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A Wavelet Neural Network Based Non-linear Model Predictive Controller for a Multi-variable Coupled Tank System

International Journal of Automation and computing 2015年第2期12卷 156-170页

作者： Kayode Owa Sanjay Sharma robert sutton School of Marine Science and Engineering University of Plymouth Marine and Industrial Dynamic Analysis (MIDAS) Research Group University of Plymouth

In this paper, a novel real time non-linear model predictive controller(NMPC) for a multi-variable coupled tank system(CTS) is designed. CTSs are highly non-linear and can be found in many industrial process applications. The involvement of multi-input multi-output(MIMO) system makes the design of an effective controller a challenging task. MIMO systems have inherent couplings,interactions in-between the process input-output variables and generally have an complex internal structure. The aim of this paper is to design, simulate, and implement a novel real time constrained NMPC for a multi-variable CTS with the aid of intelligent system techniques. There are two major formidable challenges hindering the success of the implementation of a NMPC strategy in the MIMO case. The first is the difficulty of obtaining a good non-linear model by training a non-convex complex network to avoid being trapped in a local minimum solution. The second is the online real time optimisation(RTO) of the manipulated variable at every sampling time.A novel wavelet neural network(WNN) with high predicting precision and time-frequency localisation characteristic was selected for an MIMO model and a fast stochastic wavelet gradient algorithm was used for initial training of the network. Furthermore, a genetic algorithm was used to obtain the optimised parameters of the WNN as well as the RTO during the NMPC strategy. The proposed strategy performed well in both simulation and real time on an MIMO CTS. The results indicated that WNN provided better trajectory regulation with less mean-squared-error and average control energy compared to an artificial neural network. It is also shown that the WNN is more robust during abnormal operating conditions.

关键词： Wavelet neural network(WNN) non-linear model predictive control(NMPC) real time practical implementation multi-input multi-outpu

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Precision medicine for acute pancreatitis:current status and future opportunities

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Precision Clinical Medicine 2019年第2期2卷 81-86页

作者： Rajarshi Mukherjee Quentin Nunes Wei Huang robert sutton Liverpool Pancreatitis Research Group Royal Liverpool University Hospital and Institute of Translational MedicineUniversity of LiverpoolLiverpool L693GEUK

Acute pancreatitis is a common inflammatory condition affecting the pancreas,predominantly caused by gallstones,alcohol excess,and hypertriglyceridaemia,with severe disease carrying up to 50%*** significant research and preclinical promise,no targeted drug treatments exist for the disease and precision medicine approaches are lacking significantly,when compared to other health *** in omics applications will facilitate improved preclinical models and target identification as well as biomarker discovery for refined trial design,focusing on risk stratification,subject selection,and outcome *** treatment of Acute Pancreatitis with Infliximab:Double-blind,placebo-controlled,multi-centre trial(RAPID-I)is a pioneering trial,currently under way in acute pancreatitis,which may serve as an innovative model for the implementation of precision medicine strategies for acute pancreatitis in the future.

关键词： precision medicine acute pancreatitis animal models clinical trials

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Validation of the moderate severity category of acute pancreatitis defined by determinant-based classification

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Hepatobiliary & Pancreatic Diseases International 2014年第3期13卷 323-327页

作者： Tao Jin Wei Huang Xiao-Nan Yang Ping Xue Muhammad A Javed Kiran Altaf robert sutton Qing Xia Department of Integrated Traditional Chinese and Western Medicine Sichuan Provincial Pancreatitis Center West China Hospital Sichuan University NIHR Liverpool Pancreas Biomedical Research Unit Royal Liverpool and Broadgreen University Hospitals Trust and University of Liverpool

