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SARS-CoV-2 induced myocarditis:Current knowledge about its molecular and pathophysiological mechanisms

BIOCELL 2022年第8期46卷 1779-1788页

作者： DOMENICO MARIA CARRETTA MARINA DI DOMENICO roberto LOVERO roberto arrigoni ANGELIKA ELZBIETA WEGIERSKA MARIAROSARIA BOCCELLINO ANDREA BALLINI IOANNIS ALEXANDROS CHARITOS LUIGI SANTACROCE AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII Cardiology UnitPoliclinico University Hospital of BariBari70124Italy Department of Precision Medicine University of Campania Luigi VanvitelliNaples80138Italy AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII Clinical Pathology UnitPoliclinico University Hospital of BariBari70124Italy CNR Institute of Biomembranes Bioenergetics and Molecular Biotechnologies(IBIOM)Bari70125Italy Department Interdisciplinary of Medicine University of Bari Aldo MoroBari70124Italy School of Medicine University of Bari Aldo MoroBari70124Italy Department of Emergency and Urgency National Poisoning CentreRiuniti University Hospital of FoggiaFoggia71122Italy

The existence of an inflammatory process in the heart muscle,related to a progressive worsening of myocardial function,different etiopathogenetic mechanisms concur and often overlap,thus making the diagnosis and the therapeutic approach *** the COVID-19 pandemic progresses,the effects of the disease on the organ systems and in particular on the cardiovascular system are becoming more and more *** involvement is a well-known event with a high percentage of findings in the heart’s magnetic field,even in asymptomatic *** are numerous uncertainties regarding their evolution,in the long and short term,due not only to a difficult to determine the varied clinical expression and the rarely performed intramyocardial biopsy which additionally presents diagnostic problems but also in part to different clinical ***,the new SARS-CoV-2 virus that uses the angiotensin converting enzyme 2(ACE2)which is present at high levels in myocardial cells as its entrance it can create even severe heart *** pathophysiology in all of these cases can involve multiple immune and non-immune mechanisms within organs and vessels and can be occur in the clinical *** mechanisms of direct and indirect myocardial infarction in patients with COVID-19 include additional lesion and oxygen-rich and generalized inflammation response with myocardial immune hyperactivity(myocarditis).Therefore,these can occur through the excessive release of cytokines,the presence of thrombocytopenia,endocrine damage,heart failure,arrhythmias and *** can show average signs of myocardial damage,and some develop spontaneous cardiac complications,such as heart failure,arrhythmias and,rarely,rare cardiogenic *** in all of these may involve multiple mechanisms within the cytokine cephalic membrane,endocrine damage and *** diagnosis of this myocardial injuri is mainly based on the myocardial enzyme *** viewpoint paper

关键词： Viruses Infections SARS-CoV-2 Pandemics Myocarditis Molecular diagnosis

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Single-particle spectral function of the Hubbard chain:frustration induced

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Chinese Physics B 2009年第6期18卷 2475-2480页

作者：王竞 Enrico arrigoni Department of Physics Fudan University Institute of Theoretical Physics and Computational Physics Graz University of Technology

The one-electron spectral function of a frustrated Hubbard chain is computed by making use of the cluster perturbation theory. The spectral weight we found turns out to be strongly dependent on the frustrating next-nearest-neighbor hopping t′. A frustration induced pseudogap arises when the system evolves from a gapful Mott insulator to a gapless conductor for an intermediate value of the frustration parameter ｜t′｜. Furthermore, the opening of a pseudogap in the density of states already in the metallic side leads to a continuous opening of the true gap in the insulator. For the hole-doped case, the pseudogap is pinned at the Fermi energy, while the Mott gap is shifted in energy with increasing Hubbard interaction U. The separation of the pseudogap and Mort gap in the hole-doped system demonstrates the validity of the existence of a pseudogap.

关键词： cluster perturbation theory pseudogap metal-insulator transitions

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Evolutionary computing and machine learning for discovering of low-energy defect configurations

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npj Computational Materials 2021年第1期7卷 628-640页

作者： Marco arrigoni Georg K.H.Madsen Institute of Materials Chemistry TU WienViennaAustria

Density functional theory(DFT)has become a standard tool for the study of point defects in ***,finding the most stable defective structures remains a very challenging task as it involves the solution of a multimodal optimization problem with a high-dimensional objective ***,the approaches most commonly used to tackle this problem have been mostly empirical,heuristic,and/or based on domain *** this contribution,we describe an approach for exploring the potential energy surface(PES)based on the covariance matrix adaptation evolution strategy(CMA-ES)and supervised and unsupervised machine learning *** resulting algorithm depends only on a limited set of physically interpretable hyperparameters and the approach offers a systematic way for finding low-energy configurations of isolated point defects in *** demonstrate its applicability on different systems and show its ability to find known low-energy structures and discover additional ones as well.

