检索结果-南通市图书馆

Use of donepezil for neurocognitive recovery after brain injury in adult and pediatric populations:a scoping review

Neural Regeneration Research 2024年第8期19卷 1686-1695页

作者： avery L.Miller Nathan k.Evanson J.Michael Taylor University of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options for the treatment of cognitive deficits associated with traumatic brain injury in pediatric *** inhibitors such as donepezil have been evaluated in adult patients after traumatic brain injury,but relatively less is known about the effect in pediatric *** goal of this review is to identify knowledge gaps in the efficacy and safety of acetylcholinesterase inhibito rs as a potential a djuvant treatment fo r neurocognitive decline in pediatric patients with traumatic brain *** queried PubMed to identify literature published from database inception thro ugh June 2023 desc ribing the use of donepezil in young adult traumatic brain injury and pediatric patients with predefined *** on preselected search criteria,340 unique papers we re selected for title and abstra ct ***-two reco rds were reviewed in full after eliminating preclinical studies and pape rs outside the scope of the *** adult traumatic brain injury,we review results from 14 papers detailing 227 subjects where evidence suggests donepezil is well tole rated and shows both objective and patient-reported efficacy for reducing cognitive *** children,3 pape rs report on 5 children recovering from traumatic brain injury,showing limited *** additional 15 pediatric studies conducted in populations at risk for cognitive dysfunction provide a broader look at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adults with traumatic brain injury and tole rability in pediatric patients,we believe further study of donepezil for children and adolescents with traumatic brain injury is warranted.

关键词： acetylcholinesterase inhibitor adult cognition donepezil pediatrics traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections

引用

World Journal of Transplantation 2014年第2期4卷 43-56页

作者： Christopher S kovacs Jr Christine E koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez robin k avery Steven D Mawhorter kyle D Brizendine Eric D Cober Cyndee Miranda Rabin k Shrestha Lucileia Teixeira Sherif B Mossad Department of Infectious Diseases Medicine InstituteCleveland ClinicClevelandOH 44195United States Division of Infectious Diseases Immunocom-promised Host Infectious Disease ProgramUniversity of North CarolinaChapel HillNC 27599United States Infectious Disease and Internal Medicine Augusta HealthFishersvilleVA 22939United States Department of Pediatric Infectious Diseases Cleveland Clinic Children’sClevelandOH 44195United States Division of Infectious Disease (Transplant/On-cology) Johns HopkinsBaltimoreMD 21205United States

Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor.

关键词： Donor selection Infection Transplantation Mass screening Treatment outcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese

引用

Stroke & Vascular Neurology 2024年第4期9卷 399-406,I0044-I0065页

作者： Songchun Yang Zhijia Sun Dong Sun Canqing Yu Yu Guo Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona Y Millwood robin G Walters Yiping Chen Huaidong Du Yan Lu Sushila Burgess Daniel avery Robert Clarke Junshi Chen Zhengming Chen Liming Li Jun Lv On behalf of the China kadoorie Biobank Collaborative Group Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunanChina Peking University Center for Public Health and Epidemic Preparedness&Response BeijingChina key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina Fuwai Hospital Chinese Academy of Medical Sciences BeijingChina Medical Research Council Population Health Research Unit at the University of Oxford OxfordUK Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordUK NCDs Prevention and Control Department Suzhou CDCSuzhouJiangsuChina China National Center for Food Safety Risk Assessment BeijingChina State key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijingChina 不详

Background and purpose Previous studies,mostly focusing on the European population,have reported polygenic risk scores(PRSs)might achieve risk stratification of *** aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese *** Participants with genome-wide genotypic data in China kadoorie Biobank were split into a potential training set(n=22191)and a population-based testing set(n=72150).Four previously developed PRSs were included,and new PRSs for stroke and its subtypes were *** PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing *** proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes(ischaemic stroke(IS),intracerebral haemorrhage(ICH)and subarachnoid haemorrhage(SAH)).Results In the testing set,during 872919 person-years of follow-up,8514 incident stroke events were *** PRSs of any stroke(AS)and IS were both positively associated with risks of AS,IS and ICH(pk of ICH(HR_(SD)=1.07,95%CI 1.01 to 1.14).PRSS_(AH) was not associated with risks of stroke and its *** addition of current PRSs offered little to no improvement in stroke risk prediction and risk *** In this Chinese population,the association strengths of current PRSs with risks of stroke and its subtypes were moderate,suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asia

