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Urological Emergencies at Kara Teaching Hospital (Togo): Epidemiological, Clinical and Therapeutic Profile

Open Journal of Urology 2023年第1期13卷 1-8页

作者： Komi Hola Sikpa Tchilabalo Matchonna Kpatcha Kodjo Tengue Gnimdou Botcho Edoe Viyome Sewa Sabi Rachid Sade Messan Semefa Agbedey Pwerew rodolphe Plante Kossi Edem Gueouguede Kara Teaching Hospital Kara Togo

Background: The urology department of the teaching hospital of Kara is the second urology department in Togo, after that of the teaching hospital Sylvanus Olympio, in Lomé the capital. It is a very young service, created less than 5 years ago. Urological emergencies were previously managed by general surgeons, for lack of urologists. The influx of patients with urological pathologies has increased with the arrival of urologists. The update on urological emergencies having been made in Lomé, we therefore wanted to take stock of urological emergencies at the teaching hospital of Kara. Objective: To describe the epidemiological, clinical, and therapeutic aspects of urological emergencies received at the teaching hospital of Kara. Patients and Methods: This was a descriptive study with retrospective data collection. The study took place in the urology department, and in the surgical emergency department of the teaching hospital of Kara, over a period of 18 months, from January 2021 to June 2022. The on-call medical team consisted of the intern in on-call medicine, and an on-call urologist, whom the intern called upon when he received a urological emergency. Pediatric urological emergencies were managed by the pediatric surgeon and were not considered in our study. The operating room register, the surgical emergency consultation register, the urology department consultation register, and the records of patients hospitalized in the urology department were used for data collection. The following parameters were studied: age, sex, type of urological emergency, and therapeutic management;epi info 7 software was used for data processing. Results: The average age of the patients was 52.5 ± 19.6 years with extremes ranging from 16 years to 102 years. Note that 57.7% of the patients were over 50 years old. The sex ratio was 8.9. Urinary retention was the most common urological emergency in 47.7% (52) of cases;follow-up of infectious pathologies in 30.2% (33) of cases. Among the

关键词： Urological Emergencies Profile Kara Togo

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Brain Amyloidoma: Case Report and Literature Review

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Open Journal of Modern Neurosurgery 2020年第4期10卷 403-421页

作者： Abd El Kader Moumouni Daniel Memia Zolo Essossinam Kpelao Pascal Compaore Dabou Abiba Tamou Tabe Latevi Lawson Pwerew rodolphe Plante Edem Kossi Gueouguede Benedicte Souho Abderrahmane Hamlat Department of Neurosurgery CHU Martinique Martinique France Department of Neurosurgery CHU Kara Kara Togo Department of Neurosurgery CHU Sylvanus Olympio Lomé Togo Departments of Radiology CHR Kara Kara Togo

Introduction: Primary deposition of amyloid can take several forms including amyloidoma organ restricted among which is brain. Brain amyloidoma can mimic several lesions and offers a diagnostic challenge to the physician. The present work reports an additional case and summarizes the salient characteristics of previously published cases. Case Report: A 61-year-old, woman experienced paroxystic auditory hallucinations followed at times by generalized tonico-clonic seizures. Examination revealed a mild left pyramidal weakness. Head CT scan and MRI revealed a lobular lesion of the right atrium with contrast enhancement. The diagnosis of amyloidoma Lambda light chain (λLC) type was performed by means of a stereotactic biopsy. The patient was treated by 3 cures of high dose methotrexate (15 mg/m2). At 24 months follow up the patient remains stable clinically and biologically. The 2 years follow-up MRI showed the same findings. Conclusion: No guidelines can be suggested for brain amyloidoma treatment;the “wait and see” was the mind-set in the literature. However, a non-tumour like pattern of a cerebral mass developing near the ventricle with a fine, irregular radiating margin enhancement and lack of oedema, and mass effect are important MRI clues for brain amyloidoma diagnosis. The diagnosis is histological after biopsy or excision.

