检索结果-南通市图书馆

Avian introgression in the genomic era

Avian Research 2017年第4期8卷 181-191页

作者： Jente Ottenburghs robert H.S.Kraus Pim van Hooft Sipke E.van Wieren Ronald C.Ydenberg Herbert H.T.Prins Resource Ecology Group Wageningen UniversityDroevendaalsesteeg 3a6708 PB WageningenThe Netherlands Department of Biology University of Konstanz78457 ConstanceGermany Department of Migration and Immuno-Ecology Max Planck Institute for OrnithologyAm Obstberg 178315 RadolfzellGermany Centre of Wildlife Ecology Simon Fraser UniversityBurnabyBC V5A 1S6Canada

Introgression,the incorporation of genetic material from one(sub)species into the gene pool of another by means of hybridization and backcrossing,is a common phenomenon in birds and can provide important insights into the speciation *** the last decade,the toolkit for studying introgression has expanded together with the development of molecular *** this review,we explore how genomic data,the most recent step in this methodological progress,impacts different aspects in the study of avian ***,the detection of hybrids and backcrosses has improved *** most widely used software package is *** discordance(*** loci resulting in discordant gene trees) is another means for the detection of introgression,although it should be regarded as a starting point for further analyses,not as a definitive proof of ***,disentangling introgression from other biological processes,such as incomplete lineage sorting,remains a challenging endeavour,although new techniques,such as the D-statistic,are being *** addition,phylogenetics might require a shift from trees to ***,the study of hybrid zones by means of geographical or genomic cline analysis has led to important insights into the complex interplay between hybridization and ***,because each hybrid zone study is just a single snapshot of a complex and continuously changing interaction,hybrid zones should be studied across different temporal and/or spatial scales.A third powerful tool is the genome *** debate on which evolutionary processes underlie the genomic landscape is still ongoing,as is the question whether loci involved in reproductive isolation cluster together in ‘islands of speciation' or whether they are scattered throughout the *** genomic landscapes across the avian tree of life will be an exciting field for further ***,the findings from these different methods shoul

关键词： Admixture Cline theory D-statictic Genomic landscape Hybridization Phylogenetic discordance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat

引用

Journal of Animal Science and Biotechnology 2023年第4期14卷 1759-1776页

作者： Stephan van Vliet Amanda D.Blair Lydia M.Hite Jennifer Cloward robert E.Ward Carter Kruse Herman A.van Wietmarchsen Nick van Eekeren Scott L.Kronberg Frederick D.Provenza Center for Human Nutrition Studies Department of NutritionDieteticsand Food SciencesCollege of Agriculture and Applied SciencesUtah State UniversityLoganUT 84322USA Department of Wildland Resources Utah State UniversityLoganUT 84332USA Department of Animal Science South Dakota State UniversityBrookingsSD 57707USA Turner Institute of Ecoagriculture BozemanMT 59718USA Louis Bolk Institute Bunnik 3981AJthe Netherlands Northern Great Plains Research Laboratory USDA-Agricultural Research ServiceMandanND 58554USA

Background With rising concerns regarding the effects of red meat on human and environmental health,a growing number of livestock producers are exploring ways to improve production systems.A promising avenue includes agro-ecological practices such as rotational grazing of locally adapted ***,growing consumer interest in pasture-finished meat(i.e.,grass-fed)has raised questions about its nutritional ***,the goal of this study was to determine the impact of two common finishing systems in North American bison—pasture-finished or pen-finished on concentrates for 146 d—on metabolomic,lipidomic,and fatty acid profiles of striploins(*** lumborum).Results Six hundred and seventy-one(671)out of 1570 profiled compounds(43%)differed between pasture-and penfinished conditions(n=20 animals per group)(all,Pvanced lipoxidation(4-hydroxy-nonenal-glutathione;~2-fold)and glycation end-product(N6-carboxymethyllysine;~1.7-fold)(all P<0.05).In contrast,vitamins B5,B6,and C,gamma/beta-tocopherol,and three phenolics commonly found in alfalfa were~2.5-fold higher in pen-finished animals(all P<0.05);suggesting some concentrate feeding,or grazing plants rich in those compounds,may be *** Pasture-finishing(i.e.,grass-fed)broadly improves bison metabolic health and accumulates additional po

关键词： Bison Grass-fed Meat Nutrition Omega-3 fats Pasture-raised Phytochemicals

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts

引用

Cancer Drug Resistance 2019年第4期2卷 1153-1163页

作者： Evan J.Brettrager robert C.A.M.van Waardenburg Department of Pharmacology and Toxicology University of Alabama at BirminghamBirminghamAL 35294-0019USA

