检索结果-南通市图书馆

Is the near coming xenotransplantation era relieving us from needing to look for more non-living organ donors?

World Journal of Transplantation 2022年第12期12卷 388-393页

作者： Fernando M Gonzalez Francisca del roc.. Gonzalez Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile Web Intelligence Centre Faculty of Physics and Mathematical SciencesUniversidad de ChileSantiago 8370397Chile

Despite organ transplantation being the most successful treatment for end-stage organ dysfunction,the number of annual solid organ transplantations is much lower than that required to satisfy the demand of patients on waiting *** explanation for this phenomenon is the relative scarcity of non-living organ donors due to several factors,such as:(1)Late arrival of patients with a neuroc..tical condition to an emergency service;(2)lack of detection of those patients as possible organ donors by health professionals dedicated to proc..ement or by clinicians at emergency and intensive care units,for instance;(3)late transfer of the patient to an intensive care unit to try to recover their health and to provide hemodynamic,ventilatory,and metabolic support;(4)lack of confirmation of the physiological status of the possible donor;(5)late or incorrect positive diagnosis of the subject’s death,either due to brain or cardiac death;(6)difficulty in obtaining legal authorization,either by direct relatives or by the authority,for the extraction of organs;and(7)deficient retrieval surgery of the organs actually *** recent reports of relatively successful xenotransplants from genetically modified pigs open the possibility to fix this mismatch between supply and demand,but some technical(organ rejection and opportunistic infections),and economic issues,still remain before accepting a progressive replacement of the organ sources for *** approximate economic cost analysis suggests that the hypothetical acquisition cost of any genetically modified pig derived organ is high and would not even satisfy the solid organ demand of the wealthiest countries.

关键词： Organ donation Xenotransplantation proc..ement Kidney transplantation Costs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Susceptibility to gravitational proc..ses due to land cover change in the Río Chiquito-Barranca del Muerto subbasin(pico De Orizaba Volcano, México)

引用

Journal of Mountain Science 2017年第12期14卷 2511-2526页

作者： alanis-anaya roc.. marisol legorreta-paulin gabriel mas jean francois granados-ramirez guadalupe rebeca college of geography faculty of philosophy and lettersnational autonomus university of mexico(unam)Mexico City 04510Mexico department of physical geography institute of geographynational autonomus university of mexico(unam)Mexico City 04510Mexico center for research in environmental geography national autonomus university of mexico(unam)Mexico City 58190Mexico

instability associated Land cover change can lead to slope by accelerating erosive proc..ses with agriculture, forestry, and infrastructure. The Rio Chiquito-Barranca del Muerto subbasin has experienced an increase in land cover change due to government programs and the establishment of agricultural and urban areas. The aim of this study was to provide a model to map the susceptibility to gravitational proc..ses along sites where anthropogenic land cover change has occurred. The method was based on the stratification of the subbasin according to landforms and cartographic variables. These variables were used in a multi- criteria assessment to assign weights according to their contribution to the onset of new gravitationalproc..ses. Those weights were used to create a susceptibility map based on a weighted linear sum. The accuracy of the resulting map was validated in an error matrix with a random stratified design based on susceptibility classes per landform. The results produced a map of areas with susceptibility to gravitational proc..ses due to land cover change; this susceptibility is very high in the undifferentiated pyroc..stic slope and limestone mountain, where it derives not only from anthropogenie effects on natural vegetation cover, but also from steep slopes, weathered materials, low apparent density, high erosivity, and previous gravitational proc..ses. The results support other studies that concluded that loss of vegetation is a triggering factor in the formation of gravitational proc..ses, but also show that excessive reforestation can increase gravitational proc..ses.

关键词： Gravitational proc..ses susceptibility Land cover change Multi-criteria assessment pico de Orizaba volcano

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Green Extraction of Bioactive Compounds from Microalgae

引用

Journal of Analysis and Testing 2018年第2期2卷 109-123页

作者： roc.. Gallego Lidia Montero Alejandro Cifuentes Elena Ibáñez Miguel Herrero Laboratory of Foodomics Institute of Food Science Research(CIALCSIC-UAM)Nicolás Cabrera 928049 MadridSpain Laboratory of Applied Analytical Chemistry University Duisburg-EssenUniversitaetsstr.545141 EssenGermany

At present,there is an increasing demand for natural bioactive compounds able to provide health benefits when included and consumed in a functional food or in a *** this regard,microalgae are promising natural sources with great potential,not only considering that these organisms are largely underexplored,but also because microalgae can be produced at large scale and their chemical composition might be tuned to over-synthesize a particular target *** use of advanced sustainable extraction techniques to recover these bioactive compounds is a must *** work presents an overview on the use of compressed fluid-based extraction techniques to obtain bioactive compounds from microalgae that can be seen also as a first step towards its recovery at larger *** relevant,the description of the analytical proc..ure used to chemically characterize the bioactive compounds is also included.

