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中国建筑装饰装修 2012年第6期 46-55页

作者： robert mcbride Debbie Ryan John Gollings 墨尔本mcbride Charles Ryan建筑事务所

精选理由这是为两个年级的男学生而设计的学校,所以除了满足基本的功能需求,还要让他们从整体的环境中获得一种迈出独立步伐的体验。东立面的黑色瓷砖在如银色影般的清晰轮廓映衬下,赋予了建筑更浓厚的神秘色彩。与主入口立面上几条不... 详细信息

精选理由这是为两个年级的男学生而设计的学校,所以除了满足基本的功能需求,还要让他们从整体的环境中获得一种迈出独立步伐的体验。东立面的黑色瓷砖在如银色影般的清晰轮廓映衬下,赋予了建筑更浓厚的神秘色彩。与主入口立面上几条不同颜色条纹相呼应,室内采用了诸多不规则的弯曲形状和条纹元素,如较为柔和的、造型如流云一般的墙面和屋顶设计。

关键词：银色墨尔本屋顶设计功能需求弯曲形状条纹相建筑入口

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Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use

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Asian Journal of Andrology 2016年第3期18卷 373-380,I0007页

作者： J Abram mcbride robert M Coward Department of Urology University of North Carolina School of Medicine Chapel Hill NC 27599-7235 USA.

The use of testosterone replacement therapy （TRT） for hypogonadism continues to rise, particularly in younger men who may wish to remain fertile. Concurrently, awareness of a more pervasive use of anabolic-androgenic steroids （AAS） within the general population has been appreciated. Both TRT and AAS can suppress the hypothalamic-pituitary-gonadal （HPG） axis resulting in diminution of spermatogenesis. Therefore, it is important that clinicians recognize previous TRT or AAS use in patients presenting for infertility treatment. Cessation of TRT or AAS use may result in spontaneous recovery of normal spermatogenesis in a reasonable number of patients if allowed sufficient time for recovery. However, some patients may not recover normal spermatogenesis or tolerate waiting for spontaneous recovery. In such cases, clinicians must be aware of the pathophysiologic derangements of the HPG axis related to TRT or AAS use and the pharmacologic agents available to reverse them. The available agents include injectable gonadotropins, selective estrogen receptor modulators, and aromatase inhibitors, but their off-label use is poorly described in the literature, potentially creating a knowledge gap for the clinician. Reviewing their use clinically for the treatment of hypogonadotropic hypogonadism and other HPG axis abnormalities can familiarize the clinician with the manner in which they can be used to recover spermatogenesis after TRT or AAS use.

关键词： anabolic steroids hypogonadism infertility spermatogenesis testosterone testosterone replacement therapy vasectomy reversal

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Diagnosis and management of testosterone deficiency

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Asian Journal of Andrology 2015年第2期17卷 177-186,I0006页

作者： James A mcbride Culley C Carson robert M Coward Department of Urology University of North Carolina School of Medicine NC USA.

Testosterone supplementation therapy （TST） use has dramatically increased over the past decade, due to the availability of newer agents, aggressive marketing, and an increasing incidence of testosterone deficiency （TD）. Despite the increase in TST, a degree of ambiguity remains as to the exact diagnostic criteria of TD, and administration and monitoring of TST. One explanation for this phenomenon is the complex role testosterone plays in multiple physiologic pathways. Numerous medical co-morbidities and medications can alter testosterone levels resulting in a wide range of nonspecific clinical signs and symptoms of TD. The diagnosis is also challenging due to the lack of a definitive serum total testosterone level that reliably correlates with symptoms. This observation is particularly true in the aging male and is exacerbated by inconsistencies between different laboratory assays. Several prominent medical societies have developed guideline statements to clarify the diagnosis, but they differ from each other and with expert opinion in several ways. Aside from diagnostic dilemmas, there are numerous subtle advantages and disadvantages of the various testosterone agents to appreciate. The available TST agents have changed significantly over the past decade similar to the trends in the diagnosis of TD. Therefore, as the usage of TST increases, clinicians will be challenged to maintain an up-to-date understanding of TD and TST. The purpose of this review is to provide a clear description of the current strategies for diagnosis and management of TD.

关键词： androgens erectile dysfunction hormones hypogonadism testosterone

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4-D Framework of Continental Crust

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丛书名： GSA Memoirs

2007年

作者： robert D. Hatcher, Jr. Marvin P. Carlson John H. mcbride José R. Martínez Catalán

来源：畅想之星图书光盘版（南... 评论

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Gene Copy number variation and associated polymorphisms of complement component C4 in human SLE

Gene Copy number variation and associated polymorphisms of c...

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The 8th International Congress on SLE

作者： Erwin K Chung Yee Ling Wu Stephanie Savelli Haikady N Nagaraja Maddie Hebert Karla Jones Kathryn Kitzmiller Carol A Blanchong NatalieJacobsen-Longman Kim mcbride Gloria C Higgins robert M Rennebohm robert R Rice Kevin V Hackshaw robert A Roubey Jennifer M Grossman Betty P Tsao Daniel J Birmingham Brad H Rovin Lee A Hebert C Yung Yu Columbus Children’s Research Institute College of Medicine and Public HealthThe Ohio State UniversityColumbusOhioUSA Division of Rheumatology Allergy and ImmunologyThe University of North Carolina at Chapel HillChapel Hill.NC.USA Department of Internal Medicine University of California.Los AngelesCaliforniaUSA

＜正＞Purpose:To determine the inter-individual gene copy number variation（GCNV）of complement C4 and its associated polymorphisms in gene size（long and short）and protein isotypes（C4A and C4B）in human SLE. Method...

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Utilization of Extracorporeal Membrane Oxygenation for Pulmonary Toxicity Caused by Inhaled Synthetic Cannabinoid. A Harbinger of Future Complications Associated with Inhaled Cannabinoid Products

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International Journal of Clinical Medicine 2020年第2期11卷 53-61页

作者： robert March Paul Guentert Elizabeth Kloska-Kearney David Kwak Cody Yerger Michael mcbride J. R. Majewski Ross McCauley Jordan Hatch Jacob Speybroeck Allen Betts Mat Marsee Sufyan Zackariya Faisal Shariff Shivani Patel Ali Sualeh Anthony Thomas Edward Evans Donald Westerhausen Mark Walsh Saint Joseph Regional Medical Center Mishawaka IN USA Indiana University School of Medicine—South Bend South Bend IN USA Department of Pulmonary and Critical Care Medicine Methodist Hospital Indianapolis IN USA

There has been a dramatic increase in medical complications related to synthetic cannabinoid (SC) use either by water pipe or vaping. The legalization of marijuana in an increasing number of states has also resulted in an increase in a number of complications related not just to marijuana, but in particular, to SC. As a result, there have been recent increased reports of acute pulmonary injury related to inhaled SC products. We describe that rarely endotracheal intubation with mechanical ventilation has been required to treat the acute respiratory distress syndrome (ARDS) and the diffuse alveolar hemorrhage (DAH) associated with the acute toxicity of SC inhalation. We describe the second reported case of successful utilization of mechanical ventilation and extracorporeal membrane oxygenation (ECMO) in order to treat acute pulmonary toxicity caused by SC inhalation by a water pipe. While the exact pathophysiology of these interesting and recent pulmonary complications is unknown, the recent increase in exposure to SC via water pipe systems and vaping suggests that there will be many more cases of patients that will require ECMO as a form of life-saving therapy.

关键词： Synthetic Cannabinoid Extracorporeal Membrane Oxygenation Mechanical Ventilation Water Pipe Vaping Pulmonary Toxicity

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