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Impact of colorectal cancer screening participation in remote northern Canada:A retrospective cohort study

World Journal of Gastroenterology 2020年第48期26卷 7652-7663页

作者： Heather A Smith Andrew D Scarffe Nicole Brunet Cait Champion Kami Kandola Alisha Tessier robin boushey Craig Kuziemsky Department of Surgery University of OttawaOttawa K1Y4E9OntarioCanada Telfer School of Management University of OttawaOttawa K1N6N5OntarioCanada Faculty of Medicine University of OttawaOttawa K1Y4E9OntarioCanada Department of Surgery Northern Ontario School of MedicineSudbury P3E2C6OntarioCanada Department of Health and Social Services Government of the Northwest TerritoriesYellowknife X1A1P5Northwest TerritoriesCanada Department of Surgery Stanton Territorial Health AuthorityYellowknife X1A0H1Northwest TerritoriesCanada Division of General Surgery University of OttawaOttawa K1H 8L6OntarioCanada Office of Research Services MacEwan UniversityEdmonton T5J4S2AlbertaCanada

BACKGROUND Screening provides earlier colorectal cancer(CRC)detection and improves *** remains poorly understood if these benefits are realized with screening guidelines in remote northern populations of Canada where CRC rates are nearly twice the national average and access to colonoscopy is *** To evaluate the participation and impact of CRC screening guidelines in a remote northern *** This retrospective cohort study included residents of the Northwest Territories,a northern region of Canada,age 50-74 who underwent CRC screening by a fecal immunohistochemical test(FIT)between January 1,2014 to March 30,*** assess impact,individuals with a screen-detected CRC were compared to clinically-detected CRC cases for stage and location of CRC between *** assess participation,we conducted subgroup analyses of FIT positive individuals exploring the relationships between signs and symptoms of CRC at the time of screening,wait-times for colonoscopy,and screening *** sample Welch t-test was used for normally distributed continuous variables,Mann-Whitney-Wilcoxon Tests for data without normal distribution,and Chi-square goodness of fit test for categorical variables.A P value of<0.05 was considered to be statistically *** 6817 fecal tests were completed,meaning an annual average screening rate of 25.04%,843(12.37%)were positive,629 individuals underwent a follow-up colonoscopy,of which,24.48%had advanced neoplasia(AN),5.41%had *** were no significant differences in stage,pathology,or location between screen-detected cancers and clinically-detected *** assessing participation and screening outcomes,we observed 49.51%of individuals referred for colonoscopy after FIT were ineligible for CRC screening,most often due to signs and symptoms of *** were more likely to have AN if they had signs and symptoms of cancer at the time of screening,waited over 180 d for colonoscopy,or were indigenous[

关键词： Gastroenterology Rural health services Public health Colorectal neoplasms Early detection of cancer Northwest Territories

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Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages

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World Journal of Gastroenterology 2014年第48期20卷 18390-18396页

作者： Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed robin boushey James H Mckerrow Maha-Hamadien Abdulla Colorectal Research Center Department of Surgery King Saud University Riyadh 11472 Saudi Arabia Department of Pathology King Saud University Riyadh 11472 Saudi Arabia Division of General Surgery Ottawa Hospital University of Ottawa Ontario K1H 8L6 Canada Center for Discovery and Innovation in Parasitic Diseases University of California San Francisco San Francisco CA 94158-2330 United States

AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of ***:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University *** demographic information,including age and gender,tumor sites,and histological type of CRC,was *** measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal *** transcription and reverse transcription polymerase chain reaction were *** tissue microarrays were constructed to investigate the protein expression of TNF-a by ***:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal *** TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were *** showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of ***:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC.

关键词： Tumor necrosis factor-a Colorectal cancer Real time polymerase chain reaction Immunohistochemistry m RNA

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肛裂临床诊治指南（第三次修订）

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中华胃肠外科杂志 2013年第7期16卷 689-690页

作者： Farshid Araghizadeh ~ robin boushey Sridhar Chalasani George Chang Robert Cima Gary Dunn Daniel Feingold Philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson P. Terry Phang Feza Remzi David Rivadeneira Howard Ross Peter Senatore Elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna Martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) 美国结直肠外科医师协会不详

“美国结直肠外科医师协会（American Societyof ColonandRectal ***）”（协会）致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高，给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成... 详细信息