关键词： Amyloidoma Brain Literature Review

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激光选区熔化成形nano-WC/CX钢微观组织及机械性能初探

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材料研究与应用 2021年第4期15卷 309-317页

作者：常成闫星辰 GARDAN Julien DENG Sihao BOLOT rodolphe LIAO Hanlin ICD-LASMIS UMR CNRS 6281University of Technology of TroyesTroyes Cedex 10004France EPF Ecole d’ingenieursCedex 10004France 广东省科学院新材料研究所广东省现代表面工程技术重点实验室现代材料表面工程技术国家工程实验室广东广州510650 ICB-PMDM UMR 6303 CNRSUniversity Bourgogne Franche-ComtéUBFCBelfort 90010France

为进一步提高激光3D打印CX不锈钢材料的机械性能,首先使用静电自组装方法对CX钢粉末表面进行了纳米WC粉末的修饰,之后对经纳米WC表面修饰的CX钢粉末进行了激光选区熔化成形(Selective laser melting,SLM),对比了添加体积分数5%的WC前后... 详细信息

为进一步提高激光3D打印CX不锈钢材料的机械性能,首先使用静电自组装方法对CX钢粉末表面进行了纳米WC粉末的修饰,之后对经纳米WC表面修饰的CX钢粉末进行了激光选区熔化成形(Selective laser melting,SLM),对比了添加体积分数5%的WC前后的SLM CX钢试样的机械性能.结合金相显微镜(OM)、扫描电子显微镜(SEM)、能谱分析(EDS)及电子背散射衍射(EBSD)等材料表征手段,对SLM nano-WC/CX钢试样的微观组织结构、元素分布及相应机械性能进行了对比分析.结果表明:体积分数为5%的纳米WC的加入,对SLM nano-WC/CX钢的硬度提升有所帮助,使硬度值从352±8.2 HV_(0.2)提升至361±23.5 HV_(0.2);尽管纳米WC的加入使SLM nano-WC/CX钢的延伸率有所降低,但其最大拉伸强度则由1091.4±6.12 MPa提升到了1109.7±15.26 MPa.总之,初步探索可以发现,通过静电自组装方法,在CX钢粉末表面添加适量的纳米WC颗粒可以有效改善SLM CX钢的最终机械性能.

关键词：激光选区熔化 CX钢纳米WC 静电自组装机械性能

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Urological Endoscopy: Results of the First 15 Months, in Kara (Togo)

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Open Journal of Urology 2022年第9期12卷 492-498页

作者： Komi Hola Sikpa Gnimdou Botcho Messan Semefa Agbedey Essodina Padja Essomindelou Leloua Kossi Edem Gueouguede Pwerew rodolphe Plante Edoe Viyome Sewa Kodjo Kevin Tengue Matchonna Tchilabalo Kpatcha Centre Hospitalier Universitaire Kara Kara Togo Centre Hospitalier Regional Sokodé Sokodé Togo Centre Hospitalier Universitaire Sylvanus Olympia Lomé Togo

Background: The urology department of the Teaching Hospital of Kara is the 2nd urology department in Togo, Kara being a semi-urban town located 400 km from Lomé the capital. While for a long time only open surgery was used, the acquisition of urological endoscopic equipment in February 2021, has revolutionized the urological management of patients. Objective: Report the results of the first 15 months of urological endoscopy practice at the Kara Teaching Hospital, identify the particularities, announce the prospects. Patients and Methods. This was a retrospective and descriptive study, which took place in the urology department of the Kara Teaching Hospital, from February 2021 to April 2022, i.e. a period of 15 months. The register of operative reports and patient records were used for data collection. The following parameters were studied: age, sex, diagnosis, indication, diagnostic or therapeutic nature of the procedure, and results. EPI INFO 7.***.4.0 software was used for data analysis. Results: A total of 102 urological procedures (endoscopic and non-endoscopic) were performed during the study period;of the 102 interventions, 62 were endoscopic urological interventions, i.e., 60.7% of the interventions. The average age of patients treated was 55.5 years (±16.4) with extremes ranging from 28 to 87 years. Men accounted for 84% of patients treated. Prostatic hypertrophy was the most common urological pathology in our study, requiring endoscopic intervention in 40% of cases. Transurethral resection of the prostate was the most performed endoscopic procedure in our study with 43.5% of cases. The various endoscopic interventions resulted in success in 96.7% of cases. Conclusion: Urology nowadays cannot be done without endoscopy. At the Kara Teaching Hospital, the results are already promising after less than 24 months of endoscopic practice in urology. Advocacy must be made to political decision-makers, so that the situation is even better, for the good of both urologis