关键词： function configuration finding

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Radiomics and artificial intelligence applications in pediatric brain tumors

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World Journal of Pediatrics 2024年第8期20卷 747-763页

作者： Francesco Pacchiano Mario Tortora Chiara Doneda Giana Izzo Filippo arrigoni Lorenzo Ugga Renato Cuocolo Cecilia Parazzini Andrea Righini Arturo Brunetti Department of Precision Medicine University of Campania“L.Vanvitelli”CasertaItaly Department of Advanced Biomedical Sciences University of Naples“Federico Ⅱ”Via Pansini 580131NaplesItaly Department of Head and Neck Neuroradiology UnitAORN MoscatiAvellinoItaly Department of Pediatric Radiology and Neuroradiology V.Buzzi Children’s HospitalMilanItaly Department of Medicine Surgery and DentistryUniversity of SalernoBaronissiItaly

Background The study of central nervous system(CNS)tumors is particularly relevant in the pediatric population because of their relatively high frequency in this demographic and the significant impact on disease-and treatment-related morbidity and *** both morphological and non-morphological magnetic resonance imaging techniques can give important information concerning tumor characterization,grading,and patient prognosis,increasing evidence in recent years has highlighted the need for personalized treatment and the development of quantitative imaging parameters that can predict the nature of the lesion and its possible *** this purpose,radiomics and the use of artificial intelligence software,aimed at obtaining valuable data from images beyond mere visual observation,are gaining increasing *** brief review illustrates the current state of the art of this new imaging approach and its contributions to understanding CNS tumors in *** sources We searched the PubMed,Scopus,and Web of Science databases using the following key search terms:(“radiomics”AND/OR“artificial intelligence”)AND(“pediatric AND brain tumors”).Basic and clinical research literature related to the above key research terms,i.e.,studies assessing the key factors,challenges,or problems of using radiomics and artificial intelligence in pediatric brain tumors management,was *** A total of 63 articles were *** included ones were published between 2008 and *** nervous tumors are crucial in pediatrics due to their high frequency and impact on disease and *** serves as the cornerstone of neuroimaging,providing cellular,vascular,and functional information in addition to morphological features for brain *** can provide a quantitative approach to medical imaging analysis,aimed at increasing the information obtainable from the pixels/voxel grey-level values and their ***“radiomic workflow”in

关键词： Machine learning Neuroradiology Pediatric brain tumors Radiomics

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Attention-based Sampling Distribution for Motion Planning in Autonomous Driving

Attention-based Sampling Distribution for Motion Planning in...

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第三十九届中国控制会议

作者： Jikun Rong Stefano arrigoni Nan Luan Francesco Braghin School of Mechanical Engineering Shanghai Jiao Tong University Department of Mechanical Engineering Politecnico di Milano

Sampling-based motion planning（SMPs） approach has been very popular for its ability of computing collision-free and asymptotically optimal path without explicit formulation of the configuration space. SMPs use sampling to generate a discrete representation of the problem and then run graph searching algorithm on this representation. Which means the representation itself is at least as important as graph searching algorithm. In general this is enabled by uniformly sampling the configuration space. This paper proposes a machine learning based biased sampling approach for autonomous driving. The sampling distribution was learned from previous demonstrations using conditional variational encoder（CVAE） with attention *** with a sampling-based algorithm called rapidly-exploring random tree*（RRT*）, we proposed Attention-RRT*. This approach was proved to be effective in several driving scenarios.

关键词： Motion Planning Autonomous Driving Machine Learning

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简单点更好:货币政策和金融稳定性的融资条件测度~

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中国货币市场 2020年第9期 64-67页

作者： Simone arrigoni Alina Bobasu Fabrizio Venditti 不详

文章基于在全球GOP中占比达70%的18个发达和新兴经济体的月度数据,评估了使用简单平均而非时变参数多因子模型来构建融资条件指数(FCIs)的优点。并使用四条标准来评转这些指数的表现,即分位数回归、指数预测银行业危机的能力、结构向量... 详细信息

文章基于在全球GOP中占比达70%的18个发达和新兴经济体的月度数据,评估了使用简单平均而非时变参数多因子模型来构建融资条件指数(FCIs)的优点。并使用四条标准来评转这些指数的表现,即分位数回归、指数预测银行业危机的能力、结构向量自回归(VAR),及其对美国货币政策冲击的反应。研究发现,使用判断性权重产生的FCIs的实证表现会比采用复杂计量方法构建的指数更好。

关键词：融资条件银行业危机金融稳定性新兴经济体分位数回归判断性时变参数指数预测

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超快激光器推动生命科学的创新

超快激光器推动生命科学的创新

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第十七届十三省（市）光学学术年会暨“五省一市光学联合年会”

作者： Marco F.arrigoni Coherent Inc.