“美国结直肠外科医师协会（American Societyof ColonandRectal ***）”（协会）致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高，给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展，以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的，非指令性的，目的是为临床决策提供信息，而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。

关键词：诊治指南临床决策结直肠外科修订肛裂医师协会肛门疾病循证医学证据

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Optimal control of a hybrid microgrid for hydrogenbased heat supply using deep reinforcement learning

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Clean Energy 2023年第5期7卷 940-951页

作者： robin Heckmann Faculty of Computer Science University of Library Studies and Information Technologies119Tsarigradsko shosse Blvd1784SofiaBulgaria

Green hydrogen is considered one of the key technologies of the energy transition,as it can be used to store surpluses from renewable energies in times of high solar radiation or wind speed for use in dark *** paper examines the decarbonization potential of hydrogen for the heating ***,99%of hydrogen is produced from fossil fuels,because hydrogen derived from renew-able energy sources remains prohibitively expensive compared with its conventional ***,due to the expansion of renewable energy sources and the current energy crisis of conventional energy sources,hydrogen from renewable energy sources is becoming more and more *** optimize the efficiency of green hydrogen production and make it more price-competitive,the author simulates a hydrogen production plant consisting of a photovoltaic plant,a power grid,hydrogen storage,an electro-lyser,a natural gas purchase option,a district heating plant and *** the deep deterministic policy gradient algorithm from deep reinforcement learning,the plant is designed to optimize itself by simulating different production scenarios and deriving *** connected district heating plant is used to map how hydrogen can be optimally used for heat supply.A demonstrable outcome of this paper is that the utilization of deep deterministic policy gradient,over the course of a full year,can result in a com-petitive production of hydrogen derived from renewable or stored energy sources for the heating industry as a natural gas substitute.

关键词： hydrogen renewable energy hybrid microgrid deep reinforcement learning deep deterministic policy gradient

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THE VACUUM IN NONISENTROPIC GAS DYNAMICS

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Acta Mathematica Scientia 2012年第1期32卷 339-351页

作者： Geng Chen robin Young Department of Mathematics Pennsylvania State University University Park PA 16802 USA Department of Mathematics University of Massachusetts Amherst MA 01003 USA

We investigate the vacuum in nonisentropic gas dynamics in one space vari- able, with the most general equation of states allowed by thermodynamics. We recall physical constraints on the equations of state and give explicit and easily checkable conditions under which vacuums occur in the solution of the Riemann problem. We then present a class of models for which the Riemann problem admits unique global solutions without vacuums.

关键词： nonisentropic gas dynamics conservation laws vacuum large data Riemann problem

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LINEAR WAVES THAT EXPRESS THE SIMPLEST POSSIBLE PERIODIC STRUCTURE OF THE COMPRESSIBLE EULER EQUATIONS

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Acta Mathematica Scientia 2009年第6期29卷 1749-1766页

作者： Blake Temple robin Young Department of Mathematics University of California Davis CA 95616 USA Department of Mathematics and Statistics University of Massachusetts Amherst MA 01003 USA

In this paper we show how the simplest wave structure that balances compression and rarefaction in the nonlinear compressible Euler equations can be represented in a solution of the linearized compressible Euler equations. Such waves are exact solutions of the equations obtained by linearizing the compressible Euler equations about the periodic extension of two constant states separated by entropy jumps. Conditions on the states and the periods are derived which allow for the existence of solutions in the Fourier 1-mode. In [3, 4, 5] it is shown that these are the simplest linearized waves such that, for almost every period, they are isolated in the kernel of the linearized operator that imposes periodicity, and such that they perturb to nearby nonlinear solutions of the compressible Euler equations that balance compression and rarefaction along characteristics in the formal sense described in [3]. Their fundamental nature thus makes them of interest in their own right.

关键词： compressible Euler periodic solutions conservation laws

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Mapping urban building stocks for vulnerability assessment preliminary results

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International Journal of Digital Earth 2011年第S01期4卷 117-130页

作者： Keiko Saito robin Spence Department of Architecture University of CambridgeCambridgeUK Cambridge Architectural Research Ltd CambridgeUK Willis Research Fellow Willis Research Network

This paper discusses a methodology to collect building inventory data by combining image processing techniques,field work or tools such as Google Street View and applying statistical *** the methodology outlined in Marinescu(2002),a family of Gabor filters are first constructed,which are then applied to an optical high-resolution *** output from the processed image is segmented using Self-Organising *** paper examines the relationship between the segmented areas in the image and the building type distribution within each segmented area,by deriving the distribution from field *** relationship between the average number of buildings in these cells against the number of grid cells allocated to each segmentation cluster is also ***,using these results,the overall building inventory distribution for the whole of the case study site of Pylos is presented.

