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Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis

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World Journal of Gastroenterology 2023年第22期29卷 3440-3468页

作者： Henrique Inhauser Riceti Magalhães Felipe Alexandre Machado Roberta Figueiroa Souza Marcos Antônio Ferreira Caetano Vanessa Ribeiro Figliuolo robson coutinho-silva Patricia Castelucci Department of Surgery School of Veterinary Medicine and Animal SciencesUniversity of São PauloSão Paulo 05508-270Brazil Department of Anatomy University of São PauloSão Paulo 05508-000Brazil Biophysics Institute Carlos Chagas Filho Federal University of Rio de JaneiroRio de Janeiro 21941-902Brazil

BACKGROUND The literature indicates that the enteric nervous system is affected in inflammatory bowel diseases(IBDs)and that the P2X7 receptor triggers neuronal ***,the mechanism by which enteric neurons are lost in IBDs is *** To study the role of the caspase-3 and nuclear factor kappa B(NF-κB)pathways in myenteric neurons in a P2X7 receptor knockout(KO)mouse model of *** Forty male wild-type(WT)C57BL/6 and P2X7 receptor KO mice were euthanized 24 h or 4 d after colitis induction by 2,4,6-trinitrobenzene sulfonic acid(colitis group).Mice in the sham groups were injected with *** mice were divided into eight groups(n=5):The WT sham 24 h and 4 d groups,the WT colitis 24 h and 4 d groups,the KO sham 24 h and 4 d groups,and the KO colitis 24 h and 4 d *** disease activity index(DAI)was analyzed,the distal colon was collected for immunohistochemistry analyses,and immunofluorescence was performed to identify neurons immunoreactive(ir)for calretinin,P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,and total NF-κ*** analyzed the number of calretinin-ir and P2X7 receptor-ir neurons per ganglion,the neuronal profile area(μm^(2)),and corrected total cell fluorescence(CTCF).RESULTS Cells double labeled for calretinin and P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,or total NF-κB were observed in the WT colitis 24 h and 4 d *** number of calretinin-ir neurons per ganglion was decreased in the WT colitis 24 h and 4 d groups compared to the WT sham 24 h and 4 d groups,respectively(2.10±0.13 vs 3.33±0.17,P<0.001;2.92±0.12 vs 3.70±0.11,P<0.05),but was not significantly different between the KO *** calretinin-ir neuronal profile area was increased in the WT colitis 24 h group compared to the WT sham 24 h group(312.60±7.85 vs 278.41±6.65,P<0.05),and the nuclear profile area was decreased in the WT colitis 4 d group compared to the WT sham 4 d group(104.63±2.49 vs 117.41±1.14,P<0.01).The number of

关键词： Cell death Enteric nervous system Gastroenterology Inflammatory bowel diseases P2X7 receptor Purinergic signaling

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ZnO/CeO_(2)/carbon xerogel composites with direct Z-scheme heterojunctions:Enhancing photocatalytic remediation of 4-chlorophenol under visible light

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Journal of Rare Earths 2024年第2期42卷 314-322,I0003页

作者： Nicolas Perciani de Moraes Maite Birkett de Campos Sanmartin robson da silva Rocha Abner de Siervo Marcos Roberto de Vasconcelos Lanza D.Amaranatha Reddy Lianqing Yu Liana Alvares Rodrigues Escola de Engenharia de Lorena-EEL/USP Estrada Municipal do Campinho S/NCEP 12602-810LorenaSao PauloBrazil Institute of Physics"Gleb Wataghin" Applied Physics DepartmentState University of Campinas13083-859CampinasSPBrazi Instituto de Quimica de Sao Carlos Universidade de Sao PauloAv.Trab.Sao Carlense400-Parque Arnold SchimidtSao CarlosSP13566-590Spain Department of Sciences Indian Institute of Information Technology Design and ManufacturingKurnoolAndhra Pradesh518007India School of Materials Science and Engineering China University of PetroleumQingdao266580China

