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Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock

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Molecular Plant 2020年第3期13卷 446-458页

作者： Yan Wang Yuqing He Chen Su rodolfo Zentella Tai-ping Sun Lei Wang Key Laboratory of Plant Molecular Physiology CAS Center for Excellence in Molecular Plant SciencesInstitute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China Department of Biology Duke UniversityDurhamNC 27708USA

Post-translational modifications play essential roles in finely modulating eukaryotic circadian clock *** plants,the effects of O-glycosylation on the circadian clock and the underlying mechanisms remain largely *** O-fucosyltransferase SPINDLY(SPY)and the O-GIcNAc transferase SECRET AGENT(SEC)are two prominent O-glycosylation enzymes in higher plants,with both overlapped and unique functions in plant growth and *** the critical role of O-GIcNAc in regulating the animal circadian clock,here we report that nuclear-localized SPY,but not SEC,specifically modulates the pace of the Arabidopsis circadian *** identifying the interactome of SPY,we identified PSEUDORESPONSE REGULATOR 5(PRR5),one of the core circadian clock components,as a new SPY-interacting ***5 can be O-fucosylated by SPY in pianta,while point mutation in the catalytic domain of SPY abolishes the O-fucosylation of *** protein abundance of PRR5 is strongly increased in spy mutants,while the degradation rate of PRR5 is much reduced,suggesting that PRR5 proteolysis is promoted by SPY-mediated ***,multiple lines of genetic evidence indicate that PRR5 is a major downstream target of SPY to specifically mediate its modulation of the circadian ***,our findings provide novel insights into the specific role of the O-fucosyltransferase activity of SPY in modulating the circadian clock and implicate that O-glycosylation might play an evolutionarily conserved role in modulating the circadian clock system,via O-GIcNAcylation in mammals,but via O-fuco-sylation in higher plants.

关键词： circadian clock O-fucosyltransferase SPY proteolysis PRR5

Snow damages on trees of an uneven age in mixed broadleaf forests:effects of topographical conditions and tree characteristics

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Journal of Forestry Research 2019年第4期30卷 1383-1394页

作者： Farzam Tavankar Angela Lo Monaco Mehrdad Nikooy Rachele Venanzi Amireslam Bonyad rodolfo Picchio Department of Forestry Khalkhal BranchIslamic Azad UniversityKhalkhalIran Department of Agriculture and Forest Sciences(DAFNE) Tuscia UniversityVia S.Camillo de Lellis01100 ViterboItaly Department of Forestry Faculty of Natural ResourcesUniversity of GuilanSomehsaraIran

Snow damage on natural stands is an important problem concerning mountainous forest *** the present research,the frequency and intensity of heavy snow damage on natural stands and the relationship of damages with characteristics of trees,stand and topography were studied in mountainous forests of northern Iran.A systematic sampling design was applied to the study area(140 ha),with 122 circular *** grid dimension was100 m and each plot area was 1000 m^*** four types of snow damage to trees include:crown damage(8.6%),stem breakage(5.4%),uprooting(3.2%),and bending(1.4%).The frequency of crown damage grew with an increase inthe diameter at breast height(DBH),while the frequency of stem breakage,uprooting and bending decreased with an increase the *** frequency of crown damage,stem breakage,and total damages was related to tree species(p<0.01).Not all tree species were equally susceptible to snow *** amount of damage grew with increasing elevation and slope angle and decreased with increasing soil *** trees(DBH<25 cm)were more susceptible to snow damage than other *** damage decreased by as the trees in the stand became more mixed in *** susceptibility of trees to snow damage increased by height and slenderness *** adequate silvicultural operation,snow damage can be reduced to a minimum level in these natural forests.

