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i.tegri.s and thei. potenti.l roles i. mammali.n pregnancy

Journal of Ani.al Sci.nce and Bi.technology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson robert C.Burghardt Fuller w.Bazer Heewon Seo Joe w.Cai. Department of Veteri.ary i.tegrati.e Bi.sci.nces School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Ani.al Sci.nce College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

i.tegri.s are a hi.hly complex fami.y of receptors that, when expressed on the surface of cells, can medi.te reci.rocal cell-to-cell and cell-to-extracellular matri.(ECM) i.teracti.ns leadi.g to assembly of i.tegri. adhesi.n complexes(i.Cs) that i.i.i.te many si.nali.g functi.ns both at the membrane and deeper wi.hi. the cytoplasm to coordi.ate processes i.cludi.g cell adhesi.n, mi.rati.n, proli.erati.n, survi.al, di.ferenti.ti.n, and metaboli.m. All metazoan organi.ms possess i.tegri.s, and i. i. generally agreed that i.tegri.s were associ.ted wi.h the evoluti.n of multi.ellulari.y, bei.g essenti.l for the associ.ti.n of cells wi.h thei. nei.hbors and surroundi.gs, duri.g embryoni. development and many aspects of cellular and molecular bi.logy. i.tegri.s have i.portant roles i. many aspects of embryoni. development, normal physi.logy, and di.ease processes wi.h a multi.ude of functi.ns di.covered and eluci.ated for i.tegri.s that di.ectly i.fluence many areas of bi.logy and medi.i.e, i.cludi.g mammali.n pregnancy, i. parti.ular i.plantati.n of the blastocyst to the uteri.e wall, subsequent placentati.n and conceptus(embryo/fetus and associ.ted placental membranes) development. Thi. revi.w provi.es a succi.ct overvi.w of i.tegri. structure, li.and bi.di.g, and si.nali.g followed wi.h a conci.e overvi.w of embryoni. development, i.plantati.n, and early placentati.n i. pi.s, sheep, humans, and mi.e as an example for rodents. A bri.f ti.eli.e of the i.i.i.l locali.ati.n of i.tegri. subuni.s to the uteri.e lumi.al epi.heli.m(LE) and conceptus trophoblast i. then presented, followed by sequenti.l summari.s of i.tegri. expressi.n and functi.n duri.g gestati.n i. pi.s, sheep, humans, and rodents. As appropri.te for thi. journal, summari.s of i.tegri. expressi.n and functi.n duri.g gestati.n i. pi.s and sheep are i. depth, whereas summari.s for humans and rodents are bri.f. Because si.i.ar models to those i.lustrated i. Fi.. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans i.plantati.n i.tegri.s Pi.s Pregnancy Rodents Sheep

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Predi.ti.g the coeffi.i.nt of fri.ti.n i. a sli.i.g contact by applyi.g machi.e learni.g to acousti. emi.si.n data

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Fri.ti.n 2024年第6期12卷 1299-1321页

作者： robert GUTi.RREZ Ti.nshi.FANG robert MAi.wARi.G Tom REDDYHOFF Tri.ology Group Department of Mechanical EngineeringImperial College LondonExhibition RoadLondon SW72AZUK Shell Global Soluti.ns(US)i.c.Shell Technology Center Houston 3333 Highway 6 SouthHoustonTX 77082USA Shell i.ternati.nal Petroleum Company Li.i.ed Shell CentreYork RoadLondon SE17NAUK

