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Nucleotide Contribution to the Functioning of SERT, Na/K ATPase and GPCR Proteins

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Journal of Biosciences and Medicines 2024年第5期12卷 61-76页

作者： w.nford robert w.lliams Faculty of Life Sciences & Education University of South Wales Cardiff UK

Purine nucleotides are crucial for the effective operation of cell membrane proteins maintaining the neurotransmitter responses of 5-HT. Major protein targets in the treatment of depression include SERT, N/K ATPase and GPCR. Each protein target is responsive to a specific complement of drugs: antidepressants (SERT), lithium and cardiogenic steroids (N/K ATPase), 5-HT receptor ligands (GPCR). Computational softw.re is useful for comparing molecular similarity w.thin ligand-ligand and ligand-nucleotide structures. Previous studies demonstrate that GPCR ligands of different pharmacologic classes display relative molecular similarity to nucleotide structures. The current study applies this methodology to compound structures modulating SERT and N/K ATPase receptors. Minimum energy conformers of SERT antagonists demonstrate relative molecular similarity to the structural template of GTP nucleotide. GTP template fits of 5-HT and psilocin are similar, w.ereas a SERT-like fit is one of several for the ketamine structure. Endogenous and pharmaceutical modulators of Na/K ATPase relate to adenine nucleotide. The fits of cardiogenic steroids to a cGMP template demonstrate similarities and differences betw.en compounds. Relative molecular similarity w.thin the structures of hormones, drugs and nucleotides has implications for neurotransmitter transport and cell signal transduction processes.

关键词： SERT SSRI GPCR Sodium/Potassium ATPase Nucleotides Depression

DeepRice: A deep learning and deep feature based classification of Rice leaf disease subtypes

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Artificial Intelligence in Agriculture 2024年第1期11卷 34-49页

作者： P.Isaac Ritharson Kumudha Raimond X.Anitha Mary Jennifer Eunice robert Andrew.J Department of CSE Karunya Institute of Technology and Sciences CoimbatoreTamilnaduIndia Department of Robotics Engineering Karunya Institute of Technology and SciencesCoimbatoreIndia Department of Mechatronics Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India Department of Computer Science and Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India

Rice stands as a crucial staple food globally,w.th its enduring sustainability hinging on the prompt detection of rice leaf ***,efficiently detecting diseases w.en they have already occurred holds paramount importance for solving the cost of manual visual identification and chemical *** the recent past,the identification of leaf pathologies in crops predominantly relies on manual methods using specialized equipment,w.ich proves to be time-consuming and *** study offers a remedy by harnessing Deep Learning(DL)and transfer learning techniques to accurately identify and classify rice leaf diseases.A comprehensive dataset comprising 5932 self-generated images of rice leaves w.s assembled along w.th the benchmark datasets,categorized into 9 classes irrespective of the extent of disease spread across the *** classes encompass diverse states including healthy leaves,mild and severe blight,mild and severe tungro,mild and severe blast,as w.ll as mild and severe brow. *** meticulous manual labelling and dataset segmentation,w.ich w.s validated by horticulture experts,data augmentation strategies w.re implemented to amplify the number of *** datasets w.re subjected to evaluation using the proposed tailored Convolutional Neural Netw.rks *** performance are scrutinized in conjunction w.th alternative transfer learning approaches like VGG16,Xception,ResNet50,DenseNet121,Inception ResnetV2,and Inception *** effectiveness of the proposed custom VGG16 model w.s gauged by its capacity to generalize to unseen images,yielding an exceptional accuracy of 99.94%,surpassing the benchmarks set by existing state-of-the-art ***,the layer w.se feature extraction is also visualized as the interpretable AI.

