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Antisense therapy:a potential breakthrough in the treatment of neurodegenerative diseases

Neural Regeneration Research 2024年第5期19卷 1027-1035页

作者： roberta romano Cecilia Bucci Department of Biological and Environmental Sciences and Technologies(DiSTeBA) University of SalentoLecceItaly

Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of neurons in the central or peripheral nervous ***,there is no cure for neurodegenerative diseases and this means a heavy burden for patients and the health system ***,it is necessary to find new therapeutic approaches,and antisense therapies offer this possibility,having the great advantage of not modifying cellular genome and potentially being *** preclinical and clinical studies aim to test the safety and effectiveness of antisense therapies in the treatment of neurodegenerative *** objective of this review is to summarize the recent advances in the development of these new technologies to treat the most common neurodegenerative diseases,with a focus on those antisense therapies that have already received the approval of the *** and Drug Administration.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis antisense oligonucleotide Huntington’s disease neurodegenerative disorders Parkinson’s disease siRNA

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Complete Valorization of Olive Mill Wastewater through an Integrated Process for Poly-3-hydroxybutyrate Production

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Journal of Life Sciences 2015年第10期9卷 481-493页

作者： Vito Emanuele Carofiglio roberta romano Maurizio Servili Antonio Goffredo Pietro Alifano Gianluca Veneziani Christian Demitri Domenico Centrone Paolo Stufano EggPlant S.r.l. via Don Minzoni 27 Polignano a Mare (Bari) 70044 Italy Department of Biological and Environmental Sciences and Technologies (DiSTeBA) University of Salento via MonteroniCampus Ecotekne Lecce 73100 Italy Department of Agricultural Food and Environmental Sciences University of Perugia via S. Costanzo Perugia 06126 Italy Department of Engineering for Innovation University of Salento via Monteroni Campus Ecotekne Lecce 73100 Italy

An economical and environmental sustainability of bioplastic production is dependent on the use of low cost and waste C-sources as raw materials. OMW （Olive Mill Wastewater） with its high organic load represents a dangerous polluting waste. Herein the authors present an integrated process for the simultaneous recovery of polyphenols, high value natural antioxidants, production of PHAs （polyhydroxyalkanotes）, thermoplastic bio-polymers, in particular of PHB （poly-3-hydroxybutyrate） starting from OMW. The combination of membrane filtration and bacterial digestion of OMW resulted in very high yields of polyphenols （3 2.5 g/L） and PHB （31.4 mg/L.h） if compared with the state of the art. These results make the technical approach described here effective for reducing the polluting effect of OMW and maximizing the valuable product yield. Moreover the process is readily suitable for an industrial scale PHB production from OMW.

关键词： Poly-3-hydroxybutyrate olive mill wastewater polyphenol Azotobacter vinelandii UWD membrane filtration.

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Interspecies variation in DNA damage induced by pollution

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Current Zoology 2014年第2期60卷 308-321页

作者： Claudia SEBBIO Claudio CARERE Giuseppe NASCETTI Bruno BELLISARIO Pasquale MOSESSO roberta CIMMARUTA Dario ANGELETTI Department of Ecological and Biological Sciences Ichthyogenic Experimental Marine Centre (CISMAR) University of TusciaBorgo Le Saline 01016 Tarquinia VT Italy

The choice of a suitable species to translate pollution signals into a quantitative monitor is a fundamental step in biomonitoring plans. Here we present the results of three years of biomonitoring at a new coal power plant in central Italy using three different aquatic and terrestrial wildlife species in order to compare their reliability as sentinel organisms for genotoxicity. The comet assay was applied to the common land snail Helix spp., the lagoon fish Aphaniusfasciatus, and the green frog Rana esculenta sampled in the area potentially exposed to the impact of the power station. The tissue concentration of some expected pollutants （As, Cd, Ni, Pb, Cr） was analysed in parallel samples collected in the same sampling sites. The three species showed different values in the comet assay （Tail Intensity） and different accumulation profiles of heavy metals. Aphanius fasciatus showed an increasing genotoxic effect over time that paralleled the temporal increase of the heavy metals, especially arsenic, and the highest correlation between heavy metals and DNA damage. Helix spp. showed levels of damage inversely related to the distance from the source of pollution and in partial accordance with the total accumulation of trace elements. On the contrary, Rana esculenta showed a low capability to accumulate metals and had inconsistent results in the comet test. The fish appeared to be the most efficient and sensitive species in detecting chemical pollution. Overall, both the fish and the snail reflected a trend of increasing pollution in the area surrounding the power plant across time and space [Current Zoology 60 （2）： 308-321, 2014].

关键词： Ecotoxicology Genotoxicity Wildlife Coal power plants Comet assay Sentinel organism

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