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Protocol for the development and validation of a clinical measurement tool for fear of disease progression and recurrence in cardiac patients

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Chronic Diseases and Translational Medicine 2024年第3期10卷 195-204页

作者： Sarah T.Clarke Michael Le Grande Barbara M.Murphy robert Hester Alun C.Jackson Melbourne School of Psychological Sciences University of MelbourneParkvilleVictoriaAustralia Australian Centre for Heart Health MelbourneVictoriaAustralia Centre on Behavioral Health University of Hong KongPokfulamHong KongChina

Introduction: One in two cardiac patients fear having another heart event or their heart condition getting worse. Research in other chronic illnesses demonstrates that screening for fear of progression and recurrence is vital for adequately addressing such concerns in clinical care. The current project aims to develop and validate a measure for fear of progression and recurrence in cardiac ***: The Fear of Cardiac Recurrence and Progression Scale (FCRP) will be developed through a multistep process. An initial item pool will be generated through a review of the literature and existing measures and consultation with and feedback from key informants. The item pool will be tested in a sample of over 250 adults who have ever had an acute coronary event, undergone cardiac surgery, or a chronic cardiac condition. Exploratory factor analysis will be used to identify the underlying factors, and Rasch analysis will be used to reduce the number of items. A short form version of the FCRP will be developed for use as a brief screening tool, informed by clinical relevance and Rasch psychometric ***: While many cardiac patients experience fears related to the progression or recurrence of their illness, there remains the need for a validated tool with which these concerns can be identified and measured. It is expected that the design and validation of the FCRP will aid identification of cardiac patients suffering from clinically significant levels of fear of progression and recurrence and facilitate the design of tailored psychological interventions to target these fears.

关键词： anxiety cardiac anxiety cardiac recovery cardiac rehabilitation depression fear of progression fear of recurrence psychological measurement psychosocial screening

Earliest megafossils of scandent calamoid palms from the Deccan Intertrappean Beds of Central India and their paleobiogeographic implications

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Journal of Palaeogeography 2024年第3期13卷 509-527页

作者： Sanchita Kumar Kaustav Roy robert A.Spicer Mahasin Ali Khan Palaeobotany and Palynology Laboratory Department of BotanySidho-Kanho-Birsha UniversityRanchi RoadPurulia-723104India CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303Yunnan ProvinceChina School of Environment Earth and Ecosystem SciencesThe Open UniversityMilton KeynesMK76AAUK State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Two well-preserved petrified palm stems from the latest Maastrichtian(Late Cretaceous) to earliest Danian(Early Paleocene) sediments of the Deccan Intertrappean Beds of Madhya Pradesh, Central India are described. Their significant anatomical characteristics include a Calamus-type general stem pattern,the presence of well-preserved fibrovascular bundles(fvbs) with two wide metaxylem vessel elements(230 μm-250 μm) and one phloem strand, uniform density of fvbs, lack of continuity between protoxylem and metaxylem vessel elements, and an absence of centrifugal differentiation of sclerenchymatous fibrous *** features reveal a close resemblance to those of extant genera of scandent Calamoideae. The permineralized stems are described as a new species namely, Palmoxylon calamoides Kumar, Roy et Khan sp. *** fossils represent the oldest reliable fossil records of this family, supporting their Gondwanan origin, their importance in tracing their migration pathways from India to Europe and other continents after the docking of the Indian subcontinent with Eurasia during the Paleocene, and an “Out-of-India” dispersal hypothesis. Today the subfamily Calamoideae is disjunctly occurred in Africa, Asia, Australia, Europe, and South America, but the poor deep-time fossil record of this subfamily with a small number of Cenozoic fossils makes hypotheses concerning its origin and dispersal difficult to evaluate. The present study has significant implications for the origin and migration of this subfamily and the paleoclimate.

关键词： Scandent Calamoideae Stem anatomy K-Pg Paleobiogeography Paleoclimate Central India

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制药公司探索在太空中制造最赚钱药物

商业周刊（中文版） 2024年第7期 16-17页

作者： robert Langreth 竹西(译) 不详

实验表明,在微重力条件下结晶高价值蛋白质类药物具有优势,可能会产生新的专利。初创公司LambdaVision Inc.有一些宏伟的计划,想为色素性视网膜炎患者开发世界上第一个基于蛋白质的人工视网膜(色素性视网膜炎是一种遗传性致盲疾病)。制... 详细信息

实验表明,在微重力条件下结晶高价值蛋白质类药物具有优势,可能会产生新的专利。初创公司LambdaVision Inc.有一些宏伟的计划,想为色素性视网膜炎患者开发世界上第一个基于蛋白质的人工视网膜(色素性视网膜炎是一种遗传性致盲疾病)。制造视网膜需要在一个聚合物网中沉积200层超薄的光敏蛋白。这些蛋白质层的沉积必须完全均匀,视网膜才能正常工作,而这个过程在地球上很难完成。

