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Infectious Diseases of Poverty 2021年第4期10卷 46-59页

作者： Carlo Delfin S.Estadilla Joshua Uyheng Elvira P.de Lara-Tuprio Timothy robin Teng Jay Michael R.Macalalag Maria Regina Justina E.Estuar Department of Mathematics Ateneo de Manila UniversityKatipunan Ave.Brgy.Loyola Heights1102 Quezon CityPhilippines Department of Psychology Ateneo de Manila UniversityQuezon CityPhilippines Department of Mathematics Caraga State UniversityButuan CityPhilippines Department of Information Systems and Computer Science Ateneo de Manila UniversityQuezon CityPhilippines

background::Around the world,controlling the COVID-19 pandemic requires national coordination of multiple intervention *** vaccinations are globally introduced into the repertoire of available interventions,it is important to consider how changes in the local supply of vaccines,including delays in administration,may be addressed through existing policy *** study aims to identify the optimal level of interventions for COVID-19 from 2021 to 2022 in the Philippines,which as a developing country is particularly vulnerable to shifting assumptions around vaccine ***,we explore optimal strategies in scenarios featuring delays in vaccine administration,expansions of vaccine supply,and limited combinations of ***::Embedding our work within the local policy landscape,we apply optimal control theory to the compartmental model of COVID-19 used by the Philippine government’s pandemic surveillance platform and introduce four controls:(a)precautionary measures like community quarantines,(b)detection of asymptomatic cases,(c)detection of symptomatic cases,and(d)*** model is fitted to local data using an L-bFGS minimization *** conditions are identified using Pontryagin’s minimum principle and numerically solved using the forward-backward sweep ***::Simulation results indicate that early and effective implementation of both precautionary measures and symptomatic case detection is vital for averting the most infections at an efficient cost,resulting in>99%reduction of infections compared to the no-control *** vaccine administration capacity to 440,000 full immunizations daily will reduce the overall cost of optimal strategy by 25%,while allowing for a faster relaxation of more resource-intensive ***,delays in vaccine administration require compensatory increases in the remaining policy levers to maintain a minimal number of *** example,dela

关键词： Optimal control COVID-19 pandemic Philippines Non-pharmaceutical interventions Vaccines

利用b细胞培养和RT-PCR技术从我国HIV-1感染者中筛选膜蛋白特异性单克隆抗体的初步研究

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病毒学报 2012年第4期28卷 358-365页

作者：汪慧敏徐柯余双庆丁林林罗海艳 robin Flinko George K Lewis 冯霞邵继荣管永军曾毅中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室北京100052 四川农业大学生命科学与理学院雅安625014 马里兰州立大学人类病毒学研究所

本研究通过采集1型人类免疫缺陷病毒(Human immunodeficiency virus-1,HIV-1)感染者抗凝全血,分离出外周血单个核细胞,然后用磁珠分选纯化记忆性b细胞和体外活化记忆性b细胞,促使其分泌抗体,用ELISA法识别阳性b细胞克隆,并提取阳性b细胞... 详细信息

本研究通过采集1型人类免疫缺陷病毒(Human immunodeficiency virus-1,HIV-1)感染者抗凝全血,分离出外周血单个核细胞,然后用磁珠分选纯化记忆性b细胞和体外活化记忆性b细胞,促使其分泌抗体,用ELISA法识别阳性b细胞克隆,并提取阳性b细胞的RNA,从中扩增抗体重链和轻链基因并克隆到表达载体中,再用携带重链基因的质粒和携带轻链基因的质粒共转染293T细胞,获得HIV-1特异性人单克隆抗体,进行抗体特性的鉴定。结果从1例HIV-1感染者的记忆性b细胞中筛选出了4株HIV-1包膜糖蛋白(Envelope glycoprotein,Env)特异性人单克隆抗体,其中2株具有较好的抗体依赖细胞介导的细胞毒作用活性,另有1株对HIV-1假病毒有较弱的中和活性。说明我们成功地引进了利用b细胞培养和RT-PCR技术从人体淋巴细胞中筛选特异性抗体基因的人单克隆抗体技术平台。用该技术可以成功获得HIV-1Env特异性单克隆抗体,为将来从能产生高滴度广谱中和抗体的感染者体内筛选广谱中和抗体打下了基础。

关键词：人类免疫缺陷病毒单克隆抗体中和活性抗体依赖细胞介导的细胞毒作用

Using compositional data analysis to explore accumulation of sedentary behavior,physical activity and youth health