关键词： testing prediction increment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ITPk1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

引用

Molecular Plant 2024年第7期17卷 1151-1157页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert k.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas krusenbaum robin Schneider Adolfo Saiardi Dorothea Fiedler Henning J.Jessen Gabriel Schaaf Ricardo F.H.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects Figures 2D,3C,4C,and 7D and Figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

引用

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den Berg Alexander kurilshikov Dasha V.Zhernakova Ranko Gacesa Shixian Hu Esteban A.Lopera-Maya Alexandra Zhernakova Lifelines Cohort Study Vincent E.de Meijer Serena Sanna robin P.F.Dullaart Hans Blokzijl Eleonora A.M.Festen Jingyuan Fu Rinse k.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United kingdom(Uk)Biobank(UkBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MRI-PDFF in UkBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCM1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,TM6SF2,and *** of FLI in UkBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between MRI-PDFF(UkBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel MRI-PDFF genetic signals(CREB3L1 and GCM1)were replicated in the FLI *** identified two novel genes for MRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between MRI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAFLD Genome-wide association study Fatty liver index Magnetic resonance imaging proton density fat fraction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sonicating bees demonstrate flexible pollen extraction without instrumental learning

引用

Current Zoology 2019年第4期65卷 425-436页

作者： Callin M. Switzer avery L. Russell Daniel R. Papaj Stacey A. Combes robin Hopkins Department of Organismic and Evolutionary Biology Harvard University Cambridge MA USA Arnold Arboretum Harvard University Boston MA USA Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ USA Department of Neurobiology Physiology and Behavior University of California at Davis Davis CA USA Department of Biology and eScience Institute University of Washington Seattle WA USA Department of Biological Sciences University of Pittsburgh Pittsburgh PA USA

Pollen collection is necessary for bee survival and important for flowering plant reproduction, yet if and how pollen extraction motor routines are modified with experience is largely unknown. Here, we used an automated reward and monitoring system to evaluate modification in a common pollen-extraction routine, floral sonication. Through a series of laboratory experiments with the bumblebee, Bombus impatiens, we examined whether variation in sonication frequency and acceleration is due to instrumental learning based on rewards, a fixed behavioral response to rewards, and/or a mechanical constraint. We first investigated whether bees could learn to adjust their sonication frequency in response to pollen rewards given only for specified frequency ranges and found no evidenee of instrumental learning. However, we found that absenee versus receipt of a pollen reward did lead to a predictable behavioral resp on se, which depe nded on bee size. Fin ally, we found some evide nee of mechanical con straints, in that flower mass affected sonication acceleration (but not frequency) through an interaction with bee size. In generalz larger bees showed more flexibility in sonication frequency and acceleration, potentially reflecting a size-based constraint on the range over which smaller bees can modify frequency and accelerati on. Overall our results show that although bees did not display instrumental learning of sonication frequency, their sonication motor routine is nevertheless flexible.

关键词： Bombus impatiens buzz pollination foraging innate behavior learned behavior Solanum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unexpectedly large energy variations from dopant interactions in ferroelectric HfO_(2) from high-throughput ab initio calculations

引用

npj Computational Materials 2018年第1期4卷 45-53页

作者： Max Falkowski Christopher künneth robin Materlik Alfred kersch Munich University of Applied Sciences Lothstr.3480335 MunichGermany

Insight into the origin of process-related properties like small-scale inhomogeneities is key for material ***,we analyze DFT calculations of randomly doped HfO_(2) structures with Si,La,and VO and relate them to the kind of production *** energies of the relevant ferroelectric Pbc2_(1) phase are compared with the competing crystallographic phases under the influence of the arising local inhomogeneities in a coarse-grained *** interaction among dopants adds to the statistical effect from the random positioning of the *** anneals after atomic layer or chemical solution deposition processes,which are short compared to ceramic process tempering,the large energy variations remain because the dopants do not *** the energy difference is the criterion for the phase stability,the large variation suggests the possibility of nanoregions and diffuse phase transitions because these local doping effects may move the system over the paraelectric-ferroelectric phase boundary.

