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Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid-and long-term prediction of hepatocellular carcinoma among cirrhotic patients

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World Journal of Gastroenterology 2021年第48期27卷 8343-8356页

作者： Antonio Gil-Gómez Ángela Rojas Chang-Hai Liu rocio gallego-duran rocio Muñoz-Hernandez Giorgio Fassina Patrizia Pontisso Javier Ampuero Manuel Romero-Gómez SeLiver Group Institute of Biomedicine of SevilleSeville 41013Spain CIBERehd Instituto de Salud Carlos IIIMadrid 28029Spain Mucosal Immunity Lab IRCCS Humanitas Research HospitalMilan 20089Italy Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610017Sichuan ProvinceChina State Key Laboratory of Biotherapy and Center of Infectious Diseases West China HospitalChengdu 610017Sichuan ProvinceChina Life Biotechnology Padua UniversityVenice 30175Italy Department of Clinical and Experimental Medicine University of PadovaPadova 35123Italy UCM Digestive Diseases Virgen del Rocío University HospitalSeville 41014Spain

BACKGROUND The combination of alpha-fetoprotein(AFP)and squamous cell carcinoma antigen immunocomplex(SCCA-IgM)have been proposed for its use in the screening of hepatocellular carcinoma(HCC).Current screening programs for all cirrhotic patients are controversial and a personalized screening is an unmet need in the precision medicine *** To determine the role of the combination of SCCA-IgM and AFP in predicting mid-and long-term appearance of *** Two-hundred and three cirrhotic patients(Child A 74.9%,B 21.2%,C 3.9%)were followed-up prospectively every six months to screen HCC by ultrasound and AFP according to European Association for the Study of the Liver *** estimation cohort was recruited in Italy(30.5%;62/203)and validation cohort from Spain(69.5%;141/203).Patients underwent to evaluate SCCA-IgM by enzyme-linked immunosorbent assay(Hepa-IC,Xeptagen,Italy)and AFP levels at *** were followed-up for 60 mo,being censored at the time of the appearance of *** There were 10.8%and 23.1%of HCC development at two-and five-years *** with HCC showed higher levels of SCCA-IgM than those without it(425.72±568.33 AU/mL vs 195.93±188.40 AU/mL,P=0.009)during the fiveyear *** multivariate analysis,after adjusting by age,sex,aspartate transaminase and Child-Pugh,the following factors were independently associated with HCC:SCCA-IgM[Hazard ratio(HR)=1.001,95%CI:1.000-1.002;P=0.003],AFP(HR=1.028,95%CI:1.009-1.046;P=0.003)and creatinine(HR=1.56495%CI:1.151-2.124;P=0.004).The log-rank test of the combination resulted in 7.488(P=0.024)in estimation cohort and 11.061(P=0.004)in the validation cohort,and a 100%of correctly classified rate identifying a low-risk group in both cohorts in the two-year *** We have constructed a predictive model based on the combination of SCCA-IgM and AFP that provides a new HCC screening method,which could be followed by tailored HCC surveillance for individual patients,esp

关键词： Squamous cell carcinoma antigen Hepatocellular carcinoma prediction Precision medicine Stratification of cirrhotic patient

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A Regulatory Module Controlling CA-Mediated Endosperm Cell Expansion Is Critical for Seed Germination in Arabidopsis

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Molecular Plant 2019年第1期12卷 71-85页

作者： rocio Sanchez-Montesino Laura Bouza-Morcillo Julietta Marquez Melania Ghita Salva duran-Nebreda Luis Gomez Michael J.Holdsworth George Bassel Luis Onate-Sanchez Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid-lnstituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria Campus de MontegancedoPozuelo de AlarconMaddd 28223Spain School of Biosciences University of NottinghamLoughborough LE12 5RDUK School of Biosciences University of BirminghamBirmingham B15 23-rUK Departamento de Sistemas y Recursos Naturales E.T.S.I.MontesForestal y del Medio NaturalCampus de Moncloa28040 MadridSpain

