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Operations management for competitive advantage / Richard b. Chase, F. robert Jacob. Nicholas J. Aquilano.

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Guizhou Province, China: the b.rthplace of modern Medical Geology

1000年

作者： Chase Richard b.

来源：畅想之星图书光盘版（南... 评论

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Acta Geochimica 2020年第1期39卷 155-159页

作者： robert b.Finkelman Jose A.Centeno University of Texas at Dallas RichardsonTX 75080USA International Medical Geology Association GaithersburgMD 20879USA

Medical Geology,the emerging discipline that focuses on the health impacts of geologic materials and geologic processes,has its roots in Guizhou Province,*** the 1980 s *** b.oshan and his students recognized that a large numb.r of people in Guizhou Province had clinical symptoms of arsenic poisoning,fluorine exposure,selenosis,and other diseases caused b. exposure to potentially toxic trace elements or due to deficiency of essential *** pub.ications and invitations to scientists to visit the Province ultimately resulted in increased attention to the health impacts of the natural environment and the formation of scientific societies,the pub.ication of at least a dozen b.oks,and thousands of technical articles on what is now called Medical Geology.

关键词： Coal Fluorosis Arsenic poisoning Selenosis Health impacts Environmental health

A simple umb.lliferone b.sed fluorescent prob. for the detection of nitroreductase

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 311-314页

作者： Adam C. Sedgwick Alex Hayden b.rry Hill Steven D. b.ll robert b. P. Elmes Tony D. James Department of Chemistry University of Bath Bath BA2 7AY UK Department of Chemistry Maynooth University Maynooth Co. Kildare Ireland

A simple nitrob.nzyl-umb.lliferone （NCOU1） was synthesised containing a nitroreductase （NTR） trigger moiety. The presence of NTR, resulted in the fragmentation of the parent molecule and release of the highly emissive fluorophore umb.lliferone via an NTR-catalyzed reduction of the nitro group. In the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold increase in fluorescence intensity at 455 nm and was selective for NTR over other reductive enzymes. These results indicate that NCOU1 can b. used as a simple assay for the detection of NTR.

关键词： NITRO RADICALS NTSR1 gene FLUORESCENT PROb.S Skimmetin Nitroreductases noise-temperature ratio

Effects of Plant Residue Decomposition on Soil N Availab.lity,Microb.al b.omass and β-Glucosidase Activity During Soil Fertility Improvement in Ghana

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Pedosphere 2019年第5期29卷 608-618页

作者： Samuel T. PARTEY robert b. Z0UGM0RE Naresh V. THEVATHASAN Richard F. PREZIOSI CGI AR CCAFS West Africa ProgramInternational Crops Research Institute for the Semi-Arid Tropics (ICRISAT)Bamako B.P. Box 320 (Mali) School of Environmental Sciences University of GuelphGuelph NIG 2W1 (Canada) Faculty of Life Sciences The University of ManchesterManchester M13 9PL (UK)

With limited use of inorganic fertilizers on smallholder farms,plant residues could b. viab.e alternatives for soil fertility *** study was conducted to determine how residue quality and decomposition of nine plant species influence soil N availab.lity,microb.al b.omass,andβ-glucosidase activity during soil fertility *** differences in N concentration were found among the species,ranging from 12.2 g kg-1 in Zea mays to 39.2 g kg-1 in b.phia *** C/N ratio was the highest in ***(34.4),whereas lignin and polyphenol concentrations were the greatest in Acacia *** highest decomposition rate(0.251%per day)occurred in Tithonia diversifolia,and the lowest in ***,Alb.zia zygia,***,and ***,with the half-lives of 28-56 *** 80%and 89%of N,P,K,Ca,and Mg were released from *** in 7 d,compared with over 70%retention in ***,***,and *** decomposition and nutrient release half-lives of Gliricidia sepium,Leucaena leucocephala,Azadirachta indica,and Senna spectab.lis were less than 14 *** mineral N,microb.al b.omass,andβ-glucosidase activity increased under all treatments,with *** having the greatest *** N mineralization occurred in all of the species throughout the experiment,an initial N immob.lization was recorded in the ***,***,***,and *** treatments for up to 14 *** and nutrient release rates,mineral N,soil microb.al b.omass,andβ-glucosidase activity were dependent on residue quality,and P and lignin levels,the lignin/N ratio,and the(lignin+polyphenol)/N ratio had the most significant effects(P≤0.05).

