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Geospatial web services pave new ways for server-based on-demand access and processing of Big Earth Data

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International Journal of Digital Earth 2018年第1期11卷 7-25页

作者： Julia Wagemann Oliver Clements Ramiro Marco Figuera Angelo Pio Rossi Simone mantovani Forecast Department European Centre for Medium-Range Weather ForecastsReadingUK Remote Sensing Group Plymouth Marine LaboratoryPlymouthUK Department of Physics and Earth Sciences Jacobs UniversityBremenGermany MEEO S.r.l. FerraraItaly

Big Earth Data has experienced a considerable increase in volume in recent years due to improved sensing technologies and improvement of numerical-weather prediction *** traditional geospatial data analysis workflow hinders the use of large volumes of geospatial data due to limited disc space and computing *** web service technologies bring new opportunities to access large volumes of Big Earth Data via the Internet and to process them at *** practical examples are presented from the marine,climate,planetary and earth observation science communities to show how the standard interface Web Coverage Service and its processing extension can be integrated into the traditional geospatial data *** service technologies offer a time-and cost-effective way to access multidimensional data in a user-tailored format and allow for rapid application development or time-series *** transport is minimised and enhanced processing capabilities are *** research is required to investigate web service implementations in an operational mode and large data centres have to become more progressive towards the adoption of geo-data standard *** the same time,data users have to become aware of the advantages of web services and be trained how to benefit from them most.

关键词： Geospatial web services interoperability Big Earth Data open data Open Geospatial Consortium(OGC)

Robotic approach with neoadjuvant chemotherapy in adult Wilms’ tumor: A feasibility study report and a systematic review of the literature

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Asian Journal of Urology 2023年第2期10卷 128-136页

作者： Simone Sforza Valeria Emma Palmieri Maria Rosaria Raspollini Giandomenico Roviello Alberto mantovani Umberto Basso Maria Carmen Affinita Alberto D’Angelo Lorenzo Antonuzzo Marco Carini Andrea Minervini Lorenzo Masieri Department of Oncologic Minimally-Invasive Urology and AndrologyCareggi HospitalUniversity of FlorenceFlorenceItaly Department of Pediatric Urology Meyer Children HospitalUniversity of FlorenceFlorenceItaly Clinical Oncologic Unit Careggi HospitalUniversity of FlorenceFlorenceItaly Histopathology and Molecular Diagnostics Careggi HospitalUniversity of FlorenceFlorenceItaly Medical Oncology Unit 1 Istituto Oncologico Veneto IOV IRCCSPaduaItaly Hematology Oncology Division Department of Women’s and Children’s HealthPadova University HospitalPaduaItaly Department of Biology and Biochemistry University of BathBathUK

Objective:The incidence of Wilms’tumor(WT)among adult individuals accounts for less than 1%of kidney cancer cases,with a prognosis usually less favorable when compared to younger individuals and an overall survival rate of 70%for the adult patients versus 90%for the pediatric *** diagnosis and treatment of WT are complex in the preoperative setting;neoadjuvant chemotherapy(NAC)or robotic surgery has rarely been *** study aimed to review the literature of robotic surgery in WT and report the first adult WT management using both NAC and robotic ***:We reported a case of WT managed in a multidisciplinary ***,according to Preferred Reporting Items for Systematic reviews and Meta-Analyses recommendations,a systematic review of the literature until August 2020 of WT treated with a robotic approach was carried ***:A 33-year-old female had a diagnosis of *** was scheduled to NAC,and according to the clinical and radiological response to a robotic radical nephrectomy with aortic lymph nodes dissection,she was managed with no intraoperative rupture,a favorable surgical outcome,and a follow-up of 25 months,which did not show any *** systematic review identified a total number of 230 cases of minimally invasive surgery reported in the literature for *** these,approximately 15 patients were carried out using robotic surgery in adolescents while none in ***,NAC has not been administered before minimally invasive surgery in adults up until ***:WT is a rare condition in adults with only a few cases treated with either NAC or minimally invasive approach so *** advantage of NAC followed by the robotic approach could lead to favorable outcomes in this complex ***,additional cases of adult WT need to be identified and investigated to improve the oncological outcome.