A key component of seed germination is the interplay of mechanical forces governing embryo growth and the surrounding restraining endosperm *** cell separation is therefore thought to play a critical role in the control of this developmental *** we demonstrate that in Arabidopsis thaliana seeds,endosperm cell expansion is a key component of *** cells expand to accommodate embryo growth prior to *** show that this is an actively regulated process supported by spatiotemporal control of the cell expansion gene EXPANSIN 2 (EXPA2).The NAC transcription factors NAC25 and NACIL were identified as upstream regulators of EXPA2 expression,gibbereliinmediated endosperm expansion,and seed *** DELLA protein RGL2 repressed activation of the EXPA2 promoter by NAC25/*** together,our findings uncover a key role of the GA/ DELLA-NAC25/NACIL-EXPA2 network in regulating endosperm cell expansion to control the seed-toseedling transition.

关键词： cell expansion cell-wall remodeling enzymes endosperm expansin NAC transcription factors seed germination

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Effect of magnesium on the aluminothermic reduction rate of zinc oxide obtained from spent alkaline battery anodes for the preparation of Al–Zn–Mg alloys

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International Journal of Minerals,Metallurgy and Materials 2016年第4期23卷 458-465页

作者： rocio Ochoa Alfredo Flores Jesus Torres Cinvestav-Saltillo

The aluminothermic reduction of zinc oxide（ZnO） from alkaline battery anodes using molten Al may be a good option for the elaboration of secondary 7000-series alloys. This process is affected by the initial content of Mg within molten Al, which decreases the surface tension of the molten metal and conversely increases the wettability of ZnO particles. The effect of initial Mg concentration on the aluminothermic reduction rate of ZnO was analyzed at the following values： 0.90wt%, 1.20wt%, 4.00t%, 4.25wt%, and 4.40wt%. The ZnO particles were incorporated by mechanical agitation using a graphite paddle inside a bath of molten Al maintained at a constant temperature of 1123 K and at a constant agitation speed of 250 r/min, the treatment time was 240 min and the ZnO particle size was 450？500 mesh. The results show an increase in Zn concentration in the prepared alloys up to 5.43wt% for the highest initial concentration of Mg. The reaction products obtained were characterized by scanning electron microscopy and X-ray diffraction, and the efficiency of the reaction was measured on the basis of the different concentrations of Mg studied.

关键词： aluminothermic reduction alkaline batteries zinc oxide waste utilization aluminum zinc magnesium alloys

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Excitatory synapse impairment and mitochondrial dysfunction in Huntington’s disease: heat shock factor 1 (HSF1) converging mechanisms

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Neural Regeneration Research 2020年第1期15卷 69-70页

作者： Nicole Zarate rocio Gomez-Pastor Department of Neuroscience School of Medicine University of Minnesota

Heat shock factor 1(HSF1)is abnormally degraded in Huntington’s disease(HD):HD is a neurodegenerative disorder characterized by severe cognitive and motor *** is caused by a CAG repeat expansion within exon 1 of the huntingtin(HTT)gene(The Huntington’s Disease Collaborative Research Group,1993).These expansions lead to the production of an aberrant mutant huntingtin protein(mHTT)that is prone to misfolding and *** and aggregation of mHTT is present in virtually all cell types in the body but preferentially affects medium spiny neurons of the striatum,a brain region that controls movement and some forms of *** of mHTT leads to,but not only,transcriptional dysregulation,DNA damage,mitochondrial dysfunction and excitatory synaptic failure ultimately causing neuronal ***,the molecular mechanisms by which mHTT exerts these defects are still unclear.

