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Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma

Bone Research 2022年第3期10卷 615-626页

作者： Qizhi Qin Mario Gomez-salazar Masnsen Cherief Chase A.Pagani Seungyong Lee Charles Hwang robert J.Tower Sharon Onggo Yuxiao Sun Abhinav Piplani Zhao Li Sowmya Ramesh Thomas L.Clemens Benjamin Levi Aaron W.James department of Pathology Johns Hopkins UniversityBaltimoreMD 21205USA Center for Organogenesis and Trauma Department of SurgeryUniversity of TexasSouthwesternTXUSA department of Plastic Surgery HarvardCambridgeMA 02138USA department of Orthopaedics Johns Hopkins UniversityBaltimoreMD 21205USA Baltimore Veterans Administration Medical Center BaltimoreMD 21201USA

The functional interdependence of nerves and blood vessels is a well-established concept during tissue morphogenesis, yet the role of neurovascular coupling in proper and aberrant tissue repair is an emerging field of interest. Here, we sought to define the regulatory relationship of peripheral nerves on vasculature in a severe extremity trauma model in mice, which results in aberrant cell fate and heterotopic ossification(HO). First, a high spatial degree of neurovascular congruency was observed to exist within extremity injury associated heterotopic ossification. Vascular and perivascular cells demonstrate characteristic responses to injury,as assessed by single cell RNA sequencing. This vascular response to injury was blunted in neurectomized mice, including a decrease in endothelial proliferation and type H vessel formation, and a downregulation of key transcriptional networks associated with angiogenesis. Independent mechanisms to chemically or genetically inhibit axonal ingrowth led to similar deficits in HO site angiogenesis, a reduction in type H vessels, and heterotopic bone formation. Finally, a combination of single cell transcriptomic approaches within the dorsal root ganglia identified key neural-derived angiogenic paracrine factors that may mediate neuron-to-vascular signaling in HO. These data provide further understanding of nerve-to-vessel crosstalk in traumatized soft tissues, which may reflect a key determinant of mesenchymal progenitor cell fate after injury.

关键词： aberrant trauma nerves

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Scintillation Arc from FRB 20220912A

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 134-142页

作者： Zi-Wei Wu robert AMain Wei-Wei Zhu Bing Zhang Peng Jiang Jia-Rui Niu Jin-Lin Han di Li Ke-Jia Lee dong-Zi Li Yuan-Pei Yang Fa-Yin Wang Rui Luo Pei Wang Chen-Hui Niu Heng Xu Bo-Jun Wang Wei-Yang Wang Yong-Kun Zhang Yi Feng de-Jiang Zhou Yong-Hua Xu Can-Min deng Yu-Hao Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Max-Planck-Institut für Radioastronomie Bonn 53121Germany Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Nevada Center for Astrophysics and department of Physics and Astronomy University of NevadaLas VegasNV 89154USA CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy University of Chinese Academy of SciencesBeijing 100049China NAOC-UKZN Computational Astrophysics Centre University of KwaZulu-NatalDurban 4000South Africa department of Astronomy Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Cahill Center for Astronomy and Astrophysics California Institute of TechnologyPasadena 91125USA South-Western Institute For Astronomy Research Yunnan UniversityKunming 650504China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China CSIRO Space and Astronomy Epping 1710Australia department of Astronomy School of Physics and Materials ScienceGuangzhou UniversityGuangzhou 510006China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Guangxi Key Laboratory for Relativistic Astrophysics Department of PhysicsGuangxi UniversityNanning 530004China

We present the interstellar scintillation analysis of fast radio burst(FRB)20220912A during its extremely active episode in 2022using data from the Five-hundred-meter Aperture Spherical Radio Telescope(FAST).We detect a scintillation arc in the FRB’s secondary spectrum,which describes the power in terms of the scattered FRB signals’time delay and doppler *** arc indicates that the scintillation is caused by a highly localized *** analysis favors a Milky Way origin of the ionized interstellar medium(IISM)for the localized scattering medium but cannot rule out a host galaxy *** present our method for detecting the scintillation arc,which can be applied generally to sources with irregularly spaced bursts or *** methods could help shed light on the complex interstellar environment surrounding the FRBs and in our Galaxy.

