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Promising diagnostic biomarkers of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: From clinical proteomics to microbiome

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World Journal of Hepatology 2021年第11期13卷 1494-1511页

作者： Carolina Castillo-Castro Alexandro JoséMartagón-Rosado rocio ortiz-lopez Luis Felipe Garrido-Treviño Melissa Villegas-Albo Francisco Javier Bosques-Padilla Tecnológico de Monterrey Escuela de Medicina y Ciencias de la SaludMonterrey 64710Mexico Unidad de Investigación de Enfermedades Metabólicas Instituto Nacional de Ciencias Médicas y NutriciónCiudad de México 14080Mexico Centro Regional para el Estudio de las Enfermedades Digestivas Servicio de GastroenterologíaFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezUniversidad Autónoma de Nuevo LeónMonterrey 64460Mexico

Fatty liver has been present in the lives of patients and physicians for almost two *** knowledge has been generated regarding its etiology and consequences,although a long path seeking novel and innovative diagnostic biomarkers for nonalcoholic fatty liver disease(NAFLD)and nonalcoholic steatohepatitis(NASH)is still *** the one hand,proteomics and lipidomics have emerged as potential noninvasive resources for NAFLD *** contrast,metabolomics has been able to distinguish between NAFLD and NASH,even detecting degrees of *** the other hand,genetic and epigenetic markers have been useful in monitoring disease progression,eventually functioning as target *** markers involved in immune dysregulation,oxidative stress,and inflammation are involved in the instauration and evolution of the ***,the fascinating gut microbiome is significantly involved in NAFLD and *** review presents state-of-the-art biomarkers related to NAFLD and NASH and new promises that could eventually be positioned as diagnostic resources for this *** is evident,despite great advances in studying these biomarkers,there is still a long path before they translate into clinical benefits.

关键词： Fatty liver Biomarkers Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

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The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

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Particuology 2024年第6期89卷 1-10页

作者： Juan Enrique Barranco-García Carolina Caicedo Enrique Javier Jiménez-Regalado Carlos Espinoza-González Graciela Morales rocio Yaneli Aguirre-Loredo Abril Fonseca-García Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca Departamento de Química y BioquímicaAvenida Ing.Víctor Bravo Ahuja No.125Esquina Calzada Tecnológico68030OaxacaMexico Faculty of Engineering Unidad Central del Valle del Cauca(UCEVA)Carrera 17a 48-144763022TuluáColombia Centro de Investigación en Química Aplicada(CIQA) Blvd.Enrique Reyna Hermosillo 14025294SaltilloCoahuilaMexico Investigadoras por México CONAHCYT-CIQA Av.Insurgentes Sur 1562Col.Crédito Constructor03940Alcaldía Benito JuárezCDMXMexico

Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical *** paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer,commercially named Pluronic®*** aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying *** with a poloxamer concentration of 3%(w/v)demonstrated a notably higher yield,especially when compared to those with 0%and 1%*** with 3%and 5%(w/v)poloxamer displayed a narrower particle size distribution,with the 3%blend showing a superior yield attributed to arrangements of blend components that improve flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between *** with increased poloxamer content showed elevated thermal degradation temperatures,with the 3%blend registering a significant rise,opening avenues for encapsulating heat-sensitive *** study primarily focuses on the preparation and basic characterization of *** underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

关键词： Biopolymer Starch Chitosan Pluronic®F127 Microparticles Spray drying

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Critical care specialists,the missing link in organ procurement for transplantation

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World Journal of Critical Care Medicine 2024年第2期13卷 1-6页

作者： Francisca Del rocio Gonzalez Cohens Fernando M Gonzalez Web Intelligence Centre Faculty of Physics and Mathematical SciencesUniversidad de ChileSantiago 8370397Chile Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile

The procurement process for organ donation begins with the identification of potential organ donors in emergency or critical care units(CCU),followed by their clinical evaluation,diagnostic procedures,and therapeutic interventions,mostly conducted in *** concludes with the request for organ donation and,if accepted,the retrieval of *** most interventions occurring in detection units,there has been a neglect of the strategic role played by critical care specialists(CCS)in managing and caring for brain-dead or near-brain-death *** arise:Are they willing to undertake this responsibility?Do they fully comprehend the nature of organ procurement?Are they aware of the specific interventions required to maintain possible organ donors in optimal physiological condition?Our objective is to examine the role of CCS in organ procurement and propose ways to enhance it,ultimately aiming to increase and enhance organ donation rates.