关键词： Huntington impairment shock

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Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review

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World Journal of Gastroenterology 2020年第37期26卷 5617-5628页

作者： Miguel Jimenez Perez rocio Gonzalez Grande UGC de Aparato Digestivo Unidad de Hepatologia-Trasplante HepaticoHospital Regional Universitario de MalagaMalaga 29010Spain

Although artificial intelligence(AI)was initially developed many years ago,it has experienced spectacular advances over the last 10 years for application in the field of medicine,and is now used for diagnostic,therapeutic and prognostic purposes in almost all *** application in the area of hepatology is especially relevant for the study of hepatocellular carcinoma(HCC),as this is a very common tumor,with particular radiological characteristics that allow its diagnosis without the need for a histological ***,the interpretation and analysis of the resulting images is not always easy,in addition to which the images vary during the course of the disease,and prognosis and treatment response can be conditioned by multiple *** vast amount of data available lend themselves to study and analysis by AI in its various branches,such as deeplearning(DL)and machine learning(ML),which play a fundamental role in decision-making as well as overcoming the constraints involved in human *** is a form of AI based on automated learning from a set of previously provided data and training in algorithms to organize and recognize *** is a more extensive form of learning that attempts to simulate the working of the human brain,using a lot more data and more complex *** review specifies the type of AI used by the various ***,welldesigned prospective studies are needed in order to avoid as far as possible any bias that may later affect the interpretability of the images and thereby limit the acceptance and application of these models in clinical *** addition,professionals now need to understand the true usefulness of these techniques,as well as their associated strengths and limitations.

关键词： Artificial intelligence Machine learning Hepatocellular carcinoma Diagnosis Treatment Prognosis

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Evaluation of an educational telephone intervention strategy to improve non-screening colonoscopy attendance:A randomized controlled trial

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World Journal of Gastroenterology 2020年第47期26卷 7568-7583页

作者： Agustin Seoane Xenia Font Juan C Perez rocio Perez Carlos F Enriquez Miriam Parrilla Faust Riu Josep M Dedeu Luis E Barranco Xavier duran Ines A Ibanez Marco A Alvarez Digestive Department Endoscopy UnitHospital del MarParc de Salut MarBarcelona 08003Spain Colorectal Cancer Research Group IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain Department of Medicine Autonomous University of BarcelonaBarcelona 08003Spain Consulting Service on Methodology for Biomedical Research IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain

BACKGROUND Colonoscopy attendance is a key quality parameter in colorectal cancer population screening *** these programmes,educative interventions with bidirectional contact carried out by trained personnel have been proved to be an important tool for colonoscopy attendance improvement,and because of its huge clinical and economic impact,they have been widely ***,outside of this population programmes,educative measures to improve colonoscopy attendance have been poorly studied and no navigation interventions are usually *** To investigate the clinical and economic impacts of an educational telephone intervention on colonoscopy attendance outside colorectal cancer screening *** This randomized controlled trial included consecutive patients referred to colonoscopy from primary care centres from November 2017 to May *** intervention group(IG)received a telephone intervention,while the control group(CG)did *** assigned to the IG received an educational telephone call 7 d before the colonoscopy *** intervention was carried out by two nurses with deep endoscopic knowledge who were previously trained for a telephone educational intervention for *** impact on patient compliance with preparedness protocols related to bowel cleansing,antithrombotic management,and sedation scheduling was also evaluated.A second call was conducted to assess patient ***-to-treat(ITT)and perprotocol(PP)analyses were *** A total of 738 and 746 patients were finally included in the IG and CG *** hundred thirteen(83%)patients were contacted in the *** non-attendance rate was lower in the IG,both in the ITT analysis(IG 8.4%vs CG 14.3%,P<0.001)and in the PP analysis(4.4%vs 14.3%,P<0.001).In a multivariable analysis,belonging to the control group increased the risk of nonattendance in both,the ITT analysis(OR 1.81,95%CI:1.27 to 2.58,P=0.001)and the PP analysis(O

关键词： Colonoscopy Quality improvement No-show patients Nursing education Patient compliance Telephone intervention

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Morpho-Anatomy of the Echium plantagineum L. (Boraginaceae) Diaspores in Relation with Water Uptake and Germination

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Phyton-International Journal of Experimental Botany 2020年第2期89卷 345-360页

作者： Maria Laura Molinelli rocio Tarifa Patricia Perisse Catedra de Botanica Morfologica Facultad de Ciencias AgropecuariasUniversidad Nacional de CordobaCordobaArgentina