关键词： fast radio burst scintillation FRB 20220912A

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早寒武纪清江丝菌牵出硫酸盐还原菌与地球环境协同演化历史

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Science Bulletin 2024年第10期69卷 1486-1494页

作者：崔琳浩朱珂磊李瑞云常超吴来源刘伟傅东静刘沛余邱浩唐国强李秋立 robert R.Gaines 陶昕王寅李金华张兴亮 State Key Laboratory of Continental dynamics Shaanxi Key Laboratory of Early Life and EnvironmentsDepartment of GeologyNorthwest UniversityXi’an 710069China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China department of Geology Pomona CollegeClaremont CA 91711USA State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

Sulfate reduction is an essential metabolism that maintains biogeochemical cycles in marine and terrestrial *** reducers are exclusively prokaryotic,phylogenetically diverse,and may have evolved early in Earth’s ***,their origin is elusive and unequivocal fossils are *** we report a new microfossil,Qingjiangonema cambria,from518-million-year-old black shales that yield the Qingjiang *** is a long filamentous form comprising hundreds of cells filled by equimorphic and equidimensional pyrite microcrystals with a light sulfur isotope *** lines of evidence indicate Qingjiangonema was a sulfate-reducing bacterium that exhibits similar patterns of cell organization to filamentous forms within the phylum desulfobacterota,including the sulfate-reducing desulfonema and sulfide-oxidizing cable *** analyses confirm separate,independent origins of multicellularity in desulfonema and in cable *** clock analyses infer that the desulfobacterota,which encompass a majority of sulfate-reducing taxa,diverged~2.41 billion years ago during the Paleoproterozoic Great Oxygenation Event,while cable bacteria diverged~0.56 billion years ago during or immediately after the Neoproterozoic Oxygenation *** together,we interpret Qingjiangonema as a multicellular sulfate-reducing microfossil and propose that cable bacteria evolved from a multicellular filamentous sulfate-reducing *** infer that the diversification of the desulfobacterota and the origin of cable bacteria may have been responses to oxygenation events in Earth’s history.

关键词： Cambrian Qingjiangonema Sulfate-reducing bacteria Cable bacteria Qingjiang biota Black shale

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Locoregional therapies and their effects on the tumoral microenvironment of pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2022年第13期28卷 1288-1303页

作者： Thomas Lambin Cyril Lafon robert Andrew drainville Mathieu Pioche Frédéric Prat LabTAU INSERMCentre Léon BérardUniversitéLyon 1Univ LyonLyon 69003France department of Gastroenterology Hospices Civils de LyonEdouard Herriot HospitalLyon 69008France Service d’Endoscopie digestive Hôpital BeaujonAssistance Publique-Hôpitaux de ParisClichy 92110France INSERM U1016 Institut CochinUniversitéde ParisParis 75014France

Pancreatic ductal adenocarcinoma(PdAC) is expected to become the second leading cause of death from cancer by 2030. despite intensive research in the field of therapeutics, the 5-year overall survival is approximately 8%, with only 20% of patients eligible for surgery at the time of diagnosis. The tumoral microenvironment(TME) of the PdAC is one of the main causes for resistance to antitumoral treatments due to the presence of tumor vasculature, stroma, and a modified immune response. The TME of PdAC is characterized by high stiffness due to fibrosis, with hypo microvascular perfusion, along with an immunosuppressive environment that constitutes a barrier to effective antitumoral treatment. While systemic therapies often produce severe side effects that can alter patients’ quality of life, locoregional therapies have gained attention since their action is localized to the pancreas and can thus alleviate some of the barriers to effective antitumoral treatment due to their physical effects. Local hyperthermia using radiofrequency ablation and radiation therapy-most commonly using a local high single dose-are the two main modalities holding promise for clinical efficacy. Recently, irreversible electroporation and focused ultrasound-derived cavitation have gained increasing attention. To date, most of the data are limited to preclinical studies, but ongoing clinical trials may help better define the role of these locoregional therapies in the management of PdAC patients.

关键词： Pancreatic ductal adenocarcinoma Tumoral microenvironment Stroma Hyperthermia Radiation therapy High-intensity focused ultrasound

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Ultrahigh frame rate digital light projector using chip-scale LEd-on-CMOS technology

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Photonics Research 2022年第10期10卷 2434-2446页