Our genomic DNA is under constant assault from endogenous and exogenous sources,which needs to be resolved to maintain cellular *** eukaryotic DNA repair enzyme Tyrosyl-DNA phosphodiesterase I(Tdp1)catalyzes the hydrolysis of phosphodiester bonds that covalently link adducts to ***1 utilizes two catalytic histidines to resolve a growing list of *** DNA-adducts can be divided into two groups:small adducts,including oxidized nucleotides,RNA,and non-canonical nucleoside analogs,and large adducts,such as(drug-stabilized)topoisomerase-DNA covalent complexes or failed Schiff base reactions as occur between PARP1 and *** Tdp1 substrates are generated by chemotherapeutics linking Tdp1 to cancer drug resistance,making a compelling argument to develop small molecules that target Tdp1 as potential novel therapeutic ***1’s unique catalytic cycle,which is centered on the formation of Tdp1-DNA covalent reaction intermediate,allows for two principally different targeting strategies:(1)catalytic inhibition of Tdp1 catalysis to prevent Tdp1-mediated repair of DNA-adducts that enhances the effectivity of chemotherapeutics;and(2)poisoning of Tdp1 by stabilization of the Tdp1-DNA covalent reaction intermediate,which would increase the half-life of a potentially toxic DNA-adduct by preventing its resolution,analogous to topoisomerase targeted poisons such as topotecan or *** catalytic Tdp1 mutant that forms the molecular basis of the autosomal recessive neurodegenerative disease spinocerebellar ataxia with axonal neuropathy best illustrates this concept;however,no small molecules have been reported for this ***,we concisely discuss the development of Tdp1 catalytic inhibitors and their results.

关键词： Tdp1 small molecules DNA topoisomerases Camptothecins oxidative DNA damage DNA adducts Etoposide chain terminating nucleotides/nucleoside analogs DNA metabolism drug development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nature Conservation versus Scenic Quality:A GIS Approach towards Optimized Tourist Tracks in a Protected Area of Northwest Yunnan,China

引用

Journal of Mountain Science 2014年第1期11卷 142-155页

作者： YANG Ming-yu van COILLIE Frieke HENS Luc DE WULF robert OU Xiao-kun ZHANG Zhi-ming Institute of Ecology and Geobotany Yunnan University Laboratory of Forest Management and Spatial Information Techniques Universiteit Gent Flemish Institute for Technological Research

Development of appropriate tourism infrastructure is important for protected areas that allow public access for tourism *** is meant to avoid or minimize unfavourable impacts on natural resources through guiding tourists for proper *** this paper,a GIS-based method,the least-cost path(LCP) modelling,is explored for planning tourist tracks in a World Heritage site in Northwest Yunnan(China),where tourism is increasing rapidly while appropriate infrastructure is almost *** modelling process contains three steps:1) selection of evaluation criteria(physical,biological and landscape scenic) that are relevant to track decision; 2) translation of evluation criteria into spatially explicit cost surfaces with GIS,and 3) use of Dijkstra's algorithm to determine the least-cost *** tracks that link main entrances and scenic spots of the study area are proposed after optimizing all evaluation *** tracks feature lowenvironmental impacts and high landscape qualities,which represent a reasonable solution to balance tourist use and nature conservation in the study *** addtion,the study proves that the LCP modelling can not only offer a structured framwork for track planning but also allow for different stakeholders to participate in the planning *** therefore enhances the effectivenss of tourism planning and managemnt in protected areas.

关键词： Tourist track Spatial optimisation Nature conservation Landscape scenic quality Protected area

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The temporal fluctuations and development of faecal microbiota in commercial layer flocks

引用

Animal Nutrition 2023年第4期15卷 197-209页

作者： Nitish Joat Yadav S.Bajagai Thi Thu Hao van Dragana Stanley Kapil Chousalkar robert J.Moore School of Animal and Veterinary Sciences The University of AdelaideRoseworthySouth Australia5371Australia Institute for Future Farming Systems Central Queensland UniversityRockhamptonQueensland4701Australia School of Science RMIT UniversityBundooraVictoria3083Australia

The microbiota of the gastrointestinal tract influences gut health,which in turn strongly impacts the general health and productivity of laying *** is essential to characterise the composition and temporal development of the gut microbiota in healthy layers raised under different management systems,to understand the variations in typical healthy microbiota structure,so that deviations from this might be recognised and correlated with production and health issues when they *** present investigation aimed to study the temporal development and phylogenetic composition of the gut microbiota of four commercially raised layer flocks from hatch to end of the production ***-intrusive faecal sampling was undertaken as a proxy to represent the gut *** of 16S rRNA gene amplicons was used to characterise the *** diversity analysis indicated that each faecal microbiota was different across the four flocks and had subtly different temporal development *** these inter-flock differences,common patterns of microbiota development were *** and Proteobacteria were dominant at an early age in all *** microbiota developed gradually during the rearing phase;richness and diversity increased after 42 d of age and then underwent significant changes in composition after the shift to the production farms,with Bacteroidota becoming more dominant in older *** developing a more profound knowledge of normal microbiota development in layers,opportunities to harness the microbiota to aid in the management of layer gut health and productivity may be more clearly seen and realised.

