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Solid-state NMR of vulcanized natural rubber/butadiene rubber blends:Local organization and cross-linking heterogeneities This article is part of the virtual special issue“Solid-state NMR studies on polymers and biological solids”

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Magnetic Resonance Letters 2024年第4期4卷 49-61页

作者： Pierre daniel Cristina Coelho-diogo Valérie Gaucher Grégory Stoclet Clément robin Cédric Lorthioir Sorbonne Université CNRSLaboratoire de Chimie de la Matière Condensée de ParisLCMCPUMR 757475005 ParisFrance Sorbonne Université CNRSFédération Chimie et Matériaux de Paris-CentreFR 248275005 ParisFrance Univ.Lille CNRSINRAECentrale LilleUnitéMatériaux et TransformationsUMETUMR 820759000 LilleFrance Hutchinson Research and Innovation Center 45120 Châlette-sur-LoingFrance

Elastomer blends,among which natural rubber(NR)and butadiene rubber(BR),are involved in many components of the automotive/tire industry.A comprehensive understanding of their mechanical behavior requires,among other features,a detailed description of the crosslink density in these *** the case of vulcanized immiscible blends,the distribution of the cross-link density within each of the NR-and BR-rich domains is key information,but difficult to determine using the conventional approaches used for one-component crosslinked *** this study,the vulcanization within NR/BR blends is investigated using a robust^(1)H double-quantum(dQ)MAS recoupling experiment,*** kinds of cross-linked NR/BR blends were considered with two different microstructures for the BR *** bulk organization of the resulting blends was first probed by analyzing the^(1)H spin-lattice relaxation *** a second step,BaBa-xy16 was used to investigate,in a selective way,the cross-link heterogeneities within NR/BR *** particular,for immiscible NR/BR mixtures,the distribution of the cross-link density between both phases was compared and the observed differences were discussed.

关键词： Rubbers Blends Cross-linking 1H solid-state NMR Relaxation double-quantum NMR dipolar recoupling

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Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2017年第2期23卷 204-215页

作者： Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large david J hughes CN Bio Innovations Limited Welwyn Garden City AL7 3AXUnited Kingdom

AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLd), utilising primary hepatocytes cultured in a three-dimensional(3d) perfused platform. METHOdS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3d perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLd and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLd patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture *** The 3d in vitro NAFLd model recapitulates many features of clinical NAFLd and is an ideal tool for analysing the efficacy of anti-steatotic compounds.

关键词： Non-alcoholic fatty liver disease Liver disease Three-dimensional cell culture Organ-on-chip Primary cell culture Fatty liver Hepatocytes

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中子衍射分析时效处理对镍基单晶高温合金相结构的影响

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物理学报 2011年第8期60卷 467-478页

作者：孙光爱陈波吴二冬李武会张功汪小琳 V. Ji T. Pirling d. hughes 中国工程物理研究院核物理与化学研究所绵阳621900 中国科学院金属研究所材料科学国家实验室沈阳110016 巴黎第十一大学奥赛分子化学与材料学院法国巴黎91405 劳厄-朗之万研究所法国格勒诺贝尔38042

采用φ振荡和φ固定两种数据采集模式的中子衍射实验结果表明较高的时效温度对消除枝晶最有效,微应变(晶粒区域间的变形不协调性)主要存在于γ'相.利用中子衍射结合扫描电子显微镜对合金的微观组织形貌进行了细致观察,给出了时效温度和... 详细信息

采用φ振荡和φ固定两种数据采集模式的中子衍射实验结果表明较高的时效温度对消除枝晶最有效,微应变(晶粒区域间的变形不协调性)主要存在于γ'相.利用中子衍射结合扫描电子显微镜对合金的微观组织形貌进行了细致观察,给出了时效温度和时间对γ'相的影响状况,超晶格测量发现了γ'相晶粒之间出现的独特取向差.由不同晶面的中子衍射结果判断时效后合金出现了轻微的四方对称性(a

关键词：单晶高温合金中子衍射超晶格时效处理

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高压断路器灭弧过程的数字分析

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华东电力 2007年第C期35卷 89-96页

作者： robin-Jouan d. dufournet G. F. Montillet Areva T&d France Areva T&d USA

论述为了分析和研究高压断路器灭弧室内的气体流动以及减少试验次数，越来越多使用的计算性流体动力工具（CFd工具）。这些工具通过集成十分复杂的模型，建立在传统物理流体动力方程式的基础上。SF6灭弧室的可变参数量如今根据具体应用... 详细信息