This paper aims to create visible light driven ternary photocatalysts using zinc oxide(ZnO),cerium(IV)oxide(CeO_(2)),and carbon xerogel(CX) as constituent *** use of CeO_(2) is based on the creation of direct-Z-scheme heterojunctions with the ZnO and the consequent diminishing of charge recombination,whereas the carbon xerogel inclusion is predicted to minimize bandgap energy,decrease electro n-hole reco mbination,and boost specific surface *** re,the choice of the black-wattle tannin as a carbonaceous precursor was targeted at the development of an environmentally friendly and affordable *** existence of the hexagonal phase of zinc oxide and cubic structure of the cerium(IV) oxide in the ternary material was confirmed by X-ray diffractometry and X-ray photoelectron spectroscopy,with the latter also suggesting chemical bonding between the ZnO and the CX due to the creation of zinc oxycarbide *** inclusion of the carbon xerogel provokes a significant modification in the morphology of the ternary material,resulting in an increased surface area and smaller particle *** CX/ZnO-CeO_(2) ternary composite obtains the highest photocatalytic efficiency among all the materials studied,degrading 100% of 4-chlorophenol under simulated sunlight and 68% under visible radiation,after 5 *** increased photocatalytic activity can be attributed to the formation of direct Z-scheme heterojunctions between the semiconductors,higher visible light response,and higher specific surface area,as evidenced by the results obtained by active radical scavenging,chronoamperometry,diffuse reflectance spectroscopy,and N_(2) adsorption-desorption isotherms.

关键词： Zinc oxide Cerium(Ⅳ)oxide Carbon xerogel Photocatalysis Direct Z-scheme heterojunction 4-Chlorophenol Rare earths

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.O’Connell Matthew J.robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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Effects of Yerba Mate Consumption (Ilex paraguariensis) on Cardiac Remodeling in Rats

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Food and Nutrition Sciences 2024年第8期15卷 827-845页

作者： Carlos Eduardo Brochini de Paiva Thaíssa Baptista Brochini de Paiva Isabelle Tiburcio Pecin Ferreira Sandra Cristina Genaro Danilo silva Martins Santos Thaoan Bruno Mariano robson Chacon Castoldi Rafael Stuani Floriano Julia Amanda Rodrigues Fracasso Lucas Pires Guarnier Marina Politi Okoshi Francis Lopes Pacagnelli Postgraduate Program in Health Sciences Unoeste Presidente Prudente Brazil Faculty of Medicine Unoeste Presidente Prudente Brazil Department of Physiotherapy Unoeste Presidente Prudente Brazil Department of Nutrition Unoeste Presidente Prudente Brazil Postgraduate Program in Science and Movement Unesp Rio Claro Brazil Postgraduate Program in Health Promotion University of Northern Paran (UNOPAR) Londrina Brazil School of Dentistry So Paulo State University (UNESP) Araatuba Brazil Department of Genetics Ribeiro Preto Medical School University of So Paulo USP Ribeiro Preto Brazil Internal Medicine Department Botucatu Medical School So Paulo State University (UNESP) Botucatu Brazil

This study investigated the effects of yerba mate consumption, a South American beverage, on cardiac remodeling in rats. For this purpose, 24 male Wistar rats were divided into Control Group (CG) which received filtered water and a standard diet, and Yerba Mate Group (YM), 6 g of Ilex paraguariensis in 100 ml water and the same diet, for 30 days. The YM group showed a reduction in final body weight and food consumption without altering weight gain. Regarding cardiac remodeling, the YM group exhibited a decrease in the right ventricle weight/final body weight ratio, suggesting cardiac atrophy, without affecting the atria and left ventricle. There was no change in cardiomyocyte area or nuclear fractal dimension in both groups. However, animals that consumed yerba mate showed increased collagen deposition and a smaller fractal dimension in the left ventricle. The consumption of yerba mate at room temperature for 30 days induced changes in cardiac remodeling, as evidenced by increased collagen deposition and alterations in fractal dimension in the left ventricle.

关键词： Tereré Ilex paraguariensis Yerba Mate Cardiac Remodeling Fractal Dimension Hypertrophy

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Metabolic disease and the liver: A review

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World Journal of Hepatology 2024年第1期16卷 33-40页

