姆大学理学院化学系伊朗伊拉姆69315516

Peptide nanofibers decorated with palladium nanoparticles catalyzed direct coupling of aryl halides with hydroxybenzotriazole to afford the corresponding biaryls in good to excellent *** coupling reactions proceeded under simple,green,and mild *** peptide nanofibers were used as recyclable supports in the coupling *** approach is the first to use hydroxybenzotriazole as a phenylating agent.

关键词： Peptide nanofiber Hydroxybenzotriazole Biaryl PEG Palladium

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Line of sight waypoint guidance for a container ship based on frequency domain identification of Nomoto model of vessel

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Journal of Central South University 2016年第8期23卷 1944-1953页

作者： M.T.ghorbani Instituto Superior Tecnico Torre Norte-8.17 1049-001 Lisboa Portugal

CIFER software is used to identify steering and roll dynamics of a container ship. In this software, advanced features such as the Chirp-Z transform(CZT) and composite window optimization are applied to the time history of steering and roll dynamics to extract high quality frequency responses. From the extracted frequency responses, two linear transfer functions of Nomoto model are fitted for yaw and roll dynamics of the vessel. Based on the identified Nomoto model, a PID heading controller and a Kalman filter observer are constructed. The simulation results of heading controller for line of sight(LOS) waypoint guidance show excellent tracking of pilot inputs in the presence of wave induced motions and forces.

关键词： container ship Nomoto model Kalman filter frequency domain identification CIFER software

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