关键词： Urological Endoscopy Results Kara Togo

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Biological Profile of HIV-Positive Patients in Bangui, Central African Republic, in 2017

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World Journal of AIDS 2018年第1期8卷 11-20页

作者： Yawo Tufa Nyasenu Alain Farra Brice Martial Yambiyo Alexandre Manirakiza Fernand Didier Padou Ferdinand Yapou Pulcherie Pelembi rodolphe Mambely-Nzako Marie-Joelle Mandeng Alain Berlioz-Arthaud Pierre-Alain Rubbo Jean-Pierre Lombart Institut Pasteur of Bangui Medical Analysis LaboratoryBanguiCentral African Republic Institut Pasteur of Bangui Epidemiology ServiceBanguiCentral African Republic

Background: The biological profile of HIV-positive patients is essential for diagnosing treatment failure and the prognosis of infection. We determined the virological and immunological profiles and biological anomalies of HIV-positive people on antiretroviral therapy (ART) in Bangui, Central Afri-can Republic. Methods: We conducted an analytical, descriptive study be-tween 4 April and 30 September 2017 of all patients who had received ART for more than 12 months and who attended the Medical Analysis Laboratory of the Institut Pasteur in Bangui for a complete biological work-up, including viral load. A blood sample was taken for quantification of RNA HIV-1, CD4 lymphocytes and blood count in two tubes containing ethylenediamine te-traacetic acid, and another sample was taken in a dry tube for measurement of creatinine and transaminases. Results: The total population comprised 1748 patients, with a mean age of 38.7 years (±14.3;median, 41 years;range, 2 - 79 years);33.3% of patients were between 40 and 49 years old. Females predo-minated (71.3%), for a sex ratio of 0.4. Immunological failure was observed in 20.2% of patients (CD4 Conclusion: The abnormalities observed in this study concerned the haematopoietic system, the liver and the kidneys. As other or-gans and systems may be affected, periodic multidisciplinary biological and clinical follow-up is necessary for people living with HIV in order to improve their management.

关键词： Anaemia Biological Abnormalities HIV-1 Bangui

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大位阻二茂铁盐单分子磁体性质研究

大位阻二茂铁盐单分子磁体性质研究

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2018年中西部地区无机化学化工学术研讨会

作者：丁美 Ann K.Hickey rodolphe Clérac Jeremy M.Smith Department of Chemistry Indiana University 长沙理工大学材料科学与工程学院

自1951年首次报道以来,二茂铁以其合成灵活、氧化还原性质优良等优点,得到了研究者的广泛关注[1]。六十多年来,基于二茂铁及其衍生物的报道层出不穷,比如最近报道的含Fe（Ⅳ）的[Fe（η5-C5Me5）2]2+[2].我们研究了一系列二茂铁盐分子... 详细信息

自1951年首次报道以来,二茂铁以其合成灵活、氧化还原性质优良等优点,得到了研究者的广泛关注[1]。六十多年来,基于二茂铁及其衍生物的报道层出不穷,比如最近报道的含Fe（Ⅳ）的[Fe（η5-C5Me5）2]2+[2].我们研究了一系列二茂铁盐分子的磁行为,并且为了减少分子间的磁偶极相互作用,选择用大位阻苯基取代的环戊二烯作为配体,得到分子组成为[Fe（η5-C5Bn5）2]BF4的二茂铁盐分子,57Fe穆斯堡尔谱测试结果表明,Fe（Ⅲ）的基态自旋值S=1/2 （Fig. 1）.交流磁化率测试结果表明,当外加磁场为200 Oe时,该二茂铁分子表现出交流磁化率的缓慢磁弛豫行为（Fig. 2）。更多的表征结果表明,这种缓慢磁弛豫行为来源于分子本身,因此该二茂铁盐分子表现出场诱导的单分子磁体性质。