i. i. i.creasi.gly i.portant to moni.or sli.i.g i.terfaces wi.hi. machi.es,si.ce thi. i. where both energy i. lost,and fai.ures *** emi.si.n(AE)techni.ues offer a way to moni.or contacts remotely wi.hout requi.i.g transparent or electri.ally conducti.e ***,acousti. data from sli.i.g contacts i. notori.usly complex and di.fi.ult to ***,we si.ultaneously measure coeffi.i.nt of fri.ti.n(wi.h a conventi.nal force transducer)and acousti. emi.si.n(wi.h a pi.zoelectri. sensor and hi.h acqui.i.i.n rate di.i.i.er)produced by a steel‒steel rubbi.g *** data i. then used to trai. machi.e learni.g(ML)algori.hms(e.g.,Gaussi.n process regressi.n(GPR)and support vector machi.e(SVM))to correlated acousti. emi.si.n wi.h *** trai.i.g requi.es the dense AE data to fi.st be reduced i. si.e and a range of processi.g techni.ues are assessed for thi.(e.g.,down-sampli.g,averagi.g,fast Fouri.r transforms(FFTs),hi.tograms).Next,fresh,unseen AE data i. gi.en to the trai.ed model and the resulti.g fri.ti.n predi.ti.ns are compared wi.h the di.ectly measured *** i. excellent agreement between the measured and predi.ted fri.ti.n when the GPR model i. used on AE hi.togram data,wi.h root mean square(RMS)errors as low as 0.03 and Pearson correlati.n coeffi.i.nts reachi.g ***,predi.ti.ns remai. accurate despi.e changes i. test condi.i.ns such as normal load,reci.rocati.g frequency,and stroke *** paves the way for remote,acousti. measurements of fri.ti.n i. i.accessi.le locati.ns wi.hi. machi.ery to i.crease mechani.al effi.i.ncy and avoi. costly fai.ure/needless mai.tenance.

关键词： acousti. emi.si.n condi.i.n moni.ori.g fri.ti.n machi.e learni.g Gaussi.n process regressi.n support vector machi.e

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Angular unconformi.y i. Pennsylvani.n strata from 3-D sei.mi. i.terpretati.n,Goldsmi.h Fi.ld,west Texas

Energy Geoscience

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Energy Geosci.nce 2024年第2期5卷 298-303页

作者： Edwi. i.Egbobawaye Nelly Omoruyi.Abdulmutalli. Ami.u robert Trentham Mohamed K.Zobaa Sumi. Verma Ki.der Morgan MidlandTX79705USA Department of Geosci.nces University of Texas Permian BasinOdessaTX79762USA

The Pennsylvani.n unconformi.y,whi.h i. a detri.al surface,separates the beds of the Permi.n-aged strata from the Lower Paleozoi. i. the Central Basi. *** data i.terpretati.n i.di.ates that the unconformi.y i. an angular unconformi.y,overlyi.g multi.le normal faults,and accompani.d wi.h a thrust fault whi.h maxi.i.es the regi.n's structural ***,the Pennsylvani.n angular unconformi.y creates pi.ch-outs between the beds above and *** computed the spectral decomposi.i.n and reflector convergence attri.utes and analyzed them to characteri.e the angular unconformi.y and *** spectral decomposi.i.n attri.ute di.i.es the broadband sei.mi. data i.to di.ferent spectral bands to resolve thi. beds and show thi.kness *** contrast,the reflector convergence attri.ute hi.hli.hts the locati.n and di.ecti.n of the pi.ch-outs as they di. south at angles between 2° and 6°.After revi.wi.g fi.di.gs from RGB blendi.g of the spectrally decomposed frequenci.s along the Pennsylvani.n unconformi.y,we observed channel-li.e features and multi.le li.ear bands i. addi.i.n to the faults and *** can be i.ferred that the i.enti.i.d li.ear bands could be the result of di.ferent li.hologi.s associ.ted wi.h the ti.ti.g of the beds,and the faults may possi.ly i.fluence hydrocarbon mi.rati.n or act as a flow barri.r to entrap hydrocarbon *** i.enti.i.ati.n of thi. angular unconformi.y and the associ.ted features i. the study area are vi.al for the followi.g reasons:1)the unconformi.y surface represents a natural strati.raphi. boundary;2)the strati.raphi. pi.ch-outs act as flui. flow connecti.i.y boundari.s;3)the areal extent of compartmentali.ed reservoi.s'boundari.s created by the angular unconformi.y are better defi.ed;and 4)fault di.placements are better understood when planni.g well locati.ns as faults can be flow barri.rs,or permeabi.i.y condui.s,dependi.g on faci.s heterogenei.y and/or seal effecti.eness of a fault,whi.h

关键词： Pennsylvani.n unconformi.y Sei.mi. data i.terpretati.n Spectral decomposi.i.n Reflector convergence Reservoi. characteri.ati.n

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A general mi.ror equi.alence theorem for coset vertex operator algebras

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Sci.nce Chi.a Mathemati.s 2024年第10期67卷 2237-2282页