关键词： Bioactives Compressed fluids Green extraction techniques Microalgae pressurized liquids Supercritical fluids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical Treatment of Craniopharyngiomas in Adults:Comparison between primary Surgery and Surgery for Recurrence

引用

Current Medical Science 2022年第6期42卷 1119-1130页

作者： roc.. Evangelista Zamora Florian Grimm Sasan Darius Adib Antje Bornemann Jürgen Honegger Department of Neurosurgery University of TübingenTübingen72076Germany Department of Neurosurgery Hospital Universitario Marqués de ValdecillaSantander39008Spain Institute of Neuropathology University of TübingenTübingen72076Germany

Objective Few studies have investigated the differences in outcomes between primary and repeat surgery for a craniopharyngioma in *** a result,a treatment concept for adult patients with a craniopharyngioma has not yet been *** present study aimed to retrospectively analyze adult patients with craniopharyngioma to compare surgical outcomes between primary surgery and surgery for *** The demographic and clinical data of 68 adult patients with craniopharyngioma who had primary surgery(n=50)or surgery for recurrence(n=18)were retrospectively *** addition,the patients were followed up for an average of 38.6 months(range:1–133 months).Results The cohorts of patients undergoing primary surgery or repeat surgery did not differ preoperatively in terms of demographic data,or radiological tumor ***,patients with recurrent craniopharyngioma had significantly more pituitary hormone deficits and hypothalamo-pituitary disorders before surgery compared with patients with newly diagnosed *** success rate of complete resection in primary surgery was 53.2%.Even after repeat surgery,a satisfactory rate of complete resection of 35.7%was *** morbidity was increased neither in patients with repeat surgery compared with those with primary surgery(postoperative bleeding p=0.560;meningitis p=1.000;CSF leak p=0.666;visual disturbance p=0.717)nor in patients with complete resection compared with those with partial *** found no difference in recurrence-free survival between initial surgery and repeat surgery(p=0.733).The recurrence rate was significantly lower after complete resection(6.9%)than after partial resection(47.8%;ppting complete resection is justified for not only those with newly diagnosed craniopharyngioma but also for those with recurrent ***,the surgeon must settle for less than total resection if postoperative morbidity is anticipated.

关键词： craniopharyngioma adulthood transcranial transsphenoidal primary surgery recurrence recurrence-free survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ET-1、IL-6以及可溶性白介素-2受体与颅脑损伤后脑血管痉挛的相关性分析

引用

医学理论与实践 2024年第5期37卷 734-737,747页

作者：皮亮周雷廷李子博河南省周口市中心医院神经外科 466700

目的:探讨内皮素-1(ET-1)、白细胞介素-6(IL-6)以及可溶性白介素-2受体(SIL-2R)与颅脑损伤后脑血管痉挛的相关性。方法:选取我院2019年10月—2022年10月收治的102例颅脑损伤患者作为研究对象,均对所有患者采用经颅多普勒血流分析仪检测... 详细信息

目的:探讨内皮素-1(ET-1)、白细胞介素-6(IL-6)以及可溶性白介素-2受体(SIL-2R)与颅脑损伤后脑血管痉挛的相关性。方法:选取我院2019年10月—2022年10月收治的102例颅脑损伤患者作为研究对象,均对所有患者采用经颅多普勒血流分析仪检测其平均血流速度,根据血流速度划分为单纯颅脑损伤组(36例)、轻症痉挛组(41例)、重症痉挛组(25例)。对比三组患者ET-1、IL-6、SIL-2R表达水平,并分析ET-1、IL-6、SIL-2R与颅脑损伤后脑血管痉挛的相关性。随后建立受试者特征工作(roc..线,分析ET-1、IL-6、SIL-2R对颅脑损伤后脑血管痉挛的诊断效能。对66例颅脑损伤后脑血管痉挛患者进行随访,将治疗后重新进入ICU与院内死亡的21例患者分为预后不良组,将其余45例患者分为预后良好组,对比预后不良组和预后良好组患者临床一般情况,并分析ET-1、IL-6、SIL-2R对颅脑损伤后脑血管痉挛的预后预测价值。结果:重症痉挛组血清ET-1、IL-6、SIL-2R水平高于轻症痉挛组和单纯颅脑损伤组(ppearman相关分析结果显示,ET-1、IL-6、SIL-2R与颅脑损伤后脑血管痉挛呈正相关(proc..面积(AUC)依次为0.688、0.667、0.656、0.821;且三者联合的诊断灵敏度(74.58%)和特异度(86.32%)高于单独诊断;预后良好组与预后不良组患者性别、年龄、BMI、颅脑损伤类型对比无明显差异(p>0.05),预后良好组和预后不良组患者脑挫伤范围、就诊时间、ApACHEⅡ评分、平均血流速度、ET-1、IL-6、SIL-2R水平对比差异显著(ppACHEⅡ评分、平均血流速度、ET-1、IL-6、SIL-2R为颅脑损伤后脑血管痉挛预后不良的独立影响因素(p<0.05)。结论:颅脑损伤后重症脑血管痉挛患者血清ET-1、IL-6、SIL-2R水平明显升高,三者联合对于脑血管痉挛的诊断价值较高,且三者为颅脑损伤后脑血管痉挛预后不良的独立影响因素,因此,临床上对于ET-1、IL-6、SIL-2R水平升高的颅脑损伤后脑血管痉挛需及时改良方案,提升患者预后水平。