关键词：二茂铁盐分子缓慢磁弛豫单分子磁体

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Nature Communications:地表侵蚀作用可能引发地震

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地球科学进展 2014年第12期29卷 1414-1414页

作者：刘学 Philippe Steer Martine Simoes rodolphe Cattin Bruce H Shyu J

11月21日，Nature Communications刊登文章《侵蚀作用影响活动断层的地震活动性》（Erosion Influences the Seismicity of Active Thrust Faults），来自中国台湾和法国的研究团队经研究指出，地表的侵蚀作用可以对于活动断层造成显著... 详细信息

11月21日，Nature Communications刊登文章《侵蚀作用影响活动断层的地震活动性》（Erosion Influences the Seismicity of Active Thrust Faults），来自中国台湾和法国的研究团队经研究指出，地表的侵蚀作用可以对于活动断层造成显著的应力变化，进而影响地震活动的发生。

关键词：地震活动性侵蚀作用地表引发活动断层应力变化

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Trends of HIV Viral Load in Patients under Combined Antiretroviral Treatment in Bangui, Central African Republic

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World Journal of AIDS 2018年第2期8卷 53-62页

作者： Yawo Tufa Nyasenu Alain Farra Serge Ghislain Djorie Brice Martial Yambiyo Alexandre Manirakiza Gilles Stephane Ngaya Sandrine Moussa Pulcherie Pelembi Davy Martial Golongba Aubin Bere rodolphe Mambely-Nzako Marie-Joelle Mandeng Alain Berlioz-Arthaud Pierre-Alain Rubbo Jean-Pierre Lombart Institut Pasteur of Bangui Medical Analysis LaboratoryBanguiCentral African Republic Institut Pasteur of Bangui Epidemiology ServiceBanguiCentral African Republic Institut Pasteur of Bangui Retrovirus ServiceBanguiCentral African Republic

Background: The success of antiretroviral therapy requires better virological monitoring. We described the virological profile of patients on combined antiretroviral therapy (cART) for HIV/AIDS in Bangui, Central African Republic (CAR). Methods: In this prospective cohort study of patients who had been on combined antiretroviral therapy treatment (cART) for at least 12 months in Bangui, only one HIV plasma viral load per patient was realized at the Institut Pasteur of Bangui, between April 4th and November 28th, 2017. Sociodemographic and biological data were collected. Blood samples were taken for viral load. The biocentric generic human immunodeficiency virus (HIV) load test was used to quantify a ribonucleic acid (RNA) HIV-1. Data were analyzed with Stata software version 14. Chi-squared test was used to analyse viral load according to sex and age. The level of significance was set at P ≤ 0.05. Results: A total of 3569 patients were recruited, with a mean age of 40 years (median, 42 years;range, 1 - 84), patients aged 40 - 49 predominating (34.2%). The sex ratio was 0.4. No virus was detectable in plasma from 49.2% of patients, while 42.4% had virological failure (viral load, ≥1000 copies/mL) according to WHO criteria. The risk for virological failure decreased with age (P = 0.001) and was higher among females than males (P = 0.001). Conclusions: The rate of virological failure among patients on cART is very high in the CAR, despite the availability of and access to monitoring of HIV plasma viral load in Bangui. Therefore, adherence to treatment should be evaluated and reinforced in Bangui, CAR.

关键词： Plasma Viral Load Failure HIV-1 Bangui CAR

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Hepatocyte apoptosis fragment product cytokeratin-18 M30 level and non-alcoholic steatohepatitis risk diagnosis:an international registry study

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Chinese Medical Journal 2023年第3期136卷 341-350页

