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电子设计应用 2005年第6期 24-24,26页

作者： robert blake Altera公司

引言系统设计人员在实现最具成本效益的芯片方案时面临多种选择.为了获取最大利润,需要综合考虑这些方案的最终预期产量、开发成本以及产品能否及时上市等因素.

关键词： ASIC FPGA 结构化难题成本效益设计人员最大利润开发成本方案预期上市

Aircraft Brake Dust Dispersion (Airwash) Testing

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Occupational Diseases and Environmental Medicine 2022年第4期10卷 255-261页

作者： Charles L. blake robert E. Bailey Kevin M. Guth Raymond D. Harbison Apex Companies Marietta GA USA ESi Colorado Springs CO USA Center for Environmental and Occupational Risk Analysis and Management College of Public Health University of South Florida Tampa FL USA

Prior industrial hygiene research involving wheel brake changing on a light general aviation aircraft has shown negligible potential for asbestos fiber exposure to mechanics that perform such work. This is despite the use of organic-style brake friction pads that contained asbestos. It has been otherwise established that chrysotile asbestos is largely degraded to a non-crystalline, amorphous substance by the heat and mechanical shear forces inherent to the braking process. However, trace (<1.0%) quantities of chrysotile have been found in brake wear dust. Disc-style brakes, the types used on aircraft, are of open design, such that wear dust is typically dispersed into the ambient air during and after brake application. For fixed-gear aircraft, the brake assemblies are also subject to substantial air velocities while the aircraft is in flight. This research was undertaken to measure and characterize the airflows experienced by aircraft wheel assemblies during takeoff, cruise, and landing maneuvers. No wear (brake) dust was observed at any point during the study.

关键词： Aircraft Brakes Asbestos Airwash

Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 374-382页

作者： Yasser Fouad Melissa Palmer Minjun Chen Arie Regev Rajarshi Banerjee Rob Myers robert Riccio Richard Torstenson Ramy Younes Puneet SArora Henrik Landgren Morten A.Karsdal Martin blake David A.Shapiro Hans-Juergen Gruss Muhammad Y.Sheikh Dina Attia Steven Bollipo Alastair D.Smith Bradley Freilich robert G.Gish Detlef Schuppan Department of Gastroenterology Hepatologyand Endemic MedicineFaculty of MedicineMinia UniversityMiniaEgypt Gan-nex/Ascletis Pharma Co Ltd BeijingChina Liver Consulting LLC New YorkNYUSA Division of Bioinformatics and Biostatis-tics National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonARUSA Eli Lilly and Company IndianapolisINUSA Perspectum Diagnostics Ltd OxfordUK Gilead Sciences Inc Foster CityCAUSA Syneos Health LLC MorrisvilleNCUSA Allergan Marlow International BuckinghamshireUKAstraZenecaCambridgeUK Boehringer Ingel-heim International GmbHIngelheimGermany Genentech IncSouth San FranciscoCAUSA AbbVie MarlowBuck-inghamshireUK Nordic Bioscience A/S HerlevDenmark Resonance Health BurswoodWAAustralia Intercept Phar-maceuticals Inc San DiegoCAUSA Fresno Clinical Research Center FresnoCAUSA Gastroenterology and Hepatology Department Beni-Suef UniversityBeni SuefEgypt Department of Gastroenterology and Endoscopy John Hunter HospitalNewcastleNSWAustralia School of Medicine and Public Health University of NewcastleNewcastleNSWAustralia Kan-sas City Research Institute Kansas CityMOUSA Division of Gastroenterology and Hepatology Loma Linda UniversityLoma LindaCAUSA Institute of Translational Immunology and Research Center for Immune Therapy University Medical CenterMainzGermany Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Metabolic(dysfunction)-associated fatty liver disease(MAFLD)affects a third of the population and is a leading cause of liver-related *** no effective treatments exist,novel approaches to drug development are ***,outdated terminology and definitions of the disease are hampering efforts to develop new drugs and *** international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease(NAFLD)to MAFLD,includ-ing a proposal for how the disease should be *** allies with the many stakeholders in MAFLD care―including patients,patients’advocates,clinicians,researchers,nurse and allied health groups,regional societies,and others―we are aware of the negative consequences of the NAFLD term and *** share the sense of urgency for change and will act in new ways to achieve our *** there is much work to be done to overcome clinical inertia and reverse worrisome recent trends,the MAFLD initiative provides a firm foundation to build *** provides a roadmap for moving for-ward toward more efficient care and affordable,sustainable drug and device innovation in MAFLD *** hope it will bring promising new opportunities for a brighter future for MAFLD care and improve care and outcomes for patients of one of the globe’s largest and costliest public health *** this viewpoint,we have revisited this initiative through the perspectives of drug development and regulatory science.