作者： Márcia Vargas Sheila de Castro Cardoso Toniasso Patricia G Riedel Camila Pereira Baldin Francielle Lopes dos Reis robson Martins Pereira Maria Carlota Borba Brum Dvora Joveleviths Mario Reis Alvares-da-silva Program of Graduate Science in Gastroenterology and Hepatology Federal University of Rio Grande do SulPorto Alegre 90040-060Rio Grande do SulBrazil School of Medicine Federal University of Rio Grande do SulPorto Alegre 90040-060Brazil Program of Graduate Science in Gastroenterology and Hepatology Clinicas Hospital of Porto AlegrePorto Alegre 90410000Brazil Medicine Faculty Federal University of Rio Grande do Sul Federal University of Rio Grande do SulPorto Alegre 90040-060Brazil Division of Gastroenterology and Hepatology Clinicas Hospital of Porto AlegrePorto Alegre 90035007Brazil

Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common liver disease worldwide,with an estimated prevalence of 31%in Latin *** presence of metabolic comorbidities coexisting with liver disease varies substantially among *** is acknowledged that obesity is boosting the type 2 diabetes mellitus“epidemic,”and both conditions are significant contributors to the increasing number of patients with *** steatohepatitis represents a condition of chronic liver inflammation and is considered the most severe form of *** diagnosis is based on the presence of steatosis,noninvasive scores and altered liver *** scores of liver fibrosis,such as serum biomarkers,which should be used in primary care to rule out advanced fibrosis,are simple,inexpensive,and widely ***,guidelines from international hepatology societies recommend using noninvasive strategies to simplify case finding and management of high-risk patients with MASLD in clinical ***,there is no definite pharmacological treatment for the *** public health policies to treat patients with risk factors for MASLD prevention is essential.

关键词： Nonalcoholic fatty liver disease Primary care Metabolic risk Liver Metabolism

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Exploring effects of property variation on fragmentation of metal rings using a simple model

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Defence Technology（防务技术） 2023年第5期23卷 1-7页

作者： J.D.robson Department of Materials The University of ManchesterManchesterM139PLUK

A simple finite element implementation of the Mott model for fragmentation of a thin walled ring has been implemented and used to explore the effect of local variations in fracture strain around the *** model has successfully reproduced the fragment size distributions previously reported,which follow a characteristic“Mott distribution”form,providing sufficient(1000)simulations are *** has been shown that this form is retained even when there are large differences in the random distribution of fracture strains or a different choice of function used to describe the fracture strain *** these cases,the strain rate has a much stronger effect than fracture strain distribution the on the average fragment size and fragment ***,for cases where there are a small number of local defects that strongly reduce the fracture strain at certain locations around the ring,the predicted fragment size distribution develops a bimodal *** is also the case for large but gradual variations in fracture strain with position around the *** results have implications for cases where a small number of large pre-existing defects exist,or processing has led to macrozones in the *** utility of a simple fast running model to study these cases is discussed.

关键词： Fragmentation Mott model Property variation

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Abiotic stress on seed germination and plant growth of Zeyheria tuberculosa

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林业研究:英文版 2023年第5期34卷 1511-1522页

作者： robson Luis silva de Medeiros Rinaldo Cesar de Paula Joao Vitor Oliveira de Souza Joao Pedro Peixoto Fernandes Department of Agricultural Sciences School of Agricultural and Veterinarian SciencesSao Paulo State University(Unesp)14884-900JaboticabalSao PauloBrazil

Zeyheria tuberculosa(Vell.)Bureau ex *** among the Brazilian flora threatened with *** has high-quality wood and can be used to recover herbicidecontaminated ***,abiotic stresses can harm seed germination and seedling development under adverse conditions and need to be understood to improve autochthonous or indigenous biodiversity conservation and strengthen reforestation *** study evaluated the effects of temperature,water and saline stress on *** seed germination and water stress on seedling *** laboratory experiments evaluated germination under:(1)different temperatures(20,25,30,35 and 40℃);(2)different water potentials simulated with polyethylene glycol(PEG6000)at 25 and 30℃;and,(3)different osmotic potentials simulated with NaCl at 25 and 30℃.In addition,a greenhouse experiment subjected seedlings to five water regimes(20%,35%,50%,65%and 80%of maximum substrate water holding capacity).In the laboratory,seedling biometry and germination were evaluated,while physiological and morphological parameters were assessed in the *** potential of seeds increased at 25 and 30℃.Germination and vigor decreased as water and saline stresses *** tolerance thresholds for water and salt stresses were-0.6 and-0.4 MPa,*** the greenhouse,the most restrictive water regimes reduced seedling physiological and morphological *** development was compromised at moisture levels below50%field capacity.