关键词： Organ procurement Transplantation Brain death Cardiac death Organ donation

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The Beneficial Effects of Components of Garlic (Allium sativum L.) in the Poultry Industry

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Food and Nutrition Sciences 2024年第1期15卷 27-57页

作者： Alejandra Meza-Rios Gilberto Velazquez-Juarez Inkar Castellanos-Huerta rocio Ivette lopez-Roa Luis A. Anguiano-Sevilla Xochitl Hernanez-Velasco Xochitl Hernanez-Velasco Saeed El-Ashram Ebtsam Al-Olayan Billy Hargis Guillermo Tellez-Isaias Adelaida Sara Minia Zepeda-Morales Departamento de Farmacobiología CUCEI Universidad de Guadalajara Blvd. M. García Barragán Guadalajara México Laboratorio de Análisis Fisicoquímicos Externos Departamento de Química CUCEI Universidad de Guadalajara Boulevard Marcelino García Barragán Guadalajara México Center of Excellence for Poultry Science Department of Poultry Science Dale Bumpers College of Agricultural Food and Life Sciences University of Arkansas Cumberland United States Laboratorio de Investigación y Desarrollo Farmacéutico Departamento de Farmacobiología CUCEI Universidad de Guadalajara Boulevard Marcelino García Barragán Guadalajara México Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia UNAM Mexico Mexico Zoology Department Faculty of Science Kafrelsheikh University Kafr El-Sheikh Egypt Department of Zoology College of Science King Saud University Riyadh Saudi Arabia Laboratorio de Análisis Clínicos y Bacteriológicos (vinculación) Departamento de Farmacobiología CUCEI Universidad de Guadalajara Boulevard Marcelino García Barragán Guadalajara México

Plant-based antimicrobial agents are readily available, cost-effective, and exhibit low toxicity, making them promising alternatives in combatting microbial infections. Among these plants, garlic (Allium sativum) stands out for its traditional medicinal use in effectively combating various microorganisms. In the poultry industry, preventing avian virus and bacterial infections is paramount for chicken husbandry. However, using conventional drugs poses potential risks to human health. Garlic, a widely used Asian plant in traditional medicine for various pathologies, has shown potential as an herbal prophylactic remedy against viral and bacterial infections. Recently, researchers explored garlic and its derivatives as a scientific strategy in veterinary practices for diverse purposes, such as improving poultry production characteristics and acting as antibiotic growth promoters. This comprehensive review delves into garlic and its derivatives as preventive and corrective treatments for viral diseases in laying hens and broilers. The paper highlights their potential effectiveness and safety as a natural means to enhance poultry health and welfare while mitigating the risks associated with conventional drug usage in the food industry.

关键词： Garlic Antiviral Veterinary Chickens Allium sativum

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Risk of progression of Barrett's esophagus in patients with cirrhosis

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World Journal of Gastroenterology 2017年第18期23卷 3287-3294页

作者： Tehilla Apfel rocio lopez Madhusudhan R Sanaka Prashanthi N Thota Department of General Internal Medicine Cleveland Clinic Foundation Department of Biostatistics Cleveland Clinic Foundation Department of Gastroenterology and Hepatology Digestive Disease and Surgery InstituteCleveland Clinic Foundation

AIM To study Barrett's esophagus(BE) in cirrhosis and assess progression to esophageal adenocarcinoma(EAC) compared to non-cirrhotic BE *** Cirrhotic patients who were found to have endoscopic evidence of BE confirmed by the presence of intestinal metaplasia on histology from 1/1/2000 to 12/1/2015 at Cleveland Clinic were included. Cirrhotic patients were matched 1:4 to BE controls without cirrhosis. Age, gender, race, BE length, hiatal hernia size, Child-Pugh(CP) class and histological findings were recorded. Cases and controls without high-grade dysplasia(HGD)/EAC and who had follow-up endoscopies were studied for incidence of dysplasia/EAC and to assess progression rates. Univariable conditional logistic regression was done to assess differences in baseline characteristics between the two groups. RESULTS A total of 57 patients with cirrhosis and BE were matched with 228 controls(BE without cirrhosis). The prevalence of dysplasia in cirrhosis and controls weresimilar with 8.8% vs 12% with low grade dysplasia(LGD) and 12.3 % vs 19.7% with HGD or EAC(P = 0.1). In the incidence cohort of 44 patients with median follow-up time of 2.7 years [interquartile range 1.0, 4.8], there were 7 cases of LGD, 2 cases of HGD, and 2 cases of EAC. There were no differences in incidence rates of HGD/EAC in nondysplastic BE between cirrhotic cases and noncirrhotic controls(1.4 vs 1.1 per 100 person-years, P = 0.8). In LGD, cirrhotic patients were found to have higher rates of progression to HGD/EAC compared to control group though this did not reach statistical significance(13.7 vs 8.1 per 100 personyears, P = 0.51). A significant association was found between a higher CP class and neoplastic progression of BE in cirrhotic patients(HR =7.9, 95%CI: 2.0-30.9, P = 0.003). CONCLUSION Cirrhotics with worsening liver function are at increased risk of progression of BE. More frequent endoscopic surveillance might be warranted in such patients.

