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Novel technique for anastomotic salvage using transanal minimally invasive surgery:A case report

World Journal of Gastrointestinal Surgery 2019年第5期11卷 271-278页

作者： Oscar A Olavarria robert l Kress Shinil K Shah Amit K Agarwal Center for Surgical Trials and Evidence-Based Practice McGovern Medical School at the University of Texas Health Science Center at HoustonHoustonTX 77033United States Department of Surgery McGovern Medical School at the University of Texas Health Science Center HoustonHoustonTX 77033United States

BACKGROUND Anastomotic leak(Al) after low anterior resection(lAR) can be a highly morbid *** incidence of Al ranges from 5% to 20% depending on patient characteristics and the distance of the anastomosis from the anal *** anastomoses and leaks pose technical challenges for endoscopic *** aim of this report was to describe the use of a commercially available laparoscopic energy device through a transanal minimally invasive surgery(TAMIS) port for the management of a symptomatic leak not requiring relaparotomy(grade B) after a lAR with diverting loop *** SUMMARY A TAMIS GelPOINT Path port was inserted into the anus to access the distal *** was achieved with AirSeal insufflation and a 30 degree laparoscope was introduced through a trocar.A ligaSure TM Retractable l-Hook device was then used to perform a septotomy of the chronic sinus tract identified posterior to the *** procedure was then repeated twice in three weeks intervals with ultimate resolution of the chronic leak *** months after serial TAMIS septotomies,barium enema demonstrated a patent anastomosis with no evidence of persistent leak or *** patient subsequently underwent ileostomy reversal and has had no significant postoperative *** TAMIS septotomy with the ligaSure TM Retractable l-Hook is a feasible andeffective,minimally invasive salvage technique for the treatment of grade B *** studies are needed to assess the generalizability and long-term results of this technique.

关键词： Transanal minimally invasive surgery ligasure hook Anastomotic leak low anterior resection Septotomy Case report

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SlC11A1 polymorphisms in inflammatory bowel disease and Mycobacterium avium subspecies paratuberculosis status

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World Journal of Gastroenterology 2010年第45期16卷 5727-5731页

作者： lucy C Stewart Andrew S Day John Pearson Murray l Barclay Richard B Gearry Rebecca l roberts robert W Bentley Department of Paediatrics University of OtagoChristchurch 8140New Zealand Department of Paediatrics Christchurch HospitalChristchurch 8140New Zealand Department of Pathology University of OtagoChristchurch 8140New Zealand Department of Medicine University of OtagoChristchurch 8140New Zealand Department of Gastroenterology Christchurch HospitalChristchurch 8140New Zealand Department of Biochemistry University of OtagoDunedin 9054New Zealand

AIM: To test for association of SlC11A1 with inflammatory bowel disease (IBD) and Mycobacterium avium subspecies paratuberculosis (MAP) status in a Caucasian cohort. METHODS: Five hundred and seven Crohn's disease (CD) patients, 474 ulcerative colitis (UC) patients, and 569 healthy controls were genotyped for SlC11A1 1730G>A and SlC11A1 469+14G>C using pre-designed TaqMan  SNP assays. χ 2 tests were applied to test for association of single nucleotide polymorphisms (SNPs) with disease, and the presence of MAP ***:SlC11A1 1730G>A and SlC11A 1469+14G>C were not associated with CD, UC, or IBD. The SlC11A1 1730A minor allele was over-represented in patients who did not require immunomodulator therapy (P = 0.002, OR: 0.29, 95% CI: 0.13-0.66). The frequency of the SlC11A1 469+14C allele was higher in the subset of study participants who tested positive for MAP DNA (P = 0.02, OR: 1.56, 95% CI: 1.06-2.29). No association of SlC11A1 1730G>A with MAP was ***: Although SlC11A1 was not associated with IBD, association with MAP suggests that SlC11A1 is important in determining susceptibility to bacteria implicated in the etiology of CD.

关键词： NRAMP1 Crohn’s disease Ulcerative colitis IS900 polymerase chain reaction

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Principal Eigenvalue for Cooperative (p,q)-biharmonic Systems

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Journal of Partial Differential Equations 2019年第1期32卷 33-51页

作者： lEADI liamidi A. TOYOU robert l. Departement de Mathematic/ues Faculte des Sciences et Techniques (FAST) Institut de Mathematiques et de Sciences Physiques (IMSP) Univer site d'Abomey- Calavi (UAC) 01 BP: 673 Porto-Novo Benin Republic Institut de Mathematiques et de Sciences Physiques (IMSP) Universite d'Abomey- Calavi (UAC) 01 BP: 673 Porto-Novo Benin Republic.