Echium plantagineum(Boraginaceae)is native of the Mediterranean regions,has been introduced and become widespread within the American continent(North to South),South Africa,New Zealand and *** plant has seed dormancy,aggressively spreads to infest vast areas of predominantly agricultural land and is considered a toxic weed to *** objectives of this research were:(i)to study the morpho-anatomy of the diaspores of ***;(ii)to identify the pathway of water uptake;and(iii)to characterize the germination and the *** morpho-anatomical studies were carried out analyzing semi-permanent slides of transverse and longitudinal sections of the fruits,seeds and ***,histochemical and conventional staining techniques by using stereoscopic,optical and scanning electron microscopy were *** the diaspores,the water uptake pathway was determined by fast green staining,germination tests were performed and the morpho-anatomy of seedlings was *** diaspores showed acrescent calyx surrounding the fruit,composed by 4 rough tuberculate *** indehiscent mericarpid encloses an exalbuminous seed with a thin coat and a spatulate embryo with folded *** uptake took place through the vascular trace“protuberance”in the cicatrix of the mericarpid,which triggers the germination *** was epigeal,the cotyledons were photosynthetically active at the emergence,and a rudimentary developed gemmula was *** percentage was 66.5%.The macrosclereids of the pericarp functions as an obstacle to water uptake,which is overcome when the mericarpid is detached from the gynobase,and the protuberance that acts as a water uptake path is exposed,leading to *** morpho-anatomical characteristics of diaspore,explain the successful dispersal for this aggressive weed,and provide important information in relation to the necessary care for its control.

关键词： Echiumplantagineum fruit germination imbibition mericarpid seed

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New Precipitation and Temperature Grids for Northern Patagonia： Advances in Relation to Global Climate Grids

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Journal of Meteorological Research 2016年第1期30卷 38-52页

作者： Emilio Bianchi Ricardo Villalba Maximiliano Viale Fleur Couvreux rocio Marticorena instituto nacional de tecnología agropecuaria estación experimental agropecuaria barilocheModesta Victoria 4450BarilocheArgentina consejo nacional de investigaciones científicas y tcnicas Argentina instituto argentino de nivología glaciología y ciencias ambientales-consejo nacional de investigaciones científicas y tcnicasMendozaRuiz LealMendozaArgentina centre national de recherches mtorologiques(cnrm-game) Mdtdo-FranceToulouseFrance autoridad interjurisdiccional de cuencas Argentina

Climate data of mean monthly temperature and total monthly precipitation compiled from different sources in northern Patagonia were interpolated to 20-km resolution grids over the period 1997-2010. This northern Patagonian climate grid （NPCG） improves upon previous gridded products in terms of its spatial resolution and number of contributing stations, since it incorporates 218 and 114 precipitation and temper- ature records, respectively. A geostatistical method using surface elevation from a Digital Elevation Model （DEM） as the ancillary variable was used to interpolate station data into even spaced points. The maps provided by NPCG are consistent with the broad spatial and temporal patterns of the northern Patagonian climate, showing a comprehensive representation of the latitudinal and altitudinal gradients in temperature and precipitation, as well as their related patterns of seasonality and continentality. We compared the per- formance of NPCG and various other datasets available to the climate community for northern Patagonia. The grids used for the comparison included those of the Global Precipitation Climatology Project, ERA- Interim, Climate Research Unit （University of East Anglia）, and University of Delaware. Based on three statistics that quantitatively assess the spatial coherence of gridded data against available observations （bias, MAE, and RMSE）, NPCG outperforms other global grids. NPCG represents a useful tool for understand- ing climate variability in northern Patagonia and a valuable input for regional models of hydrological and ecological processes. Its resolution is optimal for validating data from the general circulation models and working with raster data derived from remote sensing, such as vegetation indices.