关键词：初创公司制药公司微重力条件人工视网膜光敏蛋白

Natural variables separate the endemic areas of Clonorchis sinensis and Opisthorchis viverrini along a continuous, straight zone in Southeast Asia

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贫困所致传染病(英文) 2024年第2期13卷 1-13页

作者： Zheng Jin-Xin Zhu Hui-Hui Xia Shang Qian Men-Bao Nguyen Hung Manh Sripa Banchob Sayasone Somphou Khieu Virak Bergquist robert Zhou Xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China One Health Center Shanghai Jiao Tong University The University of Edinburgh Shanghai China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasites and Vectors Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases Shanghai China Institute of Ecology and Biological Resources Graduate University of Science and Technology Vietnam Academy of Science and Technology Hoang Quoc Viet Street Hanoi Vietnam WHO Collaborating Centre for Research and Control of Opisthorchiasis (Southeast Asian Liver Fluke Disease) Tropical Disease Research Laboratory Department of Tropical Medicine Faculty of Medicine Khon Kaen University Mittraparb Road Khon Kaen Thailand Lao Tropical and Public Health Institute Ministry of Health Vientiane Lao PDR National Centre for Parasitology Entomology and Malaria Control Ministry of Health Phnom Penh Cambodia Ingerod Brastad Sweden (formerly at the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases) World Health Organization Geneva Switzerland

Background Clonorchiasis and opisthorchiasis, caused by the liver flukesClonorchis sinensis andOpisthorchis viverrini respectively, represent significant neglected tropical diseases (NTDs) in Asia. The co-existence of these pathogens in overlapping regions complicates effective disease control strategies. This study aimed to clarify the distribution and interaction of these diseases within Southeast *** We systematically collated occurrence records of human clonorchiasis (n = 1809) and opisthorchiasis (n = 731) across the Southeast Asia countries. Utilizing species distribution models incorporating environmental and climatic data, coupled machine learning algorithms with boosted regression trees, we predicted and distinguished endemic areas for each fluke species. Machine learning techniques, including geospatial analysis, were employed to delineate the boundaries between these *** Our analysis revealed that the endemic range ofC. sinensis andO. viverrini in Southeast Asia primarily spans across part of China, Vietnam, Thailand, Laos, and Cambodia. During the period from 2000 to 2018, we identifiedC. sinensis infections in 84 distinct locations, predominantly in southern China (Guangxi Zhuang Autonomous Region) and northern Vietnam. In a stark contrast,O. viverrini was more widely distributed, with infections documented in 721 locations across Thailand, Laos, Cambodia, and Vietnam. Critical environmental determinants were quantitatively analyzed, revealing annual mean temperatures ranging between 14 and 20 °C in clonorchiasis-endemic areas and 24–30 °C in opisthorchiasis regions (P < 0.05). The machine learning model effectively mapped a distinct demarcation zone, demonstrating a clear separation between the endemic areas of these two liver flukes with AUC from 0.9 to1. The study in Vietnam delineates the coexistence and geographical boundaries ofC. sinensis andO. viverrini, revealing distinct endemic zones and a transitional area where both live

关键词： Liver fluke Clonorchiasis Opisthorchiasis Clonorchis sinensis Opisthorchis viverrine Southeast Asia Machine learning Ecological study

Digital twin technology for thermal comfort and energy efficiency in buildings:A state-of-the-art and future directions

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Energy and Built Environment 2024年第5期5卷 641-656页

作者： Victor Adetunji Arowoiya robert Christian Moehler Yihai Fang Department of Civil engineering Monash University ClaytonVIC 3800Australia

In recent years,the integration of digital technologies has grown rapidly in the field of thermal comfort and energy efficiency for *** concept of a digital twin,incorporating multiple digital technologies,has gained increasing *** literature lacks a review of the digital twin concept in thermal comfort and energy consumption for existing *** paper conducts a review of the current state-of-the-art in digital twin(DT)technology for thermal comfort/energy consumption in *** review employs a scientometric approach and examines various technologies used in creating DTs and a systematic analysis of the methods,technologies,algorithms,and approaches used in digital twin *** results show a growing number of studies in this area,with a focus on thermal comfort monitoring,visualization,tracking,energy management,prediction,and optimization for existing ***,the prediction of energy consumption using algorithms such as Artificial Neural Networks(ANN),Artificial Intelligence(AI),deep neural networks,and YOLOv4 have been used in ***,the wider adoption of a DT that can facilitate occupants,and thermal sensations,enhance human-centered solutions,and improve energy prediction levels are *** is a need for further international collaboration to expand the studies on digital twins for thermal comfort and energy *** review highlights the limitations and areas of improvement,such as the limited adoption of sensors for environmental measures,the need for more focus on the subjective perception of occupants,and the need for more comparative studies of algorithms for predicting energy *** studies can be conducted in areas such as understanding occupant psychological responses/behaviors to comfort in the digital *** will enhance a more consolidated and robust validation for building performance.