作者： robert McRae Yau Mathemati.al Sci.nces Center Tsinghua UniversityBeijing 100084China

we prove a general mi.ror duali.y theorem for a subalgebra U of a si.ple conformal vertex algebra A and i.s commutant V=ComA(U).Speci.i.ally,we assume that A≌■_(i.i.U_(i.■V_(i. as a U■V-module,where the U-modules Ui.re si.ple and di.ti.ct and are objects of a semi.i.ple brai.ed ri.bon category of Umodules,and the V-modules Vi.re semi.i.ple and contai.ed i. a(not necessari.y ri.i.) brai.ed tensor category of *** also assume U=ComA(V).Under these condi.i.ns,we construct a brai.-reversed tensor equi.alence τ:u_(A)→v_(A),where u_(A)i. the semi.i.ple category of U-modules wi.h si.ple objects Ui.i.i.and v_(A)i. the category of V-modules whose objects are fi.i.e di.ect sums of *** parti.ular,the V-modules Vi.re si.ple and di.ti.ct,and v_(A)i. a ri.i. tensor *** an appli.ati.n,we fi.d a ri.i. semi.i.ple tensor subcategory of modules for the Vi.asoro algebra at central charge 13+6p+6p^(-1),p∈Z_(≥2), whi.h i. brai.ed tensor equi.alent to an abeli.n 3-cocycle twi.t of the category of fi.i.e-di.ensi.nal ***,the Vi.asoro vertex operator algebra at central charge 13+6p+6p^(-1)i. the PSL_(2)(C)-fi.ed-poi.t subalgebra of a si.ple conformal vertex algebra w(-p),analogous to the reali.ati.n of the Vi.asoro vertex operator algebra at central charge 13-6p-6p^(-1)as the PSL_(2)(C)-fi.ed-poi.t subalgebra of the tri.let algebra w(p).

关键词： vertex operator algebras coset conformal eld theory brai.-reversed tensor equi.alence Vi.asoro algebra

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A di.i.trovi.us i.creases pupal mortali.y i. Spodoptera frugi.erda by suppressi.g protease acti.i.y and i.hi.i.i.g larval di.t consumpti.n

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Journal of i.tegrati.e Agri.ulture 2024年第8期23卷 2723-2734页

作者： Mei.ue Sun Tong Li.Yi.gji. Li. Kenneth wi.son Xi.gyu Chen robert i.Graham Xi.nmi.g Yang Guangwei.Ren Pengjun Xu Key Laboratory of Tobacco Pest Moni.ori.g&i.tegrated Management Tobacco Research InstituteChinese Academy of Agricultural SciencesQingdao 266101China i.sti.ute of Plant Protecti.n Henan Academy of Agricultural SciencesZhengzhou 450000China Staff Development i.sti.ute of Chi.a Nati.nal Tobacco Corporati.n Zhengzhou 450000China Lancaster Envi.onment Centre Lancaster UniversityLancaster LA14YWUK Department of Rural Land Use Scotland’s Rural CollegeCraibstone CampusAberdeen AB01ABUK State Key Laboratory for Bi.logy of Plant Di.eases and i.sect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China

Understandi.g i.teracti.ns between vi.uses and thei. hosts i. conduci.e to enabli.g better appli.ati.n of vi.uses as bi.control *** vi.uses carri.d by parasi.i. wasps enhance the parasi.i. effi.i.ncy of wasp-larvae by protecti.g them agai.st the i.mune system of thei. Lepi.opteran ***,the relati.nshi. between prey pests and vi.uses found i. predatory natural enemi.s remai.s ***,we report the i.teracti.n between Arma chi.ensi. vi.us-1(AcV-1),ori.i.ally i.olated from a predatory natural enemy,Arma chi.ensi.(Hemi.tera:Pentatomi.ae),and one of i.s prey speci.s,Spodoptera frugi.erda(Lepi.optera:Noctui.ae).The results showed that the AcV-1 vi.us appeared harmful to the novel host *** by i.hi.i.i.g larval di.t consumpti.n and i.creasi.g pupal ***,sequenci.g data i.di.ated that the vi.us altered the gene expressi.n profi.es of *** analysi. showed that the proteasome and phagosome pathways related to protei. degradati.n and i.mune response were si.ni.i.antly *** the expressi.n levels of di.esti.e enzyme genes di. not change si.ni.i.antly,the total protease acti.i.y of AcV-1 vi.us-posi.i.e i.di.i.uals was si.ni.i.antly decreased,suggesti.g that the vi.us i.hi.i.ed di.t consumpti.n of *** vi. the down-regulati.n of di.esti.e enzyme *** results i.di.ate that a vi.us i.i.i.lly i.olated i. a predatory natural enemy can decrease the fi.ness of i.s prey *** vi.us was found to i.pact the host proteasome and phagosome pathways related to protei. degradati.n and i.muni.y,provi.i.g a potenti.l mechani.m to enhance controlli.g effi.i.ncy.

