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Complementary and alternative medicines in irritable bowel syndrome: An integrative view

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World Journal of Gastroenterology 2014年第2期20卷 346-362页

作者： Oliver grundmann Saunjoo L Yoon Department of Medicinal Chemistry College of PharmacyUniversity of FloridaFL 32610United States Department of Adult and Elderly Nursing College of NursingUniversity of FloridaFL 32610United States

Irritable bowel syndrome(IBS)is a common gastrointestinal disorder with a high incidence in the general *** diagnosis of IBS is mainly based on exclusion of other intestinal conditions through the absence of inflammatory markers and specific *** current pharmacological treatment approaches available focus on reducing symptom severity while often limiting quality of life because of significant side *** has led to an effectiveness gap for IBS patients that seek further relief to increase their quality of *** and alternative medicines(CAM)have been associated with a higher degree of symptom management and quality of life in IBS *** the past decade,a number of important clinical trials have shown that specific herbal therapies(peppermint oil and Iberogast?),hypnotherapy,cognitive behavior therapy,acupuncture,and yoga present with improved treatment outcomes in IBS *** propose an integrative approach to treating the diverse symptoms of IBS by combining the benefits of and need for pharmacotherapy with known CAM therapies to provide IBS patients with the best treatment outcome *** steps in this direction are already being considered with an increasing number of practitioners recommending CAM therapies to their patients if pharmacotherapy alone does not alleviate symptoms sufficiently.

关键词： Irritable bowel syndrome Complementary and alternative medicine Hypnotherapy Cognitive behavioral therapy Herbal therapy Peppermint

Modeling and Measurements of Heat Transfer Phenomena in Two-Phase PbSn Alloy Solidification in an External Magnetic Field

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Journal of Thermal Science 2003年第4期12卷 357-362页

作者： P.A.Nikrityuk K.Eckert R.grundmann B. Willers S. Eckert Institute for Aerospace Engineering Dresden University of Technology D-01062 Dresden GermanyInstitute for Aerospace Engineering Dresden University of Technology D-01062 Dresden GermanyInstitute for Aerospace Engineering Dresden University of Technology D-01062 Dresden GermanyResearch Center Rossendorf P.O. Box 510119 D-01314 Dresden GermanyResearch Center Rossendorf P.O. Box 510119 D-01314 Dresden Germany

The main aim of this work is to study numerically the influence of an external magnetic field on the solidification processes of two-component materials. Based on the continuum model of two-phase flow a mathematical model for the directional solidification of a binary alloy in a magnetic field is presented. The model includes mass, momentum, energy and species mass conservation equations written in compressible form and additional relationships describing the temperature-solute coupling. The geometry under study is a cylindrical mold with adiabatic walls and cooled bottom. The macroscale transport in the solidification of alloys is governed by the progress of the two-phase mushy zone, which is treated by means of a porous medium approach. The volume fraction of liquid and solid phases, respectively, is calculated from a 2D approximation of the phase diagram. The results of calculation are compared with experimental data.

关键词： solidification measurements mushy zone Lorentz force rotating magnetic field.

Effect of replacement of soybean oil by Hermetia illucens fat on performance,digestibility,cecal microbiome,liver transcriptome and liver and plasma lipidomes of broilers

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1466-1484页

作者： Lea Schäfer Sarah M.grundmann Garima Maheshwari Marcus Höring Gerhard Liebisch Erika Most Klaus Eder Robert Ringseis Institute of Animal Nutrition and Nutrition Physiology Justus Liebig University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany Institute of Nutritional and Food Sciences Molecular Food TechnologyUniversity of BonnFriedrich-Hirzebruch-Allee 753115 BonnGermany Institute of Clinical Chemistry and Laboratory Medicine University Hospital of RegensburgFranz-Josef-Strauss-Allee 1193053 RegensburgGermany.