关键词： building inventory data collection remote sensing high-resolution optical satellite images Gabor filters Self-Organising Maps field data

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Continuous flow synthesis of plasmonic gold patches and nearly-complete nanoshells on polystyrene core particles

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Particuology 2023年第4期75卷 137-150页

作者： Thomas Meincke robin N.Klupp Taylor Institute of Particle Technology Friedrich-Alexander University Erlangen-NürnbergCauerstrasse 491058ErlangenGermany Collaborative Research Center 1411-Design of Particulate Products Friedrich-Alexander University Erlangen-Nürnberg Cauerstrasse 391058 Erlangen Germany

We describe the development of a T-mixer based continuous flow process for the coating of 86-500 nm diameter spherical polystyrene particles with thin gold patches by heterogeneous nucleation and *** establishing a suitable flow rate for good mixing and sufficiently uniform product morphology we systematically investigate the main reaction *** reveals a considerable tunability of the patch morphology and,by virtue of the localized surface plasmon resonance of gold,the optical properties of the product *** order to further widen the range of nanostructures accessible by our process,a second T-mixer was *** introduced new gold precursor,leading to further growth of the patches that were formed after the first *** this approach,nearly-complete gold nanoshells could be produced in high yield on both small and large core particles,without the unwanted production of free-standing gold *** to the pronounced optical properties of nearly-complete gold nanoshells on small core particles,we could estimate from electrodynamic sim-ulations the equivalent shell thickness to be as low as 8.6 *** is significantly thinner than can be routinely achieved using the standard seeded growth approach to synthesise gold *** results are therefore highly promising for the gram-scale synthesis of plasmon resonant nanostructures with designed optical properties.

关键词： Continuous flow Core-shell particles Patchy particles Nucleation Diffusion limited growth

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N-heterocyclic carbene-catalyzed arene formation reactions

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Science China Chemistry 2022年第2期65卷 210-223页

作者： Tingting Li Zhichao Jin Yonggui robin Chi State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China Division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

N-heterocyclic carbene-catalyzed reactions for the formation of aromatic compounds are *** reactions are subdivided into 4 types based on their activation modes.A brief summary on the achievements and the challenges remaining in Nheterocyclic carbene(NHC)-catalyzed arene construction processes is provided at the end of this *** outlook into the future research direction within this field is also given based on our own opinion and knowledge on the trends of the development of NHC organocatalysis.

关键词： N-heterocyclic carbene arene construction cycloaddition organocatalysis

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Gym-ANM: Reinforcement learning environments for active network management tasks in electricity distribution systems

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Energy and AI 2021年第3期5卷 171-193页

作者： robin Henry Damien Ernst School of Engineering Sanderson BuildingThe University of EdinburghEdinburgh EH93FBUK Department of Electrical Engineering and Computer Science Montefiore InstituteUniversity of LiegeLiege B-4000Belgium

Active network management(ANM)of electricity distribution networks include many complex stochastic sequential optimization *** problems need to be solved for integrating renewable energies and distributed storage into future electrical *** this work,we introduce Gym-ANM,a framework for designing reinforcement learning(RL)environments that model ANM tasks in electricity distribution *** environments provide new playgrounds for RL research in the management of electricity networks that do not require an extensive knowledge of the underlying dynamics of such *** with this work,we are releasing an implementation of an introductory toy-environment,ANM6-Easy,designed to emphasize common challenges in *** also show that state-of-the-art RL algorithms can already achieve good performance on ANM6-Easy when compared against a model predictive control(MPC)***,we provide guidelines to create new Gym-ANM environments differing in terms of(a)the distribution network topology and param-eters,(b)the observation space,(c)the modeling of the stochastic processes present in the system,and(d)a set of hyperparameters influencing the reward ***-ANM can be downloaded at https://***/robinhenr y/gym-anm.

关键词： Gym-ANM Reinforcement learning Active network management Distribution networks Renewable energy

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