关键词： Nephroblastoma Nephrectomy Renal neoplasm Minimally invasive surgery Rare tumor

Geodynamics of the South Balkan and Northern Aegean Regions Driven by the Westward Escape of Anatolia

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International Journal of Geosciences 2023年第5期14卷 480-504页

作者： Enzo mantovani Marcello Viti Daniele Babbucci Caterina Tamburelli Ismail Hoxha Luigi Piccardi Dipartimento di Scienze Fisiche della Terra e dell’Ambiente Università di Siena Siena Italy Institute of Geosciences Polytechnic University of Tirana Tirana Albania CNR-Institute of Geosciences and Earth Resources Florence Italy

The Plio-Quaternary deformation pattern of the northern Aegean and south Balkan regions is interpreted as an effect of the interaction between the Anatolian-Aegean-Pelagonian system (Tethyan belt), undergoing westward extrusion and strong deformation, and the surrounding plates (Nubia, Europe and Adriatic). Since the middle-late Miocene, the collision of the Tethyan belt with the continental Adriatic domain has caused strong E-W shortening in the outer Hellenides and Albanides, also involving the southward extrusion of the Peloponnesus wedge, at the expense of the Ionian oceanic domain. The roughly E-W extension recognized in the western South Balkan zones (Macedonia and eastern Albania) is related to the divergence between the Pelagonian belt (Albanides and Hellenides) and the Rhodope-Moesia domain. Stressed by the westward displacement of the central Anatolian plateau and by the southward bowing of the Cycladic Arc, the northern Aegean zone has contemporaneously undergone E-W compression and N-S extension, which has generated a series of dextral shear faults, delimiting a number of slats. The westward displacement and deformation of such slats can explain the morphological features of the northern Aegean zone. During this phase, the push of the central Anatolian plateau also caused the separation of the Rhodope massif from the Moesian European domain, with the consequent formation of the upper Thrace basin. This hypothesis can explain the Plio-Quaternary compressional deformations recognized in a sector of the North Anatolian fault system, the Ganos-Gelibolu zone. The proposed geodynamic/tectonic interpretation may help to explain some features of the time-space distribution of major earthquakes in the study area.

关键词： South Balkan North Aegean Geodynamics Tectonics Seismicity

Effects of total replacement of corn silage with sorghum silage on milk yield,composition, and quality

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Journal of Animal Science and Biotechnology 2017年第3期8卷 652-659页

作者： M.Cattani N.Guzzo R.mantovani L.Bailoni Department of Comparative Biomedicine and Food Science(BCA) University of PadovaViale dell'Universita 1635020 LegnaroPDItaly Department of Agronomy Food Natural resources Animals and Environment(DAFNAE) University of PadovaViale dell'Università1635020 LegnaroPDItaly

Background： In the last years, difficulties occurring in corn cultivation（i.e., groundwater shortages, mycotoxin contamination） have been forcing dairy farmers to consider alternative silages. Some experiments conducted on lactating cows have proven that the total replacement of corn silage with sorghum silage did not reduce milk ***, this kind of substitution involves supplementing sorghum-based diets with grains, to compensate for the lower starch content of sorghum silage compared to corn silage. Change of silage type and inclusion of starch sources in the diet would influence rumen fermentations, with possible effects on milk composition（i.e., fatty acid profile） and coagulation properties. A worsening of milk coagulation properties would have a negative economic impact in Italy, where most of the milk produced is processed into *** study was designed to compare milk composition and quality, with emphasis on fatty acid profile and coagulation properties, in dairy cows fed two diets based on corn or sorghum ***： The sorghum diet reduced milk yield（P = 0.043） but not 4% fat corrected milk（P = 0.85）. Feeding sorghum silage did not influence milk contents of protein（P = 0.07） and lactose（P = 0.65）, and increased fat content（P = 0.024）.No differences emerged for milk concentrations of saturated（P = 0.61） and monounsaturated fatty acids（P = 0.50）,whereas polyunsaturated fatty acids were lower（P 〈 0.001） for the sorghum diet. Concentrations of n-6（P 〈 0.001） and n-3 fatty acids（P = 0.017） were lower in milk of cows fed the sorghum diet. Milk coagulation properties did not differ between the two diets, except the ＂a30＂（the curd firmness, expressed in mm, 30 min after rennet addition）, that was lower（P = 0.042） for the sorghum ***： Feeding a forage sorghum silage, properly supplemented with corn meal, as total replacement of corn silage maintained milk composition and did not influence negatively milk coagulation properties, whic

