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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen robert j.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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生物量浓度实时在线检测方法的研究

生物化学与生物物理进展 2000年第4期27卷 387-390页

作者：王贻俊樊育 L.OLSSON j.nielsen j.nielsen 山东轻工业学院自动化系济南250100 Department of Biotechnology Technical University of Denmark

微生物的存在会改变发酵液的电特性 ,发酵液在无线电频率范围内的电容率增量是测量频率和生物量浓度的函数 .基于对发酵液电容率分布的研究 ,提出了测量生物量浓度的新方法 .用此方法不用取样就能对发酵液中的生物量进行实时在线测量 ,... 详细信息

微生物的存在会改变发酵液的电特性 ,发酵液在无线电频率范围内的电容率增量是测量频率和生物量浓度的函数 .基于对发酵液电容率分布的研究 ,提出了测量生物量浓度的新方法 .用此方法不用取样就能对发酵液中的生物量进行实时在线测量 ,而且测得的是活的生物量浓度 .制作的电极直接插入发酵器中并满足高温蒸气灭菌条件 .此方法在生化制药、食品发酵、啤酒酿造、污水检测等工业领域里有很好的推广应用前景 .

关键词：发酵液生物量浓度实时在线检测高温灭菌

Effects of 3 months of full-court and half-court street basketball training on health profile in untrained men

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journal of Sport and Health Science 2018年第2期7卷 132-138页

作者： Morten B.Randers Marie Hagman jonathan Brix jesper F.Christensen Mogens T.Pedersen jens j.nielsen Peter Krustrup Department of Sports Science and Clinical Biomechanies SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 5230 Denmark Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen 2200 Denmark Centre oflnflammation and Metabolism (CIM) and Centre for Physical Activity Research (CFAS) Rigshospitalet Faculty of Health Science Copenhagen University Hospital 7641 University of Copenhagen Copenhagen 2100 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The aim of the present study was to investigate whether street basketball organized as 3 v 3 on either a half court(HC) with 1 basket or a full court(FC) with 2 baskets could improve fitness and health profiles of untrained men after 3 months of supervised ***: Thirty-five untrained men(aged 20—42 years) completed the pre-and post-intervention testing(FC: n = 13, HC: n = 12, CO(control):n = 10). The training attendance was 2.0 ± 0.4 and 1.9 ± 0.3 times per week in FC and HC, respectively. Mean heart rate(HR) was 83.8 ± 6.0 percent of maximal heart rate(%HR_(max)) and 84.5 ± 2.9 %HR_(max) in FC and HC, ***: The 3 months of street basketball training on an FC with 2 baskets increased maximal oxygen uptake(2.4 mL/min/kg(95% confidence interval(CI): 1.0—3.9)), time to exhaustion(47 s(95%CI: 26—67)), lean body mass(0.8 kg(95%CI: 0.1—1.5)), and bone mineral density(0.021 g/cm^2(95%CI: 0.011—0.031)), whereas mean arterial pressure(—5.6 mm Hg(95%CI: —7.5 to 3.7)), body fat percentage(—1.6%,(95%CI: —2.5 to —0.7)), heart rate(—18 bpm(95%CI: —24 to —12)), and blood lactate(median: —1.4 mmol/L(interquartile range: —1.5 to —0.6)) during submaximal running were lowered. The changes were less pronounced after the training period when playing on an HC with 1 basket, but increases in maximal oxygen uptake(1.6 mL/min/kg(95%CI: —0.1 to 3.3)), time to exhaustion(28 s(95%CI: 9—47)), lean body mass(1.3 kg(95%CI: 0.3—2.4)), and lower body fat percentage(—0.9%(95%CI: —1.9 to —0.1)) were observed in this ***: Three months of 3 v 3 street basketball training improved fitness and led to broad-spectrum improvements in variables related to overall health profile, with the most marked effects observed when playing on an FC with 2 baskets.

关键词： Blood pressure Body composition Cardiovascular fitness Maximal oxygen uptake Muscoloskeletal fitness Physical demands Small-sided games Team sport

Multimodal processes optimization subject to fuzzy operation time constraints:declarative modeling approach

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Frontiers of Information Technology & Electronic Engineering 2016年第4期17卷 338-347页

作者： Izabela nielsen robert WOjCIK Grzegorz BOCEWICZ Zbigniew BANASZAK Department of Mechanical and Manufacturing Engineering Aalborg UniversityAalborg 9220Denmark Department of Computer Engineering Faculty of ElectronicsWroctaw University of TechnologyWroclaw 50-370Poland Department of Electronics and Computer Science Koszalin University of TechnologyKoszalin 75-453Poland Department of Business Informatics Warsaw University of TechnologyWarsaw 00-661Poland

We present an extension of the resource-constrained multi-product scheduling problem for an automated guided vehicle(AGV) served flow shop, where multiple material handling transport modes provide movement of work pieces between machining centers in the multimodal transportation network(MTN). The multimodal processes behind the multi-product production flow executed in an MTN can be seen as processes realized by using various local periodically functioning processes. The considered network of repetitively acting local transportation modes encompassing MTN's structure provides a framework for multimodal processes scheduling treated in terms of optimization of the AGVs fleet scheduling problem subject to fuzzy operation time constraints. In the considered case, both production takt and operation execution time are described by imprecise data. The aim of the paper is to present a constraint propagation(CP) driven approach to multi-robot task allocation providing a prompt service to a set of routine queries stated in both direct and reverse way. Illustrative examples taking into account an uncertain specification of robots and workers operation time are provided.