作者： NAVId BANI HASSAN FAHIMEH dEHKHOdA ENYUAN XIE JOHANNES HERRNSdORF MICHAEL J.STRAIN robert HENdERSON MARTIN d.dAWSON Institute of Photonics Department of PhysicsUniversity of StrathclydeTechnology and Innovation CentreGlasgow G11RDUK School of Engineering Institute for Integrated Micro and Nano SystemsUniversity of EdinburghEdinburgh EH93JLUK

digital light projector systems are crucial components in applications,including computational imaging,fluorescence microscopy,and highly parallel data *** technology based on digital micromirror displays are limited to absolute frame rates in the few tens of kiloframes per second and require the use of external light sources and coupling ***,to realize gray-scale pixel values using duty cycle control,frame rates are reduced proportionally to the number of gray levels *** we present a self-emissive chip-scale projector system based on micro-LEd pixels directly bonded to a smart pixel CMOS drive *** 128×128 pixel array can project binary patterns at up to 0.5 Mfps and toggle between two stored frames at megahertz *** projector has a 5-bit gray-scale resolution that can be updated at up to 83 kfps,and can be held in memory as a constant bias for the binary pattern ***,the projector can be operated in a pulsed mode,with individual pixels emitting pulses down to a few nanoseconds in ***,this mode can be used in conjunction with the high-speed spatial pattern *** a demonstration of the data throughput achievable with this system,we present an optical camera communications application,exhibiting data rates of>5 Gb/s.

关键词： frame frames light

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Effects of Chemical Products on Fire Blight Suppression,and Fruit Production and Quality in Apple(Malus domestica Borkh.)*** Glory

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Phyton-International Journal of Experimental Botany 2022年第7期91卷 1341-1351页

作者： Álvaro Rodríguez-Peña Ana C.Gonzalez-Franco Jared Hernández-Huerta Nora A.Salas-salazar dámaris L.Ojeda-Barrios Esteban Sánchez Loreto Robles-Hernández Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaPascual OrozcoChihuahua31350México Centro de Investigación y desarrollo A.C. DeliciasChihuahua33089México

Antibiotics are widely used in fire blight management programs,yet there are no studies that demonstrate the evaluation of their efficacy in ***,the present study was conducted to investigate the effects of the active ingredients in five commercial products(Kasumin■2L,Agrygent Plus■,Agricultural Terramycin■,Agrimicin100,and Actigard■)on fire blight suppression,and fruit yield and quality of apple(Malus domestica Borkh.)*** *** experiment was conducted in a commercial orchard using a completely randomized block design,with six treatments:(1)Oxytetracycline[Ox],110 mg L^(−1);(2)Kasugamycin[Kas],4.7 mL L^(−1);(3)Oxytetracycline+Gentamicin[Ox+Gen],48 mg L^(−1)+12 mg L^(−1);(4)Streptomycin+Oxytetracycline[Str+Ox],90 mg L^(−1)+9 mg L^(−1);(5)Acibenzolar-S-methyl[ASM],70 mg L^(−1);and(6)Control,only water,with four replications,and three 11-year-old trees as an experimental *** of infection including flowers,shoots and fruits,yield and fruit quality were *** treatments suppressed infection in flowers,shoots,and *** provided the highest levels of reduction of flower and shoot infection,while Kas had the least effect on the reduction of infection in these *** Ox+Gen treatment had the greatest suppression of fruit infection,and the best results on fruit yield and quality,followed by Ox and *** is the first study conducted to evaluate the efficacy of the active ingredients of five commercial products used for the management of fire blight in apple trees in Mexico.

关键词： Erwinia amylovora oxytetracycline gentamicin kasugamycin streptomycin Acibenzolar-S-methyl

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Towards standardizing retinal optical coherence tomography angiography:a review

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Light(Science & Applications) 2022年第4期11卷 520-541页

作者： danuta M.Sampson Adam M.dubis Fred K.Chen robert J.Zawadzki david d.Sampson Surrey Biophotonics Centre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildford GU27XHUK NIHR Biomedical Research Centre at Moorflelds Eye Hospital NHS Trust and UCL Institute of Ophthalmology London EC1V 2PDUK. Centre for Ophthalmology and Visual Science(incorporating Lions Eye Institute) The University of Western AustraliaNedlandsWestern Australia 6009Australia. department of Ophthalmology Royal Perth HospitalPerthWestern Australia 6000Australia. Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneVictoria 3002Australia. department of Ophthalmology&Vision Science University of California DavisSacramentoCA 95817USA. Surrey Biophotonics Advanced Technology InstituteSchool of Physics and School of Biosciences and MedicineUniversity of SurreyGuildfordSurrey GU27XHUK