关键词： Dairy cows Forage sorghum silage Mean particle size Milk coagulation properties Milk fatty acid profile

Short-Term Kinematics of the Adria Plate and Space-Time Distribution of Major Peri-Adriatic Earthquakes

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International Journal of Geosciences 2022年第12期13卷 1057-1081页

作者： Enzo mantovani Marcello Viti Daniele Babbucci Caterina Tamburelli Massimo Baglione Vittorio D’Intinosante Dipartimento di Scienze Fisiche della Terra e dell’Ambiente Università di Siena Siena Italy Prevenzione Sismica Settore Sismica della Regione Toscana Italy

Seismic activity is quite strong in the peri-Adriatic zones, whereas the internal part of the Adria plate is almost aseismic. This pattern suggests that Adria is a solid block that interacts with the surrounding belts, trying to move roughly northward. Each major earthquake in a peri-Adriatic zone triggers the acceleration of the decoupled Adria sector, which induces a perturbation of the stress/strain fields in the still blocked boundaries of the plate. Step by step, the displacement of Adria involves more and more northern zones to finally reach the northern front of the plate (eastern Southern Alps). This interpretation seems to be compatible with the time patterns of seismic activity in the main peri-Adriatic zones since 1600 A.D., which may suggest repeated northward migrations of seismic crises. Each supposed migrating sequence involves major earthquakes in most zones. The main features of the first 4 seismic sequences (1600-1930) are used to get insights into possible regularities in the progressive activations of the peri-Adriatic zones. This information and the main features of the ongoing migrating sequence (since 1931) are then used to tentatively recognize the peri-Adriatic zones where the occurrence of next major earthquakes may be most likely.

关键词： Tectonics Adriatic Short-Term Plate Kinematics Seismicity Distribution

Prevalence and incidence of intra-and extrahepatic complications of NAFLD in patients with type 2 diabetes mellitus

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Hepatoma Research 2020年第11期6卷 39-60页

作者： Alessandro mantovani Giorgia Beatrice Roberta Stupia Andrea Dalbeni Section of Endocrinology Diabetes and MetabolismUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVerona 37126Italy Section of General Medicine Hypertension and Liver UnitUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVerona 37126Italy

Nonalcoholic fatty liver disease(NAFLD)is linked to abdominal obesity,insulin resistance and type 2 diabetes mellitus(T2DM).The association of NAFLD with T2DM is *** fact,evidence suggests that abdominal obesity,T2DM and metabolic syndrome play a part in the development and progression of ***,NAFLD is associated with an increased risk of having T2DM and metabolic *** to this background,it is unsurprising that patients with T2DM patients also have a higher prevalence of NAFLD than those with no T2DM,as well as an increased risk of developing liver-related and extrahepatic complications,mainly cardiovascular and renal *** the relationship of NAFLD with insulin resistance,obesity and T2DM,recent consensus proposes a change in nomenclature from NAFLD to metabolic associated fatty liver *** this review,we will discuss the prevalence and incidence of NAFLD(as detected by imaging techniques or liver biopsy)in patients with type T2DM with particular regard to hepatic and extrahepatic complications.

关键词： Nonalcoholic fatty liver disease NASH metabolic associated fatty liver disease diabetes type 2 diabetes

Hepatitis C virus burden:Treating and educating people without prejudice

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World Journal of Hepatology 2022年第7期14卷 1495-1503页

作者： Elettra Merola Elisa Menotti Giovanna Branz Andrea Michielan Sonia Seligmann Annora Ratti Flora Agugiaro Luisa Moser Giovanni Vettori Anna Franceschini William mantovani Riccardo Pertile Giovanni de Pretis Cecilia Pravadelli Department of Gastroenterology Santa Chiara HospitalAzienda Provinciale Per I Servizi Sanitari(APSS)Trento 38122Italy Department of SerD Service for Drug AddictionAzienda Provinciale Per I Servizi Sanitari(APSS)Trento 38122Italy Department of Prevention Azienda Provinciale Per I Servizi Sanitari(APSS)Trento 38122Italy Department of Clinical and Evaluative Epidemiology Azienda Provinciale Per I Servizi Sanitari(APSS)Trento 38122Italy

