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Pituitary macroadenoma apoplexy as a rare complication of Bruton tyrosine kinase inhibitor in chronic lymphoid leukaemia

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Chinese Neurosurgical Journal 2023年第4期9卷 320-325页

作者： Aysha Gomaa robert Skelly East Sussex Healthcare NHS Trust EastbourneUK East Suffolk and North Essex NHS Foundation Trust ColcchesterUK

Background Pituitary apoplexy is a neurosurgical emergency and is a known yet rare complication of pituitary *** typically present with visual field defects,headache and altered *** are multiple risk factors for this complication and a thorough drug history is essential to exclude iatrogenic causes of *** present an extremely rare case of newly diagnosed pituitary insufficiency unveiled by ibrutinib therapy(a Bruton tyrosine kinase inhibitor).Furthermore,after initial withdrawal of ibrutinib because of the erroneous diagnosis of Syndrome of Inappropriate Antidiuretic Hormone Secretion(SIADH),its re-administration led to the development of classical pituitary apoplexy 4 months after treatment was *** presentation A male patient in his 60s with a background of chronic lymphocytic leukaemia(CLL)on ibrutinib and venetoclax presents with acute confusion and deranged *** is found to be hyponatraemic and is diagnosed with Syndrome of Inappropriate Antidiuretic Hormone Secretion(SIADH)and treated with fluid *** represents again 3 weeks later with hyponatraemia and further investigations reveal pituitary insufficiency and *** was restarted on ibrutinib and venetoclax at the time of *** months later,he presents with sudden retro-orbital headache associated with *** findings include cranial nerve iii,IV and XI ***’s visual field examination revealed a left visual field index(VFI)of only 1%while the right was 64%with temporal *** pupils were mid-dilated and poorly reactive to *** pituitary with contrast showed features of pituitary apoplexy and optic nerve *** was urgently referred to the neurosurgical team and underwent an emergency trans-sphenoidal hypophysectomy with circumferential excision of the ***-operative recovery was uneventful with marked improvement in vision *** patient was restarted on ibruti

关键词： Pituitary apoplexy Pituitary macroadenoma Chronic lymphocytic leukaemia Chemotherapy

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PathoDNA, an Advanced Diagnostic for Lyme Disease &Co-Infections Utilizing Next Generation DNA Sequencing with Greater Sensitivity and Selectivity than ELISA/Western Blot

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Advances in Infectious Diseases 2021年第4期11卷 405-429页

作者： robert Schettig Ruth Tan-Lim Daniel Warren Zachary Poteet Rory Sears Michael Hummel Connor Coffin Kendra Quart Christopher Aussems Ronald Matthias Jr. David Medina Matthew Klein Gayle roberts John C. Oertle iii Dino Prato Envita Scottsdale USA

The controversial subject of chronic Lyme disease has occupied medical discourse for years while contributing to unprecedented patient suffering in the United States and abroad. A general misunderstanding of Lyme disease and overconfidence in the Center for Disease Control’s (CDC) recommended two-step test for Lyme disease has led to misdiagnosis and incorrect treatment over the years. This leads to increasing medical expenses and worse outcomes for patients. The two-step test, an ELISA immunoblot followed by a confirmatory Western blot, yields accuracy rates as low as 29% for acute Lyme disease and 75% for chronic Lyme disease. While these practices have been a staple of microbiology for decades, these accuracy rates are unacceptable for diagnostic tests when better technology is available. PathoDNA, a Next-Generation DNA sequencing test for Lyme disease and other tick-borne pathogens, achieves accuracy rates of 98% for B. burgdorferi and 95% or greater for other common tick-borne pathogens with superior sensitivity and selectivity. PathoDNA is a Clinical Laboratory Improvement and Amendments (CLIA)-validated laboratory test that achieves these results utilizing Next Generational DNA Sequencing and a proprietary bioinformatics database. Thus, it allows for rapid results and specific identification of tick-borne illnesses. In this article, we will compare this promising technology against the existing standards for diagnosing and testing Lyme disease. We believe that PathoDNA can set a new standard for identifying Borrelia and diagnosing Lyme disease along with other tick-borne infections.