关键词： Mixed forest Slenderness coefficient Snow damage Stem breakage Uprooting

Endotics system vs colonoscopy for the detection of polyps

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World Journal of Gastroenterology 2010年第43期16卷 5452-5456页

作者： Emanuele Tumino rodolfo Sacco Marco Bertini Michele Bertoni Giuseppe Parisi Alfonso Capria Operative Unit of Gastroenterology and Metabolic Diseases Department of Gastroenterology Pisa University Hospital Institute of Internal Medicine University of Foggia

AIM: To compare the endotics system (ES), a set of new medical equipment for diagnostic colonoscopy, with video-colonoscopy in the detection of polyps. METHODS: Patients with clinical or familial risk of colonic polyps/carcinomas were eligible for this study. After a standard colonic cleaning, detection of polyps by the ES and by video-colonoscopy was performed in each patient on the same day. In each single patient, the assessment of the presence of polyps was performed by two independent endoscopists, who were randomly assigned to evaluate, in a blind fashion, the presence of polyps either by ES or by standard colonoscopy. The frequency of successful procedures (i.e. reaching to the cecum), the time for endoscopy, and the need for sedation were recorded. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the ES were also calculated. RESULTS: A total of 71 patients (40 men, mean age51.9 ± 12.0 years) were enrolled. The cecum was reached in 81.6% of ES examinations and in 94.3% of colonoscopies (P = 0.03). The average time of endoscopy was 45.1 ± 18.5 and 23.7 ± 7.2 min for the ES and traditional colonoscopy, respectively (P < 0.0001). No patient required sedation during ES examination, compared with 19.7% of patients undergoing colonoscopy (P < 0.0001). The sensitivity and specificity of ES for detecting polyps were 93.3% (95% CI: 68-98) and 100% (95% CI: 76.8-100), respectively. PPV was 100% (95% CI: 76.8-100) and NPV was 97.7% (95% CI: 88-99.9). CONCLUSION: The ES allows the visualization of the entire colonic mucosa in most patients, with good sensitivity/specificity for the detection of lesions and without requiring sedation.

关键词： Colonoscopy Diagnosis Endotics system Polyps Sedation

Movement initiation of millimeter particles on a rotating rough surface: The role of adhesion

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Particuology 2020年第6期18卷 92-99页

作者： Karina de los Angeles Valenzuela Aracena rodolfo O.Unac Irene Ippolito Ana M.Vidales INFAP CONICETDepartamento de FisicaFacultad de Ciencias Fisico Matematicas y NaturalesUniversidad Nacional de San LuisEjercito de los Andes 950D5700HHWSan LuisArgentina Universidad de Buenos Aires Facultad de IngenieriaGrupo de Medios PorososPaseo Colon 850C1063ACV Buenos AiresArgentina

We performed experiments to determine the critical moment for movement initiation of a millimeter bead on a rotating rough *** corresponding critical angular velocities were measured for glass and stainless-steel ball bearings over two different rough surfaces with glued glass beads.A basic theoretical analysis was developed to explain the observed *** the expectation of a simple approach with the presence of the obstacles offered by a rough surface could be sufficient to describe the problem,we prove here that the sole con sideration of these obstacles,and even friction,are insufficient to explain the results in the range of a few-millimeter glass *** the thermodynamic work of adhesion between surfaces is significant,the adhesion forces must be considered in the force balance for particle detachment:.This effect is a determinant for describing theoretically and numerically the dynamics of millimeter particles.

关键词： Detachment Adhesion Centrifugation

Transcriptional Programs Related to Phytochrome A Function in Arabidopsis Seed Germination

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Molecular Plant 2013年第4期6卷 1261-1273页

作者： Silvia E. Ibarra Gabriela Auge rodolfo A. Sanchez Javier F. Botto IFEVA Facultad de Agronomfa Universidad de Buenos Aires y Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. San Martin 4453 C1417DSECiudad de Buenos Aires Argentina