关键词：内皮素-1 白细胞介素-6 可溶性白介素-2受体颅脑损伤脑血管痉挛预后预测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Expert System Oriented towards the Detection of Influenza and Dengue Developed on Mobile platforms

引用

Journal of Software Engineering and Applications 2015年第6期8卷 295-301页

作者： Raúl Beltrán Ramírez roc.. Maciel Arellano Carlos González Sandoval Adauto Casas Flores Departamento de Sistemas de Información Universidad de Guadalajara Periférico NorteZapopanMéxico Centro de Ensenanza Técnica Industrial GuadalajaraMéxico

Nowadays, mobile technology makes it possible for us to realize proc..ses in a relatively short amount of time, showing the user friendly and efficient interfaces that any person is capable of adapting to. Continuing this trend, we develop a mobile application that aids in giving an early diagnosis of Influenza and Dengue, two diseases that affect approximately 5% of the world population (in the case of Dengue) and 5% - 15% of the northern hemisphere (in the case of influenza). Our application consists of an expert system based on fuzzy logic that analyzes symptoms introduced by the user and formulates a diagnosis in approximately 2 - 4 minutes. This system considerably reduced the diagnostic time, improving the recuperation proc..s from these diseases due to their early detection.

关键词： Mobile Technology Mobile Applications Dengue Influenza Expert System

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Management of hepatitis B virus infection after liver transplantation

引用

World Journal of Gastroenterology 2015年第42期21卷 12083-12090页

作者： Miguel Jiménez-pérez roc.. González-Grande José Mostazo Torres Carolina González Arjona Francisco Javier Rando-Mu?oz Liver Transplantation and Hepatology Unit UGC de Aparato Digestivo Hospital Regional Universitario Department of Abdominals Diseases Hospital Nij Smellinghe Ziekenhuis

Chronic hepatitis B virus(HBV) infection is responsible for up to 30% of cases of liver cirrhosis and up to 53% of cases of hepatocellular carcinoma. Liver transplantation(LT) is the best therapeutic option for patients with end-stage liver failure caused by HBV. The success of transplantation, though, depends on receiving prophylactic treatment against post-transplant viral reactivation. In the absence of prophylaxis, liver transplantation due to chronic hepatitis B(CHB) is associated with high rates of viral recurrence and poor survival. The introduction of treatment with hepatitis B immunoglobulins(HBIG) during the 1990 s and later the incorporation of oral antiviral drugs have improved the prognosis of these patients. Thus, LT for CHB is now a universally accepted option, with an estimated 5 years survival of around 85% vs the 45% survival seen prior to the introduction of HBIG. The combination of lamivudine plus HBIG has for many years been the most widely used prophylactic regimen. However, with the appearance of new more potent oral antiviral agents associated with less resistance(e.g., entecavir and tenofovir) for the treatment of CHB, new prophylactic strategies are being designed, either in combination with HBIG or alone as a monotherapy. These advances have allowed for more personalized prophylaxis based on the individual risk profile of a given patient. In addition, the small pool of donors has required the use of anti-HBc-positive donors(with the resulting possibility of transmitting HBV from these organs), which has been made possible by suitable prophylactic regimens.