关键词： Lyme Disease Ticks Tick-Borne Borrelia Sequencing Diagnosis

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Multidisciplinary management of Mirizzi syndrome with cholecystobiliary fistula: the value of minimally invasive endoscopic surgery

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 543-547页

作者： Fabien Le Roux Charles Sabbagh Brice robert Thierry Yzet Laurent Dugue Jean-Paul Joly Jean-Marc Regimbeau Department of Digestive and Oncological Surgery Amiens University Hospital Jules Verne University of Picardie Department of Interventional and Diagnostic Imaging Amiens University Hospital Jules Verne University of Picardie Department of Digestive Surgery Saint-Camille Hospital Department of Hepatogastroenterology Amiens University Hospital Jules Verne University of Picardie

Mirizzi syndrome, a rare complication of gallstones, is defined by obstruction of the main bile duct. This obstruction may worsen and thus result in cholecystobiliary fistula. Surgical management of Mirizzi syndrome is complicated by the presence of inflamed tissue around the hepatic pedicle, making it impossible to distinguish between the main bile duct and the gallbladder. The surgeon＇s first task is to perform subtotal cholecystotomy（from the fundus of the gallbladder to the neck） without trying to locate the cystic duct. In a second step, the gallstones are extracted and the main bile duct is then repaired. In most cases, a T-tube is used to drain the main bile duct, and abdominal drainage is left in place（in case a bile fistula forms）. This study concluded that preoperative drainage of the main bile duct in the treatment of Mirizzi syndrome types II and iii is feasible and might help to decrease the postoperative complication rate.

关键词： jaundice Mirizzi syndrome cholecystobiliary fistula endoscopic treatment cholecystectomy T-tube drain

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Current Status and Future Challenges of Weather Radar Polarimetry: Bridging the Gap between Radar Meteorology/Hydrology/Engineering and Numerical Weather Prediction

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Advances in Atmospheric Sciences 2019年第6期36卷 571-588页

作者： Guifu ZHANG Vivek N.MAHALE Bryan J.PUTNAM Youcun QI Qing CAO ANDrew D.BYRD Petar BUKOVCIC Dusan S.ZRNIC Jidong GAO Ming XUE Youngsun JUNG Heather D.REEVES Pamela L.HEINSELMAN AlexANDer RYZHKOV robert D.PALMER Pengfei ZHANG Mark WEBER Greg M.MCFARQUHAR Berrien MOORE iii Yan ZHANG Jian ZHANG J.VIVEKANANDAN Yasser AL-RASHID Richard L.ICE Daniel S.BERKOWITZ Chong-chi TONG Caleb FULTON Richard J.DOVIAK University of Oklahoma NOAA/National Weather Service Enterprise Electronics Corporation NOAA/National Severe Storms Laboratory National Center for Atmospheric Research Raytheon Company Radar Operations Center

After decades of research and development, the WSR-88 D(NEXRAD) network in the United States was upgraded with dual-polarization capability, providing polarimetric radar data(PRD) that have the potential to improve weather observations,quantification, forecasting, and warnings. The weather radar networks in China and other countries are also being upgraded with dual-polarization capability. Now, with radar polarimetry technology having matured, and PRD available both nationally and globally, it is important to understand the current status and future challenges and opportunities. The potential impact of PRD has been limited by their oftentimes subjective and empirical use. More importantly, the community has not begun to regularly derive from PRD the state parameters, such as water mixing ratios and number concentrations, used in numerical weather prediction(NWP) *** this review, we summarize the current status of weather radar polarimetry, discuss the issues and limitations of PRD usage, and explore potential approaches to more efficiently use PRD for quantitative precipitation estimation and forecasting based on statistical retrieval with physical constraints where prior information is used and observation error is included. This approach aligns the observation-based retrievals favored by the radar meteorology community with the model-based analysis of the NWP community. We also examine the challenges and opportunities of polarimetric phased array radar research and development for future weather observation.

关键词： weather radar polarimetry radar meteorology numerical weather prediction data assimilation microphysics parameterization forward operator

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Freasure Island（iii）

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考试与评价（英语人教高二版） 2009年第6期 37-40页

作者： robert Louis Stevenson

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Freasure Island（iii）

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考试与评价（英语高二专刊） 2009年第6期 37-40页

作者： robert Louis Stevenson

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Treasure Island （iii）

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考试与评价（英语外研新标准高二版） 2009年第6期 31-33页

作者： robert Louis Stevenson

终于离宝藏越来越近了，吉姆也面临险境，他们最后能成功吗？请看——

关键词：高中英语课外阅读教材

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基于ReaxFF反应力场的多元金属氧化物（MMO）MoVNbTeO结构解析及丙烯氨氧化制丙烯腈的催化机理研究

基于ReaxFF反应力场的多元金属氧化物（MMO）MoVNbTeO结构解析及...

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第十六届全国分子筛大会

作者：刘连池孙淮 Jonathan E.Mueller robert J.Nielsen William A Goddard iii 上海交通大学化学化工学院学院 Materials and Process Simulation Center California Institute of Technology

＜正＞多元金属氧化物（MMO）Mo VNb Te O是工业上丙烯制丙烯腈重要的催化剂。但是由于晶体结构中的多个位点由Mo,V,Nb混合占据,难以获得晶体结构中各金属的确切分布,从而难以对催化机理进行研究。我们运用Reax FF反应力场和蒙特卡洛-...