The visualization and assessment of retinal microvasculature are important in the study,diagnosis,monitoring,and guidance of treatment of ocular and systemic *** the introduction of optical coherence tomography angiography(OCTA),it has become possible to visualize the retinal microvasculature volumetrically and without a contrast *** lab-based and commercial clinical instruments,imaging protocols and data analysis methods and metrics,have been applied,often inconsistently,resulting in a confusing picture that represents a major barrier to progress in applying OCTA to reduce the burden of *** data and software sharing,and cross-comparison and pooling of data from different studies are *** inabilities have impeded building the large databases of annotated OCTA images of healthy and diseased retinas that are necessary to study and define characteristics of specific *** paper addresses the steps needed to standardize OCTA imaging of the human retina to address these *** review of the OCTA literature,we identify issues and inconsistencies and propose minimum standards for imaging protocols,data analysis methods,metrics,reporting of findings,and clinical practice and,where this is not possible,we identify areas that require further *** hope that this paper will encourage the unification of imaging protocols in OCTA,promote transparency in the process of data collection,analysis,and reporting,and facilitate increasing the impact of OCTA on retinal healthcare delivery and life science investigations.

关键词： transparency steps inconsistent

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Linear logistic regression with weight thresholding for flow regime classification of a stratified wake

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Theoretical & Applied Mechanics Letters 2023年第2期13卷 120-127页

作者： Xinyi L.d.Huang robert F.Kunz Xiang I.A.Yang department of Mechanical Engineering Penn State UniversityUniversity Park16802PAUSA

A stratified wake has multiple flow regimes,and exhibits different behaviors in these regimes due to the competing physical effects of momentum and *** work aims at automated classification of the weakly and the strongly stratified turbulence regimes based on information available in a full Reynolds stress ***,we generate a direct numerical simulation database with Reynolds numbers from 10,000 to 50,000 and Froude numbers from 2 to ***(100)independent realizations of temporally evolving wakes are computed to get converged ***,we train a linear logistic regression classifier with weight thresholding for automated flow regime *** classifier is designed to identify the physics critical to *** against data at one flow condition,the classifier is found to generalize well to other Reynolds and Froude *** results show that the physics governing wake evolution is universal,and that the classifier captures that physics.

关键词： Stratified wake Classification Supervised learning Full Reynolds stress modelling

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Nanocrystalline and Nanocomposite Magnetic Materials and Their Applications

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Journal of Iron and Steel Research(International) 2007年第4期14卷 69-74页

作者： robert d Shull Magnetic Materials Group National Institute of Standards and TechnologyGaithersburg MD 20899MarylandUSA

Nanocrystalline materials can possess bulk properties quite different from those commonly associated with conventional large-grained materials. Nanocomposites, a subset of nanocrystalline materials, in addition have been found to possess magnetic properties which are similar to, but different from, the properties of the individual constituents. New magnetic phenomena, unusual property combinations, and both enhanced and diminished magnetic property values are just some of the changes observed in magnetic nanocomposites from conventional magnetic materials. Here, a description will be presented of some of the exciting new properties discovered in nanomaterials and the magnetic applications envisioned for them.

关键词： nanocomposite ferromagnet magnetoresistance magnetic refrigeration domain imaging

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Structural and biological engineering of 3d hydrogels for wound healing

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生物活性材料(英文) 2023年第6期24卷 197-235页

作者： Mohammad Hadi Norahan Sara Cristina Pedroza-González Mónica Gabriela Sánchez-salazar Mario Moisés Álvarez Grissel Trujillo de Santiago Escuela de Ingeniería y Ciencias Tecnológico de MonterreyMonterreyNL64849Mexico Centro de Biotecnología-FEMSA Tecnológico de MonterreyMonterreyNuevo LeónCP64849Mexico departamento de Bioingeniería Tecnológico de MonterreyMonterreyNuevo LeónCP64849Mexico

Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause of death *** dressings are necessary to facilitate wound *** wound dressings may substantially reduce healing time,reduce the risk of recurrent infections,and reduce the disability and costs *** the path of engineering of an ideal wound dressing,hydrogels have played a leading *** are 3d hydrophilic polymeric structures that can provide a protective barrier,mimic the native extracellular matrix(ECM),and provide a humid *** to their advantages,hydrogels(with different architectural,physical,mechanical,and biological properties)have been extensively explored as wound dressing *** we describe recent studies on hydrogels for wound healing applications with a strong focus on the interplay between the fabrication method used and the architectural,mechanical,and biological performance ***,we review different categories of additives which can enhance wound regeneration using 3d hydrogel *** engineering for wound healing applications promises the generation of smart solutions to solve this pressing problem,enabling key functionalities such as bacterial growth inhibition,enhanced re-epithelialization,vascularization,improved recovery of the tissue functionality,and overall,accelerated and effective wound healing.

关键词： Wound healing Wound dressing Hydrogel Tissue engineering 3d culture

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