关键词： NAFLD MAFLD NASH Fatty liver disease Liver Fibrosis

Recent advances in operational tropical cyclone genesis forecast

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Tropical Cyclone Research and Review 2023年第4期12卷 323-340页

作者： K.K.Hon robert Ballard Eric blake Steph Bond Robb Gile Daniel Halperin Charles Helms Hoang Lam Xinyan Lyu Mrutyunjay Mohapatra Monica Sharma Akira Shimokobe Ralf Toumi Seonghee Won Hong Kong Observatory Hong KongChina Regional Specialized Meteorological Center Honolulu HonoluluUSA National Hurricane Center Miami FLUSA Bureau of Meteorology MelbourneAustralia Philippine Atmospheric Geophysicaland Astronomical Services AdministrationDepartment of Science and TechnologyQuezon CityPhilippines Embry-Riddle Aeronautical University USA National Aeronautics and Space Administration MarylandUSA Vietnam Meteorological and Hydrological Administration HanoiViet Nam China Meteorological Administration BeijingChina Regional Specialized Meteorological Center New Delhi New DelhiIndia Regional Specialized Meteorological Center Tokyo-Typhoon Centre TokyoJapan Department of Physics Imperial College LondonUK Korea Meteorological Administration SeoulRepublic of Korea

Tropical cyclone(TC)genesis prediction is a major scientific challenge to the TC operation and research *** report surveys the current status of TC genesis forecasts by a number of major operational centers covering the key ocean basins across both *** IWTC-9,we see an emergence of probabilistic TC genesis forecast products by operational centers,typically supported by the statistical processing of a combination of ensemble prediction and satellite analysis,covering time periods of couple of days to weeks *** prevalence of multi-center grand ensemble approach highlights the uncertainties involved and the forecast challenges in quantitative genesis *** operational practice might differ across agencies,verification efforts generally report a steady or slightly improving skill level in terms of reliability,which likely results from the continual improvement in global numerical weather prediction capability.

关键词： Cyclogenesis Tropical cyclone genesis Ensemble Prediction Operational Forecasting Probabilistic Verification Survey Global

Magnetic Field Configurations Corresponding to Electric Field Patterns That Evoke Long-Term Potentiation Shift Power Spectra of Light Emissions from Microtubules from Non-Neural Cells

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Open Journal of Biophysics 2014年第4期4卷 112-118页

作者： blake T. Dotta David A.E. Vares Carly A. Buckner robert M. Lafrenie Michael A. Persinger Biomolecular Sciences and Behavioural Neuroscience Programs Laurentian University Sudbury Canada

Photon counts were measured every 15 ms for 75 s from microtubule-enriched preparations (and nuclei) from mouse melanoma cells during baseline and after 2 min exposures to 1 μT magnetic fields. The magnetic fields were generated from a circular array of solenoids and presented with accelerating or decelerating rotation velocities. The range of photon radiant flux density was in the order of 10-12 W·m-2. Microtubules preparations that had been exposed for only 2 min to a magnetic field configuration corresponding to the electric field pattern that induced long-term potentiation in neural tissue when applied as electric current displayed peaks of spectral power densities within 7 - 8 Hz, 9.5 Hz, 14 - 15 Hz, and 22 Hz bands. The major peak (9.4 Hz) bandwidth was approximately 0.1 Hz. While microtubule preparations exposed for 2 min to a 7 Hz sine-wave or in the absence of a field emitted an overall similar level of spectral power density, the peaks in power density were not present. Treatment with the LTP patterned fields, compared to the baseline or sine-wave fields primarily altered the frequency band in which the amplitude of the photon field was expressed. These results suggest that the photon emissions from microtubule preparations have the capacity to respond to specifically-patterned or geometric shapes of magnetic fields by altering spectral configurations rather than the absolute numbers of photons.

关键词： Microtubules Photon Emissions Spectral Density Shifts Physiologically-Patterned Magnetic Fields

Role of the complement cascade in cerebral aneurysm formation,growth,and rupture

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 93-101页

作者： blake E.S.Taylor Geoff Appelboom robert Zilinyi Ariana Goodman David Chapel Melissa LoPresti Edward Sander Connolly Jr. Department of Neurosurgery Cerebrovascular LabColumbia University Medical CenterNew YorkNY 100027USA Department of Neurosurgery Columbia UniversityNew YorkNY 100027USA College of Physicians and Surgeons Columbia UniversityNew YorkNY 100027USA Department of Pathology and Cell Biology Columbia UniversityNew YorkNY 100027USA New York University School of Medicine New YorkNY 100027USA Neuro-intensive Care Unit Columbia University Medical CenterNew YorkNY 100027USA