关键词： Chicken microbiota Faecal microbiota Firmicutes Housing condition Proteobacteria

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic ***

引用

Journal of Animal Science and Biotechnology 2017年第1期8卷 143-153页

作者： Jae Cheol Kim Bruce P. Mullan John L. Black robert J. E. Hewitt robert J. van barnevel. John R. Pluske School of Veterinary and Life Sciences Murdoch University Murdoch WA 6150 Australia Department of Agriculture and Food Pork Innovation South Perth WA 6151 Australia John L Black Consulting Warrimoo NSW 2774 Australia SunPork Farms Solutions Loganholme QLD 4129 Australia barnevel. Nutrition Pry Ltd Loganholme QLD 4129 Australia

Background： This experiment was conducted to test the hypothesis that vitamin E（Vit E） and acetylsalicylic acid（ASA）, a cyclooxygenase-2（COX-2） inhibitor, will additively reduce the production of the immunosuppressive molecule prostaglandin E_2（PGE_2） and hence reduce inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E. ***： The experiment was conducted in a research facility with 192 individually-housed male weaner pigs（Landrace × Large White） weighing 6.6 ± 0.04 kg（mean ± SEM）. The pigs were experimentally infected with an enterotoxigenic strain of E. coli and were allocated to a 2 × 3 factorial design with the respective factors being without and with 125 ppm ASA and three levels of Vit E supplementation（50, 100 or 200 IU/kg diet, dl-α-tocopheryl acetate）.Results： Acetylsalicylic acid supplementation improved average daily gain（P 〈 0.05） and tended to improve feed：gain ratio（P 〈 0.10） during the first 14 d after weaning. Acetylsalicylic acid supplementation also improved（P 〈 0.001） amino acid utilization efficiency（as assessed by plasma urea level） and tended to decrease（P 〈 0.10） PGE2 production in the liver without affecting smal intestinal histology and tight junction protein mR NA expression in the jejunal epithelium. Vitamin E supplementation greater than 100 IU/kg diet sustained both the plasma Vit E concentration（P 〈 0.001） and plasma haptoglobin content（P 〈 0.001） after weaning. However, there was no additive effects of the combined supplementation of ASA and Vit E on performance, intestinal barrier function and inflammatory responses of weaned ***： Although ASA and vitamin E improved amino acid utilization efficiency and reduced acute inflammatory responses, ASA and vitamin E did not additively reduce production of PGE2 and inflammatory responses in weaner pigs experimental y infected with an enterotoxigenic strain of E. coli.

关键词： Acetylsalicylic acid E.coli infection PGE_2 Vitamin E Weaner pigs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeting DNA repair pathways to overcome cancer drug resistance

引用

Cancer Drug Resistance 2021年第4期4卷 837-841页

作者： robert C.A.M.van Waardenburg Eddy S.Yang Department of Pharmacology and Toxicology University of Alabama at BirminghamBirminghamAL 35233USA Department of Radiation Oncology University of Alabama at BirminghamBirminghamAL 35233USA O’Neal Comprehensive Cancer Center University of Alabama at BirminghamBirminghamAL 35233USA

DNA damage response and DNA repair pathways are evolutionarily conserved from prokaryotes to eukaryotes to protect the host from genomic *** of proteins involved in these pathways in mammalian cells increases genomic alterations leading to genomic instability,a well-established hallmark of cancer^([1,2]).However,our understanding of the signaling pathways to repair DNA damage in cancers has grown exponentially over the last decades.

关键词： damage alterations cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phylogeny of the industrial relevant,thermophilic genera Myceliophthora and Corynascus

引用

Fungal Diversity 2012年第1期52卷 197-207页

作者： Joost van den Brink robert A.Samson Ferry Hagen Teun Boekhout Ronald P.de Vries CBS-KNAW Fungal Biodiversity Centre P.O.Box 851673508 AD UtrechtThe Netherlands

Species of the genus Myceliophthora and its teleomorph Corynascus have attracted increasing interest due to their potential to produce thermostable *** study re-assessed the phylogenetic relationship of 49 isolates of nine species belonging to Myceliophthora and *** species,***,was shown not to belong to the genus Myceliophthora and should be placed in the genus *** other species belonged to two phylogenetic clusters:mesophilic fungi with the type species *** and ***,and thermophilic fungi with ***,*** and *** phylogenetic data provides no clear separation of the two genera Corynascus and *** avoid confusion in future taxonomic studies,it is proposed that all existing Corynascus species be renamed to Myceliophthora,which is the old name and the one more frequently ***,this study identified two groups within the isolates listed as *** and assigned one group(five isolates)to *** based on AFLP analysis and mating *** study provides new insights into the genetic differences within the genus Myceliophthora and will therefore be essential for the interpretation of future genomic and physiological studies of these species.