In this article, we are interested in the simplicity and the existence of the first strictly principal eigenvalue or semitrivial principal eigenvalue of the (p,q)-biharmonic systems with Navier boundary conditions.

关键词： Nonlinear eigenvalue problem (p,q)-biharmonic systems Navier boundary conditions.

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NOD2 and ATG16l1 polymorphisms affect monocyte responses in Crohn's disease

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World Journal of Gastroenterology 2011年第23期17卷 2829-2837页

作者： Dylan M Glubb Richard B Gearry Murray l Barclay Rebecca l roberts John Pearson Jacqui I Keenan Judy McKenzie robert W Bentley Department of Medicine University of ChicagoIL 60637-1470United States Department of Medicine University of OtagoChristchurch8140New Zealand Department of Gastroenterology Christchurch HospitalChristchurch8140New Zealand Department of Biochemistry University of OtagoDunedin9054New Zealand Department of Pathology University of OtagoChristchurch8140New Zealand Department of Surgery University of OtagoChristchurch8140New Zealand Department of Haematology University of OtagoChristchurch8140New Zealand Department of Paediatrics University of OtagoChristchurch8140New Zealand

AIM： TO assess whether polymorphisms in NOD2 and ATG16l1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis （MAP） survival in monocytes from Crohn＇s disease （CD） patients METHODS： Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16l1, Monocytes were challenged with MAP and bacterial per- sistence assessed at subsequent time-points. Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines. RESUlTS： Monooltes heterozygous for a NOD2 polymorphism （R702W, P268S, or 1007fs） were more permissive for growth of MAP （P = 0.045） than those without. There was no effect of NOD2 genotype on subsequent cytokine expression. The T300A polymorphism of ATG16l1 did not affect growth of MAP in our model （P = 0.175）, but did increase expression of cytokines interleukin （Il）-10 （P = 0.047） and Il-6 （P = 0.019）. CONClUSION： CD-associated polymorphisms affected the eliminaUon of MAP from ex v/vo monooltes （NOD2）, or expression of certain oltokines （ATG16lI）, implying independent but contributory roles in the pathogenesis of CD.

关键词： Inflammatory bowel disease Mycobacteriumavium subspecies paratuberculosis Cytokine CARD15 Autophagy

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Encapsulated Fe(IV)Molecular Complex for Photoacoustic Imaging

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CCS Chemistry 2024年第5期6卷 1184-1197页

作者： Ye Xu Chao li Zhong-Yu Yu Jiamin Wang Zhaoyang liu Chao Jiang Zhen-Feng Chen Xiaoyu Wu Ming-Xing li Hong Yang Zhao-Xi Wang Jonathan l.Sessler Department of Chemistry Center for Supramolecular Chemistry and CatalysisInnovative Drug Research CenterShanghai UniversityShanghai 200444 College of Chemistry and Materials Science Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234 Sijing Community Health Service Center of Songjiang District Shanghai 201601 Key laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224

stable neutral Fe(IV)complex(Fe-HDCl),readily accessible on the g scale,was found to possess high water solubility and good stability(<5%degradation over 4 h upon photoirradiation).Fe-HDCl is green and absorbs light e... 详细信息

stable neutral Fe(IV)complex(Fe-HDCl),readily accessible on the g scale,was found to possess high water solubility and good stability(l is green and absorbs light effectively in the visible region(500–800 nm)with aλmax at 650 nm(ɛ=7830 M^(−1)cm^(−1)).Fe-HDCl also exhibits photothermal(PT)behavior comparable to single-wall carbon nanotubes in the solid *** aqueous solution,high PT conversion(η=72.6%)is achieved,and a strong hyperthermia-based inhibition of cell growth is observed upon subjecting Fe-HDCl to near-infrared 730 nm laser *** biological studies in vitro and in vivo confirmed that Fe-HDCl is biocompatible,clears readily,and allows the visual detection of blood *** subjecting mice to intravenous injection at low doses(e.g.,50μmol·kg^(−1)),Fe-HDCl also permits the photoacoustic(PA)imaging of kidneys and the evaluation of renal fibrosis in mouse *** addition,Fe-HDCl allows PA-based imaging of brain tissues,presumably reflecting its ability to pass through the blood-brain *** thus propose that Fe-HDCl has a role to play as PT agent and as a photodiagnostic.