关键词： Hepatitis B virus Liver tra nsplantation Recurrence prophylaxis Hepatitis B immunoglobulin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel regulatory region controls IgH locus transcription and switch recombination to a subset of isotypes

引用

Cellular & Molecular Immunology 2019年第11期16卷 887-889页

作者： roc.. Amoretti-Villa Mélanie Rogier Isabelle Robert Vincent Heyer Bernardo Reina-San-Martin Institut de Génétique et de Biologie Moléculaire et Cellulaire(IGBMC) IllkirchFrance Institut National de la Santéet de la Recherche Médicale(INSERM) U1258IllkirchFrance Centre National de la Recherche Scientifique(CNRS) UMR7104IllkirchFrance Universitéde Strasbourg IllkirchFrance

Class switch recombination(CSR)occurs at the IgH locus and replaces the immunoglobulin(Ig)isotype expressed from IgM to IgG,IgE or IgA,endowing the B cell receptor with novel effector *** is triggered by activation-induced cytidine deaminase(AID),1 an enzyme that deaminates cytosines to uracils in single-stranded DNA exposed by *** distinct antibody isotypes are encoded in the IgH locus in individual transcription units composed of a cytokine-inducible promoter,an intronic exon,and a switch region(Sx),followed by the exons encoding the constant region(Cx)(Fig.S1a).During CSR,the choice of recombination to a particular isotype is determined by the stimulation-dependent activation of specific promoters,triggering the generation of noncoding germline transcripts(GLTs).2 Thus far,the transcriptional regulation of the IgH locus is known to be controlled by the Eμenhancer,located downstream of the variable region and upstream of the donor switch region(Sμ),and the 3′regulatory region(3′RR)super-enhancer located downstream of Cα.

关键词： IgH stimulation replace

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HoD Detector, a System to Create Indicators about the Happiness of Citizens in a Smart City: Case of Study—GDL Smart City

引用

Journal of Software Engineering and Applications 2016年第10期9卷 524-532页

作者： Raúl Beltrán Ramírez roc.. Maciel Arellano Leopoldo Gómez Víctor Larios Rosillo Carlos González Sandoval Departamento de Sistemas de Información Universidad de Guadalajara Periférico Norte Zapopan México Centro de Enseñ anza Técnica Industrial Guadalajara México

Happiness is the ultimate goal for every living human being, and this condition motivates people to stay active and want to be alive. Having this feeling also fosters the proactivity of citizens. The opposite is depression, a condition capable of significantly affecting a person’s behavior or perception. HoD Detector is a low-cost, easy to use application that aids in the diagnosis of a depressive disorder and motivates the user to seek professional help. The purpose of this study is to propose a way to measure happiness through the measurement of depression;to develop HoD Detector, evaluate the accuracy and usability of this application (with university students) for future enhancements of the system. The development of this application involved basic algorithms and the use of a database to successfully make a diagnosis and store the results of each user for further reference. The application is capable of giving a proper diagnosis with the time interval of 2 - 5 minutes. HoD Detector has the potential to become an extremely useful tool to diagnose depression and motivate users to seek professional help not only in Mexico, but also on an international scale for improving in people’s happiness condition.

关键词： Smart Cities Smart City Metrics Mental Health Happiness Depression mHealth App

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vitamin C twice a day enhances health

引用

Health 2010年第8期2卷 819-823页

作者： Alfred roc..rdman 不详

This review provides information determining how much vitamin C to take, including analysis of the recent findings, which demonstrate advantages and problems with higher daily doses. The Daily Value for vitamin C was raised to 90 mg for men in 2000, and Upper Limit of 2,000 mg per day was established as being safe. This followed a study of urinary excretion of vitamin C (AA) that demonstrated 500 mg twice a day provides levels sufficient to cause continuous urinary excretion in humans. That is the lowest oral dosage evaluated that significantly saturates blood plasma. A later study endorsed 200 mg from dietary sources for the RDA. Even though plasma concentration of AA is then significantly lower, at 200 mg daily certain white blood cells are saturated with AA. Recently many studies have indicated the benefit of high levels of AA to maintain the brain, bones, and heart, reduce damage from stroke, brain trauma, and cataracts, and lower the risk of cancer metastasis and colds. pro-oxidant activity has been found only for i.v. adminstration, where high concentrations appear effective destroying tumor cells while not harming normal cells. This review evaluates recent research and finds it consistent with the hypothesis that people, especially older people and soldiers in combat environments, are likely to benefit if they maintain the saturating level of AA by taking 500mg supplements twice a day.

关键词： Antioxidant Vitamin C Ascorbic Acid Stroke Alzheimer’s Oxidative Stress Cardiovascular Disease Cataracts Osteoporosis Mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：