关键词：肝肝硬化 Barretts 食管发育异常食道的瘤前进

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Finding middle ground:Flow regimes designed for salmon and energy value

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Water Biology and Security 2023年第3期2卷 19-29页

作者： Henriette I.Jager rocio Uria-Martinez Oak Ridge National Laboratory Oak RidgeTN37831-6038USA

In regulated rivers,shaping seasonal flows to recover species at risk depends on understanding when to expect conflicts with competing water users and when their interests are ***-objective optimization can be used to reveal such conflicts and *** species are involved,multi-objective optimization is challenged by the need to simulate complex species responses to flow ***,we addressed that challenge by developing a simplified salmon model(Quantus)that defines cohorts of salmon by the river section and time in which they were *** in these space-time cohorts are tracked from the time redds(nests)are constructed until the cohort exits the tributary en route to the *** this study,we modeled seasonal patterns in energy value and developed a Pareto-optimal frontier of seasonal flow patterns to maximize in-river salmon survival and hydropower *** flow regimes were characterized by two pulse flows varying in magnitude,timing,and duration and constrained by a total annual flow near the historical *** analysis revealed times when economic and salmon objectives were aligned and times when they *** flows that favored higher energy value were timed to meet demand during extreme *** salmon and hydropower objectives produced optimal flow regimes with pulse flows in early summer,but only solutions favoring hydropower value included high flows in *** favoring higher age-0 salmon survival provided an extended pulse flow in late winter/early spring,which suggests that access to productive floodplain habitat allowed faster growth and earlier out-migration and reduced the need for higher temperature-moderating flows later in *** flows were also higher among solutions favoring salmon over *** tools used to produce these results can help to design simplified seasonal flow regimes by revealing compromise solutions that satisfy both fish and energy producers

关键词： Optimization Environmental flows Reservoir release schedule Genetic algorithm Pareto optimal frontier Electricity price model Fall chinook salmon Pulse flows Multi-objective

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The promise of precision medicine:how biomarkers are shaping the future of cholangiocarcinoma treatment

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 457-461页

作者： rocio I.R.Macias Lorenza Rimassa Angela Lamarca Experimental Hepatology and Drug Targeting(HEVEPHARM) IBSALUniversity of SalamancaSalamancaSpain National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehd) Carlos III National Health InstituteMadridSpain Department of Biomedical Sciences Humanitas UniversityPieve Emanuele(Milan)Italy Medical Oncology and Hematology Unit Humanitas Cancer CenterIRCCS Humanitas Research HospitalRozzano(Milan)Italy Department of Oncology OncoHealth InstituteFundación Jiménez Díaz University HospitalMadridSpain Department of Medical Oncology The Christie NHS FoundationManchesterUK Division of Cancer Sciences University of ManchesterManchesterUK

Cholangiocarcinoma(CCA)is the second most frequent primary malignant neoplasm of the hepatobiliary ***,CCA is often diagnosed at an advanced stage,when potentially curative surgical treatments are not *** probability of achieving complete resection in patients who undergo surgery is about 25%(1)and even when complete tumor removal is achieved,the risk of recurrence is greater than 50%.Identification and validation of reliable biomarkers is crucial for the early detection,accurate diagnosis,appropriate staging/prognosis,therapy selection and effective monitoring of patients with biliary tract cancers(BTCs)(Figure 1).Achieving early diagnosis remains a challenge to improve survival and,although many promising biomarkers have been identified(2),to date none have reached clinical practice.

关键词： Biliary cancer biomarker immunotherapy precision medicine targeted therapy

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现在和未来如何进行虚构文学创作——华文作家与西语作家圆桌对话

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世界华文文学论坛 2024年第1期 84-100页

作者：赵彦罗茜奥·奥维耶多史志龙(翻译) 不详马德里康普顿斯大学文学系西班牙拉美文学研究协会尼加拉瓜西班牙语学院北美西班牙语学院

主持人语:在作家们几乎已穷尽了虚构文学所有创新方面的今天,我们面临了如何用新手段来写我们的新故事。除了作家们本人自觉在文本创作上面的积极探索和努力尝试外,社交媒体的多手段、即时更新和瞬息变化也给我们作家的文学创作发展提... 详细信息

主持人语:在作家们几乎已穷尽了虚构文学所有创新方面的今天,我们面临了如何用新手段来写我们的新故事。除了作家们本人自觉在文本创作上面的积极探索和努力尝试外,社交媒体的多手段、即时更新和瞬息变化也给我们作家的文学创作发展提供了一些可能是消极也可能是积极的新手段,换句话说,现在它们也成了我们文本创新的一种工具。当然,这种“新的写作工具”也带来了一定程度上的困惑,甚至有可能对文学本身会造成一种伤害。