Background In contrast to protein-rich insect meal,the feed potential of insect fat is generally less explored and knowledge about the suitability of insect fat as a fat source specifically in broiler diets is still *** view of this,the present study aimed to comprehensively investigate the effect of partial(50%) and complete replacement of soybean oil with insect fat from Hermetia illucens(HI) larvae in broiler diets on performance,fat digestibility,cecal microbiome,liver transcriptome and liver and plasma ***,100 male,1-day-old Cobb 500 broilers were randomly assigned to three groups and fed three different diets with either 0(group HI-0,n cens(HI) larvae fat for 35 d.= 30),2.5%(group HI-2.5,n %(HI-5.0,n = 35) or 5.0= 35) Hermetia illuResults Body weight gain,final body weight,feed intake,and feed:gain ratio during the whole period and apparent ileal digestibility coefficient for ether extract were not different between *** microbial diversity did not differ between groups and taxonomic analysis revealed differences in the abundance of only four low-abundance bacterial taxa among groups;the abundances of phylum Actinobacteriota,class Coriobacteriia,order Coriobacteriales and family Eggerthellaceae were lower in group HI-5.0 compared to group HI-2.5(P < 0.05).Concentrations of total and individual short-chain fatty acids in the cecal digesta were not different between the three *** transcriptomics revealed a total of 55 and 25 transcripts to be differentially expressed between groups HI-5.0 ***-0 and groups HI-2.5 ***-0,respectively(P < 0.05).The concentrations of most lipid classes,with the exception of phosphatidylethanolamine,phosphatidylglycerol and lysophosphatidylcholine in the liver and cholesterylester and ceramide in plasma(P < 0.05),and of the sum of all lipid classes were not different between *** Partial and complete replacement of soybean oil with HI larvae fat in broiler diets had no effect on gro

关键词： Broilers Cecal microbiota Hermetia illucens Insect fat Liver lipidome Medium-chain fatty acids

Primary colon resection or Hartmann's procedure in malignant left-sided large bowel obstruction? The use of stents as a bridge to surgery

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World Journal of Gastrointestinal Surgery 2013年第1期5卷 1-4页

作者： Reinhart T grundmann Formerly Kreiskliniken Alt tting D-84489 BurghausenGermany

There is still significant debate regarding the best surgical treatment for malignant left-sided large bowel *** resection and anastomosis offers the advantages of a definite procedure without need for further *** main disadvantages are related to the increased technical challenge and to the potential higher risk of anastomotic leakage that occurs in the emergency *** resection with end colostomy(Hartmann's procedure) is considered the safer *** et al compared in a systematic review and meta-analysis the use of self-expanding metallic stents(SEMS) as a bridge to surgery vs emergency surgery in the management of acute malignant left-sided large bowel *** authors concluded that the technical and clinical success rates for stenting were lower than *** was associated with a high incidence of clinical and silent *** instead of loop colostomy can be recommended only if the appropriate expertise is available in the *** goal of stenting,a decrease of the stoma rate,may be advocated only if the complication rates of stenting are lower than those of stoma creation in the emergency *** now,this was not demonstrated in a prospective randomized trial.

关键词： Left-sided large bowel obstruction Hartmann’s procedure Primary anastomosis Bowel stent Emergency treatment

Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population

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Journal of Geriatric Cardiology 2018年第9期15卷 559-566页

作者： Madeleine Eickhoff Stefanie Schupke Alexander Khandoga Julia Fabian Moritz Baquet David Jochheim David grundmann Manuela Thienel Axel Bauer Hans Theiss Stefan Brunner Jorg Hausleiter Steffen Massberg Julinda Mehilli Department of Cardiology Munich University Clinic Ludwig-Maximilians University Munich Germany German Centre for Cardiovascular Research (DZHK) Partner Site Munich Heart Alliance Germany Deutsches Herzzentrum Miinchen Klinik fiir Herz- und Kreislauferkrankungen ISAResearch Center Munich Germany

