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应用固相核酸杂交检测口蹄疫病毒

动物检疫 1991年第1期8卷 20-22页

作者： robin G.McFarlane 蒋正军

口蹄疫(FMD)是由微小RNA病毒引起偶蹄兽的急性高度传染性疾病。由于发病率高,经济损失大,此病被称为“全世界家畜中最可怕的疾病”。大多数国家实施严格的进口检疫措施,以防FMDV的侵进。有许多诊断方法用来监测和控制此病的流行。FMDV... 详细信息

口蹄疫(FMD)是由微小RNA病毒引起偶蹄兽的急性高度传染性疾病。由于发病率高,经济损失大,此病被称为“全世界家畜中最可怕的疾病”。大多数国家实施严格的进口检疫措施,以防FMDV的侵进。有许多诊断方法用来监测和控制此病的流行。FMDV有七个血清型(即A、O、c型,亚洲—1型、SAT—

关键词：固相核酸杂交口蹄疫病毒检测

Infant male circumcision: An evidence-based policy statement

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Open Journal of Preventive Medicine 2012年第1期2卷 79-92页

作者： Brian J. Morris Alex D. Wodak Adrian Mindel Leslie Schrieber Karen A. Duggan Anthony Dilley robin J. Willcourt Michael Lowy David A. cooper Eugenie R. Lumbers c. Terry Russell Stephen R. Leeder School of Medical Sciences and Bosch Institute The University of Sydney Sydney Australia

Here we review the international evidence for benefits and risks of infant male circumcision (Mc) and use this to develop an evidence-based policy statement for a developed nation setting, focusing on Australia. Evidence from good quality studies that include meta-analyses and randomized controlled trials showed that Mc provides strong protection against: urinary tract infections and, in infancy, renal parenchymal disease;phimosis;paraphimosis;balanoposthitis;foreskin tearing;some heterosexually transmitted infections including HPV, HSV-2, trichomonas, HIV, and genital ulcer disease;thrush;inferior hygiene;penile cancer and possibly prostate cancer. In women, circumcision of the male partner protects against HPV, HSV-2, cervical cancer, bacterial vaginosis, and possibly chlamydia. Mc has no adverse effect on sexual function, sensitivity, penile sensation or satisfaction and may enhance the male sexual experience. Adverse effects are uncommon (convenience and cost savings, Mc should be performed in infancy and with local anesthesia. A risk-benefit analysis shows benefits exceed risks by a large margin. Over their lifetime up to half of uncircumcised males will suffer a medical condition as a result of retaining their foreskin. The ethics of infant Mc and childhood vaccination are comparable. Our analysis finds Mc is beneficial, safe and cost-effective, and should optimally be performed in infancy. In the interests of public health and individual wellbeing, adequate parental education, and steps to facilitate access and affordability should be encouraged in developed countries.

关键词： Male circumcision Public Health Infant Infections Sexually Transmitted Infections cervical cancer

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大气臭氧层破坏与人类患癌危险

世界科学 1988年第8期 49-51页

作者： robin.R.J. 张敬方黄林

大气同温层中的臭氧在保护地球生物中起着关键的作用。大约3%的太阳输出以紫外线(UV)释放出来,但其中只有一小部分到达地球表面。波长在240～290nm的紫外线c(UVc)几乎全部被大气中的臭氧消除,只有一部分紫外线B(UVB)(290～320nm)穿过大... 详细信息

大气同温层中的臭氧在保护地球生物中起着关键的作用。大约3%的太阳输出以紫外线(UV)释放出来,但其中只有一小部分到达地球表面。波长在240～290nm的紫外线c(UVc)几乎全部被大气中的臭氧消除,只有一部分紫外线B(UVB)(290～320nm)穿过大气到达地球表面。由于紫外线B与紫外线c不在DNA的吸收光谱内,所以臭氧对原始生命形式很关键,尤其对水中生态系统。对人类,臭氧能大大限制太阳辐射的致癌作用。

