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Surgical management in pediatric neuroblastoma diagnosis and treatment:a 20-year,single-center experience

World Journal of Pediatrics 2022年第2期18卷 120-125页

作者： Brianna Spencer Akshilkumar Patel robert cilley Christa N.Grant Department of Surgery Penn State Health Milton SHershey Medical Center500 University DriveHersheyPA 17033USA Pennsylvania State University College of Medicine HersheyPAUSA Division of Pediatric Surgery Penn State Health Milton SHershey Medical CenterHersheyPAUSA

Background The currently utilized International Neuroblastoma Risk Group(INRG)staging system developed in 2009 uses image-defined risk factors as a measure of surgical risk,separating resectable neuroblastoma from those best preceded by *** previous International Neuroblastoma Staging System was based primarily on surgical *** hypothesized there would be a change to the role of the surgeon in neuroblastoma treatment in the more recent *** This is a single center 20-year retrospective analysis of 104 patients with International Classification of Diseases-9 and-10 codes for *** demographics,tumor site,cancer treatment modality,survival,biopsy technique,surgical intervention,and pathology staging were *** was analyzed by analysis of variance(ANOVA)and Student’s t *** There was a decrease in open surgeries for extra-adrenal neuroblastomas in the later decade(77%,31%,P=0.01).There was a narrowing of the time interval to surgery in the later cohort,likely as a result of uniformity in surgical timing on treatment protocols relying on INRG *** Our findings mirror changes in practice patterns *** found an increase in minimally invasive approaches but did not find a difference in the role of the surgeon under the INRG staging system.

关键词： International Neuroblastoma Risk Group International Neuroblastoma Staging System MYCN Neuroblastoma Resection

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