Background The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery （SYNTAX）-score is a validated tool for risk stratification and revascularization strategy selection in patients with complex coronary artery disease. The aim of this study was to analyse its age-related prognostic value. Methods SYNTAX-score was calculated in 1331 all-comer patients undergoing percutaneous coronary intervention （PCI）： 463 patients ≥ 75 years and 868 patients 〈 75 years. Outcomes of interest were all-cause mortality at one and two years. Results A significant interaction of age and SYNTAX-score for mortality was observed at two-year （Pinteraction= 0.019） but not at one-year follow-up （Pinteraction= 0.594）. In multivariable analysis, SYNTAX-score independently predicted 1-year mortality in both age groups （〈 75 years, hazard ratio （HR）： 1.43, 95% confidence intervals （CI）： 1.03-2.00, P = 0.034; and 〉 75 years, HR： 1.37, 95% CI： 1.01-1.85, P = 0.042）, but only two-year mortality among younger patients （〈 75 years, HR： 1.33, 95% CI： 1.01-1.76, P = 0.041; and ≥ 75 years, HR： 1.11, 95% CI： 0.87-1.41, P = 0.394）. SYNTAX-score tertiles were useful to stratify 1-year mortality in both, patients 〈 75 years （SYNTAX-score 〈 9, 3.8%; 9-20, 5.3%; 〉 20, 10.3%; P = 0.004） and 〉 75 years （SYNTAX-score 〈 11, 5.7%; 11-22.5, 16.1%; 〉 22.5, 18.7%; P = 0.003）, but two-year mortality only among patients 〈 75 years （SYNTAX-score 〈 9, 6.5%; 9-20, 7.6%; ≥ 20, 15%; P 〈 0.001） and not among ≥ 75 years old patients （SYNTAX-score 〈 11, 19.4%; 11-22.5, 26.3%; _〉 22.5, 27.9%; P = 0.138）. Conclusions Age modi- fies the impact of the SYNTAX-score on longer-term mortality after PCI. Among patients 〈 75 years, the SYNTAX-score independently predicts the risk of death at one and two years after PCI, while among patients 〉 75 years its predictive role is limited to the first year after PCI. Further studies are needed to evaluate the value of SYNTAX-score for selecting the most appropriate re

关键词： Age Mortality Percutaneous coronary intervention Syntax-score The elderly

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猩球行将消亡？

新发现 2017年第11期 48-51页

作者： Emmanuelle grundmann 葛皓

一项新的研究显示,由于人类对环境的大肆破坏,近60％的猿猴有灭绝之虞。如在印度尼西亚,大片的森林被夷为平地,猩猩的数量也随之不断减少……

关键词：猿猴印度尼西亚自然环境生物学

弹上计算机软件结构的研究第一部分计算机执行任务的描述及数据交换的基本方式

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导弹与航天运载技术(中英文) 1986年第Z1期 114-125页

作者： A.grundmann 白树智

1.第二级飞行段的任务目前,在第二级飞行期间,弹上计算机必须完成下述各项任务: a)导航、识别和制导 b)姿态控制 c)主发动机控制和推进剂的利用 d)时序系统 e)计算机自检由于执行a)-d)项任务所用的计算时间只占60％,因此还应有时间执行... 详细信息

1.第二级飞行段的任务目前,在第二级飞行期间,弹上计算机必须完成下述各项任务: a)导航、识别和制导 b)姿态控制 c)主发动机控制和推进剂的利用 d)时序系统 e)计算机自检由于执行a)-d)项任务所用的计算时间只占60％,因此还应有时间执行一些附加的任

关键词：时序伴随系统积分常数第一个目的地址线性函数终点地址弹上计算机状态变量运载火箭数据处理数据交换

Current state of surgical treatment of liver metastases from colorectal cancer

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World Journal of Gastrointestinal Surgery 2011年第12期3卷 183-196页

作者： Reinhart T grundmann Kreiskliniken Alttting-Burghausen In den Grüben 144D-84489 BurghausenGermany