BACKGROUND: Recent international multidisciplinary consultation proposed the use of local (sterile or infected pancreatic necrosis) and/or systemic determinants (organ failure) in the stratification of acute pancreatitis. The present study was to validate the moderate severity category by international multidisciplinary consultation definitions. METHODS: Ninety-two consecutive patients with severe acute pancreatitis (according to the 1992 Atlanta classification) were classified into (i) moderate acute pancreatitis group with the presence of sterile (peri-) pancreatic necrosis and/or transient organ failure; and (ii) severe/critical acute pancreatitis group with the presence of sterile or infected pancreatic necrosis and/ or persistent organ failure. Demographic and clinical outcomes were compared between the two groups. RESULTS: Compared with the severe/critical group (n=59), the moderate group (n=33) had lower clinical and computerized tomographic scores (both P<0.05). They also had a lower incidence of pancreatic necrosis (45.5% vs 71.2%, P=0.015), infection (9.1% vs 37.3%, P=0.004), ICU admission (0% vs 27.1%, P=0.001), and shorter hospital stay (15 +/- 5 vs 27 +/- 12 days; P<0.001). A subgroup analysis showed that the moderate group also had significantly lower ICU admission rates, shorter hospital stay and lower rate of infection compared with the severe group (n=51). No patients died in the moderate group but 7 patients died in the severe/critical group (4 for severe group). CONCLUSIONS: Our data suggest that the definition of moderate acute pancreatitis, as suggested by the international multidisciplinary consultation as sterile (pen-) pancreatic necrosis and/or transient organ failure, is an accurate category of acute pancreatitis.

关键词： acute pancreatitis pancreatic necrosis organ failure determinant-based classification

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Adjuvant therapy in pancreatic cancer

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World Journal of Gastroenterology 2001年第4期7卷 482-489页

作者： Paula Ghaneh John Slavin robert sutton Mark Hartley John P Neoptolemos Department of Surgery.University of Liverpool 5~(th)Floor UCD Building.Daulby StreetLiverpool.L69 3GA.UK

The outlook for patients with pancreatic cancer has been grim. There have been major advances in the surgical treatment of pancreatic cancer, leading to a dramatic reduction in post-operative mortality from the development of high volume specialized centres. This stimulated the study of adjuvant and neoadjuvant treatments in pancreatic cancer including chemoradiotherapy and chemotherapy. Initial protocols have been based on the original but rather small GITSG study first reported in 1985. There have been two large European trials totalling over 600 patients (EORTC and ESPAC-1) that do not support the use of chemoradiation as adjuvant therapy. A second major finding from the ESPAC-1 trial (541 patients randomized) was some but not conclusive evidence for a survival benefit associated with chemotherapy. A third major finding from the ESPAC-1 trial was that the quality of life was not affected by the use of adjuvant treatments compared to surgery alone. The ESPAC-3 trial aims to assess the definitive use of adjuvant chemotherapy in a randomized controlled trial of 990 patients.

关键词： Pancreatic Neoplasms Antineoplastic Agents Combined Modality Therapy Humans Research Support, Non-U.S. Gov't

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Prophylactic intra-peritoneal drain placement following pancreaticoduodenectomy:A systematic review and metaanalysis

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World Journal of Gastroenterology 2015年第8期21卷 2510-2521页

作者： Yi-Chao Wang Peter Szatmary Jing-Qiang Zhu Jun-Jie Xiong Wei Huang Ilias Gomatos Quentin M Nunes robert sutton Xu-Bao Liu Department of Thyroid and Breast Surgery West China Hospital Sichuan University NIHR Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital University of Liverpool Department of Pancreatic Surgery West China Hospital Sichuan University

AIM:To conduct a meta-analysis comparing outcomes after pancreaticoduodenectomy(PD)with or without prophylactic ***:Relevant comparative randomized and nonrandomized studies were systemically searched based on specific inclusion and exclusion *** outcomes were compared between patients with and those without routine *** odds ratios(OR)with 95%CI were calculated using either fixed effects or random effects ***:One randomized controlled trial and four non-randomized comparative studies recruiting 1728patients were *** without prophylactic drainage after PD had significantly higher mortality(OR=2.32,95%CI:1.11-4.85;P=0.02),despite the fact that they were associated with fewer overall complications(OR=0.62,95%CI:0.48-0.82;P=0.00),major complications(OR=0.75,95%CI:0.60-0.93;P=0.01)and readmissions(OR=0.77,95%CI:0.60-0.98;P=0.04).There were no significant differences in the rates of pancreatic fistula,intraabdominal abscesses,postpancreatectomy hemorrhage,biliary fistula,delayed gastric emptying,reoperation or radiologic-guided drains between the two ***:Indiscriminate abandonment of intraabdominal drainage following PD is associated with greater mortality,but lower complication *** randomized trials should compare routine vs selective drainage.

