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四川大山区血吸虫病传播动力学及控制的研究

中华预防医学杂志 2008年第8期42卷 565-568页

作者：钟波梁松许发森吴子松杨长虹陈琳张奕蒙先洪邱东川 robert c spear 四川省疾病预防控制中心寄生虫病防治所成都610041 四川省疾病预防控制中心信息所成都610041 college of Public Health The Ohio State University Columbus OH 43210 USA School of Public Health University of California Berkeley CA 94720 USA

目的利用数学流行病学和计算机模拟方法研究山区血吸虫病的传播因素及其控制策略。方法基于在四川西昌20个村的血吸虫病流行病学调查，建立基于本地传播因素的血吸虫病传播模型。利用蒙特卡罗模拟对模型进行模拟，采用二分法用3个村的... 详细信息

目的利用数学流行病学和计算机模拟方法研究山区血吸虫病的传播因素及其控制策略。方法基于在四川西昌20个村的血吸虫病流行病学调查，建立基于本地传播因素的血吸虫病传播模型。利用蒙特卡罗模拟对模型进行模拟，采用二分法用3个村的数据来效验模型，并用经效验的模型来分析在3种控制策略下本地血吸虫病传播的趋势。结果现场调查显示以村为单位的人群血吸虫病感染率和感染强度分别在3％～73％和平均克粪虫卵数（epg）在0．1至100．0之间。流行因素包括居民职业、疫水接触、微环境参数（气温、降雨），被整合塌入模型中。经二分法效验的模型预测显示连续化疗（50％～60％的覆盖率）在6年内能将感染强度降低30％～80％，但不能降低传播潜力；所以化疗一旦停止，传播即反弹。持续的局部的环境干预，如灭螺和虫卵控制（30％～50％覆盖率），可以将传播控制在半稳定水平；只有持续的包括化疗和环境干预在内的综合控制，在5～10年间才能将传播控制到很低的水平，甚至阻断传播。结论利用传播模型结合现场数据能够帮助分析影响血吸虫病本地传播的因素，并帮助制定相应的控制策略；血吸虫病的控制应建立在对本地因素的认识和可持续的环境干预基础上。

关键词：血吸虫病流行病学模型理论感染控制

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某织布厂工人个体噪声暴露水平的测量与评价

中华劳动卫生职业病杂志 2001年第3期19卷 217-218页

作者：成小如黄爱群王滨燕 robert c.spear 赵一鸣北京大学第三医院中心实验室 100083 安徽医科大学生物医学研究所美国伯克利加州大学公卫学院 ca94720

我们用个体计量仪对织布生产过程中几个典型的工种进行个体噪声暴露水平的测量,并与经典方法测量的噪声数据进行比较.一、对象与方法1.对象:以某棉纺织厂的织布分厂为研究单位.该厂的生产工序为:经纱→整经→浆纱→穿筘→织布←纬纱,织... 详细信息

我们用个体计量仪对织布生产过程中几个典型的工种进行个体噪声暴露水平的测量,并与经典方法测量的噪声数据进行比较.一、对象与方法1.对象:以某棉纺织厂的织布分厂为研究单位.该厂的生产工序为:经纱→整经→浆纱→穿筘→织布←纬纱,织布→验布→修织补→成包→入库.其主要生产工种有:穿筘工、挡车工、加梭工、验布工,将这些工种的工人作为研究对象.根据个体噪声暴露评价的原则,将每个工种中所有的工人定义为1个组,在每组研究对象中选取3～7人作为实际观察对象.

关键词：织布厂噪声暴露水平噪声测量

累积噪声暴露量与高血压患病率的剂量-反应关系

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中华劳动卫生职业病杂志 1993年第6期11卷 325-327页

作者：赵一鸣张书珍 robert c.spear Steve Selvin 北京医科大学第三医院中心实验室 100083 北京医科大学公共卫生学院劳动卫生教研室美国伯克利加州大学公共卫生学院

本文应用累积噪声暴露量的概念,在Logistic回归模型中分析了噪声暴露与纺织女工高血压患病率的关系。发现应用累积噪声暴露量可以解决噪声作业工龄与年龄高度相关在Logistic回归模型中互相干扰的问题。调整后的累积噪声暴露量的Odds Ra... 详细信息