作者： Huai Zhang Rafael S.Rios Jerome Boursier rodolphe Anty Wah-Kheong Chan Jacob George Yusuf Yilmaz Vincent Wai-Sun Wong Jiangao Fan Jean-Francois Dufour George Papatheodoridis Li Chen Jorn M.Schattenberg Junping Shi Liang Xu Grace Lai-Hung Wong Naomi F.Lange Margarita Papatheodoridi Yuqiang Mi Yujie Zhou Christopher D.Byrne Giovanni Targher Gong Feng Minghua Zheng Department of Biostatistics and Medical Record The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Service d’Hépato-Gastroentérologie et Oncologie Digestive Centre Hospitalier Universitaire d’AngersAngersFrance Laboratoire HIFIH UPRES EA3859SFR ICAT 4208Universitéd’AngersAngersFrance Université Cote d’Azur CHUINSERMU1065C3M06204 NiceFrance Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyNSWAustralia Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Department of Gastroenterology School of MedicineRecep Tayyip Erdogan UniversityRizeTurkey Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong 999077China Department of Gastroenterology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China University Clinic for Visceral Surgery and Medicine InselspitalUniversity Hospital BernBernSwitzerland Graduate School for Health Sciences University of BernBernSwitzerland Academic Department of Gastroenterology Medical School of National and Kapodistrian University of AthensGeneral Hospitalof Athens“Laiko”AthensGreece Department of Gastroenterology Ruijin HospitalShanghai 200000China Metabolic Liver Research Program I Department of MedicineUniversity Medical Center MainzMainzGermany The Affiliated Hospital of Hangzhou Normal University HangzhouZhejiang 310000China Tianjin Second People’s Hospital Tianjin 300000China Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and HepatologyMinistry of HealthRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Institute of Digestive DiseaseShanghai 200000Ch

Background:Liver biopsy for the diagnosis of non-alcoholic steatohepatitis(NASH)is limited by its inherent invasiveness and possible sampling *** studies have shown that cytokeratin-18(CK-18)concentrations may be useful in diagnosing NASH,but results across studies have been *** aimed to identify the utility of CK-18 M30 concentrations as an alternative to liver biopsy for non-invasive identification of ***:Individual data were collected from 14 registry centers on patients with biopsy-proven non-alcoholic fatty liver disease(NAFLD),and in all patients,circulating CK-18 M30 levels were *** with a NAFLD activity score(NAS)≥5 with a score of≥1 for each of steatosis,ballooning,and lobular inflammation were diagnosed as having definite NASH;individuals with a NAS≤2 and no fibrosis were diagnosed as having non-alcoholic fatty liver(NAFL).Results:A total of 2571 participants were screened,and 1008(153 with NAFL and 855 with NASH)were finally *** CK-18 M30 levels were higher in patients with NASH than in those with NAFL(mean difference 177 U/L;standardized mean difference[SMD]:0.87[0.69–1.04]).There was an interaction between CK-18 M30 levels and serum alanine aminotransferase,body mass index(BMI),and hypertension(P<0.001,P=0.026 and P=0.049,respectively).CK-18 M30 levels were positively associated with histological NAS in most *** area under the receiver operating characteristics(AUROC)for NASH was 0.750(95%confidence intervals:0.714–0.787),and CK-18 M30 at Youden’s index maximum was 275.7 U/*** sensitivity(55%[52%–59%])and positive predictive value(59%)were not ***:This large multicenter registry study shows that CK-18 M30 measurement in isolation is of limited value for non-invasively diagnosing NASH.

关键词： Apoptosis Diagnosis Cytokeratin-18 Liver histology Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease

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霍尼韦尔为城市空中交通提供混合动力推进系统解决方案

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航空动力 2019年第5期 10-10页

作者：羅迪霍尼韦尔中国

尽管电动推进是未来的方向,但在电池技术、基础设施、适航规章及其他障碍被克服之前,混合动力推进是一种较为可行的解决方案。按照美国国家航空航天局(NASA)的定义,混合动力推进是一种用飞机燃油和电力共同驱动推进系统的方式,目的是减... 详细信息

尽管电动推进是未来的方向,但在电池技术、基础设施、适航规章及其他障碍被克服之前,混合动力推进是一种较为可行的解决方案。按照美国国家航空航天局(NASA)的定义,混合动力推进是一种用飞机燃油和电力共同驱动推进系统的方式,目的是减少燃油消耗、降低运营成本,减少CO2和NOx的排放。

关键词：混合动力空中交通霍尼韦尔系统解决方案

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