关键词： Arma chi.ensi. vi.us-1 di.t consumpti.n fi.ness transcri.tome protease acti.i.y

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Necroti. enteri.i. and anti.i.ti.-free producti.n of broi.er chi.kens:Challenges i. testi.g and usi.g alternati.e products

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Ani.al Nutri.i.n 2024年第1期16卷 288-298页

作者： robert J.Moore School of Sci.nce RMIT University

The global trend towards rai.i.g broi.er chi.kens wi.hout the use of i.-feed anti.i.ti.s(i.As) means that there i. an ongoi.g need to develop alternati.e treatments capable of deli.eri.g the benefi.s that i.As previ.usly provi.ed. i.As supported the producti.i.y performance of chi.kens and played a key role i. mai.tai.i.g thei. health. Necroti. enteri.i.(NE) i. an i.portant di.ease of broi.ers that affects health,producti.i.y, and welfare, and was previ.usly well controlled by i.As. However, wi.h the reducti.n i. i.A use, NE i. resurgent i. some countri.s. Vacci.es and vari.us feed addi.i.es, i.cludi.g pre-, pro-, and postbi.ti.s, phytobi.ti.s, fatty aci.s, and phage therapi.s have been i.troduced as alternati.e methods of NE control. whi.e some of these feed addi.i.es have speci.i. acti.i.y agai.st the NE pathogen, Clostri.i.m perfri.gens, most have the more general goal of rei.forci.g gut health. Extensi.e revi.ws of the effects of many of these feed addi.i.es on gut health have been publi.hed recently. Hence, rather than cover previ.usly well revi.wed areas of research thi. revi.w focuses on the challenges and pi.falls i. undertaki.g experi.ental assessment of alternati.e NE treatments and translati.g laboratory research to real world commerci.l producti.n setti.gs. The revi.w i. based on the author's parti.ular experi.nce,readi.g, thoughts, and analysi. of the avai.able i.formati.n and i.evi.ably presents a parti.ular understandi.g that i. li.ely to be at odds wi.h others thi.ki.g on these i.sues. i. i. put forward to sti.ulate thi.ki.g and di.cussi.n on the i.sues covered.

关键词： Necroti. enteri.i. Clostri.i.m perfri.gens Vacci.es Feed addi.i.e Farm management

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Volumetri. latti.e Boltzmann method for pore-scale mass di.fusi.nadvecti.n process i. geopolymer porous structures

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Journal of Rock Mechani.s and Geotechni.al Engi.eeri.g 2024年第6期16卷 2126-2136页

作者： Xi.oyu Zhang Zi.ui.Mao Floyd w.Hi.ty Yulan Li.Agnes Grandjean robert Montgomery Hans-Conrad zur Loye Hui.an Yu Shenyang Hu Purdue Uni.ersi.y IndianapolisIN46202USA Paci.i. Northwest Nati.nal Laboratory RichlandWA99352USA CEA DESISECDMRCUniv.MontpellierMarcouleFrance Department of Chemi.try and Bi.chemi.try University of South CarolinaColumbiaSC29208USA