本文应用累积噪声暴露量的概念,在Logistic回归模型中分析了噪声暴露与纺织女工高血压患病率的关系。发现应用累积噪声暴露量可以解决噪声作业工龄与年龄高度相关在Logistic回归模型中互相干扰的问题。调整后的累积噪声暴露量的Odds Ratio为1.033,与另一模型中调整后噪声强度的Odds Ratio的1.03l非常接近,同时P值降低。表明噪声暴露与高血压病的发生之间有累积效应关系。应用累积噪声暴露量后,年龄的Odds Ratio由1.101上升为1.157,P值也由0.323降低为<0.001;父母高血压史和吃菜咸淡的Odds Ratio与应用噪声强度和噪声作业工龄的模型非常接近。用后退法比较最大似然值差值的方法证实,年龄对高血压病的危险性约为噪声的3倍、父母高血压史和吃莱咸淡分别为噪声的2倍和1.6倍。作者对年龄与工龄高度相关在职业流行病学研究中造成的困难以及应用累积噪声暴露量解决这一困难的机理进行了讨论。

关键词：高血压噪声暴露 Logistic 噪声

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两组空压工个体噪声暴露的测量及评价

中国工业医学杂志 2000年第4期13卷 203-205页

作者：周盛林成小如张超彦 robert c spear 赵一鸣 711医院职业病科北京100076 北京大学第三医院北京100083 伯克利加州大学公卫学院美国ca94720

目的　测量和评价空压工的噪声暴露。方法　采用SH 12 6记录式声级计测量两组空压工在不同工作日内的噪声暴露 ,同时用声级计按经典方法在典型工作位多点测量噪声水平。结果　在 4小时工作期间 ,空压工的个体噪声暴露水平呈波动状 ,波... 详细信息

目的　测量和评价空压工的噪声暴露。方法　采用SH 12 6记录式声级计测量两组空压工在不同工作日内的噪声暴露 ,同时用声级计按经典方法在典型工作位多点测量噪声水平。结果　在 4小时工作期间 ,空压工的个体噪声暴露水平呈波动状 ,波动范围可达 10dB (A) ,主要由空压机间歇工作和工人工作位移动所致。低压空压机操作工平均个体噪声暴露为 (85 8± 2 9)dB (A) ,高压空压机操作工平均个体噪声暴露为 (85 7± 2 2 )dB (A) ,每组内工人间和工作日间的噪声暴露差异均无显著意义。声级计测量低压空压机生产环境噪声 (86 1± 2 7)dB (A) ,高压空压机 (83 8± 2 7)dB (A)。结论　个体噪声暴露测量可以较好地解决现场复杂情况下的噪声暴露评价问题。个体间和工作日间噪声暴露的变异不容忽视 ,应有相应的设计和评价方法。本文使用的方法有待改进和简化。

关键词：个体暴露空压工噪声测量评价

Airway management of a patient with linear immunoglobulin A bullous dermatosis:A case report

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World Journal of clinical cases 2024年第13期12卷 2263-2268页

作者： Olga c Nin robert Hutnik Neil N chheda David Hutchinson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BAcKGROUND There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare mucocutaneous disorder that leads to the development of friable *** clinical decision making is necessary when there is a risk of bleeding into the airway,and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios,especially when confronted with an unusual cause for *** SUMMARY A 45-year-old African American female presented to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous *** diagnosis of IgA dermatosis was recent,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required transfer to the intensive care unit where a multidisciplinary team was involved in her *** patient was extubated on postoperative day *** A multidisciplinary approach to treating this disease is the best course of action before a surgical *** our case,key communication between the surgery,anesthesia,and dermatology teams led to the quick and safe treatment of our patient’s *** surgery should not be considered for these cases unless they are in full remission and there is no mucous membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisciplinary approach Outpatient procedure case report

A general mirror equivalence theorem for coset vertex operator algebras

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Science china Mathematics 2024年第10期67卷 2237-2282页

作者： robert McRae Yau Mathematical Sciences center Tsinghua UniversityBeijing 100084China