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Journal of Sport and Health Science 2022年第2期11卷 234-243页

作者： Simone J.J.M.Verswijveren Karen E.Lamb Josep A.Martín-Fernández Elisabeth Winkler Rebecca M.Leech Anna Timperio Jo Salmon robin M.Daly Ester Cerin David W.Dunstan Rohan M.Telford Richard D.Telford Lisa S.Olive Nicola D.Ridgers Institute for Physical Activity and Nutrition School of Exercise and Nutrition SciencesDeakin UniversityGeelongVIC 3216Australia Melbourne School of Population and Global Health University of MelbourneParkvilleVIC 3053Australia Department of Computer Science Applied Mathematics and StatisticsUniversity of GironaGirona 17003Spain School of Public Health University of QueenslandHerstonQLD 4006Australia Mary MacKillop Institute for Health Research Australian Catholic UniversityFitzroyVIC 3065Australia School of Public Health University of Hong KongHong KongChina baker Heart and Diabetes Institute MelbourneVIC 3004Australia Research Institute for Sport and Exercise University of CanberraBruceACT 2617Australia School of Psychology Deakin UniversityBurwoodVIC 3125Australia IMPACT Research Institute Deakin UniversityBurwoodVIC 3125Australia ANU Medical School Australian National UniversityGarranACT 2605Australia

Purpose:The study aimed to describe youth time-use compositions,focusing on time spent in shorter and longer bouts of sedentary behavior and physical activity(PA),and to examine associations of these time-use compositions with cardiometabolic ***:Accelerometer and cardiometabolic biomarker data from 2 Australian studies involving youths 7-13 years old were pooled(complete cases with accelerometry and adiposity marker data,n=782).A 9-component time-use composition was formed using compositional data analysis:time in shorter and longer bouts of sedentary behavior;time in shorter and longer bouts of light-,moderate-,or vigorous-intensity PA;and"other time"(i.e.,non-wear/sleep).Shorter and longer bouts of sedentary time were defined as5 min,*** bouts of light-,moderate-,and vigorous-intensity PA were defined asbouts were defined as≥1 *** models examined associations between overall time-use composition and cardiometabolic ***,associations were derived between ratios of longer activity patterns relative to shorter activity patterns,and of each intensity level relative to the other intensity levels and"other time",and cardiometabolic ***:Confounder-adjusted models showed that the overall time-use composition was associated with adiposity,blood pressure,lipids,and the summary ***,more time in longer bouts of light-intensity PA relative to shorter bouts of light-intensity PA was significantly associated with greater body mass index z-score(zbMI)(β=1.79;SE=0.68)and waist circumference(β=18.35,SE=4.78).When each activity intensity was considered relative to all higher intensities and"other time",more time in light-and vigorous-intensity PA,and less time in sedentary behavior and moderate-intensity PA,were associated with lower waist ***:Accumulating PA,particularly light-intensity PA,in frequent short bursts may be more beneficial for limiting adi

关键词： Accumulation patterns Cardiometabolic health Children Compositional data analysis Time-use

拟地新线虫（Pseudoterranova spp.）细胞色素c氧化酶第一亚基DNA多态性的研究

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拟地新线虫（Pseudoterranova spp.）细胞色素c氧化酶第一亚基DNA...

中国动物学会全国第九次寄生虫学学术讨论会

作者：曹湛 Stefano D’Amelio 翁亚彪林瑞庆 Lia Paggi robin b.Gasser 宋慧群朱兴全华南农业大学兽医学院 Istituto di Parassitologia Universita di Roma" La Sapienza" RomeItaly 华南农业大学兽医学院华南农业大学兽医学院 Istituto di Parassitologia Universita di Roma"La Sapienza" RomeItaly Department of Veterinary Science The University of Melbourne Victoria Anstralia Istituto di Parassitologia Universita di Roma"La Sapienza" RomeItaly Istituto di Parassitologia Universita di Roma"La Sapienza" RomeItaly

＜正＞拟地新线虫（Pseudoterranova decipiens）属于线虫纲、蛔虫总科、异尖线虫科,广泛存在于水生动物并呈全球性分布。中间宿主为甲壳类、鱼类,终末宿主为鳍足类的动物如海豹和海狮。更重要的是它也可以感染人,并导致渔业经济的重...