关键词： Bignoniaceae Climate change Ipê-felpudo Ipê-preto Water stress

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Rodent hosts and flea vectors in Brazilian plague foci:a review

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Integrative Zoology 2021年第6期16卷 810-819页

作者： Diego Leandro REIS DA silva FERNANDES Matheus FILGUEIRA BEZERRA Marise SOBREIRA BEZERRA DA silva Nilma Cintra LEAL Christian robson DE SOUZA REIS Alzira Maria Paiva DE ALMEIDA Nacional Reference Service for Plague Institut Aggeu Magalhães-FIOCRUZ PERecifePEBrazil Department of Microbiology Institut Aggeu Magalhães-FIOCRUZ PERecifePEBrazil

Plague,caused by the Yersinia pestis bacterium,has several foci scattered throughout a large area from the Brazilian territory that ranges from the Northeastern State of Cearáto the Southeastern State ofMinas Gerais and another separated area at the State of Rio de *** review gathers data from plague control and surveillance programs on the occurrence and geographic distribution of rodent hosts and flea vectors in the Brazilian plague areas during the period of from 1952 to ***,we discuss how the interaction between *** and some rodent host species may play a role in the disease *** absence of human cases nowadays in Brazil does not mean that it was *** dynamics of plague in Brazil and in other countries where it was introduced during the 3rd pandemic are quite alike,alternating epidemics with decades of ***,it remains an important epidemic disease of global *** existence of a large animal reservoir and competent vectors demonstrate a need for continuous surveillance to prevent new outbreaks of this disease in humans.

关键词： fleas plague rodents transmission vectors

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Extracellular vesicle fingerprinting:the next generation for cancer diagnosis?

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Signal Transduction and Targeted Therapy 2020年第1期5卷 294-296页

作者： Vanessa Sandim robson Q.Monteiro Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de JaneiroRio de JaneiroBrazil

In a recent report,Hoshino and colleagues from several institutions around the world demonstrated that large-scale proteomic analysis of extracellular vesicles(EVs)and particles comprising exomeres and two distinct subpopulations of small and large exosomes(which were named as EVPs)might constitute the next generation for cancer diagnosis.

关键词： diagnosis cancer constitute

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Hydraulic energy indices reveal spatial dependence in a subtropical soil under maize crop in Southern Brazil

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Pedosphere 2021年第5期31卷 771-782页

作者： Maria Eliza TUREK robson Andre ARMINDO Ole WENDROTH Graduate Program of Environmental Engineering(PPGEA) Federal University of Paraná(UFPR)Curitiba 81531980(Brazil) Department of Physics(DFI) Federal University of Lavras(UFLA)Mailbox 3037Lavras 37200900(Brazil) Department of Plant&Soil Sciences University of Kentucky(UK)Lexington 40546-0091(USA)

Soil physical quality(SPQ)assessment is an important part in the evaluation of soil use,management,and *** can be assessed using several physical properties,hydraulic indices,and *** from tropical and temperate regions represent different physical behaviors,and the quantification of their physical properties is important to support soil evaluation and *** objective of this study was to evaluate the SPQ in a subtropical field under maize crop cultivation according to its physical properties,hydraulic indices,and functions in an attempt to infer the spatial variability and to determine the behavior of soil physical structure across a spatial *** used soil key physical variables,such as texture,bulk density,total porosity,saturated hydraulic conductivity,and organic carbon content,were measured in a regular grid with a soil sampling density of 30 points per hectare,covering an area of0.5 *** hydraulic conductivity varied strongly between subsamples and in the field,suggesting the heterogeneity of the soil structure regarding water *** physical variables were combined with other indicators,which were based on the soil water retention curve and the pore size distribution(PSD)*** analysis was performed to verify the relationship between the measured and calculated variables,and some strong linear correlations were revealed,such as between aeration energy index and microporosity(r=0.608)and water retention energy index with microporosity(r=0.532)and with bulk density(r=0.541).For most sampled locations,the shape and location parameters of PSD showed results outside of the optimum ranges,whereas the hydraulic energy indices and cumulative hydraulic energy functions presented values that were similar to those found for some tropical soils described in the *** spatial variability of these indices was described using semivariograms and kriged maps,indicating the variability of the SPQ i

关键词： geostatistics integral energy pore size distribution soil physical indicators soil physical quality soil water retention curve

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