关键词：臭氧层紫外线照射黑色素瘤死亡率平流层黑色素肿瘤紫外线辐射黑色瘤化学反应氧化氮一氧化二氮笑气基底细胞癌基底细胞上皮瘤人类

Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity

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Molecular Plant 2022年第3期15卷 520-536页

作者： Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua c.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes c.P.Hopman Jiming Jiang Walter S.De Jong Joseph c.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.craig Yencho Noelle L.Anglin christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel c.robin Buell Richard Finkers Department of Plant Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Department of Plant Science McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada Plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBG-4 Bioinformatics Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany Department of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer crop Science WoodlandCA 95695USA Averis Seeds B.V. 9640 AA Veendamthe Netherlands International Potato center 1895 Avenida La MolinaLimaPeru USDA-ARS ProsserWA 99350USA Agriculture and Agri-Food canada Fredericton Research and Development centre FrederictonNB E3B 4Z7Canada School of Integrative Plant Science Cornell UniversityIthacaNY 14853-1901USA Department of Plant Sciences University of IdahoMoscowID 83844USA USDA-ARS Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZPc Research B.V. Edisonweg 58501 XG Jourethe Netherlands Department of crop and Soil Science Oregon State UniversityHermistonOR 97838USA School of Biology and Ecology University of Maine5735 Hitchner Hall OronoME 04469USA Department of Horticultural Sciences Texas A&M UniversityCollege StationTX 77843-2133USA Department of Horticulture Oregon State UniversityCorvallisOR 97331USA Department of Horticultural Science North Carolina State UniversityRaleighNC 27695-7609USA Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Institute for Biological Data Science Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA Present address:GenNovation B.V. Wageningenthe Netherlands

cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous *** assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous *** species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding *** a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid *** a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic *** StcDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StcDF1 are correlated with maturity in a dosage-dependent *** of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids.

关键词： potato allele diversity phased assembly polyploid pan-genome wild introgressions

Impact of vaccine supplies and delays on optimal control of the cOVID-19 pandemic:mapping interventions for the Philippines

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Infectious Diseases of Poverty 2021年第4期10卷 46-59页

作者： carlo Delfin S.Estadilla Joshua Uyheng Elvira P.de Lara-Tuprio Timothy robin Teng Jay Michael R.Macalalag Maria Regina Justina E.Estuar Department of Mathematics Ateneo de Manila UniversityKatipunan Ave.Brgy.Loyola Heights1102 Quezon CityPhilippines Department of Psychology Ateneo de Manila UniversityQuezon CityPhilippines Department of Mathematics Caraga State UniversityButuan CityPhilippines Department of Information Systems and computer Science Ateneo de Manila UniversityQuezon CityPhilippines

Background::Around the world,controlling the cOVID-19 pandemic requires national coordination of multiple intervention *** vaccinations are globally introduced into the repertoire of available interventions,it is important to consider how changes in the local supply of vaccines,including delays in administration,may be addressed through existing policy *** study aims to identify the optimal level of interventions for cOVID-19 from 2021 to 2022 in the Philippines,which as a developing country is particularly vulnerable to shifting assumptions around vaccine ***,we explore optimal strategies in scenarios featuring delays in vaccine administration,expansions of vaccine supply,and limited combinations of ***::Embedding our work within the local policy landscape,we apply optimal control theory to the compartmental model of cOVID-19 used by the Philippine government’s pandemic surveillance platform and introduce four controls:(a)precautionary measures like community quarantines,(b)detection of asymptomatic cases,(c)detection of symptomatic cases,and(d)*** model is fitted to local data using an L-BFGS minimization *** conditions are identified using Pontryagin’s minimum principle and numerically solved using the forward-backward sweep ***::Simulation results indicate that early and effective implementation of both precautionary measures and symptomatic case detection is vital for averting the most infections at an efficient cost,resulting in>99%reduction of infections compared to the no-control *** vaccine administration capacity to 440,000 full immunizations daily will reduce the overall cost of optimal strategy by 25%,while allowing for a faster relaxation of more resource-intensive ***,delays in vaccine administration require compensatory increases in the remaining policy levers to maintain a minimal number of *** example,dela