We prove a general mirror duality theorem for a subalgebra U of a simple conformal vertex algebra A and its commutant V=comA(U).Specifically,we assume that A≌■_(i∈I)U_(i)■V_(i) as a U■V-module,where the U-modules Uiare simple and distinct and are objects of a semisimple braided ribbon category of Umodules,and the V-modules Viare semisimple and contained in a(not necessarily rigid) braided tensor category of *** also assume U=comA(V).Under these conditions,we construct a braid-reversed tensor equivalence τ:u_(A)→v_(A),where u_(A)is the semisimple category of U-modules with simple objects Ui,i∈I,and v_(A)is the category of V-modules whose objects are finite direct sums of *** particular,the V-modules Viare simple and distinct,and v_(A)is a rigid tensor *** an application,we find a rigid semisimple tensor subcategory of modules for the Virasoro algebra at central charge 13+6p+6p^(-1),p∈Z_(≥2), which is braided tensor equivalent to an abelian 3-cocycle twist of the category of finite-dimensional ***,the Virasoro vertex operator algebra at central charge 13+6p+6p^(-1)is the PSL_(2)(c)-fixed-point subalgebra of a simple conformal vertex algebra w(-p),analogous to the realization of the Virasoro vertex operator algebra at central charge 13-6p-6p^(-1)as the PSL_(2)(c)-fixed-point subalgebra of the triplet algebra W(p).

关键词： vertex operator algebras coset conformal eld theory braid-reversed tensor equivalence Virasoro algebra

Integrins and their potential roles in mammalian pregnancy

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Journal of Animal Science and Biotechnology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson robert c.Burghardt Fuller W.Bazer Heewon Seo Joe W.cain Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(EcM) interactions leading to assembly of integrin adhesion complexes(IAcs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnancy Rodents Sheep

Non-linear dynamic state-space network modeling for decoding neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 1879-1880页

作者： Venkata c.chirumamilla chi Wang Ip Martin Reich robert Peach Jens Volkmann Bahman Nasseroleslami Muthuraman Muthuraman Prenatal Pediatrics Institute Children’s National HospitalWashingtonDCUSA Neural Engineering with Signal Analytics and Artificial Intelligence Department of NeurologyUniversity of WürzburgWürzburgGermany Academic Unit of Neurology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Neurodegenerative disorders represent a pervasive global health challenge,yet therapeutic options remain conspicuously *** disorders are inherently dynamic processes within the central nervous system,unfolding across distinct sub-stages:initial structural neuronal alterations(sub-stage 1),functional impairment(sub-stage 2),and culminating in neuronal death(sub-stage 3).

关键词： alterations impairment dynamic

西昌邛海周边地区地理环境与血吸虫病流行的关系

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实用寄生虫病杂志 2001年第4期9卷 145-148页

作者：陈琳钟波沙开友赵联国尹洪智杨长虹梁松 robert c.spear 辜学广四川省寄生虫病防治研究所四川成都610041 西昌市血吸虫病防治站四川西昌615000 University of california

目的本文通过调查四川省西昌市邛海湖盆地区 4个乡 1 96个村民组中的 2 0个组的居民血吸虫病的感染情况 ,了解当地地理环境、生产条件对血吸虫病流行的影响。方法用 Kato-Katz法进行粪检 ,得出感染率 ;对 2 0个组进行地理环境分类、种... 详细信息

目的本文通过调查四川省西昌市邛海湖盆地区 4个乡 1 96个村民组中的 2 0个组的居民血吸虫病的感染情况 ,了解当地地理环境、生产条件对血吸虫病流行的影响。方法用 Kato-Katz法进行粪检 ,得出感染率 ;对 2 0个组进行地理环境分类、种植作物分类及生产条件和外围环境因素的调查。结果该地区的地势是由平地、阶地向梯地过渡 ,相对应的居民血吸虫病感染率也随梯 (阶 )地面积比例的增大而增高 ,两者呈正相关 ( rs=0 .739,P<0 .0 0 1 )。环境复杂的汇水区及环山堰的多少也与感染率呈正相关 ( rs=0 .793,P<0 .0 0 1及 rs=0 .75 8,P<0 .0 0 1 )。水稻种植比例的大小与血吸虫病感染率呈负相关 ( rs=-0 .72 6 ,P<0 .0 0 1 ) ,而经济作物如蔬菜、烤烟等的种植比例大小与血吸虫病感染率呈正相关 ( rs=0 .781 ,P<0 .0 0 1 )。结论平坝种植水稻区已不再是严重的血吸虫病流行区 ,而环境复杂的梯阶地区。

关键词：血吸虫病地理环境生产条件