关键词： stable Fe(IV)complex blood-brain barrier molecular cage photoacoustic imaging renal fibrosis

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ZmGns,a maize class I β-1,3-glucanase,is induced by biotic stresses and possesses strong antimicrobial activity

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Journal of Integrative Plant Biology 2015年第3期57卷 271-283页

作者： Yu-Rong Xie Yenjit Raruang Zhi-Yuan Chen robert l.Brown Thomas E.Cleveland Department of Plant Pathology and Crop Physiology Louisiana State University Agricultural Center Biotechnology Research Institute the Chinese Academy of Agricultural Sciences Southern Regional Research Center USDA-ARS

Plant b-1,3-glucanases are members of the pathogenesis-related protein 2（PR-2） family,which is one of the 17 PR protein families and plays important roles in biotic and abiotic stress *** of the differentially expressed proteins（spot 842） identified in a recent proteomic comparison between five pairs of closely related maize（Zea mays l.） lines differing in aflatoxin resistance was further investigated in the present ***,the corresponding cDNA was cloned from maize and designated as *** encodes a protein of338 amino acids containing a potential signal *** expression of Zm Gns was detectible in all tissues studied with the highest level in *** was significantly induced by biotic stresses including three bacteria and the fungus Aspergillus *** was also induced by most abiotic stresses tested and growth hormones including salicylic *** vivo,ZmGns showed a significant inhibitory activity against thebacterial pathogen Pseudomonas syringae *** DC3000 and fungal pathogen Botrytis cinerea when it overexpressed in *** high level of expression in the silk tissue and its induced expression by phytohormone treatment,as well as by bacterial and fungal infections,suggest it plays a complex role in maize growth,development,and defense.

关键词： β-1 3-Glucanase biological activity expression profiles Zea mays ZmGns

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Potential adaptation of a Q biotype whitefly population from poinsettia to field crops

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Insect Science 2011年第6期18卷 719-728页

作者： Xiangshun Hu Timothy J. Dennehy Xinzhi Ni Huiyan Zhao robert l. Nichols Xianchun li College of Plant Protection NorthwestA ＆ F University Yangfing Shaanxi Province China Department of Entomology and BI05 Institute University of Arizona Tucson Arizona USDA-ARS Crop Genetics and Breeding Research Unit Tifton Georgia Cotton Incorporated Cary North Carolina USA

The invasive Q biotype whitefly was first detected in the US on poinsettia in 2004 and is still not a pest outside of greenhouse environments in the US. To assess the potential for the establishment of the Q biotype on field crops, population cage experiments were conducted to compare the performance of a poinsettia-derived Q population named P＇06 on poinsettia and six field crops （alfalfa, tomato, melon, cotton, cowpea and cabbage）. P＇06 adults reared on poinsettia as nymphs laid eggs on all six field crops. Significantly more eggs were laid on alfalfa, tomato, melon and cotton than on cabbage, cowpea and poinsettia. These eggs hatched and the nymphs developed to adults on the six field crops. Relative to poinsettia, whitefly survival was similar on cowpea, alfalfa, tomato and cabbage, but significantly higher on cotton and melon. Moreover, P＇06 had significantly shorter development times from egg to adult on cotton, melon, cowpea, tomato and alfalfa than they did on poinsettia. However, the F1 adults raised on the six field crops had significantly shorter lifespans and laid 11- to 18-fold fewer eggs than did the F1 adults raised on poinsettia. Taken together, while P＇06 may have some potential to establish on field crops, the shorter lifespans and extremely low fectmdities of the F1 adults raised on the six field crops suggests that P＇06 is incapable of rapidly adapting to them. Poor adaptation to field crops may explain, at least partially, why the Q biotype has not established in the US field system.

关键词： Bemisia tabaci host adaptation life history traits population establishment,Q-biotype.

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The role of phase impurities and lattice defects on the electron dynamics and photochemistry of CuFeO2 solar photocathodes

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Nano Research 2019年第9期12卷 2390-2399页

作者： Elizabeth A. Fugate Somnath Biswas Mathew C. Clement Minkyu Kim Dongjoon Kim Aravind Asthagiri l. robert Baker Department of Chemistry and Biochemistry The Ohio State UniversityColumbusOH 43210USA Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA

CuFeO2 is a promising photocathode for H2 evolution and CO2 reduction *** better understand the complex defect chemistry and role of impurity phases in this material and their effect on the photochemical performance,we employ visible light transient absorption spectroscopy and density functional theory(DFT)calculations to investigate the electron dynamics in electrochemically deposited Cu-Fe oxide thin *** analysis of carrier lifetime shows a fast,sub-ps contribution to relaxation followed by persistence of a Iong-lived state to time delays greater than 2 *** amplitude of the Iong-lived state is shown to correlate with the rate of fast initial relaxation,and this is explained in terms of a competition between charge carrier trapping and charge *** separation in CuFeO2 occurs via hole thermalizati on from O 2p to Cu 3d vale nee band states leadi ng to segregatio n of electr ons and holes across layers in the CuFeO2 *** between transient absorption measurements and DFT calculations suggest that Cu vacancies enhanee photochemical performance by facilitating charge separation *** contrast,O interstitials are predicted to switch the relative positions of O 2p and Cu 3d vale nee band states,which would in hibit charge separatio n by in ter-band hole thermal izatio *** ally,we find no evide nee for electron in jecti on from CuFeO2 to CuO suggest!ng that charge separati on at this heterostructure in terface does not play a role in the carrier lifetime or photochemical performance of the catalysts studied here.