关键词：华文作家文本创作即时更新社交媒体虚构文学文学创作文本创新写作工具

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Healthcare utilization and costs associated with gastroparesis

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World Journal of Gastroenterology 2017年第24期23卷 4428-4436页

作者： Vaibhav Wadhwa Dhruv Mehta Yash Jobanputra rocio lopez Prashanthi N Thota Madhusudhan R Sanaka Department of Internal Medicine Fairview HospitalCleveland Clinic Department of Internal Medicine Westchester Medical Center Department of Gastroenterology and Hepatology Digestive Disease InstituteCleveland Clinic Center for Advanced Endoscopy Digestive Disease InstituteCleveland Clinic

AIM To use a national database of United States hospitals to evaluate the incidence and costs of hospital admissions associated with *** We analyzed the National Inpatient Sample Database(NIS)for all patients in whom gastroparesis(ICD-9 code:536.3)was the principal discharge diagnosis during the period,*** NIS is the largest publicly available all-payer inpatient care database in the United *** contains data from approximately eight million hospital stays each *** statistical significance of the difference in the number of hospital discharges,length of stay and hospital costs over the study period was determined by regression *** In 1997,there were 3978 admissions with a principal discharge diagnosis of gastroparesis as compared to16460 in 2013(P<0.01).The mean length of stay for gastroparesis decreased by 20%between 1997 and 2013from 6.4 d to 5.1 d(P<0.001).However,during this period the mean hospital charges increased significantly by 159%from$13350(after inflation adjustment)per patient in 1997 to$34585 per patient in 2013(P<0.001).The aggregate charges(i.e.,"national bill") for gastroparesis increased exponentially by 1026%from$50456642±4662620 in 1997 to$568417666±22374060 in 2013(P<0.001).The percentage of national bill for gastroparesis discharges(national bill for gastroparesis/total national bill)has also increased over the last 16 years(0.0013%in 1997 vs 0.004%in2013).During the study period,women had a higher frequency of gastroparesis discharges when compared to men(1.39/10000 vs 0.9/10000 in 1997 and 5.8/10000vs 3/10000 in 2013).There was a 6-fold increase in the discharge diagnosis of gastroparesis amongst type 1 DM and 3.7-fold increase amongst type 2 DM patients over the study period(P<0.001).CONCLUSION The number of inpatient admissions for gastroparesis and associated costs have increased significantly over the last 16 ***

关键词：住院病人承认评价 Gastroparesis 癌症传染病学国家住院病人数据库

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Medications in type-2 diabetics and their association with liver fibrosis

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World Journal of Gastroenterology 2020年第23期26卷 3249-3259页

作者： Mohamed Tausif Siddiqui Hina Amin Rajat Garg Pravallika Chadalavada Wael Al-Yaman rocio lopez Amandeep Singh Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteCleveland ClinicClevelandOH 44195United States Department of Hospital Medicine Cleveland ClinicOH 44195United States Department of Quantitative Health Sciences Cleveland ClinicOH 44195United States

BACKGROUND The prevalence of nonalcoholic fatty liver disease(NAFLD) is significantly rising worldwide. Type-2 diabetes(T2D) is a major risk factor for NAFLD *** To assess the association of commonly used medications to advanced fibrosis(AF) in patients with biopsy-proven NAFLD and *** We used the International Classification of Disease 9 th Revision Clinical Modification coding system to identify patients with T2D and included patients who underwent liver biopsy for suspected NAFLD between January 1, 2000 to December 31, 2015. We compared demographics, clinical characteristics, and differences in pattern of medication use in patients who had biopsy-proven AF to those without it. A univariate and multivariate analysis was performed to assess the association of different classes of medication with the presence of *** A total of 1183 patients were included in the final analysis, out of which 32%(n =381) had AF on liver biopsy. Mean age of entire cohort was 52 years and majority were females(65%) and Caucasians(85%). Among patients with AF, 51% were on oral hypoglycemics, 30% were on insulin, 66% were on antihypertensives and 27% were on lipid lowering agents for the median duration of 19 mo, 10 mo, 26 mo, and 24 mo respectively. Medications associated with decreased risk of AF included metformin, liraglutide, lisinopril, hydrochlorothiazide, atorvastatin and simvastatin while the use of furosemide and spironolactone were associated with higher prevalence of *** In our cohort of T2D with biopsy proven NAFLD, the patients who were receiving metformin, liraglutide, lisinopril, hydrochlorothiazide, atorvastatin and simvastatin were less likely to have AF on biopsy, while patients who were receiving furosemide and spironolactone had a higher likelihood of having AF when they underwent liver biopsy. Future studies are needed to confirm these findings and to establish measures for prevention of NAFLD progression in patients with T2D.

关键词： Diabetes medications Anti-lipid medications Antihypertensive medication Fatty liver Advanced fibrosis

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