Hepatitis C virus(HCV)infection has a worldwide incidence of 1.1%.In Italy,60%of people who inject drugs(PWIDs)and are receiving assistance for substance use disorder are infected with ***,this subset of patients has extremely limited access to care due to multiple factors,including alcohol abuse,psychological comorbidities,and homeless *** To describe the impact of our HCV-dedicated service for substance use disorder(SSUD)service on PWIDs receiving anti-HCV *** A dedicated,multidisciplinary team was set up at the SSUD of Trento in October 2020 to provide antiviral treatment to HCV RiboNucleic Acid-positive patients with an active or previous history of substance *** treatment was followed by a health education *** were treated with Direct-Acting Antivirals(DAAs).Data were retrospectively analyzed to assess the efficacy of our dedicated program in terms of therapy completion,HCV eradication,and compliance(primary endpoint).The rate of HCV reinfection and DAA-related toxicity were also assessed(secondary endpoints).RESULTS A total of 40 patients were enrolled in the study:28(70.0%)were treated with Sofosbuvir/Velpatasvir,while 12(30.0%)received Glecaprevir/*** the time of inclusion in the study,36 patients were receiving opioid agonist maintenance therapy,whilst another 4 had just finished the treatment.37.5%had a history of alcoholism and 42.5%received concomitant psychiatric *** 40 patients(100.0%)completed the therapy cycle and 92.5%of patients adhered to the *** patients tested negative for viral load at the end of the *** were no significant drug interactions with common psychiatric treatments and no side effects were *** sustained virological response was achieved in 92.5%of cases with good tolerability,although two patients discontinued treatment *** HCV eradication,one patient died from an overdose,another from complications of cirrhosis,and one rein

关键词： Hepatitis C virus Service for substance use disorder Direct-acting antivirals Sustained virologic response Compliance Tolerability

Hepatobiliary surgeons meet immunologists: the case of colorectal liver metastases patients

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 370-377页

作者： Matteo Donadon Nina Cortese Federica Marchesi Matteo Cimino Alberto mantovani Guido Torzilli Department of Hepatobiliary and General Surgery Humanitas UniversityPieve EmanueleItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Department of Immunology and Inflammation Humanitas Clinical and Research CenterRozzanoMilanItaly Department of Medical Biotechnology and Translational Medicine University of MilanMilanItaly The William Harvey Research Institute Queen Mary University of LondonLondonUK

The burgeoning field of cancer immunology demands a change in the paradigm of cancer patient management. The understanding of the course of a given malignant disease should also include the host immune system as one of the key factors in determining the patient's prognosis. Surgical and medical oncologists need to understand the basic and advanced applications of immunotherapies, which are rapidly evolving, and are nowadays an integral part of the armamentarium for the treatment of cancer patients. In the present work, we review the current knowledge concerning the immune landscape of colorectal cancer (CRC) patients with liver metastases, as recently discovered.

关键词： Host immune system colorectal liver metastases (CLM) colorectal cancer liver metastases colorectal cancer (CRC) immune response immunotherapy

Energy Efficiency Technologies for Hydroelectric Power Plants: A Case Study in Brazil

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Journal of Power and Energy Engineering 2022年第5期10卷 90-115页

作者： Thiago Averaldo Bimestre José Antonio mantovani Júnior Eliana Vieira Canettieri Celso Eduardo Tuna Pedro Magalhães Sobrinho Chemistry and Energy Department School of Engineering S&#227o Paulo State University UNESP Guaratinguetá Brazil Center for Weather Forecasting and Climate Studies National Institute for Space Research CPTEC/INPE Cachoeira Paulista Brazil

Hydroelectricity has great importance for the global macroeconomy. In Brazil, hydroelectricity has been highlighted as the main source of generation of the electric system both for its economic competitiveness and for the abundance of this energy resource. Based on a diagnosis methodology, this article presents a case study in a Brazilian hydroelectric plant in order to optimize the use of energy and propose improvements regarding the rationalization of its application. The systems associated with energy generation were evaluated and the results proved to be potentially advantageous with an estimated savings of 2910 MWh/year in the electricity consumption of the installation itself, with better use of the equipment and the possibility of increasing the power generated.

关键词： Hydropower Plant Renewable Energy Technology Energy Efficiency Energetic Diagnosis Sustainable