关键词： delafossite CuFeO2 charge-carrier dynamics transient absorption spectroscopy Cu vacancy O interstitial

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Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic ***

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Journal of Animal Science and Biotechnology 2017年第1期8卷 143-153页

作者： Jae Cheol Kim Bruce P. Mullan John l. Black robert J. E. Hewitt robert J. van Barneveld John R. Pluske School of Veterinary and life Sciences Murdoch University Murdoch WA 6150 Australia Department of Agriculture and Food Pork Innovation South Perth WA 6151 Australia John l Black Consulting Warrimoo NSW 2774 Australia SunPork Farms Solutions Loganholme QLD 4129 Australia Barneveld Nutrition Pry ltd Loganholme QLD 4129 Australia

Background： This experiment was conducted to test the hypothesis that vitamin E（Vit E） and acetylsalicylic acid（ASA）, a cyclooxygenase-2（COX-2） inhibitor, will additively reduce the production of the immunosuppressive molecule prostaglandin E_2（PGE_2） and hence reduce inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E. ***： The experiment was conducted in a research facility with 192 individually-housed male weaner pigs（landrace × large White） weighing 6.6 ± 0.04 kg（mean ± SEM）. The pigs were experimentally infected with an enterotoxigenic strain of E. coli and were allocated to a 2 × 3 factorial design with the respective factors being without and with 125 ppm ASA and three levels of Vit E supplementation（50, 100 or 200 IU/kg diet, dl-α-tocopheryl acetate）.Results： Acetylsalicylic acid supplementation improved average daily gain（P 〈 0.05） and tended to improve feed：gain ratio（P 〈 0.10） during the first 14 d after weaning. Acetylsalicylic acid supplementation also improved（P 〈 0.001） amino acid utilization efficiency（as assessed by plasma urea level） and tended to decrease（P 〈 0.10） PGE2 production in the liver without affecting smal intestinal histology and tight junction protein mR NA expression in the jejunal epithelium. Vitamin E supplementation greater than 100 IU/kg diet sustained both the plasma Vit E concentration（P 〈 0.001） and plasma haptoglobin content（P 〈 0.001） after weaning. However, there was no additive effects of the combined supplementation of ASA and Vit E on performance, intestinal barrier function and inflammatory responses of weaned ***： Although ASA and vitamin E improved amino acid utilization efficiency and reduced acute inflammatory responses, ASA and vitamin E did not additively reduce production of PGE2 and inflammatory responses in weaner pigs experimental y infected with an enterotoxigenic strain of E. coli.

关键词： Acetylsalicylic acid E.coli infection PGE_2 Vitamin E Weaner pigs

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Tunable photocycle kinetics of a hybrid bacteriorhodopsin/quantum dot system

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Nano Research 2019年第2期12卷 365-373页

作者： Terianna J. Wax Jordan A. Greco Shutang Chen Nicole l. Wagner Jing Zhao robert R. Birge 55 North Eagleville Rd Department of Chemistry University of Connecticut Storrs CT 06269-3060 USA

The inclusion of inorganic nanoparticles in biological environments has led to the creation of hybrid nanosystems that are employed in a variety of applications. One such system includes quantum dots (QDs) coupled with the photoactive protein, bacteriorhodopsin (BR), which has been explored in developing enhanced photovoltaic devices. In this work, we have discovered that the kinetics of the BR photocycle can be manipulated using CdSe/CdS (core/shell) QDs. The photocycle lifetime of protein samples with varying QD amounts were monitored using time-resolved absorption spectroscopy. Concentration-dependent elongations of the bR and M state lifetimes were observed in the kinetic traces, thus suggesting that excitonic coupling occurs between BR and QDs. We propose that the pairing of BR with QDs has the potential to be utilized in protein-based computing applications, specifically for real-time holographic processors, which depend on the temporal dynamics of the bR and M photointermediates.

关键词： bacteriorhodopsin photocycle bionanotechnology photochromism quantum dot hybrid materials

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