上世纪80年代,共聚焦显微技术的发明将激光器带进了生命科学实验室,采用连续波蓝光和绿光氩离子激光器进行细胞结构成像,可以获得传统白光照明方式无法达到的高分辨率。1990年,多光子激发显微(MPE)的出现[1],自然而然地引入了超快激光器...

上世纪80年代,共聚焦显微技术的发明将激光器带进了生命科学实验室,采用连续波蓝光和绿光氩离子激光器进行细胞结构成像,可以获得传统白光照明方式无法达到的高分辨率。1990年,多光子激发显微(MPE)的出现[1],自然而然地引入了超快激光器,引起了生命科学研究的重大变革。这是由于,首先,美国和欧洲的生物

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微管蛋白相关性小脑发育不良:一种特殊类型的小脑畸形

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国际医学放射学杂志 2018年第1期 120-121页

作者： R.Romaniello F.arrigoni E.Panzeri A.Poretti A.Micalizz A.Citterio 汤若薇 Neuropsychiatry and Neurorehabilitation Unit Scientific InstituteIRCCS Eugenio Medea

摘要目的探究微管蛋白基因突变相关性小脑发育不良(CD)及其他后颅窝畸形的神经影像学模式,及其临床表现及基因学相关性。方法采用1.5 T(10例)或3.0 T(18例)

关键词：微管蛋白发育不良相关性

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Reporting rotator cuff tears on magnetic resonance arthrography using the Snyder's arthroscopic classification

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World Journal of Radiology 2017年第3期9卷 126-133页

作者： Alberto Aliprandi Carmelo Messina Paolo arrigoni Michele Bandirali Giovanni Di Leo Stefano Longo Sandro Magnani Chiara Mattiuz Filippo Randelli Silvana Sdao Francesco Sardanelli Luca Maria Sconfienza Pietro Randelli Servizio di Radiologia IRCCS Policlinico San Donato Scuola di Specializzazione in Radiodiagnostica Università degli Studi di Milano Unità Operativa di Ortopedia e Traumatologia Ⅱ IRCCS Policlinico San Donato Dipartimento di Scienze Biomediche per la Salute Università degli Studi di Milano Unità Operativa di Ortopedia e Traumatologia V IRCCS Policlinico San Donato Unità Operativa di Radiologia/Diag-nostica per Immagini con Servizio di Radiologia Interventistica IRCCS Istituto Ortopedico Galeazzi Unità Operativa Complessa I Divisione Istituto Ortopedico Gaetano Pini

AIM To determine diagnostic performance of magnetic resonance arthrography(MRA) in evaluating rotator cuff tears(RCTs) using Snyder's classification for *** One hundred and twenty-six patients(64 males, 62 females; median age 55 years) underwent shoulder MRA and arthroscopy, which represented our reference standard. Surgical arthroscopic reports were reviewed and the reported Snyder's classification was recorded. MRA examinations were evaluated by two independent radiologists(14 and 5 years' experience) using Snyder's classification system, blinded to arthroscopy. Agreement between arthroscopy and MRA on partial-and fullthickness tears was calculated, first regardless of their extent. Then, analysis took into account also the extent of the tear. Interobserver agreement was also calculated the quadratically-weighted Cohen kappa *** On arthroscopy, 71/126 patients(56%) had a fullthickness RCT. The remaining 55/126 patients(44%) had a partial-thickness RCT. Regardless of tear extent, out of 71 patients with arthroscopically-confirmed fullthickness RCTs, 66(93%) were correctly scored by both readers. All 55 patients with arthroscopic diagnosis of partial-thickness RCT were correctly assigned as having a partial-thickness RCT at MRA by both readers. Interobserver reproducibility analysis showed total agreement between the two readers in distinguishing partial-thickness from full-thickness RCTs, regardless of tear extent(k = 1.000). With regard to tear extent, in patients in whom a complete tear was correctly diagnosed, correct tear extent was detected in 61/66 cases(92%); in the remaining 5/66 cases(8%), tear extent was underestimated. Agreement was k = 0.955. Interobserver agreement was total(k = 1.000).CONCLUSION MRA shows high diagnostic accuracy and reproducibility in evaluating RCTs using the Snyder's classification for reporting. Snyder's classification may be adopted for routine reporting of MRA.

关键词： Arthroscopy Magnetic resonance imaging Shoulder Arthrography Supraspinatus tendon Rotator cuff tear

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TBM及其在中国的应用(2)

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现代隧道技术 2002年第2期39卷 1-7页

作者： Reilly John arrigoni Gianni Xu Shulin Grasso Piergiorgio 钱七虎李兴碧美国地下建筑协会主席 JRAI公司总裁国际专家组组长

3工程和技术实例3.1在长大和深埋隧道工程方面其它国家的经验3.1.1工程实例在国际上,许多地铁、公路和水利方面的隧道正投入使用或正在建设之中,还有的才处于计划阶段.

关键词： TBM 中国隧道工程施工技术特点

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