关键词： Pancreaticoduodenectomy Drain Metaanalysis Morbidi

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Roux-en-Y versus BillrothⅠreconstruction after distal gastrectomy for gastric cancer:A meta-analysis

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World Journal of Gastroenterology 2013年第7期19卷 1124-1134页

作者： Jun-Jie Xiong Kiran Altaf Muhammad A Javed Quentin M Nunes Wei Huang Gang Mai Chun-Lu Tan Rajarshi Mukherjee robert sutton Wei-Ming Hu Xu-Bao Liu Department of Hepato-Biliary-Pancreatic Surgery West China HospitalSichuan University NIHR Liverpool Pancreas Biomedical Research Unit Royal Liverpool University HospitalUniversity of LiverpoolLiverpool L69 3GAMerseyside CountyUnited Kingdom

AIM: To conduct a meta-analysis to compare Roux-en-Y (R-Y) gastrojejunostomy with gastroduodenal Billroth?I?(B-I) anastomosis after distal gastrectomy (DG) for gastric cancer.METHODS: A literature search was performed to identify studies comparing R-Y with B-I?after DG for gastric cancer from January 1990 to November 2012 in Medline, Embase, Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in The Cochrane Library. Pooled odds ratios (OR) or weighted mean differences (WMD) with 95%CI were calculated using either ?xed or random effects model. Operative outcomes such as operation time, intraoperative blood loss and postoperative outcomes such as anastomotic leakage and stricture, bile re?ux, remnant gastritis, re?ux esophagitis, dumping symptoms, delayed gastric emptying and hospital stay were the main outcomes assessed. Meta-analyses were performed using RevMan 5.0 software (Cochrane library).RESULTS: Four randomized controlled trials (RCTs) and 9 non-randomized observational clinical studies (OCS) involving 478 and 1402 patients respectively were included. Meta-analysis of RCTs revealed that R-Y reconstruction was associated with a reduced bile re?ux (OR 0.04, 95%CI: 0.01, 0.14; P < 0.00?001) and remnant gastritis (OR 0.43, 95%CI: 0.28, 0.66; P = 0.0001), however needing a longer operation time (WMD 40.02, 95%CI: 13.93, 66.11; P = 0.003). Meta-analysis of OCS also revealed R-Y reconstruction had a lower incidence of bile re?ux (OR 0.21, 95%CI: 0.08, 0.54; P = 0.001), remnant gastritis (OR 0.18, 95%CI: 0.11, 0.29; P < 0.00?001) and re?ux esophagitis (OR 0.48, 95%CI: 0.26, 0.89; P = 0.02). However, this reconstruction method was found to be associated with a longer operation time (WMD 31.30, 95%CI: 12.99, 49.60; P = 0.0008).CONCLUSION: This systematic review point towards some clinical advantages that are rendered by R-Y compared to B-I?reconstruction post DG. However there is a need for further adequately powered, well-desig

关键词： Gastric cancer Distal gastrectomy Roux-en-Y Billroth I Reconstruction Meta-analysis

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Management of necrotizing pancreatitis

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World Journal of Gastroenterology 2001年第4期7卷 476-481页

作者： John Slavin Paula Ghaneh robert sutton Mark Hartley Peter Rowlands Conall Garvey Mark Hughes John Neoptolemos Departments of Surgery Royal Liverpool University Hospital Departments of Radiology Royal Liverpool University Hospital

Infection complicating pancreatic necrosis leads to persisting sepsis, multiple organ dysfunction syndrome and accounts for about half the deaths that occur following acute pancreatitis. Severe cases due to gallstones require urgent endoscopic sphincterotomy. Patients with pancreatic necrosis should be followed with serial contrast enhanced computed tomography (CE-CT) and if infection is suspected fine needle aspiration of the necrotic area for bacteriology (FNAB) should be undertaken. Treatment of sterile necrosis should initially be non-operative. In the presence of infection necrosectomy is indicated. Although traditionally this has been by open surgery, minimally invasive procedures are a promising new alternative. There are many unresolved issues in the management of pancreatic necrosis. These include, the use of antibiotic prophylaxis, the precise indications for and frequency of repeat CE-CT and FNAB,and the role of enteral feeding.