In Arabidopsis seeds, germination is promoted only by phytochromes, principally phytochrome B （phyB） and phytochrome A （phyA）. Despite the abundant information concerning the molecular basis of phyB signaling downstream of PIF1/PIL5, the signaling network inducing germination by phyA is poorly known. Here, we describe the influence of phyA on the transcriptome of Arabidopsis seeds when germination is induced by a far-red （FR） pulse. The expression of 11% of the genome was significantly regulated by phyA. Most of the genes were up-regulated and the changes noted late （i.e. 5 h after a FR pulse）, whereas changes in down-regulated genes were more abundant earlier （i.e. 0.5 h after a FR pulse）. Auxin- and GA-associated elements were overrepresented in the genes that were modified by phyA. A significant number of genes whose expression was affected by phyA had not been previously reported to be dependent on PIL5. Among them, homozygotic mutant seeds of MYB66, a SAUR-like protein, PIN7, and GASA4 showed an impaired promo- tion of germination by phyA. Natural variation at the transcriptional level was found in early signaling and GA metabolic genes, but not in ABA metabolic and expansin genes between Columbia and Landsberg erecta accessions. Although phyA and phyB/PIL5 signaling pathways share some molecular components, our data suggest that phyA signaling is partially independent of PIL5 when germination is promoted by very low fluences of light.

关键词： transcriptome germination light Arabidopsis seeds PIF1/PIL5 phytochrome A (phyA) phytochrome B (phyB).

Nodes Effect on the Bending Performance of Laminated Bamboo Lumber Unit

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Journal of Renewable Materials 2021年第6期9卷 1143-1156页

作者： Yiwei Xuan Haitao Li Zhemin Bei Zhenhua Xiong rodolfo Lorenzo Ileana Corbi Ottavia Corbi College of Civil Engineering Nanjing Forestry UniversityNanjing210037China Ganzhou Sentai Bamboo Company Ltd. Ganzhou341001China University of Melbourne Melbourne3010Australia University College London LondonWC1E 6BTUK University of Naples Federico II Naples80133Italy

This research studied the ultimate bearing capacity of laminated bamboo lumber(LBL)unit and thereby calculated the maximum bending *** load-displacement chart for all specimens was *** the flexural capacity of members with and without bamboo nodes in the middle section was *** bending experiment phenomenon of LBL unit was *** failure modes of bending components were analysed and ***,the bending behaviour of LBL units is coMPared with other bamboo and timber *** is shown that the average ultimate load of BS members is 866.1 N,the average flexural strength is 101 MPa,the average modulus of elasticity is 8.3 GPa,and the average maximum displacement is 17.02 *** average ultimate load of BNS members is 1008.1 N,the average flexural strength is 118.02 MPa,the average modulus of elasticity is 9.9 GPa,and the average maximum displacement is 18.26 *** bamboo lumber(LBL)unit without bamboo nodes(BNS)has relatively higher flexural strength coMPared with LBL unit with bamboo nodes(BS).The presence of bamboo nodes reduces the strength of the entire *** failure modes were concluded for BS members,and two failure modes were observed for BNS members during the experimental *** to a coMParison between the LBL unit and other products,the flexural strength and bending modulus of elasticity of the LBL unit are similar as bamboo scrimber and raw bamboo components,which is much higher than timber components.

关键词： Laminated Bamboo Lumber bending test flexural strength bamboo node

Effects of Freeze-Thaw Cycles on Physical and Mechanical Properties of Glulam Exposed to Outdoor Environment

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Journal of Renewable Materials 2021年第7期9卷 1293-1307页

作者： Ruyuan Yang Haitao Li Assima Dauletbek Mahmud Ashraf rodolfo Lorenzo Youfu Sun Yuehong Wu College of Materials Science and Engineering Nanjing Forestry UniversityNanjingChina College of Civil Engineering Nanjing Forestry UniversityNanjingChina University College London LondonWC1E 6BTUK School of Engineering Deakin UniversityGeelongVIC 3216Australia