＜正＞多元金属氧化物（MMO）Mo VNb Te O是工业上丙烯制丙烯腈重要的催化剂。但是由于晶体结构中的多个位点由Mo,V,Nb混合占据,难以获得晶体结构中各金属的确切分布,从而难以对催化机理进行研究。我们运用Reax FF反应力场和蒙特卡洛-反应动力学（Reax FF-MC-RD）算法对多元金属氧化物Mo VNb Te O的结构进行了解析,并在此基础上对丙烯氨氧化制丙烯腈的催化反应机理做了初步探讨。

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A phase 1b randomized clinical trial of CT1812 to measure Aβoligomer displacement in Alzheimer’s disease using an indwelling CSF catheter

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Translational Neurodegeneration 2023年第1期12卷 568-571页

作者： Kelsie M.LaBarbera Yvette I.Sheline Nicholas J.Izzo Carla M.Yuede Lora Waybright Raymond Yurko Hannah M.Edwards Woodrow D.Gardiner Kaj Blennow Henrik Zetterberg Anne Börjesson-Hanson Roger Morgan Charles S.Davis robert J.Guttendorf Lon S.Schneider Steven DeKosky Harry LeVine iii Michael Grundman Anthony O.Caggiano John R.Cirrito Susan M.Catalano Mary E.Hamby Cognition Therapeutics Inc. PittsburghPAUSA University of Pennsylvania PhiladelphiaUSA Washington University St.LouisUSA University of Gothenburg MölndalSweden Department of Psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden Clinical Neurochemistry Laboratory Sahlgrenska University HospitalMölndalSweden Department of Neurodegenerative Disease UCL Institute of NeurologyQueen SquareLondonUK UK Dementia Research Institute at UCL LondonUK Hong Kong Center for Neurodegenerative Diseases Clear Water BayHong KongChina Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWIUSA Karolinska University Hospital StockholmSweden MedSurgPI LLCRaleighNCUSA CSD Biostatistics Inc.Oro ValleyAZUSA Aclairo Pharmaceutical Development Group IncViennaVAUSA Keck School of Medicine of USC Los AngelesCAUSA McKnight Brain Institute University of FloridaGainesvilleFLUSA Sanders-Brown Center on Aging University of KentuckyLexingtonKYUSA Global R&D Partners LLCSan DiegoCAUSA Department of Neurosciences University of CaliforniaSan DiegoUSA

Trial Registration:May 11th,2018 *** Identifier:NCT03522129 https://clini caltr ***/ct2/show/*** therapies for Alzheimer’s disease(AD)target a wide range of mechanisms,yet promising dis-ease-modifying therapies remain a huge unmet *** evidence indicates that the oligomeric form of amyloid-beta(Aβ)is a toxic species contributing to AD through synaptic damage and neuronal toxicity[1].

关键词： Alzheimer Aβ damage

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Structure of unliganded membrane-proxima domains FN4-FN5-FN6 of DCC

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Protein & Cell 2017年第9期8卷 701-705页

作者： Lorenzo I. Finci Jie Zhang Xiaqin Sun robert G. Smock Rob Meijers Yan Zhang Junyu Xiao Jia-huai Wang State Key Laboratory of Biomembrane and Membrane Biotechnology College of Life Sciences Peking University Dana-Farber Cancer Institute Harvard Medical School Boston MA 02215 USA European Molecular Biology Laboratory (EMBL) Hamburg Out-station Hamburg Germany PKU-IDG/McGovern Institute for Brain Research Peking University Beijing 100871 China State Key Laboratory of Protein and Plant Gene Research School of Life Sciences and Peking-Tsinghua Center for Life Sciences Peking University Beijing 100871 China Beijing Advanced Innovation Center for Struc tural Biology Tsinghua-Peking Center for Life Sciences School of Life Sciences and School of Medicine Tsinghua University Beijing 100084 China The Francis Crick Institute London NW12BE UK

Dear Editor, Deleted in colorectal cancer （DCC） is a single pass transmembrane glycoprotein that was originally identified in humans as a candidate tumor suppressor （Fearon et al., 1990）. DCC belongs to the immunoglobulin superfamily, and the extracellular fragment is composed of four immunoglobu- lin-like （Ig-like） domains followed by six fibronectin type iii （FN） domains. DCC plays a pivotal role in axon guidance by mediating a combination of attractive and repulsive effects through interactions with the diffusible guidance cue,

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