Porous materi.ls present si.ni.i.ant advantages for absorbi.g radi.acti.e i.otopes i. nuclear waste *** i.prove absorpti.n effi.i.ncy i. nuclear waste treatment,a thorough understandi.g of the di.fusi.n-advecti.n process wi.hi. porous structures i. essenti.l for materi.l *** thi. study,we present advancements i. the volumetri. latti.e Boltzmann method(VLBM)for modeli.g and si.ulati.g pore-scale di.fusi.n-advecti.n of radi.acti.e i.otopes wi.hi. geopolymer porous *** structures are created usi.g the phase fi.ld method(PFM)to preci.ely control pore *** our VLBM approach,we i.troduce a concentrati.n fi.ld of an i.otope seamlessly coupled wi.h the veloci.y fi.ld and solve i. by the ti.e evoluti.n of i.s parti.le populati.n *** address the computati.nal i.tensi.y i.herent i. the coupled latti.e Boltzmann equati.ns for veloci.y and concentrati.n fi.lds,we i.plement graphi.s processi.g uni.(GPU)*** of the developed model i.volves exami.i.g the flow and di.fusi.n fi.lds i. porous ***,good agreement i. observed for both the veloci.y fi.ld from VLBM and multi.hysi.s object-ori.nted si.ulati.n envi.onment(MOOSE),and the concentrati.n fi.ld from VLBM and the fi.i.e di.ference method(FDM).Furthermore,we i.vesti.ate the effects of background flow,speci.s di.fusi.i.y,and porosi.y on the di.fusi.n-advecti.n behavi.r by varyi.g the background flow veloci.y,di.fusi.n coeffi.i.nt,and pore volume fracti.n,***,all three parameters exert an i.fluence on the di.fusi.n-advecti.n *** background flow and di.fusi.i.y markedly accelerate the process due to i.creased advecti.n i.tensi.y and enhanced di.fusi.n capabi.i.y,***,i.creasi.g the porosi.y has a less si.ni.i.ant effect,causi.g a sli.ht slowdown of the di.fusi.n-advecti.n process due to the expanded pore *** comprehensi.e parametri. study provi.es valuable i.si.hts i.to the ki.eti.s of i.otope

关键词： Volumetri. latti.e Boltzmann method(VLBM) Phase fi.ld method(PFM) Pore-scale di.fusi.n-advecti.n Nuclear waste treatment Porous medi. flow Graphi.s processi.g uni.(GPU) paralleli.ati.n

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A detai.ed rock densi.y model of the Hong Kong terri.ori.s

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Geodesy and Geodynami.s 2024年第1期15卷 75-81页

作者： Alberti.i.Nsi.h Ababi. robert Tenzer Department of Land Surveyi.g and Geo-i.formati.s Hong Kong Polytechnic UniversityHong KongChina

we used the geologi.al map and publi.hed rock densi.y measurements to compi.e the di.i.al rock densi.y model for the Hong Kong *** then esti.ated the average densi.y for the whole *** to our result,the rock densi.y values i. Hong Kong vary from 2101 to 2681 kg·m^(-3).These densi.y values are typi.ally smaller than the average densi.y of 2670 kg·m^(-3),often adopted to represent the average densi.y of the upper conti.ental crust i. physi.al geodesy and gravi.etri. geophysi.s *** fi.di.g reflects that the geologi.al confi.urati.n i. Hong Kong i. mai.ly formed by li.ht volcani. formati.ns and lava flows wi.h overlyi.g sedi.entary deposi.s at many locati.ns,whi.e the percentage of heavi.r metamorphi. rocks i. very low(less than 1%).Thi. product wi.l i.prove the accuracy of a detai.ed geoi. model and orthometri. hei.hts.

关键词： Densi.y model Rock types Gravi.etri. modeli.g Hong Kong

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Surgeon preferences i. the treatment of thumb carpometacarpal osteoarthri.i.

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world Journal of Orthopedi.s 2024年第5期15卷 435-443页

作者： Edward J wu Bradley w Fossum wyatt Vander Voort Chri.topher O Bayne robert M Szabo Department of Orthopedi. Surgery University of Minnesota Medical SchoolMinneapolisMN 55455United States Department of Orthopaedi. Surgery UC Davis School of MedicineSacramentoCA 95817United States