关键词： northern Patagonia precipitation temperature co-kriging climate grids Cordillera de los Andes

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Well-controlled autoimmune hepatitis treatment withdrawal may be safely accomplished without liver-biopsy guidance

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Gastroenterology Report 2018年第4期6卷 284-290,I0002页

作者： John Guirguis Yilien Alonso rocio Lopez William Carey Department of Internal Medicine Blake Medical CenterBradentonFLUSA Department of Gastroenterology Ochsner Health SystemNew OrleansLAUSA Department of Quantitative Health Sciences Cleveland ClinicClevelandOHUSA Digestive Disease Institute Department of Gastroenterology and HepatologyCleveland ClinicClevelandOHUSA

Background:Autoimmune hepatitis may flare up after treatment withdrawal,especially in those who had not achieved histological remission but had normal liver *** European Association for the Study of the Liver(EASL)and the American Association for the Study of Liver Disease(AASLD)Guidelines recommend performing liver biopsy before treatment *** aim of the study is to define the outcome of treatment withdrawal in adults with wellcontrolled disease for 2 years with and without liver-biopsy ***:A retrospective observational study was conducted on biopsy-proven autoimmune hepatitis patients who were treated for 2 years and with persistently normal aspartate aminotransferase(AST)and alanine aminotransferase(ALT)or nearly so for 6 months prior to treatment *** were:juvenile onset autoimmune hepatitis and prior treatment or use of agents other than corticosteroids and *** primary endpoint was to define freedomfrom flare-ups for 1 year after treatment ***:Thirty-four consecutive subjectsmeeting study criteria were *** withdrawal was accomplished in 24 subjects without liver-biopsy guidance and 10 had pre-treatment withdrawal liver ***,immunosuppressive usage,pre-treatment cirrhosis and pre-treatment liver enzymes were similar between the two groups,and 25%had an enzyme flare-up within 12months after treatment withdrawal,which was similar in the two groups(20.8 vs 30.0%,P=0.57).Conclusions:Adults with autoimmune hepatitis and excellent response to therapy for 2 years are candidates for treatment withdrawal without the need for liver biopsy.

关键词： Autoimmune hepatitis liver biopsy treatment withdrawal liver enzyme

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Vedolizumab for chronic antibiotic-refractory pouchitis

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Gastroenterology Report 2019年第2期7卷 121-126,I0002页

作者： Amandeep Singh Freeha Khan rocio Lopez Bo Shen Jessica Philpott Department of Gastroenterology Hepatology and NutritionCleveland Clinic9500 Euclid AvenueClevelandOH 44195USA Center for Populations Health Sciences&Quantitative Health Sciences Cleveland Clinic9500 Euclid AvenueClevelandOH 44195USA

Background:Chronic antibiotic-refractory pouchitis(CARP)is a complication of ileal pouch-anal anastomosis(IPAA),which poses a therapeutic ***,a gut-selective monoclonal antibody to the a4b7 of integrin,has been used in such patients,but data on its efficacy are *** aim was to assess the efficacy and safety of vedolizumab as induction therapy in CARP ***:In this single-center,historic cohort,patients with CARP who received vedolizumab between January 2015 to June 2017 were identified and *** were included if they had active pouchitis with a total of modified pouch disease activity index(mPDAI)score5 or if unavailable clinician diagnosis of active ***-treatment and at 3-month posttherapy pouchoscopy and clinical visits were used to calculate ***:A total of 19 patients were included in the *** mean age was 26.7612.8 years,with 10(53%)***(47%)patients had been treated with anti-tumor necrosis factor(TNF)agents before colectomy and 10(53%)had anti-TNFs after colectomy and ***(32%)patients had improvement in the mPDAI symptom subscores(P=0.031)and 14(74%)had improvement in both endoscopic and total mPDAI scores with a median change of-2 units(both P=0.031).Adverse events were noted only in two(11%)patients and four(21%)required surgery for ***:Our study suggests that vedolizumab has efficacy and can be safely used for CARP *** studies with a higher number of patients are required to confirm these findings.

关键词： Vedolizumab chronic antibiotic-refractory puchitits modified pouch disease activity index

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