Hepatic resection is the procedure of choice for curative treatment of colorectal liver metastases(CLM).Objectives of surgical strategy are low intraoperative blood loss,short liver ischemic times and minor postoperative morbidity and *** loss is an independent predictor of mortality and compromises,in common with postoperative complications,long-term outcome after hepatectomy for *** type of liver resection has no impact on the outcome of patients with CLM;wedge resections are not inferior to anatomical resections in terms of tumor clearance,pattern of recurrence or *** the lack of proof of survival benef it,routine lymphadenectomy has been advocated,allowing the detection of microscopic lymph node metastases and with prognostic *** experienced hands,minimally invasive liver surgery is safe with acceptable morbidity and mortality and oncological results comparable to open hepatic surgery,but with reduced blood loss and earlier *** European Colorectal Metastases Treatment Group recommended treating up front with chemotherapy for patients with both resectable and unresectable ***,neoadjuvant chemotherapy can induce damage to the remnant liver,dependent on the number of chemotherapy ***,in our opinion,preoperative chemotherapy should be reserved for patients whose CLM are marginally resectable or unresectable.A meta analysis of randomized trials dealing with perioperative chemotherapy for the treatment of resectable CLM demonstrated a benefit of systemic chemotherapy but did not answer the question of whether a neoadjuvant or adjuvant approach should be *** of the literature demonstrates that the results of specialized centers cannot be attained in the reality of comprehensive patient *** behind the commonly poorer results seen in cancer networks as compared with literature-based data are,on the one hand,geographical disparities in access to specialized surgical and medical ***

关键词： Liver metastases Colorectal cancer Surgery Chemotherapy Outcome

心肌梗死患者其“罪犯”血管再通后CD34^+单核细胞的动员终止

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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 39-40页

作者： Müller-Ehmsen J. Scheid C. grundmann F. 孙凯 Laboratory of Muscle Research and Molecular Cardiology Department of Internal Medicine III University of Cologne Joseph-Stelzmann-Str. 24 50924 Kln Germany

Background: The mobilization of hematopoietic progenitor cells from bone marrow has been proposed to play a role in cardiac regeneration after myocardial infarction(MI). Accordingly, an increase in CD34 positive cells(CD34+) has been observed in the peripheral blood of patients after acute myocardial infarction. Here, we evaluated the influence of an acute percutaneous coronary intervention(PCI) of the occluded artery on the mobilization of CD34+in acute MI. Methods: CD34 positive cells were quantified by flow cytometry(FACS analysis) and expressed as number per million white blood cells. Peripheral blood was obtained and analyzed at day 5 after the onset of symptoms from patients with acute MI without early PCI(n=11, age 63±5 years), acute MI with rapid PCI(n=7, age 63±3), patients with pneumonia(n=5, age 51±6), patients without angiographical signs of coronary artery disease(control, n=5, age 66±8) and young healthy volunteers(n=11, age 28±1). Results: Patients with MI but without PCI had a higher CD34+count at day 5(312±48 per 106 leukocytes) than control(156±40, P=0.03) and MI with PCI(173±31, P=0.03). No increase in CD34+was observed in patients who underwent PCI vs. control. Patients with pneumonia had higher CD34+(350±44) than patients with MI with PCI(P=0.01) and control(P=0.01). Healthy individuals who were much younger than all other groups(28±1 years, P< 0.0001 vs. all groups) had the highest CD34+(526±51, P=0.006 vs. MI without PCI, P=0.00003 vs. MI with PCI, P=0.02 vs. pneumonia, P=0.00006 vs. control). Conclusions: Shorter time of ischemia and reduced cell death may be the reasons for reduced CD34+cell count after acute MI with early percutaneous intervention vs. acute MI without intervention. Besides ischemia, also inflammation as present in pneumonia may cause a mobilization of CD34+cells. Age may be a major factor that influences the mobilization of CD34+cells and the regenerative capacity of the heart.

关键词：血管再通心肌再生细胞计数合并肺炎流式细胞计量术肺炎患者缺血时间造血干细胞血管造影活性细胞