关键词： Buildings Digital twin Thermal comfort Energy consumption Scientometric review

Commentary on “Why people should run after positive affective experiences instead of health benefits”

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Journal of Sport and Health Science 2024年第4期13卷 451-452页

作者： Ting Wang Jinghua Chen robert Schinke Liye Zou Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen 518060China School of Kinesiology and Health Sciences Laurentian UniversitySudburyON P3E 2C6Canada

Maltagliati et al.1 recently highlighted the vital role of affective experiences in promoting physical activity(PA).The authors suggested that positive affective experiences,rather than health benefits,can tip the balance in favor of PA over sedentary *** authors proposed a new formal decision model between PA and sedentary alternatives and reported that when health benefits are the unique reason to action,the costs of PA(e.g.,effort)and the subjective value(SV)of sedentary alternatives(V_(sed))are the main drivers of decision-making processes.

关键词： benefits formal decision

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公园道1号超高层公寓楼

世界建筑导报 2024年第3期39卷 118-121页

作者： Iwan Baan(摄) robert Rieger(摄) 不详

特征标签。该超高层公寓塔楼位于伦敦不断扩大的金丝雀码头新区,将成为该码头新区的一部分。建筑塔楼有助于重塑码头新区最后一大片未被开发场地的发展特征。它是一座同时具有标志造型和人性化规模的公寓塔楼,体现了其之于新环境的愿景... 详细信息

特征标签。该超高层公寓塔楼位于伦敦不断扩大的金丝雀码头新区,将成为该码头新区的一部分。建筑塔楼有助于重塑码头新区最后一大片未被开发场地的发展特征。它是一座同时具有标志造型和人性化规模的公寓塔楼,体现了其之于新环境的愿景、全球活力社区的延伸以及生活化社区的全新开始。塔楼几何。以现有金丝雀码头新区的建筑为背景,新塔楼的圆形外观明显区别于其正交范围内的邻居。塔楼的形态外观是超高层公寓建筑的一份声明。这栋住宅塔楼也给商业空间占据主导位置的地区增添了全新维度。项目位于金丝雀码头新区的西端,其圆形的塔楼外观能从四面八方看到,包括金丝雀码头的街道、新长廊和周围的水道。塔楼建筑还同时处理了当下和未来的背景语境,没有任何一个立面会比另一个立面更高。

关键词：高层公寓活力社区塔楼主导位置金丝雀码头立面人性化住宅

Are we close to using Alzheimer blood biomarkers in clinical practice?

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Neural Regeneration Research 2024年第12期19卷 2583-2585页

作者： Bruno P.Imbimbo Simone Lista Camillo Imbimbo robert Nisticò Department of Research&Development Chiesi FarmaceuticiParmaItaly i+HeALTH Strategic Research Group Department of Health SciencesMiguel de Cervantes European University(UEMC)ValladolidSpain Department of Brain and Behavioral Sciences University of PaviaPaviaItaly School of Pharmacy University of Rome“Tor Vergata”RomeItaly Laboratory of Pharmacology of Synaptic Plasticity EBRI Rita Levi-Montalcini FoundationRomeItaly

Alzheimer's disease(AD) is a progressive neurodegenerative disease histologically characterized by the presence of extraneuronal plaques,mainly formed by the 42-aminoacid isoform of amyloid-(Aβ_(1-42)),and by intraneuronal neurofibrillary to ngles,mainly formed by the tau protein and its hyperphosphorylated isoforms(p-tau).AD is the most common cause of dementia,with an estimated lifetime risk of about 1 in 10 for men and 1 in 5 for women.

关键词： Alzheimer tau Aβ

Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B:A comprehensive review of phases II and III therapeutic agents

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World Journal of Hepatology 2024年第3期16卷 331-343页

作者： robert Lam Joseph K Lim Section of Digestive Diseases Yale University School of MedicineNew HavenCT 06520United States

Chronic hepatitis B virus(HBV)infection affects over 295 million people globally and an estimated 1.6 million people in the United *** is associated with significant morbidity and mortality due to cirrhosis,liver failure,and liver *** therapy with oral nucleos(t)ide analogues is associated with high rates of virologic suppression,which in turn has been associated with a decreased risk of liver ***,current antiviral regimens are limited by concerns with adverse effects,adherence,resistance,long-term treatment,and ongoing risk for liver *** investigational agents are currently in development and are targeted at achieving functional cure with sustained hepatitis B surface antigen(HBsAg)loss and suppression of HBV *** we review key evidence from phases II and III trials defining the efficacy and safety profiles for key investigational agents for functional cure of chronic hepatitis B,including core/capsid inhibitors,entry inhibitors,RNA interference(siRNA/ASO),HBsAg inhibitors,Toll-like receptor agonists,checkpoint inhibitors,and therapeutic vaccines.

关键词： Hepatitis B virus Treatment Clinical trials RNA interference Entry inhibitors Core inhibitors Immunomodulators