论述为了分析和研究高压断路器灭弧室内的气体流动以及减少试验次数，越来越多使用的计算性流体动力工具（CFd工具）。这些工具通过集成十分复杂的模型，建立在传统物理流体动力方程式的基础上。SF6灭弧室的可变参数量如今根据具体应用的不同已经非常庞大，这些工具容许更好地进行评估、分析、并且理解开断过程，可以有助于对断路器灭弧室的形状和几何参数的优化。

关键词： SF6高压断路器模型流体动力学软件

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desymmetrization of Cyclic 1,3-diketones under N-Heterocyclic Carbene Organocatalysis:Access to Organofluorines with Multiple Stereogenic Centers

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Research 2021年第1期2021卷 1495-1507页

作者： Guanjie Wang Min Zhang Yezhi Guan Ye Zhang Xianfang Hong Chenlong Wei Pengcheng Zheng donghui Wei Zhenqian Fu Yonggui robin Chi Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech) 30 South Puzhu RoadNanjing 211816China College of Chemistry and Green Catalysis Center Zhengzhou UniversityZhengzhouHenan 450001China School of Chemistry and Molecular Engineering Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816China Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang 550025China division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingaporeSingapore 637371 Frontiers Science Center for Flexible Electronics(FSCFE)&Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’an 710072China

Symmetric 1,3-diketones with fluorine or fluorinated substituents on the prochiral carbon remain to be ***,we have developed a novel prochiral fluorinated oxindanyl 1,3-diketone and successfully applied these substrates in carbene-catalyzed asymmetric ***,a versatile strategy for asymmetric generation of organofluorines with fluorine or fluorinated methyl groups has been *** stereogenic centers were selectively constructed with satisfactory *** diverse enantioenriched organofluorines were generated with excellent results in terms of yields,diastereoselectivities,and ***,exchanging fluorinated methyl groups to fluorine for this prochiral 1,3-diketones leads to switchable *** aspects and origin of stereoselectivity were studied by dFT ***,some of the prepared organofluorines demonstrated competitive antibacterial activities.

关键词： fluorine chiral asymmetric

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Evaluation of utility in shoulder pathology:Correlating the American Shoulder and Elbow Surgeons and Constant scores to the EuroQoL

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World Journal of Orthopedics 2012年第3期3卷 20-24页

作者： Blaine T Bafus Richard E hughes Bruce S Miller James E Carpenter department of Orthopaedic Surgery Cleveland Clinic Foundation Cleveland OH 44115-2325 United States department of Orthopaedic Surgery University of Michigan Ann Arbor MI 48109-2200 United States

AIM: To study whether health utility scores can be derived from shoulder-specific ***: Authors investigated two questions:(1) do the American Shoulder and Elbow Surgeons(ASES) score and the Constant score correlate with the EuroQo L(EQ-5d), a measure of health utility?(2) can the ASES and Constant scores be obtained from a complete study sample without bias? Thirty subjects with various shoulder diagnoses completed ASES, Constant, and EQ-5d instruments. Pearson correlations were calculated to assess the associations between EQ-5d score and ASES and Constant ***: The correlation between EQ-5d score and ASES score was 0.60(P d and Constant scores(P del containing ASES score, Constant score, age, and gender failed to adequately predict EQ-5d. Moreover, 25% of patients meeting the inclusion criteria did not complete the ASES questionnaire because they did not feel that specific questions, such as "do usual sport-list" and "throw ball overhand," applied to ***: Authors' results do not support the use of the ASES and Constant scores in predicting EuroQ ol health utility values. However, the Constant score was more suitable for this patient population because all patients were able to complete it.

关键词： Utility EuroQoL American Shoulder and Elbow Surgeons score Constant score Shoulder Outcomes

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供应链系统异构知识集成方法研究

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计算机科学 2005年第2期32卷 188-192页

作者：徐琪 robin Qiu 宁夏大学数学计算机学院 dept. of Information Sciences Pennsylvania State University Malvern PA 19355USA

供应链系统流动着大量的异构信息和知识,为了有效地利用现有知识对供应链进行优化管理和运作,供应链不仅要实现信息系统的集成而且需要实现知识集成。本文运用领域本体沦(Ontology)、多Agent等技术研究供应链系统异构知识集成的方法,应... 详细信息