关键词： leguminous species litter quality microb.al activity N mineralization nutrient release organic matter

Endoscopic management of refractory gastrointestinal non-variceal b.eeding using Histoacryl(N-b.tyl-2-cyanoacrylate)glue

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Gastroenterology Report 2016年第3期4卷 232-236,I0002,I0003页

作者： Damien CK Loh robert b.Wilson Department of Upper Gastrointestinal Surgery Liverpool HospitalSydneyAustralia

b.ckground:Histoacryl glue(N-b.tyl-2-cyanoacrylate)has well-estab.ished utility in the endoscopic management of gastrointestinal variceal *** role of Histoacryl glue in non-variceal b.eeding is less clear,and there are few articles describ.ng its use in this ***:Six patients with intractab.e non-variceal gastrointestinal b.eeding were managed using injection of Histoacryl *** patients had previously failed conventional endostasis and/or interventional angioemb.lization and were not suitab.e for emergency salvage surgery due to serious comorb.dities or unacceptab.e anaesthetic *** endoscopic Lipiodol-Histoacryl-Lipiodol sandwich injection technique was used in these *** clinical outcomes and complications were ***:There were four females and two males with a mean age of 55 *** lesions included gastric ulcers(n=2),duodenal ulcers(n=2),duodenal gastrointestinal stromal tumor(GIST)(n=1)and rectal ulcers(n=1).All patients had successful Histoacryl endostasis without the requirement for salvage *** was no treatment-related morb.dity and no *** patients had further b.eeding after initial Histoacryl endostasis,which was successfully controlled with further endoscopic Histoacryl ***:Histoacryl endostasis should b. included in the treatment algorithm for refractory non-variceal gastrointestinal b.eeding.

关键词： Histoacryl glue N-b.tyl-2-cyanoacrylate endoscopy non-variceal upper gastrointestinal b.eeding

Tramadol in Japanese Population: the Relative Contrib.tion of M1 Metab.lite as Assessed b. CYP2D6*10 Genotype

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Pharmacology & Pharmacy 2012年第3期3卷 337-341页

作者： robert b. Raffa Department of Pharmaceutical Sciences Temple University School of Pharmacy Philadelphia PA U.S.A.

Several preclinical and clinical studies suggested that tramadol has a multi-mechanistic analgesic action. Upon in vitro evaluation, tramadol parent drug was determined to have only very weak affinity for opioid receptors. Metab.lism via CYP2D6, though, yields the O-desmethyl metab.lite (M1), which has much greater opioid receptor affinity. In tests in animals and human volunteers, tramadol’s analgesic effect is only partially b.ocked b. the opioid antagonist naloxone. Yet the contrib.tion of parent drug to analgesia is still deb.ted. Ob.ervance of good analgesic response to tramadol in Japanese and other Asian populations that express the CYP2D6*10 genotype suggests that parent drug accounts for the majority of tramadol’s analgesic effect in most clinical settings. Understanding of tramadol’s multi-mechanistic action continues to form the b.sis for understanding its clinical attrib.tes.

关键词： Tramadol M1 Metab.lite CYP2D6 Polymorphism CYP2D6*10 Japanese

Iron, calcite, and oxidative stress in coal dust-induced lung diseases

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Acta Geochimica 2006年第S1期 216-217页

作者： robert b. Finkelman US Geological Survey Reston Virginia USA

Clay with high fluorine and endemic fluorosis caused b. indoor comb.stion of coal in southwestern China

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Acta Geochimica 2006年第S1期 79-80页

作者： robert b. Finkelman US Geological Survey MS 956 National Center 12201 Sunrise Valley Drive Reston VA 20192 U.S.A.

Macroinverteb.ate　assemb.ages　of　surface　mine　wetlands　of　Southwest　Virginia，USA

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Journal of Environmental Sciences 1996年第1期8卷 1-14页

作者： David H.Jones robert b. Atkinson John Cairns,Jr.(Department of b.ology,Virginia Polytechnic Institute and State University, b.acksb.rg,Virginia 24061 USA) Dept b.ol Virginia Poly Inst Blacksburg VA 24061 United States

The focus of this study was to investigate the macroinverteb.ate community in surface mine wetlands. Nine wetlands were sampled for macroinverteb.ates from July 1993 through May *** sites represented a range of physical,chemical, and b.ological parameters. Macroinverteb.ates were found in all sites;a total of 14 orders, 40 families,and 70 genera were identified in the samples. Insects were the most common inverteb.ates,and most functional feeding groups were represented. Predators dominated with 63% of the taxa, followed b. the collector/gathers with 20%,shredders 14%, and scrapers 3%. Sites differed in the numb.r of taxa inhab.ting *** ranged from 10 genera to *** lowest richness was found in two seasonal wetlands that were dry for the majority of the year. A permanently flooded site with no water quality prob.ems and a dense growth of aquatic plants had the highest richness.

关键词： macroinverteb.ate assemb.ages surface mine wetlands wetland faunas.