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Airway management of a patient with linear immunoglobulin A bullous dermatosis:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2263-2268页

作者： olga C Nin robert Hutnik Neil N Chheda David hutchinson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BACKGRoUND There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare mucocutaneous disorder that leads to the development of friable *** clinical decision making is necessary when there is a risk of bleeding into the airway,and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios,especially when confronted with an unusual cause for *** SUMMARY A 45-year-old African American female presented to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous *** diagnosis of IgA dermatosis was recent,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required transfer to the intensive care unit where a multidisciplinary team was involved in her *** patient was extubated on postoperative day *** A multidisciplinary approach to treating this disease is the best course of action before a surgical *** our case,key communication between the surgery,anesthesia,and dermatology teams led to the quick and safe treatment of our patient’s *** surgery should not be considered for these cases unless they are in full remission and there is no mucous membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisciplinary approach outpatient procedure Case report

Taxonomy of the White-browed Shortwing(Brachypteryx montana)complex on mainland Asia and Taiwan:an integrative approach supports recognition of three instead of one species

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Avian Research 2018年第4期9卷 281-293页

作者： Per Alstrom Pamela C.Rasmussen Canwei Xia Magnus Gelang Yang Liu Guoling Chen Min Zhao Yan Hao Chao Zhao Jian Zhao Chengte Yao James A.Eaton robert hutchinson Fumin Lei Urban olsson Department of Ecology and Genetics Animal EcologyEvolutionary Biology CentreUppsala UniversityNorbyvaen 18D752 36 UppsalaSweden Swedish Species Information Centre Swedish University of Agricultural Sciences(SLU)Box 7007750 07 UppsalaSweden Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Integrative Biology and MSU Museum Michigan State UniversityEast LansingMI 48864USA Bird Group The Natural History Museum at TringAkeman StreetTring HP23 6APUK Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China Gothenburg Natural History Museum Box 7283402 35 GoteborgSweden State Key Laboratory of Biocontrol Department of EcologySchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China University of Chinese Academy of Sciences Beijing 100049China Cloud Mountain Conservation Dali 671003YunnanChina High-Altitude Experimental Station Endemic Species Research InstituteCOAChi-chi 55244TaiwanChina Birdtour Asia 17 Keats AvenueLittleoverDerby DE23 4EEUK Department of Biology and Environmental Sciences Systematics and BiodiversityUniversity of GothenburgBox 463405 30 GoeborgSweden

Background: The White-browed Shortwing(Brachypteryx montana) is widespread from the central Himalayas to the southeast Chinese mainland and the island of Taiwan, the Philippines and Indonesia. Multiple subspecies are recognised, and several of these have recently been suggested to be treated as separate species based on differences in morphology and ***: We here analyse plumage, morphometrics, songs, two mitochondrial and two nuclear markers, and geographical distributions of the two mainland Asian taxa B. m. cruralis and B. m. sinensis and the Taiwan Residents B. m. ***: We conclude that these differ congruently in morphology, songs and DNA. Male B. m. goodfellowi is the most divergent in plumage(sexually monomorphic, unlike the two others; male similar to female), and B. m. cruralis and B. m. sinensis differ in male plumage maturation. The song of B. m. cruralis is strongly divergent from the others, whereas the songs of B. m. sinensis and B. m. goodfellowi are more similar to each other. Brachypteryx m. sinensis and B. m. goodfellowi are sisters, with an estimated divergence time 4.1 million years ago(mya; 95% highest posterior distribution [HPD] 2.8–5.5 mya), and B. m. cruralis separated from these two 5.8 mya(95% HPD 4.1–7.5 mya). We also report notable range extensions of B. m. sinensis as well as sympatry between this taxon and B. m. cruralis in Sichuan Province, China. Brachypteryx m. montana from Java is found to be more closely related to Lesser Shortwing(B. leucophris) and Rusty-bellied Shortwing(B. hyperythra) than to the mainland Asian and Taiwan Residents ***: our data support a recent proposal to treat the three mainland Asian and Taiwan Residents taxa as three species, separate from B. montana sensu stricto: B. cruralis(central Himalayas to south central China and south Vietnam), B. sinensis(north central to southeastern part of China's Mainland) and B. goodfellowi(Taiwan Island).

关键词： Integrative taxonomy Morphology Song Miocene Pliocene

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亨利八世

作者： (美)罗伯特·哈钦森(robert hutchinson)

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布拉德上校的大胆罪行

作者： (美)罗伯特·哈钦森(robert hutchinson)

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亨利八世

作者： (美)罗伯特·哈钦森(robert hutchinson)

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女王的超级间谍

作者： (美)罗伯特·哈钦森(robert hutchinson)

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西班牙无敌舰队

作者： (美)罗伯特·哈钦森(robert hutchinson)

The MYC transcription factor network： balancing metabolism, proliferation and oncogenesis

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Frontiers of Medicine 2018年第4期12卷 412-425页

作者： Patrick A. Carroll Brian W. Freie Haritha Mathsyaraja robert N. Eisenman Division of Basic Sciences Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N. Seattle WA 90109 USA

Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally. In this review we focus on the MYC network （also known as the MAX-MLX Network）, a highly conserved super-family of related basic-helix-loop-helix-zipper （bHLHZ） proteins that functions to integrate extracellular and intracellular signals and modulate global gene expression. Importantly the MYC network has been shown to be deeply involved in a broad spectrum of human and other animal cancers. Here we summarize molecular and biological properties of the network modules with emphasis on functional interactions among network members. We suggest that these network interactions serve to modulate growth and metabolism at the transcriptional level in order to balance nutrient demand with supply, to maintain growth homeostasis, and to influence cell fate. Moreover, oncogenic activation of MYC and/or loss of a MYC antagonist, results in an imbalance in the activity of the network as a whole, leading to tumor initiation, progression and maintenance.

关键词： network transcription cancer MYC MAX MLX

-lormone levels following surgical and medical castration： defining optimal androgen suppression

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Asian Journal of Andrology 2018年第4期20卷 405-406页

作者： Michael T Schweizer Michael L Hancock robert H Getzenberg Evan Y Yu Division of oncology Department of Medicine University of Washington Seattle WA 98116 USA Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA 98116 USA Veru Healthcare Miami FL 33137 USA

Dear Editor, In the 1940s, Charles Huggins discovered that surgical castration produced remarkable palliative benefits for men with advanced prostate cancer, an effect we now understand to be mediated through deprivi...

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