＜正＞拟地新线虫（Pseudoterranova decipiens）属于线虫纲、蛔虫总科、异尖线虫科,广泛存在于水生动物并呈全球性分布。中间宿主为甲壳类、鱼类,终末宿主为鳍足类的动物如海豹和海狮。更重要的是它也可以感染人,并导致渔业经济的重大损失。多基因座酶电泳（MEE）发现,***至少存在六个姊妹种。Zhu等（2002）报道,***的rDNA第一及第二内转录间隔区（ITS-1及ITS-2）序列能给每个姊妹种提供准确的遗传标记,可用于***姊妹种的鉴定。本项研究之目的是:采用DNA单链构象多

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灾害医学

Genetic and healthy lifestyle factors in relation to the incidence and prognosis of severe liver disease in the Chinese population

1992年

作者： P.·巴斯克特(Peter baskett) R.·韦勒(robin Weller)

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Chinese Medical Journal 2023年第16期136卷 1929-1936页

作者： Yuanjie Pang Jun Lv Christiana Kartsonaki Canqing Yu Yu Guo Yiping Chen Ling Yang Iona Y.Millwood robin G.Walters Silu Lv Sushila burgess Sam Sansome Junshi Chen Zhengming Chen Liming Li Department of Epidemiology and biostatistics School of Public HealthPeking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Nuffield Department of Population Health Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU)University of OxfordOxford OX37LFUK Nuffield Department of Population Health Medical Research Council Population Health Research Unit(MRC PHRU)at the University of OxfordUniversity of OxfordOxford OX37LFUK National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular DiseasesBeijing 100730China Fuwai Hospital Chinese Academy of Medical Sciences167 Beilishi RoadXicheng DistrictBeijing 100037China Licang Center for Disease Prevention and Control Licang DistrictQingdaoShandong 266041China National Center for Food Safety Risk Assessment Beijing 100021China

background:Severe liver disease(SLD),including cirrhosis and liver cancer,constitutes a major disease burden in *** aimed to examine the association of genetic and healthy lifestyle factors with the incidence and prognosis of ***:The study population included 504,009 participants from the prospective China Kadoorie biobank aged 30-79 *** individuals were from 10 diverse areas in China without a history of cancer or liver disease at *** regression was used to estimate adjusted hazard ratios(HRs)for incident SLD and death after SLD diagnosis associated with healthy lifestyle factors(smoking,alcohol,physical activity,and central adiposity).Additionally,the contribution of genetic risk for hepatitis b virus(HbV,assessed by genetic variants in major histocompatibility complex,class II,DP/DQ[HLA-DP/DQ]genes)was also ***:Compared with those with 0-1 healthy lifestyle factor,participants with 2,3,and 4 factors had 12%(HR 0.88[95%confidence interval[CI]0.85,0.92]),26%(HR 0.74[95%CI:0.69,0.79]),and 44%(HR 0.56[95%CI:0.48,0.65])lower risks of SLD,*** associations were observed among participants with both low and high genetic risks(HR per 1-point increase 0.83[95%CI:0.74,0.94]and 0.91[95%CI:0.82,1.02],respectively;P_(interaction)=0.51),although with a non-significant trend among those with a high genetic *** associations were also observed between healthy lifestyle factors and liver biomarkers regardless of the genetic *** the limited power,healthy lifestyle factors were associated with a lower risk of death after incident SLD among participants with a low genetic risk(HR 0.59[95%CI:0.37,0.96]).Conclusions:Lifestyle modification may be beneficial in terms of lowering the risk of SLD regardless of the genetic ***,it is also important for improving the prognosis of SLD in individuals with a low genetic *** studies are warranted to examine the impact of healthy lifestyles on SLD prognos

关键词： Healthy lifestyle Gene-environment interaction Liver cancer Cirrhosis Prognosis China

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对分子和晶体中的无辐射跃迁的直接测量

发光学报 1975年第6期 18-18页

作者： Melvin b.robin 美国贝尔实验室

与每一个发光过程并存而相竞争的有一个无辐射衰减过程。对室温气体可以在扫描紫外-可见光谱的同时用颤噪声法测量气体中的压力的变化,来间接测量无辐射衰减释出的热量和释热的速度。本文中将举一些典型例子来说明用这种办法能观察到的... 详细信息