关键词： Optimal control cOVID-19 pandemic Philippines Non-pharmaceutical interventions Vaccines

X-Ray Image Interpretation Guide for Aviation Aluminum Alloy castings

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Journal of Mechanics Engineering and Automation 2021年第2期11卷 46-53页

作者： robin Wang Aviocast Inc. Taichung City 40755TaiwanR.O.C.

The purpose of this paper is to introduce the basic steps of X-ray image interpretation of aviation castings,so as to provide a learning guidance for beginners and reduce the exploration *** them,the introduction of specifications,the requirements for image quality,and the application of reference radiographs are just a sorting out the key *** there is a need for practical application,we should conduct a deeper exploration and understanding of each specification,not just cite this article.

关键词： Aviation aluminum casting radiographic test standard reference radiographs X-ray indication interpretation

Using compositional data analysis to explore accumulation of sedentary behavior,physical activity and youth health

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Journal of Sport and Health Science 2022年第2期11卷 234-243页

作者： Simone J.J.M.Verswijveren Karen E.Lamb Josep A.Martín-Fernández Elisabeth Winkler Rebecca M.Leech Anna Timperio Jo Salmon robin M.Daly Ester cerin David W.Dunstan Rohan M.Telford Richard D.Telford Lisa S.Olive Nicola D.Ridgers Institute for Physical Activity and Nutrition School of Exercise and Nutrition SciencesDeakin UniversityGeelongVIC 3216Australia Melbourne School of Population and Global Health University of MelbourneParkvilleVIC 3053Australia Department of computer Science Applied Mathematics and StatisticsUniversity of GironaGirona 17003Spain School of Public Health University of QueenslandHerstonQLD 4006Australia Mary MacKillop Institute for Health Research Australian Catholic UniversityFitzroyVIC 3065Australia School of Public Health University of Hong KongHong KongChina Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Research Institute for Sport and Exercise University of CanberraBruceACT 2617Australia School of Psychology Deakin UniversityBurwoodVIC 3125Australia IMPAcT Research Institute Deakin UniversityBurwoodVIC 3125Australia ANU Medical School Australian National UniversityGarranACT 2605Australia

Purpose:The study aimed to describe youth time-use compositions,focusing on time spent in shorter and longer bouts of sedentary behavior and physical activity(PA),and to examine associations of these time-use compositions with cardiometabolic ***:Accelerometer and cardiometabolic biomarker data from 2 Australian studies involving youths 7-13 years old were pooled(complete cases with accelerometry and adiposity marker data,n=782).A 9-component time-use composition was formed using compositional data analysis:time in shorter and longer bouts of sedentary behavior;time in shorter and longer bouts of light-,moderate-,or vigorous-intensity PA;and"other time"(i.e.,non-wear/sleep).Shorter and longer bouts of sedentary time were defined as5 min,*** bouts of light-,moderate-,and vigorous-intensity PA were defined asciations between overall time-use composition and cardiometabolic ***,associations were derived between ratios of longer activity patterns relative to shorter activity patterns,and of each intensity level relative to the other intensity levels and"other time",and cardiometabolic ***:confounder-adjusted models showed that the overall time-use composition was associated with adiposity,blood pressure,lipids,and the summary ***,more time in longer bouts of light-intensity PA relative to shorter bouts of light-intensity PA was significantly associated with greater body mass index z-score(zBMI)(β=1.79;SE=0.68)and waist circumference(β=18.35,SE=4.78).When each activity intensity was considered relative to all higher intensities and"other time",more time in light-and vigorous-intensity PA,and less time in sedentary behavior and moderate-intensity PA,were associated with lower waist ***:Accumulating PA,particularly light-intensity PA,in frequent short bursts may be more beneficial for limiting adi