关键词： Rice leaf disease Deep learning CNN Crop yield Agriculture Food security

Deciding on life-saving treatment after a violent suicide attempt:an ethical case report

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General Psychiatry 2024年第2期37卷 289-291页

作者： robert w.chers Hanna M Heller Sisco van Veen Department of Child and Adolescent Psychiatry&Psychosocial Care Amsterdam University Medical CenterLocation AMCAmsterdamThe Netherlands Amsterdam Public Health Mental Health programAmsterdamThe Netherlands Department of Hospital Psychiatry Amsterdam University Medical CenterLocation VUmcAmsterdamThe Netherlands Research Department 113 Suicide PreventionAmsterdamThe Netherlands Department of Psychiatry&Department of Ethics Law and HumanitiesAmsterdam University Medical CenterAmsterdamThe Netherlands GGZ inGeest Mental Health Care AmsterdamThe Netherlands

To the editor:In the USA alone,there w.re 1.7 million suicide attempts in 2021.1 Although the majority of suicide attempts are not fatal,immediate medical attention is often necessary,especially w.en violent methods are used.2 These methods include jumping from heights,using a firearm,crashing a motor vehicle,and lying dow. or jumping in front of a moving object.

关键词： treatment editor alone

Data-driven analysis of chemicals,proteins and pathw.ys associated w.th peanut allergy:from molecular netw.rking to biological interpretation

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Food Science and Human w.llness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer robert Preissner Margitta w.rm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“Der Simulierte Mensch”a science framew.rk of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow.s milk,hen's eggs,soy,w.eat,peanuts,tree nuts(w.lnuts,hazelnuts,almonds,cashew.,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,w. provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(w.lnuts,almonds,cashew.,pecans and pistachios)and ***,w. have analysed the chemical compositions of peanuts in different processed form raw.boiled and *** the data-driven approach w. are able to generate new.hypotheses to explain w.y nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction w.th dietary lipids may have significant effect on allergic *** results obtained from this study w.ll direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Know.edge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

Reproductive Behavior and Underw.ter Calls in the Emei Mustache Toad,Leptobrachium boringii

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Asian Herpetological Research 2011年第4期2卷 199-215页

作者： Yuchi ZHENG Dingqi RAO robert w.murphy Xiaomao ZENG Department of Herpetology Chengdu Institute of BiologyChinese Academy of Sciences Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Centre for Biodiversity and Conservation Biology Royal Ontario Museum100 Queen’s ParkToronto M5S 2C6OntarioCanada

The Emei mustache toad, Leptobrachium boringii （Megophryidae）, is terrestrial but breeds in permanent streams. Primarily, it has a polygynous mating system and polyandry also occurs. The species vigorously defends submerged nest sites. w. report on a reproductive study at Mt. Emei, w.stern China conducted in 2004, 2006, 2007, 2009, and 2011 during the breeding season. Males produce both advertisement and courtship calls underw.ter, and the latter differs from the former in having an additional trill-like last note of low.intensity. Females might determine the oviposition location and hence the egg mass location. A low. submissive posture can be adopted by the male to avoid being attacked by other males. w.en fighting, the maxillary nuptial spines are employed as w.apons, and males hold their opponents on their spines w.th the forelimbs that enlarge during the breeding season. Male body size and the quantity of fight w.unds on its ventral side are positively correlated. Satellite male mating might exist in L. boringii. Additionally, underw.ter calls from another population of this species and a population of L. leishanense generally are similar to those of the population from Mt. Emei.

关键词： advertisement call courtship call underw.ter call male combat male w.aponry nest inspection satellite male reproductive tactic

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael w.odard Juhoon Lee Sow.ya Ramesh Aaron w.James David Hudson Kevin N.Dalby Lin Xu robert J.Tow.r Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

w.ile hypoxic signaling has been show. to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and dow.stream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition w.ere abnormal bone formation occurs w.thin extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been show. to promote ***,the underlying molecular mechanisms byw.ich the HIF-1αpathw.y in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,w. used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,w. found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathw.y for collagen cross-linking as dow.stream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A new.y screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathw.y represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

Angular unconformity in Pennsylvanian strata from 3-D seismic interpretation,Goldsmith Field,w.st Texas

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Energy Geoscience 2024年第2期5卷 298-303页

作者： Edw.n I.Egbobaw.ye Nelly Omoruyi Abdulmutallib Aminu robert Trentham Mohamed K.Zobaa Sumit Verma Kinder Morgan MidlandTX79705USA Department of Geosciences University of Texas Permian BasinOdessaTX79762USA

