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Nanotechnology:fundamental research to product development

Engineering Sciences 2012年第5期10卷 42-44页

作者： Graham J Davie Zahra F Rad Carl Anthony Philip Prewett Jing Peng robert nordon The University of New South Wales Sydney NSW 2025 Australi The University of Birmingham Birmingham B15 2TT UK Harbin Institute of Technology Harbin 150001 China

The concept of an integrated "lab on a chip" has long been a goal for the micro-electro-mechanical-systems(MEMS) *** would entail the integration of not only the sampling and analysis of various functions,but also the ability to transmit this information off the chip to a central *** paper describes the initial steps in the fabrication of a "lab on a chip" which would continually analyze blood sampled via microneedles using techniques such as nano plasmonics,specifically,concentrations of *** analysis could then be transmitted off the chip using digital signal *** paper describes the analysis and optimization of the microneedle shape and size and the fabrication of the resulting needles in silicon using deep reactive ion etching(DRIE).The paper also describes the opportunities for fabrication of such needles in alternative materials and describes the issues that still have to be overcome before such an integrated device is realized.

关键词：纳米技术产品开发基础研究数字信号处理反应离子蚀刻微机电系统葡萄糖浓度 MEMS

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High-fidelity replication of thermoplastic microneedles with open microfluidic channels

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Microsystems & Nanoengineering 2017年第1期3卷 96-106页

作者： Zahra Faraji Rad robert E.nordon Carl J.Anthony Lynne Bilston Philip D.Prewett Ji-Youn Arns Christoph H.Arns Liangchi Zhang Graham J.Davies Graduate School of Biomedical Engineering University of New South WalesSydneyNSW 2052Australia School of Mechanical Engineering University of BirminghamBirmingham B152TTUK School of Mechanical and Manufacturing Engineering University of New South WalesSydneyNSW 2052Australia Prince of Wales Clinical School University of New South WalesSydneyNSW 2052Australia School of Petroleum Engineering University of New South WalesSydneyNSW 2052Australia

Development of microneedles for unskilled and painless collection of blood or drug delivery addresses the quality of healthcare through early intervention at *** with submicron to millimeter features have been fabricated from materials such as metals,silicon,and polymers by subtractive machining or ***,to date,large-scale manufacture of hollow microneedles has been limited by the cost and complexity of microfabrication *** paper reports a novel manufacturing method that may overcome the complexity of hollow microneedle *** microneedles with open microfluidic channels are fabricated by laser *** replicas are manufactured from these templates by soft-embossing with high fidelity at submicron *** manufacturing advantages are(a)direct printing from computeraided design(CAD)drawing without the constraints imposed by subtractive machining or etching processes,(b)high-fidelity replication of prototype geometries with multiple reuses of elastomeric molds,(c)shorter manufacturing time compared to three-dimensional stereolithography,and(d)integration of microneedles with open-channel *** work will address development of open-channel microfluidics for drug delivery,fluid sampling and analysis.

关键词： drug delivery laser lithography microneedles point-of-care diagnostics soft embossing

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