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Cross-talk between T-cells and gut-microbiota in neurodegenerative disorders

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Neural Regeneration Research 2019年第12期14卷 2091-2092页

作者： rodrigo Pacheco Departamento de Ciencias Biológicas Facultad de Ciencias de la Vida Universidad Andres Bello Laboratorio de Neuroinmunología Fundación Ciencia & Vida

The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders: Mammals have evolved together with commensal microbiota to establish a symbiotic relationship in which they regulate reciprocally by synthesizing and responding to several common chemical substances. In this regard, gut microbiota constitutes a consortium of bacteria that not only participates in the degradation of nutrients, but also produces metabolites, fatty acids and neurotransmitters that can act on the enzymes and receptors expressed in eukaryotic cells, which considerably affects the physiology of the host and contribute to maintaining homeostasis (Lyte, 2013).

关键词： Cross-talk T-cells neurodegenerative disorders

Geostatistical seismic inversion and 3D modelling of metric flow units,porosity and permeability in Brazilian presalt reservoir

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Petroleum Science 2024年第3期21卷 1699-1718页

作者： rodrigo Penna Wagner Moreira Lupinacci Exploratory Interpretation and Reservoir Characterization Group(GIECAR) Department of Geology and GeophysicsUniversidade Federal FluminenseNiteroiRJ24210-346Brazil Petrobras Rio de JaneiroRJ20031-912Brazil

Flow units(FU)rock typing is a common technique for characterizing reservoir flow behavior,producing reliable porosity and permeability estimation even in complex geological ***,the lateral extrapolation of FU away from the well into the whole reservoir grid is commonly a difficult task and using the seismic data as constraints is rarely a subject of *** paper proposes a workflow to generate numerous possible 3D volumes of flow units,porosity and permeability below the seismic resolution limit,respecting the available seismic data at larger *** methodology is used in the Mero Field,a Brazilian presalt carbonate reservoir located in the Santos Basin,who presents a complex and heterogenic geological setting with different sedimentological processes and diagenetic *** generated metric flow units using the conventional core analysis and transposed to the well log ***,given a Markov chain Monte Carlo algorithm,the seismic data and the well log statistics,we simulated acoustic impedance,decametric flow units(DFU),metric flow units(MFU),porosity and permeability volumes in the metric *** aim is to estimate a minimum amount of MFU able to calculate realistic scenarios porosity and permeability scenarios,without losing the seismic lateral *** other words,every porosity and permeability volume simulated produces a synthetic seismic that match the real seismic of the area,even in the metric *** achieved 3D results represent a high-resolution fluid flow reservoir modelling considering the lateral control of the seismic during the process and can be directly incorporated in the dynamic characterization workflow.

关键词： Flowunits Geostatistical inversion Presalt reservoir 3D reservoir modelling Petrophysical modelling

The status of research and utilisation on the subtidal kelp along the Chilean coast:A literature review

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Acta Oceanologica Sinica 2022年第12期41卷 7-17页

作者： Simona Laukaityte rodrigo Riera School of Natural Sciences Macquarie UniversitySydney 2109Australia Groningen Institute for Evolutionary Life-Sciences University of GroningenGroningen 9747 AGthe Netherlands Biodiversity and Conservation Group(BIOCON) Instituto Universitario de Investigación en Acuicultura Sostenible y Ecosistemas Marinos(IU-ECOAQUA)Universidad de Las Palmas de Gran CanariaGran Canaria 35001Spain Departamento de Ecología Facultad de CienciasUniversidad Católica de la Santísima ConcepciónConcepción 2850Chile

The most important marine coastal ecosystem in the Chilean coast are kelp *** review is based on ecological studies regarding different aspects of subtidal kelp ecosystems along the Chilean *** highlights the most interesting findings in(1)biology of subtidal kelp in Chile,with particular reference to(2)habitats formed by kelp,and considered the successful examples and promising results in the(3)kelp as an industrial resource(Biotechnological approach of kelps and aquaculture).The impact caused by(4)El Niño-Southern Oscillation is discussed as an important climatic event that could help to forecast the future of the kelp *** addition,this literature review outlines the knowledge gaps on subtidal kelp along the Southeast Pacific Coast of Chile,so that research can be strengthened in the future.