This paper presents an experimental investigation to identify suitable indices to assess durability of glulam when subjected to freeze-thaw cycles in an exposed *** this study,two types of glulam specimens were tested for their performance when subjected to different levels of aging due to freezing and *** of aging treatment on various parameters including thickness swelling rate,static bending strength,elastic modulus,shear strength,and peeling rate of adhesive layer were *** results showed that freeze-thaw aging treatment did not affect the water-resistance of the specimens as measured by thickness swelling rate and had little effect on the dimensional stability of the ***,the applied aging treatment weakened the bending resistance of the glulam specimens with more pronounced effects on on low-density *** the other hand,bond strength of high-density wood was relatively more affected due to the appliedfreeze-thaw *** highdensity wood,it is suggested that the shear strength of the adhesive layer be taken as an important index to determine the durability of freeze-thaw cycles *** low-density wood,on the other hand,the static bending strength can be used as an index to determine the durability of glulam under freeze-thaw cycles aging.

关键词： Freeze-thaw cycles structural glulam durability wood failure percentage accelerated aging

Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders

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Neural Regeneration Research 2022年第3期17卷 469-476页

作者： Priscila Chiavellini Martina Canatelli-Mallat Marianne Lehmann rodolfo G.Goya Gustavo R.Morel Biochemistry Research Institute of La Plata(INIBIOLP)-Histology and Embryology B School of Medical SciencesNational University of La Plata(UNLP)La PlataBuenos AiresArgentina

Hippocampus serves as a pivotal role in cognitive and emotional processes,as well as in the regulation of the hypothalamus-pituitary *** is known to undergo mild neurodegenerative changes during normal aging and severe atrophy in Alzheimer's ***,dysregulation in the hippocampal function leads to epilepsy and mood *** the first section,we summarized the most salient knowledge on the role of glial cell-line-derived neurotrophic factor and its receptors focused on aging,cognition and neurodegenerative and hippocampal-related neurological diseases mentioned *** the second section,we reviewed the therapeutic approaches,particularly gene therapy,using glial cell-line-derived neurotrophic factor or its gene,as a key molecule in the development of neurological *** the third section,we pointed at the potential of regenerative medicine,as an emerging and less explored strategy for the treatment of hippocampal *** briefly reviewed the use of partial reprogramming to restore brain functions,non-neuronal cell reprogramming to generate neural stem cells,and neural progenitor cells as source-specific neuronal types to be implanted in animal models of specific neurodegenerative disorders.

关键词： aging Alzheimer's disease cell reprogramming epilepsy gene therapy glial cell line-derived neurotrophic factor hippocampus major depression

Delay Times and Clinical Outcomes in Acute Myocardial Infarction: Comparison of Periods before and during the COVID-19 Pandemic—Myocardial Infarction and the Pandemic

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World Journal of Cardiovascular Diseases 2024年第6期14卷 392-400页

作者： Clarice Teixeira Silva Araújo Arnon Salviato Mameri Thúlio Carrera Guarçoni Venturini Marcus Tadeu Aguilar Constantino Matos Igor Morais Araujo Lopes Luiz Gustavo Ribeiro de Carvalho Murad Cleberson Duartes Ovani Guilherme Vassalo Morais Fernanda Venturini de Castro Danielle Lopes Rocha Lucas Crespo de Barros rodolfo Costa Sylvestre Luiz Fernando Machado Barbosa Roberto Ramos Barbosa Internal Medicine Universidade Federal do Esprito Santo (UFES) Vitria Brazil Hospital Santa Casa de Misericrdia de Vitria Vitria Brazil Hospital Santa Rita de Cssia Vitria Brazil Hospital Estadual Dr. Jayme Santos Neves Serra Brazil Grupo Kora Sade Vitria Brazil Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIMABA) Vila Velha Brazil

Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), before and during the COVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPCI from December 2018 to July 2021. The COVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the COVID-19 pandemic. Conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the COVID-19 pandemic. Delay times to admission and reperfusion did not differ significantly between before and during the pandemic.

关键词： Myocardial Infarction Primary Percutaneous Coronary Intervention Coronary Reperfusion Pandemic COVID-19