关键词： ferroelectric dopant grain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diversity and interaction of common bacterial blight disease-causing bacteria(Xanthomonas spp.) with Phaseolus vulgaris L.

引用

The Crop Journal 2019年第1期7卷 1-7页

作者： Joab k.Tugume Geoffrey Tusiime Allan Male Sekamate robin Buruchara Clare Mugisha Mukankusi Makerere University Department of Agricultural Production International Centre for Tropical Agriculture (CIAT)/Pan African Bean Research Alliance (PABRA)

Common bacterial blight(CBB) is associated with common bean(Phaseolus vulgaris L.), an important grain legume for human consumption worldwide. The disease, caused by Xanthomonas spp. is spread mainly through seed. This paper focuses on the diversity of *** pv. phaseoli and X. fuscans subsp. fuscans and interactions between related bacteria and the bean host. Review has suggested that the diversity and taxonomic studies of these pathogens are not exhaustive, especially in areas where detailed molecular analysis has not been conducted and previous characterizations were based on phenotypic features and PCR-based techniques. Also, no study has confirmed differential pathogenicity on bean genotypes based on compatible versus incompatible reactions. However, isolates react differently to wild and domesticated bean sources of resistance in common bean genetic backgrounds. A systematic approach will be required to investigate global changes in gene expression among different sources of resistance in a common bean *** bacterial isolates that cause CBB should be functionally characterized using genotypes containing major quantitative trait loci(QTL) for CBB resistance. These studies will increase understanding of resistance and how it is manipulated by pathogens.

关键词： Xanthomonas axonopodis Interaction Gene expression Diversity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation of cement mortar incorporating Bacillus sphaericus

引用

International Journal of Smart and Nano Materials 2016年第2期7卷 91-105页

作者： kirti kanta Sahoo Aparna k.Sathyan Chandni kumari Pradip Sarkar robin Davis Department of Civil Engineering National Institute of Technology RourkelaOdishaIndia

Ureolytic-type bacteria has been used to improve the strength of cement mortar by the precipitation of calcium *** the present study Bacillus sphaericus has been used to improve the properties of cement mortar such as setting time,compressive strength and *** setting time is found to be unaffected by the presence of *** is found that compressive strength at both 7-days and 28-days of mortar cube increases with the increase of bacteria *** the optimum bacteria dosage of 107 cells/ml,the average compressive strength increases by 58%(at 7 day)and 23%(at 28 day)over the control *** sorpitivity coefficient decreases as the concentration of bac-terial cells *** mineralogy and morphology of the cal-cium carbonate precipitation have been tested by XRD and FESEM.

关键词： bacteria setting time compressive strength calcite precipitation sorptivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New Breakdown Electric Field Calculation for SF6 High Voltage Circuit Breaker Applications

引用

Plasma Science and Technology 2007年第6期9卷 690-694页

作者： Ph.robin-JOUAN M.YOUSFI AREVA T & D High Voltage Switchgear Research Centre 130 rue L.BLUM 69611 VilleurbanneFrance University of Toulouse LAPLACE-UMR 5213 CNRSUPS118 Route de Narbonne31062 Toulouse Cedex 9France

The critical electric fields of hot SF6 are calculated including both electron and ion kinetics in wide ranges of temperature and pressure, namely from 300 k up to 4000 k and 2 atmospheres up to 32 atmospheres respectively. Based on solving a multi-term electron Boltz- mann equation the calculations use improved electron-gas collision cross sections for twelve SF6 dissociation products with a particular emphasis on the electron-vibrating molecule interactions. The ion kinetics is also considered and its role on the critical field becomes non negligible as the temperature is above 2000 k. These critical fields are then used in hydrodynamics simulations which correctly predict the circuit breaker behaviours observed in the case of breaking tests.

关键词： breakdown electric field hot dissociated SF6 high voltage gas-circuit-breaker

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：