关键词： kelp macroalgae harvesting commercial kelp subtidal SE Pacific Ocean

Soil resilience assessment using soil profile descriptions and Analytic Hierarchy Process in Mediterranean mountains considering diverse fire occurrences

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Journal of Mountain Science 2024年第8期21卷 2517-2532页

作者： Jesús rodrigo-COMINO Departamento de Análisis Geográfico Regional y Geografía Física Facultad de Filosofía y LetrasCampus Universitario de CartujaUniversidad de GranadaGranada 18071Spain

Wildfires are complex natural phenomena that exert significant impacts on landscapes,societies,and *** the concept of resilience is crucial in mitigating its possible negative impacts,as it involves preparing for,responding to,and recovering from *** research aims to demonstrate the utility of in situ soil profile description in assessing land use resilience using an Analytic Hierarchy Process(AHP)through an expert panel *** study examines a catchment located in the Balearic Islands,considering two fire occurrences(once and twice),comparing abandoned agricultural terraces and natural *** results demonstrated that the priority ranking of variables to assess soil profile resilience against wildfires,determined by a panel of 10 experts,identified horizon depth(25.1%),slope inclination(21.5%),and hydrological connectivity(16.6%)as the most crucial *** variables,such as number and size of roots,structure of pedal soil material,size class structure,and rock fragments,also contributed to resilience but to a lesser extent,with scores ranging from 5.7%to 9.6%.Analyzing the priorities established by the experts using AHP,the results showed that the least resilient soil horizon was H1 of the control hillslope,especially under high and low connectivity processes,which aligned with the loss of superficial soil horizons after one and two *** showed greater changes in resilience after occurring wildfires compared to terraces,with the most significant alterations occurring after the second wildfire *** study addresses a significant knowledge gap in the field by highlighting the interconnectedness of wildfires,resilience,and land use,providing insights into land management strategies for wildfire-prone regions.

关键词： Soil profiles Soil geography Wildfires AHP Land management Expert panel survey

From BIM model to 3D construction printing:A framework proposal

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Frontiers of Architectural Research 2024年第4期13卷 912-927页

作者： rodrigo garcía-Alvarado Pedro Soza Ginnia Moroni Fernando Pedreros Martín Avendaño Pablo Banda Cristian Berríos Depto.Diseño y Teoría de La Arquitectura Universidad Del Bío-BíoConcepciónChile Depto.Arquitectura Universidad de ChileSantiagoChile Facultad de Ingeniería Arquitectura y DiseñoUniversidad San SebastiánConcepciónChile Facultad de Arquitectura Arte y DiseñoUniversidad Diego PortalesSantiagoChile

The growth of 3D construction printing needs appropriate integration into the planning and execution phases of building *** this aim,the Architecture,Engineering,and Construction sector(AEC)has been increasingly adopting building information modeling(BIM)systems to synchronize design and construction *** study proposes a technical workflow to manage 3D construction printing into BIM models,evaluating various procedures according to construction element *** on mature software platforms,the research details the data transfer process using a case study of a single-story *** case delves into design procedures for constructing walls of varied shapes,adjustments in width,joints,openings,textures,fillings,and the insertion of reinforcements and services while also discussing requirements of other building *** steps for managing design information and controlling printing machines are *** study’s outcome presents a comprehensive information flow,encompassing model segmentation,geometric data transfer,adjustments of details,and the generation of printing ***,it is offered a discussion that underlines the importance of a synergistic digital information flow that merges both design and execution phases,promoting construction efficiency and the embrace of innovative *** contribution of the paper focuses on technical design strategies for 3D construction printing,but also on suggesting an integrated process.

关键词： 3D construction printing Additive manufacturing Architectural design BIM

Meningeal T-cells in the cross-talk between memory consolidation and sleep

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Neural Regeneration Research 2023年第12期18卷 2687-2688页

作者： rodrigo Pacheco Valentina Ugalde Laboratorio de Neuroinmunología Centro Científico y Tecnológico de Excelencia Ciencia&VidaFundación Ciencia&VidaSantiagoChile Facultad de Medicina y Ciencia Universidad San SebastiánSantiagoChile

Some years ago,the infiltration of T-cells into the central nervous system(CNS) was considered a pathological condition ***,during the last two decades,a growing body of studies has shown that T-cells are essential pl... 详细信息

关键词： behavior. sleep consolidation

Inflammatory bowel disease: A descriptive study of 716 local Chilean patients

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World Journal of Gastroenterology 2016年第22期22卷 5267-5275页

作者： Daniela Simian Daniela Fluxá Lilian Flores Jaime Lubascher Patricio Ibánez Carolina Figueroa Udo Kronberg Raúl Acuna Mauricio Moreno rodrigo Quera Academic Research Unit Clinica Las Condes Santiago 7591046 Chile Gastroenterology Departament Clinica Las Condes Santiago 7591046 Chile Inflammatory Bowel Disease Program Gastroenterology Department Clinica Las Condes Santiago 7591046 Chile Inflammatory Bowel Disease Program Colorectal Surgery Department Clinica Las Condes Santiago 7591046 Chile Laboratory of Oncology and Molecular Genetics Colorectal Surgery Clinica Las Condes Santiago 7591046 Chile