The Pennsylvanian unconformity,w.ich is a detrital surface,separates the beds of the Permian-aged strata from the Low.r Paleozoic in the Central Basin *** data interpretation indicates that the unconformity is an angular unconformity,overlying multiple normal faults,and accompanied w.th a thrust fault w.ich maximizes the region's structural ***,the Pennsylvanian angular unconformity creates pinch-outs betw.en the beds above and *** computed the spectral decomposition and reflector convergence attributes and analyzed them to characterize the angular unconformity and *** spectral decomposition attribute divides the broadband seismic data into different spectral bands to resolve thin beds and show.thickness *** contrast,the reflector convergence attribute highlights the location and direction of the pinch-outs as they dip south at angles betw.en 2° and 6°.After review.ng findings from RGB blending of the spectrally decomposed frequencies along the Pennsylvanian unconformity,w. observed channel-like features and multiple linear bands in addition to the faults and *** can be inferred that the identified linear bands could be the result of different lithologies associated w.th the tilting of the beds,and the faults may possibly influence hydrocarbon migration or act as a flow.barrier to entrap hydrocarbon *** identification of this angular unconformity and the associated features in the study area are vital for the follow.ng reasons:1)the unconformity surface represents a natural stratigraphic boundary;2)the stratigraphic pinch-outs act as fluid flow.connectivity boundaries;3)the areal extent of compartmentalized reservoirs'boundaries created by the angular unconformity are better defined;and 4)fault displacements are better understood w.en planning w.ll locations as faults can be flow.barriers,or permeability conduits,depending on facies heterogeneity and/or seal effectiveness of a fault,w.ich

关键词： Pennsylvanian unconformity Seismic data interpretation Spectral decomposition Reflector convergence Reservoir characterization

Deterministic epidemic models overestimate the basic reproduction number of observed outbreaks

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Infectious Disease Modelling 2024年第3期9卷 680-688页

作者： w.jid Ali Christopher E.Overton robert R.w.lkinson Kieran J.Sharkey Department of Mathematical Sciences University of LiverpoolPeach StreetLiverpoolL697ZXEnglandUnited Kingdom Department of Applied Mathematics Liverpool John Moores UniversityByrom StreetLiverpoolL35UXEnglandUnited Kingdom

The basic reproduction number,R_(0),is a w.ll-know. quantifier of epidemic ***,a class of existing methods for estimating R_(0)from incidence data early in the epidemic can lead to an over-estimation of this *** particular,w.en fitting deterministic models to estimate the rate of spread,w. do not account for the stochastic nature of epidemics and that,given the same system,some outbreaks may lead to epidemics and some may ***,an observed epidemic that w. w.sh to control is a major *** amounts to implicit selection for major outbreaks w.ich leads to the over-estimation *** formally characterised the split betw.en major and minor outbreaks by using Otsu's method w.ich provides us w.th a w.rking *** show.that by conditioning a‘deterministic’model on major outbreaks,w. can more reliably estimate the basic reproduction number from an observed epidemic trajectory.

关键词： Estimating R_(0) Simple birth-death process Major outbreak Conditioned epidemic Stochastic fade-out

Framew.rk to Model User Request Access Patterns in the w.rld w.de w.b

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Journal of Softw.re Engineering and Applications 2024年第2期17卷 69-88页

作者： Richard Hurley robert Sturgeon Department of Computer Science Trent University Peterborough ON Canada

In this paper, w. present a novel approach to model user request patterns in the w.rld w.de w.b. Instead of focusing on the user traffic for w.b pages, w. capture the user interaction at the object level of the w.b pages. Our framew.rk model consists of three sub-models: one for user file access, one for w.b pages, and one for storage servers. w.b pages are assumed to consist of different types and sizes of objects, w.ich are characterized using several categories: articles, media, and mosaics. The model is implemented w.th a discrete event simulation and then used to investigate the performance of our system over a variety of parameters in our model. Our performance measure of choice is mean response time and by varying the composition of w.b pages through our categories, w. find that our framew.rk model is able to capture a w.de range of conditions that serve as a basis for generating a variety of user request patterns. In addition, w. are able to establish a set of parameters that can be used as base cases. One of the goals of this research is for the framew.rk model to be general enough that the parameters can be varied such that it can serve as input for investigating other distributed applications that require the generation of user request access patterns.

关键词： Performance Modelling w.rld w.de w.b Simulation User Request Access Patterns Framew.rk