BACKGROUND Pri.ary thumb carpometacarpal(CMC)osteoarthri.i. i. one of the most common condi.i.ns encountered by hand *** the vast number of operati.ns that have been proposed,none have demonstrated results si.ni.i.antly superi.r to trapezi.ctomy *** The purpose of our study was to determi.e why surgeons opt for thei. techni.ue i. treati.g CMC *** A cross-secti.nal survey of acti.e members of the Ameri.an Soci.ty for Surgery of the Hand was conducted to evaluate the reasons behi.d thei. preferred techni.ue i. the treatment of i.olated thumb CMC *** were contacted by emai. once and provi.ed wi.h a li.k to a de-i.enti.i.d survey consi.ti.g of 5 treatment questi.ns and 5 demographi. *** Of 950 responses were recei.ed.40.5%of surgeons preferred trapezi.ctomy+li.ament reconstructi.n tendon i.terposi.i.n(LRTi.,followed by trapezi.ctomy+suspensi.nplasty(28.2%),suture button suspensi.n(5.9%),trapezi.ctomy alone(4.6%),prostheti. arthroplasty(3.2%),arthrodesi.(1.1%),and other(6.6%).Proponents of trapezi.ctomy+LRTi.ci.ed fami.i.ri.y(73.2%),exposure duri.g fellowshi.(48.8%)and less proxi.al mi.rati.n(60%)to be the mai. reasons affecti.g thei. *** who preferred trapezi.ctomy+suspensi.nplasty most reported si.pli.i.y(74.9%),fewer compli.ati.ns(45.3%),less proxi.al mi.rati.n(43.8%),and avoi.ance of autogenous ti.sue harvest(42.7%).Advocates of suture button suspensi.n ci.ed avoi.ance of autogenous ti.sue harvest(80.4%),shorter i.mobi.i.ati.n(76.8%),and qui.ker recovery(73.2%)wi.h thei. *** of trapezi.ctomy alone ci.ed si.pli.i.y(97.7%),fewer compli.ati.ns(86.4%),and avoi.ance of autogenous ti.sue harvest(59.1%).i. thei. comments,45%of surgeons choosi.g trapezi.ctomy alone ci.ed evi.ence as an addi.i.nal *** of prostheti. arthroplasty ci.ed i.proved pi.ch strength(83.3%)and i.proved range of moti.n(63.3%),whi.e those preferri.g arthrodesi. ci.ed better pi.ch strength(90%)and freque

关键词： Thumb carpometacarpal Osteoarthri.i. Trapezi.ctomy Li.ament reconstructi.n tendon i.terposi.i.n Suspensi.nplasty Preferences Trends

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The concept of gene therapy for glaucoma:the dream that has not come true yet

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Neural Regenerati.n Research 2024年第1期19卷 92-99页

作者： robert Sulak Xi.onan Li. Adri.n Smedowski Department of Physi.logy Faculty of Medical Sciences in KatowiceMedical University of Silesia in KatowiceKatowicePoland i.sti.ute of Bi.technology HiLIFEUniversity of HelsinkiHelsinkiFinland GlaucoTech Co. KatowicePoland

Gene therapi.s,despi.e of bei.g a relati.ely new therapeuti. approach,have a potenti.l to become an i.portant alternati.e to current treatment strategi.s i. *** glaucoma i. not consi.ered a si.gle gene di.ease,the i.enti.i.d goals of gene therapy would be rather to provi.e neuroprotecti.n of reti.al gangli.n cells,especi.lly,i. i.traocular-pressure-i.dependent *** most commonly reported type of vector for gene deli.ery i. glaucoma studi.s i. adeno-associ.ted vi.us serotype 2 that has a hi.h tro pi.m to reti.al gangli.n cells,res ulti.g i. long-term expressi.n and low i.munogeni. *** gene thera py studi.s recrui. i.duci.le and geneti. ani.al models of opti. neuropathy,li.e DBA/2J mi.e model of hi.h-tensi.n glaucoma and the opti. nerve *** gene therapy-based neuroprotecti.n of reti.al gangli.n cells i. targeti.g speci.i. genes translati.g to growth factors(i.e.,brai. deri.ed neurotrophi. factor,and i.s receptor TrkB),regulati.n of apoptosi. and neurodegenerati.n(i.e.,Bcl-xl,Xi.p,FAS system,ni.oti.ami.e mononucleoti.e adenylyl transferase 2,Di.i.3 and Sarm1),i.munomodulati.n(i.e.,Crry,C3 complement),modulati.n of neuroi.flammati.n(i.e.,e rythropoi.ti.),reducti.n of exci.otoxi.i.y(i.e.,Com Ki.α)and transcri.ti.n regulati.n(i.e.,Max,Nrf2).On the other hand,some of gene therapy studi.s focus on loweri.g i.tra ocular pressure,by i.pacti.g genes i.volved i. both,decreasi.g aqueous humor producti.n(i.e.,aquapori. 1),and i.creasi.g outflow faci.i.y(i.e.,COX2,prostaglandi. F2a receptor,RhoA/RhoA ki.ase si.nali.g pathway,MMP1,Myoci.i.).The goal of thi. revi.w i. to summari.e the current stateof-art and the di.ecti.n of development of gene therapy strategi.s for glaucomatous neuropathy.

关键词： adeno-associ.ted vi.us gene edi.i.g gene therapy glaucoma i.P loweri.g i.P-i.dependent mechani.ms neuroprotecti.n opti. nerve opti. neuropathy reti.al gangli.n cells

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