关键词： Myceliophthora Corynascus Thermophiles M.heterothallica M.thermophila.Thermophilic fungi Multigene phylogeny AFLP analysis Mating behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

糖尿病相关的足病的定义和标准(2023年更新版)

引用

感染、炎症、修复 2024年第1期25卷 80-85页

作者： Jaap J.van Netten Sicco A.Bus Jan Apelqvist Pam Chen Vivienne Chuter robert Fitridge Frances Game robert J.Hinchliffe Peter A.Lazzarini Joseph Mills Matilde Monteiro-Soares Edgar J.G.Peters Katherine M.Raspovic Eric Senneville Dane K.Wukich Nicolaas C.Schaper on behalf of the International Working Group on the Diabetic Foot 张会峰(译) 许樟荣(审校) Department of Rehabilitation Medicine Amsterdam UMCLocation University of AmsterdamAmsterdamthe Netherlands Amsterdam Movement Sciences Program RehabilitationAmsterdamthe Netherlands Department of Endocrinology University Hospital of MalmöMalmöSweden Joondalup Health Campus Ramsay HealthcareSydneyAustralia Faculty of Health University of TasmaniaHobartAustralia School of Health Sciences Western Sydney UniversitySydneyAustralia Faculty of Health and Medical Sciences University of AdelaideAdelaideAustralia Vascular and Endovascular Service Royal Adelaide HospitalAdelaideAustralia Department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK Department of Vascular Surgery University of BristolBristolUK School of Public Health and Social Work Queensland University of TechnologyBrisbaneAustralia Allied Health Research Collaborative The Prince Charles HospitalBrisbaneAustralia Michael E.DeBakey Department of Surgery Division of Vascular Surgery and Endovascular TherapyBaylor College of MedicineHoustonTexasUSA Portuguese Red Cross School of Health–Lisbon LisbonPortugal MEDCIDS–Departamento de Medicina da Comunidade Informação e Decisão em Saúde Faculty of Medicine of the University of PortoPortoPortugal RISE@CINTESIS Faculty of Medicine Oporto UniversityPortoPortugal Department of Internal Medicine Amsterdam UMCVrije Universiteit AmsterdamSection of Infectious DiseasesAmsterdamthe Netherlands Department of Orthopaedic Surgery University of Texas Southwestern Medical CenterDallasTexasUSA Department of Infectious Diseases Gustave Dron Hospital Tourcoing Univ-lilleTourcoingFrance Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands 不详河南省人民医院内分泌科河南郑州450003 战略支援部队特色医学中心北京100101

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本... 详细信息

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本文介绍2023年IWGDF对这些定义和标准的更新,并建议在临床实践和研究中一致使用,以利于世界各地不同学科人员针对糖尿病相关的足病的专业性交流。

关键词：定义糖尿病糖尿病相关的足病国际糖尿病足工作组

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production

引用

Synthetic and Systems Biotechnology 2022年第1期7卷 554-566页

作者： Aafke C.A.van Aalsta Sophie C.de Valk Walter M.van Gulik Mickel L.A.Jansen Jack T.Pronka robert Mans Department of Biotechnology Delft University of TechnologyVan der Maasweg 92629HZ Delftthe Netherlands DSM Biotechnology Centre Alexander Fleminglaan 12613AX Delftthe Netherlands

Product yield on carbohydrate feedstocks is a key performance indicator for industrial ethanol production with the yeast Saccharomyces *** paper reviews pathway engineering strategies for improving ethanol yield on glucose and/or sucrose in anaerobic cultures of this yeast by altering the ratio of ethanol production,yeast growth and glycerol *** attention is paid to strategies aimed at altering energy coupling of alcoholic fermentation and to strategies for altering redox-cofactor coupling in carbon and nitrogen meta-bolism that aim to reduce or eliminate the role of glycerol formation in anaerobic redox *** addition to providing an overview of scientific advances we discuss context dependency,theoretical impact and potential for industrial application of different proposed and developed strategies.

关键词： Saccharomyces cerevisiae Synthetic biology Metabolic engineering Biofuels Redox metabolism Energy metabolism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：