Rupture of intracranial aneurysms is the most common cause of nontraumatic subarachnoid hemorrhage,but the intricate neuroinflammatory processes which contribute to aneurysm pathophysiology are not well‑*** evidence has implicated the complement cascade in the progression of aneurysms from their formation to *** this article,we identify and review studies that have sought to determine the role of the complement system in the aneurysm *** studies were generally conducted by immunhistological analyses on aneurysm tissue collected intraoperatively,and multiple components of the complement cascade and its modulators were identified in specific regions of the aneurysm *** results of the studies suggest that the complement cascade is locally upregulated and disinhibited in the perianeurysmal environment,and that it contributes to chronic as well as acute immunological damage to the aneurysm *** the future,understanding the mechanisms at work in complement‑mediated damage is necessary to leading the development of novel therapies.

关键词： Aneurysm complement neuroinflammation rupture subarachnoid hemorrhage

Recent advances in seasonal and multi-annual tropical cyclone forecasting

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Tropical Cyclone Research and Review 2023年第3期12卷 182-199页

作者： Yuhei Takaya Louis-Philippe Caron Eric blake Francois Bonnardot Nicolas Bruneau Joanne Camp Johnny Chan Paul Gregory Jhordanne J.Jones Namyoung Kang Philip J.Klotzbach Yuriy Kuleshov Marie-Dominique Leroux Julia F.Lockwood Hiroyuki Murakami Akio Nishimura Dushmanta R.Pattanaik Tom J.Philp Yohan Ruprich-robert Ralf Toumi Frederic Vitart Seonghee Won Ruifen Zhan Meteorological Research Institute Japan Meteorological AgencyIbarakiJapan Ouranos MontrealCanada National Hurricane Center National Oceanic and Atmospheric AdministrationMiamiUSA Meteo-France Direction Interregionale pour l'Ocean IndienSaint-Denisde La ReunionFrance Reask LondonUK Bureau of Meteorology VictoriaAustralia City University of Hong Kong Hong KongChina Asia-Pacific Typhoon Collaborative Research Center ShanghaiChina Shanghai Typhoon Institute China Meteorological AdministrationShanghaiChina Department of Earth Atmosphericand Planetary SciencesPurdue UniversityWest LafayetteUSA University Corporation for Atmospheric Research BoulderUSA Department of Geography Kyungpook National UniversityDaeguRepublic of Korea Department of Atmospheric Science Colorado State UniversityFort CollinsUSA Royal Melbourne Institute of Technology(RMIT)University MelbourneAustralia Met Office Hadley Centre ExeterUK National Oceanographic and Atmospheric Administration/Geophysical Fluid Dynamics Laboratory PrincetonUSA Japan Meteorological Agency TokyoJapan India Meteorological Department New DelhiIndia Maximum Information LondonUK Barcelona Supercomputing Center BarcelonaSpain Department of Physics Imperial College LondonLondonUK European Centre for Medium-Range Weather Forecasts(ECMWF) ReadingUK Korea Meteorological Administration JejuRepublic of Korea Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghaiChina

Seasonal tropical cyclone(TC)forecasting has evolved substantially since its commencement in the early ***,present operational seasonal TC forecasting services still do not meet the requirements of society and stakeholders:current operational products are mainly basin-scale information,while more detailed sub-basin scale information such as potential risks of TC landfall is anticipated for decision *** fill this gap and make the TC science and services move forward,this paper reviews recent research and development in seasonal tropical cyclone(TC)*** particular,this paper features new research topics on seasonal TC predictability in neutral conditions of El Ni˜no–Southern Oscillation(ENSO),emerging forecasting techniques of seasonal TC activity including Machine Learning/Artificial Intelligence,and multi-annual TC *** also review the skill of forecast systems at predicting landfalling statistics for certain regions of the North Atlantic,Western North Pacific and South Indian oceans and discuss the gap that remains between current products and potential user's *** knowledge and advanced forecasting techniques are expected to further enhance the capability of seasonal TC forecasting and lead to more actionable and fit-for-purpose products.

关键词： Tropical cyclones Seasonal forecasting Climate services

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Perception: 4th ed.