关键词： Accumulation patterns cardiometabolic health children compositional data analysis Time-use

A comprehensive Transcriptome Assembly of Pigeonpea （cajanus cajan L.） using Sanger and Second-Generation Sequencing Platforms

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Molecular Plant 2012年第5期5卷 1020-1028页

作者： Himabindu Kudapa Arvind K. Bharti Steven B. cannon Andrew D. Farmer Benjamin Mulaosmanovi robin Kramer Abhishek Bohra Nathan T. Weeks John A. crow Reetu Tuteja Trushar Shah Sutapa Dutta Deepak K. Gupta Archana Singh Kishor Gaikwad Tilak R. Sharma Gregory D. May Nagendra K. Singh Rajeev K. Varshney International crops Research Institute for the Semi-Arid Tropics (IcRISAT) Patancheru 502324 india National center for Genome Resources (NcGR) Santa Fe NM 87505 USA United States Department of Agriculture-Agricultural Research Service (USDA-ARS) Corn Insects and Crop Genetics Research Unit Ames IA USA National Research centre on Plant Biotechnology (NRcPB) Indian Agricultural Research Institute New Delhi 110 012 India Department of Agronomy Iowa State University Amens IA USA cGIAR Generation challenge Programme (GcP) c/o ClMMYT 06600 Mexico DF Mexico

A comprehensive transcriptome assembly for pigeonpea has been developed by analyzing 128.9 million short Illumina GA IIx single end reads, 2.19 million single end FLX/454 reads, and 18 353 Sanger expressed sequenced tags from more than 16 genotypes. The resultant transcriptome assembly, referred to as ccTA v2, comprised 21 434 transcript as- sembly contigs （TAcs） with an N50 of 1510 bp, the largest one being -8 kb. Of the 21 434 TAcs, 16 622 （77.5%） could be mapped on to the soybean genome build 1.0.9 under fairly stringent alignment parameters. Based on knowledge of intron junctions, 10 009 primer pairs were designed from 5033 TAcs for amplifying intron spanning regions （ISRs）. By using in silico mapping of BAc-end-derived SSR loci of pigeonpea on the soybean genome as a reference, putative mapping posi- tions at the chromosome level were predicted for 6284 ISR markers, covering all 11 pigeonpea chromosomes. A subset of 128 ISR markers were analyzed on a set of eight genotypes. While 116 markers were validated, 70 markers showed one to three alleles, with an average of 0.16 polymorphism information content （PIc） value. In summary, the ccTA v2 transcript assembly and ISR markers will serve as a useful resource to accelerate genetic research and breeding applications in pigeonpea.

关键词： cajanus cajan (L.) second-generation sequencing transcriptome assembly intron spanning region (ISR)markers.

三磷酸肌醇——一种新颖的细胞信号转换的第二信使

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世界科学 1985年第10期 21-25页

作者： Michael J. Berridge robin F. Irvine 段维

最近,在研究经肌醇脂类而产生细胞内信号的受体方面进展迅速。这些脂类之一的4,5-二磷酸磷脂酰肌醇被水解成二脂酰甘油和三磷酸肌醇,构成了控制包括分泌、代谢、光转换和细胞增殖在内的各种细胞活动的信号转换机制的一部分。二脂酰甘油... 详细信息

最近,在研究经肌醇脂类而产生细胞内信号的受体方面进展迅速。这些脂类之一的4,5-二磷酸磷脂酰肌醇被水解成二脂酰甘油和三磷酸肌醇,构成了控制包括分泌、代谢、光转换和细胞增殖在内的各种细胞活动的信号转换机制的一部分。二脂酰甘油在膜平面内起作用以激活蛋白激酶c,而三磷酸肌醇则释放到细胞质内作为动员细胞内钙的第二信使。

关键词：磷酸肌醇细胞内钙二脂酰甘油信号转换第二信使受体系统