关键词： Humans Pancreatitis, Acute Necrotizing Surgical Procedures, Minimally Invasive

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好老板要支持下属提高工作绩效

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双足与保健 2011年第2期20卷 29-31页

作者： robert sutton

忽视和践踏下属人格的老板有时也会很快获益，但从长远来看，这种短视行为通常会损害其部下的创造力、工作效率和献身精神。最好的老板非常重视提高自己员工的绩效，他们会采取一些策略，例如以下的三项策略：

关键词：工作绩效老板下属献身精神工作效率创造力

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好老板为什么得体谅员工

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当代经理人 2010年第11期 104-109页

作者： robert I.sutton 斯坦福大学

斯坦福大学的管理学教授Bob sutton为那些在组织中身居高位的领导人提供了一些直率的忠告。他建议,要懂得如何规划权力,因为你领导的那些人需要相信,你拥有的权力能被有效运用。还要使你的团队保持忠诚。

关键词：员工得体老板斯坦福大学有效运用领导人管理学权力

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Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第45期18卷 6657-6668页

作者： Jun-Jie Xiong Kiran Altaf Muhammad A Javed Wei Huang Rajarshi Mukherjee Gang Mai robert sutton Xu-Bao Liu Wei-Ming Hu Department of Hepato-Biliary-Pancreatic Surgery West China HospitalSichuan University Liverpool NIHR Pancreas Biomedical Research Unit Royal Liverpool University HospitalUniversity of LiverpoolLiverpool L69 3GAUnited Kingdom Pancreatic Diseases Research Group Department of Integrated Traditional and Western MedicineWest China HospitalSichuan University

AIM:To conduct a meta-analysis to determine the safety and efficacy of laparoscopic liver resection(LLR) and open liver resection(OLR) for hepatocellular carcinoma(HCC).METHODS:PubMed(Medline),EMBASE and Science Citation Index Expanded and Cochrane Central Register of Controlled Trials in the Cochrane Library were searched systematically to identify relevant comparative studies reporting outcomes for both LLR and OLR for HCC between January 1992 and February *** authors independently assessed the trials for inclusion and extracted the ***-analysis was performed using Review Manager Version 5.0 software(The Cochrane Collaboration,Oxford,United Kingdom).Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed effects(Mantel-Haenszel method) or random effects models(DerSimonian and Laird method).Evaluated endpoints were operative outcomes(operation time,intraoperative blood loss,blood transfusion requirement),postoperative outcomes(liver failure,cirrhotic decompensation/ascites,bile leakage,postoperative bleeding,pulmonary complications,intraabdominal abscess,mortality,hospital stay and oncologic outcomes(positive resection margins and tumor recurrence).RESULTS:Fifteen eligible non-randomized studies were identified,out of which,9 high-quality studies involving 550 patients were included,with 234 patients in the LLR group and 316 patients in the OLR *** was associated with significantly lower intraoperative blood loss,based on six studies with 333 patients [WMD:-129.48 mL;95%CI:-224.76-(-34.21) mL;P = 0.008].Seven studies involving 416 patients were included to assess blood transfusion requirement between the two *** LLR group had lower blood transfusion requirement(OR:0.49;95%CI:0.26-0.91;P = 0.02).While analyzing hospital stay,six studies with 333 patients were *** in the LLR group were found to have shorter hospital stay [WMD:-3.19 d;95%CI:-4.09-(-2.28) d;P < 0.00001] than their OLR

关键词： Hepatocellular carcinoma Laparoscopy Open liver resection Hepatectomy Meta-analysis

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