关键词： Automated guided vehicles(AGVs) Scheduling Multimodal process Fuzzy constraints Optimization

Chinese life cycle impact assessment factors

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journal of Environmental Sciences 2001年第2期13卷 205-209页

作者： Yang, j.-X. nielsen, P.H. Research Cntr. for Eco-Envtl. Sci. Chinese Academy of Sciences Beijing 100085 China

The methodological basis and procedures for determination of Chinese normalization references and weighting factors according to the EDIP-method is described. According to Chinese industrial development intensity and population density, China was divided into three regions and the normalization references for each region were calculated on the basis of an inventory of all of the region's environmental emissions in 1990. The normalization reference was determined as the total environmental impact potential for the area in question in 1990(EP(j)90) divided by the population. The weighting factor was determined as the normalization reference (ER(j)90) divided by society's target contribution in the year 2000 based on Chinese political reduction plans, ER(j)T2000. This paper presents and discuss results obtained for eight different environmental impact categories relevant for China: global warming, stratospheric ozone depletion, acidification, nutrient enrichment, photochemical ozone formation and generation of bulk waste, hazardous waste and slag and ashes.

关键词： Environmental impact Global warming Life cycle Ozone Sustainable development

Esophageal lichen planus:A case report and review of the literature

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World journal of Gastroenterology 2013年第14期19卷 2278-2281页

作者： jennifer A nielsen robert M Law Keith H Fiman Cory A roberts Division of Research ProPathDallasTX 75247United States Division of Dermatopathology ProPathDallas TX 75247United States Gastroenterology Consultants Southwest LLP Sugar LandTX 77478United States Division of Gastrointestinal Pathology ProPathDallasTX 75247United States

Esophageal involvement by lichen planus(ELP),previously thought to be quite rare,is a disease much more common in women and frequently the initial manifestation of mucocutaneous lichen planus(LP).Considering that the symptoms of ELP do not present in a predictable manner,ELP is perhaps more under-recognized than *** date,four cases of squamous cell carcinoma in association with ELP have been reported,suggesting that timely and accurate diagnosis of ELP is of importance for appropriate *** this case report,a 69-year-old female presented with dysphagia and *** reported a history of oral LP but had no active oral or skin *** examination revealed severe strictures and web-like areas in the *** examination demonstratedextensive denudation of the squamous epithelium,scattered intraepithelial lymphocytes,rare eosinophils and dyskeratotic *** immunofluorescence showed rare cytoid bodies and was used to exclude other primary immunobullous *** using clinical,endoscopic,and histologic data,a broad list of differential diagnoses can be narrowed,and the accurate diagnosis of ELP can be made,which is essential for proper treatment and subsequent follow-up.

关键词： Esophageal lichen planus Esophagus Immunofluorescence Immunobullous disorders Diagnostic accuracy

Development of fungal cell factories for the production of secondary metabolites:Linking genomics and metabolism

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Synthetic and Systems Biotechnology 2017年第1期2卷 5-12页

作者： jens Christian nielsen jens nielsen Chalmers University of Technology Kemivagen 10Sweden

The genomic era has revolutionized research on secondary metabolites and bioinformatics methods have in recent years revived the antibiotic discovery process after decades with only few new active molecules being *** computational tools are driven by genomics and metabolomics analysis,and enables rapid identification of novel secondary *** translate this increased discovery rate into industrial exploitation,it is necessary to integrate secondary metabolite pathways in the metabolic engineering *** this review,we will describe the novel advances in discovery of secondary metabolites produced by filamentous fungi,highlight the utilization of genome-scale metabolic models(GEMs)in the design of fungal cell factories for the production of secondary metabolites and review strategies for optimizing secondary metabolite production through the construction of high yielding platform cell factories.

关键词： Secondary metabolism Fungi Biosynthetic gene clusters Genome mining Metabolic modeling Cell factories

Severe steroid refractory gastritis induced by Nivolumab: A case report

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World journal of Gastroenterology 2020年第16期26卷 1971-1978页

作者： Helene Hjorth Vindum jØrgen S Agnholt Anders Winther Moelby nielsen Mette Bak nielsen Henrik Schmidt Department of Oncology Aarhus University HospitalAarhus 8200Denmark Department of Gastroenterology Aarhus University HospitalAarhus 8200Denmark Department of Pathology Aarhus University HospitalAarhus 8200Denmark

BACKGROUND Immune checkpoint inhibitors are widely used for treatment of many advanced *** gastrointestinal(GI)side effects,such as diarrhea and colitis,are common,but upper GI side effects are rarely ***,the correct treatment of upper GI adverse events has been less frequently *** SUMMARY We describe a case of a 16-year-old woman with stage IIIb malignant melanoma treated with adjuvant monotherapy using *** patient developed severe gastritis after six series of Nivolumab with weight loss,nausea,and *** was no effect of intravenous steroids,but the patient′s condition resolved after administration of *** This case report supports the same treatment for gastritis as for colitis,which is in line with current guidelines.

关键词： Gastritis Immune checkpoint inhibitors Nivolumab Case report Immune-related adverse events Infliximab

Plant exocytosis: Weaving distinct pathways to the plant plasma membrane

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Molecular Plant 2022年第3期15卷 382-384页

作者： Erik nielsen Department of Molecular Cellularand Developmental BiologyUniversity of MichiganAnn ArborMI 48109USA

During plant growth and development newly synthesized proteins and other cargo molecules must be selectively targeted to a variety of cellular *** the most important targeting involves the trafficking of proteins to the plasma membrane,where they control interactions with the environment and neighboring *** this process,proteins entering the secretory pathway are imported into the endoplasmic reticulum where they are folded and *** are then sorted and delivered to the Golgi complex,where they are further processed and modified.

关键词： neighboring processed complex