供应链系统流动着大量的异构信息和知识,为了有效地利用现有知识对供应链进行优化管理和运作,供应链不仅要实现信息系统的集成而且需要实现知识集成。本文运用领域本体沦(Ontology)、多Agent等技术研究供应链系统异构知识集成的方法,应用资源描述框架模式(RdFS)作为信息和知识的核心转换技术,实现异构知识的转换和集成,为供应链系统异构知识集成提供一个切实可行的技术解决方案。该方案可以保证全程信息数据和知识的正确性、及时性和完整性,进一步促使信息流为决策人员提供及时、可靠和科学的有效决策支持。

关键词：异构知识集成领域本体 RdFS 多Agent 资源描述框架转换技术供应链系统信息流运作

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高新技术产业发展演化规律及空间布局

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社会科学家 2015年第10期30卷 76-80页

作者：雷勋平 robin Qiu 南京航空航天大学经济与管理学院江苏南京210016 铜陵学院工商管理学院安徽铜陵244000 宾夕法尼亚州立大学信息科学系宾夕法尼亚州马尔委19355

立足国家、区域、省域和行业四个层面运用内容分析法,分别从发展规模和发展效益两个方面详细分析中国2004~2013年高新技术产业发展现状、动态演化趋势及空间布局。结果表明,中国高新技术产业总体规模稳步扩大,主营业收入与利润总额基本... 详细信息

立足国家、区域、省域和行业四个层面运用内容分析法,分别从发展规模和发展效益两个方面详细分析中国2004~2013年高新技术产业发展现状、动态演化趋势及空间布局。结果表明,中国高新技术产业总体规模稳步扩大,主营业收入与利润总额基本匹配,投资额和新增固定资产逐年增加,但在区域、省域和产业层面差距较大。R＆d经费内部支出与有效发明专利拥有量呈正比例变动,但在区域、省域和产业层面存在一定差异。就区域而言,东、西部地区电子及通信设备制造业优势明显,中部地区医药制造业优势明显;就省域而言,苏、鲁、浙、粤、沪等省市高新技术产业较发达;就产业层面而言,电子及通信设备制造业、医药制造业发展空间尤为广阔。最后,据此提出促进中国高新技术产业的发展对策和政策性建议。

关键词：高新技术产业演化规律空间布局

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Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression:a randomized controlled study

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Neural Regeneration Research 2024年第9期19卷 2036-2040页

作者： Xiaoyue Li Tao Liu Xuan Mo Runhua Wang Xueyan Kong robin Shao Roger S.Mclntyre Kwok-Fai So Kangguang Lin department of Affective disorders The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouGuangdong ProvinceChina Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina department of Psychiatry The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Mood disorders Psychopharmacology Unit Poul Hansen Family Centre for DepressionUniversity Health NetworkTorontoONCanada department of Psychiatry University of TorontoTorontoONCanada Brain and Cognition discovery Foundation TorontoCanada Ministry of Education Joint International Research Laboratory of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory ***,anti-inflammatory treatment has shown partial effectiveness in alleviating depression *** barbarum polysaccharide(LBP),derived from Goji berries,exhibits notable antioxidative and anti-inflammatory *** our recent double-blinded randomized placebo-controlled trial,we found that LBP significantly reduced depressive symptoms in adolescents with subthreshold *** is presumed that the antidepressant effect of LBP may be associated with its influence on inflammatory *** the double-blinded randomized controlled trial,we enrolled 29 adolescents with subthreshold depression and randomly divided them into an LBP group and a placebo *** the LBP group,adolescents were given 300 mg/d LBP.A 6-week follow up was completed by 24 adolescents,comprising 14 adolescents from the LBP group(15.36±2.06 years,3 men and 11 women)and 10 adolescents from the placebo group(14.9±1.6 years,2 men and 8 women).Our results showed that after 6 weeks of treatment,the interleukin-17A level in the LBP group was lower than that in the placebo *** analysis showed that LBP reduced the correlations and connectivity between inflammatory factors,which were associated with the improvement in depressive *** findings suggest that 6-week administration of LBP suppresses the immune response by reducing interleukin-17A level,thereby exerting an antidepressant effect.

关键词： adolescents cytokines efficacy Goji berry inflammatory responses interleukin-17A Lycium barbarum polysaccharide randomized controlled study subthreshold depression

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野外试验显示了新型激光雷达碲镉汞探测器的优良性能

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红外 1993年第8期14卷 12-14页

作者： hughes,d 李玲

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