2002年

作者： Sekuler robert.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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温哥华公寓

城市环境设计 2019年第2期118卷 210-219页

作者： Carl McDonald Melissa Bauld Aaron Mark Alan Tansey Alex Wu Alexandra Gustafsson Alina Tamosiunaite Amina Blacksher Aran Coakley Arash Adel Ahmadian Armen Menendian Barbora Srpkova Ben Zunkeler Benjamin Caldwell Benjamin Novacinski Bennett Gale Birk Daugaard blake Theodore Smith Brian Foster Brian Rome Carolien Schippers Christopher James Malcolm Jr. Christopher Junkin Christopher Tron David Brown David Dottelonde Deborah Campbell Doug Stechschulte Douglass Alligood Edward Yung Elena Bresciani Filip Milovanovic Francesca Portesine Gabriel Hernandez Solano Gabriel Jewell-Vitale Hector Garcia Ivy Hume Jan Leenknegt Janice Rim John Kim Josiah Poland Julian Liang Julianne Gola Julie Kaufman Karol Bogdan Borkowski Kurt Nieminen Lauren Turner Lorenz Krisai Lucio Santos Marcella Martinez Martin Voelkle Matthew Dlugosz Megan Ng Michael robert Taylor Otilia Pupezeanu Paula Domka Phillip MacDougall Ryan Yang Sean Franklin Sebastian Grogaard Simon Scheller Spencer Hayden Taylor Fulton Terrence Chew Terry Lallak Thomas Smith Tianqi Zhang Tobias Hjortdal Tran Le Valentina Mele Xinyu Wang Yaziel Juarbe Yoanna Shivarova Zach Walters Zhifei Xu Andrew Latreille Glotman Simpson Urban YVR 运小红

温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的"温哥华主义"建筑的全新解读,配合一座纤细的塔楼,试图保留城... 详细信息

温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的"温哥华主义"建筑的全新解读,配合一座纤细的塔楼,试图保留城市视觉通廊并激活步行通道。住宅塔楼借助高度和毗邻河流的地理位置,是唯一可以同时享受水景和山景的建筑,坐拥温哥华广袤的自然风光。

关键词：温哥华平面图 Dialog 立面图

Search for the doubly heavy baryons Ωbc0 and Ξbc0 decaying to Λc+π- and Ξc+π-

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Chinese Physics C 2021年第9期45卷 14-25页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.Bj?rn M.P.Blago T.blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovská M.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo J.Dalseno C.D'Amb University of Edinburgh Horia Hulubei National Institute of Physics and Nuclear Engineering INFN Sezione di Bari Università di Bari Los Alamos National Laboratory (LANL) Van Swinderen Institute University of Groningen Universiteit Maastricht AGH-University of Science and Technology Faculty of Physics and Applied Computer Science Université Clermont Auvergne Università di Cagliari Institute for Nuclear Research of the National Academy of Sciences (KINR) School of Physics University College Dublin NSC Kharkiv Institute of Physics and Technology (NSC KIPT) INFN Sezione di Perugia STFC Rutherford Appleton Laboratory School of Physics and Astronomy Monash University Novosibirsk State University CNRS/IN2P3 Department of Physics and Astronomy Uppsala University Università di Genova School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University National Center for Nuclear Research (NCBJ) Università di Roma Tor Vergata Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio) Universidade Federal do Triangulo Mineiro (UFTM) Institute of Particle Physics LPC Central China Normal University Hangzhou Institute for Advanced Study UCAS Instituto de Fisica Corpuscular Centro Mixto Universidad de Valencia-CSIC Nikhef National Institute for Subatomic Physics and VU University Amsterdam National Research Tomsk Polytechnic University AGH-University of Science and Technology Faculty of Computer Science Electronics and Telecommunications University of Michigan Università di Siena Università di Padova Scuola Normale Superiore National Research Centre Kurchatov Institute Università degli Studi di Milano MSU-Iligan Institute of Technology (MSU-IIT) Università di Firenze INFN Sezione di Roma La Sapienza Institut für Physik Universit?t Rostock INFN Sezione di Milano Departamento de Fisica Universidad Nacional de Colombia Universit?t Bonn-Helmholtz-Institut für Strahlen und Kernphysik Hanoi University of Science Università di Pisa P.N. Lebedev Physical Institute Russian Academy of Science (LPI RAS) Università

The first search for the doubly heavy Ωbc0baryon and a search for the Ξbc0baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 *** baryons are reconstructed via their decays to ∧c+π-andΞc+π-.No significant excess is found for invariant masses between 6700 and 7300 MeV/c2,in a rapidity range from2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ωbc0andΞbc0production cross-section times the branching fraction to ∧c+π-（Ξc+π-） relative to that of the ∧b0（Ξb0） baryon,for different lifetime hypotheses,at 95% confidence *** upper limits range from 0.5×10-4to 2.5×10-4for theΩbc0→∧c+π-(Ξbc0→∧c+π-) decay,and from 1.4×10-3to 6.9×10-3for the Ωbc0→Ξc+π-(Ξbc0→Ξc+π-) decay,depending on the considered mass and lifetime of the Ωbc0(Ξbc0) baryon.

关键词： B physics quarkonium spectroscopy heavy quark production