AIM: To demographically and clinically characterize inflammatory bowel disease (IBD) from the local registry and update data previously published by our ***: A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile (C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also ***: The study included 716 patients with IBD: 508 patients (71%) were diagnosed with ulcerative colitis (UC), 196 patients (27%) were diagnosed with Crohn’s disease (CD) and 12 patients (2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years (range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years (range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis (50%) and colonic involvement (44%) predominated in the patients with UC and CD, respectively. In CD patients, non-stricturing/non-penetrating behavior was more frequent (80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosupp

关键词： Inflammatory bowel disease Crohn’ s disease Ulcerative colitis South America Latin America Chile Epidemiology

Tailored optical propulsion forces for controlled transport of resonant gold nanoparticles and associated thermal convective fluid flows

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Light(Science & Applications) 2020年第1期9卷 256-266页

作者： Jose A.rodrigo Mercedes Angulo Tatiana Alieva Facultad de Ciencias Fisicas Ciudad Universitaria s/nUniversidad Complutense de Madrid28040 MadridSpain

Noble metal nanoparticles illuminated at their plasmonic resonance wavelength turn into heat *** phenomenon has prompted the development of numerous applications in science and *** optical manipulation of such resonant nanoparticles could certainly extend the functionality and potential applications of optothermal *** this article,we experimentally demonstrate optical transport of single and multiple resonant nanoparticles(colloidal gold spheres of radius 200 nm)directed by tailored transverse phase-gradient forces propelling them around a 2D optical *** show how the phase-gradient force can be designed to efficiently change the speed of the *** have found that multiple hot nanoparticles assemble in the form of a quasi-stable group whose motion around the laser trap is also controlled by such optical propulsion *** assembly experiences a significant increase in the local temperature,which creates an optothermal convective fluid flow dragging tracer particles into the ***,the created assembly is a moving heat source controlled by the propulsion force,enabling indirect control of fluid flows as a micro-optofluidic *** existence of these flows,probably caused by the temperature-induced Marangoni effect at the liquid water/superheated water interface,is confirmed by tracking free tracer particles migrating towards the *** propose a straightforward method to control the assembly size,and therefore its temperature,by using a nonuniform optical propelling force that induces the splitting or merging of the group of *** envision further development of microscale optofluidic tools based on these achievements.

关键词： thermal fluid transport

Abscisic Acid Connects Phytohormone Signaling with RNA Metabolic Pathways and Promotes an Antiviral Response that Is Evaded by a Self- Controlled RNA Virus

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Plant Communications 2020年第5期1卷 111-128页

作者： Fabio Pasin Hongying Shan Beatriz garcía Maren Müller David San León Márta Ludman David H.Fresno Károly Fátyol Sergi Munné-Bosch Guillermo rodrigo Juan Antonio garcía Centro Nacional de Biotecnología(CNB-CSIC) 28049 MadridSpain Agricultural Biotechnology Research Center Academia Sinica11529 TaipeiTaiwan Departamento de Biologı´a Evolutiva Ecologı´a y Ciencias AmbientalesFacultad de Biologı´aUniversidad de Barcelona08028 BarcelonaSpain Agricultural Biotechnology Institute National Agricultural Research and Innovation Centre2100 Godoll}oHungary Institute for Integrative Systems Biology(I2SysBio) CSIC-University of Valencia46980 PaternaSpain Present address:College of Horticulture and Gardening Tianjin Agricultural University300384 TianjinChina

A complex network of cellular receptors,RNA targeting pathways,and small-molecule signaling provides robust plant immunity and tolerance to *** maximize their fitness,viruses must evolve control mechanisms to balance host immune evasion and plant-damaging *** genus Potyvirus comprises plant viruses characterized by RNA genomes that encode large polyproteins led by the P1 protease.A P1 autoinhibitory domain controls polyprotein processing,the release of a downstream functional RNAsilencing suppressor,and viral ***,we show that P1Pro,a plum pox virus clone that lacks the P1 autoinhibitory domain,triggers complex reprogramming of the host transcriptome and high levels of abscisic acid(ABA)accumulation.A meta-analysis highlighted ABA connections with host pathways known to control RNA stability,turnover,maturation,and *** changes triggered by P1Pro infection or ABA showed similarities in host RNA abundance and *** and hormone treatment assays showed that ABA promotes plant resistance to potyviral ***,quantitative mathematical modeling of viral replication in the presence of defense pathways supported self-control of polyprotein processing kinetics as a viral mechanism that attenuates the magnitude of the host antiviral ***,our findings indicate that ABA is an active player in plant antiviral immunity,which is nonetheless evaded by a self-controlled RNA virus.

关键词： abscisic acid antiviral immune evasion mathematical modeling viral polyprotein processing Potyvirus RNA metabolism