与每一个发光过程并存而相竞争的有一个无辐射衰减过程。对室温气体可以在扫描紫外-可见光谱的同时用颤噪声法测量气体中的压力的变化,来间接测量无辐射衰减释出的热量和释热的速度。本文中将举一些典型例子来说明用这种办法能观察到的各种弛豫现象,这些例子包括表现电子振动弛豫（四氮杂苯）、离解（NO;）、系间交叉跃迁（吡嗪）、能量传递（I;/O;）和光化学弛豫(苯（甲）醛)的一些系统。在2°K的固体样品也可以直接测到无

关键词：无辐射热脉冲

鲁道夫对盲囊线虫（Contracaecum rudolphii）ITS-1及ITS-2rDNA序列的PCR-SSCP分析

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鲁道夫对盲囊线虫（Contracaecum rudolphii）ITS-1及ITS-2rDNA序...

Prevalence and Factors Associated with Overweight and Obesity among Adolescents in Schools in benin in 2016

中国动物学会全国第九次寄生虫学学术讨论会

作者：何芳 Stefano D’Amelio 翁亚彪林瑞庆曹谌 Lia Paggi robin b.Gasser 宋慧群朱兴全华南农业大学兽医学院 Istituto di Parassitologia Universita di Roma "La Sapienza" Rome Italy 华南农业大学兽医学院华南农业大学兽医学院华南农业大学兽医学院 Istituto di Parassitologia Universita di Roma "La Sapienza" Rome Italy Depaartment of Veterinary Science The University of Melboume Victoria Australia 华南农业大学兽医学院华南农业大学兽医学院

＜正＞对盲囊线虫属于异尖线虫科、对盲囊属。据记载本属有119个种,其中寄生于鱼类的有65种,鸟类的有42种,哺乳类的8种,国内报道寄生于鱼类的仅有4种。鲁道夫对盲囊线虫（***）的成虫普遍寄生于鸬鹚（Phalacrocoraxcarbosinensis）的胃...

＜正＞对盲囊线虫属于异尖线虫科、对盲囊属。据记载本属有119个种,其中寄生于鱼类的有65种,鸟类的有42种,哺乳类的8种,国内报道寄生于鱼类的仅有4种。鲁道夫对盲囊线虫（***）的成虫普遍寄生于鸬鹚（Phalacrocoraxcarbosinensis）的胃内,幼虫寄生于各种鱼类。Paggi等用同工酶技术证明,***是由两个姊妹种组成的复合种。但迄今为止,尚未见有关该线虫分子遗传学方面的研究。本项研究之目的是对***的第一及第二内转录间隔区rDNA(ITS-1

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Open Journal of Epidemiology 2019年第3期9卷 213-242页

作者： Olga Agbohoui Houinato Alphonse Kpozehouen benjamin Hounkpatin Kévin Yann Gbédji Hélène robin Carmelle Mizéhoun-Adissoda Fernand Guédou Dismand Stéphan Houinato René Xavier Perrin Epidemiologic Laboratory for Chronic and Neurological Diseases (LEMACEN) Faculty of Health Sciences University of Abomey Calavi Cotonou Benin Regional Institut of Public Healt. (IRSP) University of Abomey Calavi Cotonou Benin Centre Hospitalier Universitaire de la Mère et de l’Enfant Lagune (CHU MEL) Faculty of Health Sciences University of Abomey Calavi Cotonou Benin Health Center of Sexually Transmitted Infections (DIST) Health Center of Cotonou1 Cotonou Bénin

Introduction Overweight and obesity are considered to be global public health concerns. The objective was to estimate the prevalence of overweight and obesity and the associated factors. Methods This was a cross-sectional study conducted in 2016 and involving 3968 adolescents of 10 to 19 years from 40 secondary schools in benin. Participants were selected using a 2-level random sampling technique. Data were collected through a self-administered questionnaire and were analyzed using Epi Info and Stata softwares. Associated factors were investigated by a logistic regression. Results Mean age was 16.54 ± 0.04 years and sex ratio was 1.16. The prevalence of overweight was 8.1% and that of obesity was 1.6%. Associated risk factors were female gender, sedentary lifestyle, consumption of sugary and carbonated beverages. Consumption of fruits and vegetables, regular physical activity, age over than 15 years were protective factors. Conclusion Overweight and obesity among school adolescents are increasing in benin. The establishment of a school nutrition program and the promotion of regular physical activity should contribute to reducing their prevalence.

关键词： Prevalence Overweight Obesity Adolescent School Environment