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Acta Metallurgica Sinica(English Letters) 2017年第4期30卷 376-389页

作者： robert blair Batric Pesic Jacob Kline Ian Ehrsam Krishnan Raja Chemical and Materials Engineering University of IdahoMoscow ID 83844-3024 USA

Addition of glycerol as a viscosity modifier in concrete is proposed to decrease the permeability of corrosion- inducing ions such as chloride and sulfate. In addition to controlling the permeability of concrete, glycerol could perform as an inhibitor of corrosion of rebar steel. Cyclic polarization studies were carried out on metallographically polished rebar steel specimens in actual concrete solutions at two different pH conditions （pH 12,5 and 9.0） and different chloride concentrations. The threshold concentration of chloride for passivity breakdown at pH 12.5 was greater than 50 × 10-3 mol/L in the absence of glycerol addition. The threshold increased to 81 × 10-3 mol/L upon addition of 2 wt% glycerol. The threshold chloride concentration for passivity breakdown in pH 9.0 cement solution was 0.2 × 10-3 mol/L without glycerol addition. No beneficial effect of glycerol was observed in the low pH condition. However, glycerol enhanced the passivation kinetics of the rebar steel in saturated cement solution, but did not affect the electronic properties of the passive layer. The passive layers exhibited n-type semiconductivity with a charge carrier density in the range of 2-7.5× 10^20 cm-3. Polarization of the specimens to potentials is higher than oxygen evolution potential, resulted in transition top-type semiconducting character due to an accumulation of holes. This phenomenon could be related to the passivity breakdown.

关键词： Corrosion Passive film Electrochemical impedance spectroscopy (EIS)

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动物营养研究的新信息(上)

国外畜牧科技 1993年第2期20卷 14-17页

作者： robert blair 金小军

在1991年英国诺丁汉营养讨论会上,与会者提供了一些有关生长猪的氨基酸利用、猪的能量—蛋白质互作、反刍动物的阴阳离子平衡及其对生产性能的影响,以及反刍动物营养模式等最新资料。

关键词：畜禽营养饲料

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动物营养研究的新信息(下)

国外畜牧科技 1993年第3期20卷 16-17页

作者： robert blair 金小军

7 公牛的集约化饲养臌胀病是肉牛密集饲养带来的主要问题之一.为此,应尽量少用谷物类饲料。对同一日粮进行不同粉碎度的对比试验结果表明,饲喂细颗粒日粮的牛群臌胀病率要比粗颗粒的高3倍,而自由采食秸秆可降低该病的发生率.并进一步提... 详细信息

7 公牛的集约化饲养臌胀病是肉牛密集饲养带来的主要问题之一.为此,应尽量少用谷物类饲料。对同一日粮进行不同粉碎度的对比试验结果表明,饲喂细颗粒日粮的牛群臌胀病率要比粗颗粒的高3倍,而自由采食秸秆可降低该病的发生率.并进一步提高日增重和饲料效率。在用青贮料集约饲养的肥育期.由于青贮料的能量浓度低于谷物类精料,牛的增重减慢,甚至不得不延长屠宰月龄（约15月龄）以获得相同大小的胴体。在实际生产中,这种肥育方法的另一个主要问题是,夏季应保持青贮料的品质和减少浪费,因为夏季的环境温度较高,青贮料易变质。苏格兰农业大学通过添加标准碱（NaHCO3）的方法。

关键词：动物营养饲料家畜

Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

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Cellular & Molecular Immunology 2022年第2期19卷 222-233页

作者： Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure robert V.blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward Medicago Inc. QuébecQCCanada. Institute for Immunity Transplantation and InfectionStanford University School of MedicineStanford UniversityStanfordCAUSA. Tulane National Primate Research Center CovingtonLAUSA. New Iberia Research Center University of Louisiana at LafayetteNew IberiaLAUSA. Department of Pathology Stanford University School of MedicineStanford UniversityStanfordCAUSA. Department of Microbiology and Immunology Tulane University School of MedicineNew OrleansLAUSA. Department of Microbiology and Immunology Stanford University School of MedicineStanford UniversityStanfordCAUSA. Institute for Immunity Transplantation&InfectionStanford University School of MedicineStanford UniversityStanfordCAUSA Research Institute of the McGill University Health Centre MontrealQCCanada.

Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)***-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against ***,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)*** a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted *** micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T *** were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of *** viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with *** clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated *** CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials.

关键词： SARS-CoV-2 Virus-like particles Non-humane primates AS03 CpG1018

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1990年加拿大营养研讨会内容简介

中国畜牧兽医 1991年第2期 25-28页

作者： robert blair 罗兰

加拿大今年的营养研讨会于5月在加拿大Saskatoon举行。现将这次研讨会所提论点、研究进展以及今后研究方向进行综合归纳。一、饲用油脂质量控制作为畜禽能量来源的油脂其主要成分是甘油三脂,游离脂肪酸和磷脂。可是在计算能量

关键词：饲料报酬家畜农畜仔猪日粮水质环境质量豆科植物谷物饲料理想蛋白油脂结构性碳水化合物生长速度钙需要量加拿大北美洲瘤胃第一胃前胃研讨会生长激素释放抑制因子可皂化物营养

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Multi-Scale Dilated Convolution Network for SPECT-MPI Cardiovascular Disease Classification with Adaptive Denoising and Attenuation Correction

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 299-327页

作者： A.robert Singh Suganya Athisayamani Gyanendra Prasad Joshi Bhanu Shrestha Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia School of Computing Sastra Deemed to be UniversityThanjavur613401Tamil NaduIndia Department of Artificial Intelligence&Software Kangwon National UniversitySamcheok25913Republic of Korea Department of Information Convergence System Graduate School of Smart ConvergenceKwangwoon UniversitySeoul01897Republic of Korea

Myocardial perfusion imaging(MPI),which uses single-photon emission computed tomography(SPECT),is a well-known estimating tool for medical diagnosis,employing the classification of images to show situations in coronary artery disease(CAD).The automatic classification of SPECT images for different techniques has achieved near-optimal accuracy when using convolutional neural networks(CNNs).This paper uses a SPECT classification framework with three steps:1)Image denoising,2)Attenuation correction,and 3)Image *** denoising is done by a U-Net architecture that ensures effective image *** correction is implemented by a convolution neural network model that can remove the attenuation that affects the feature extraction process of ***,a novel multi-scale diluted convolution(MSDC)network is *** merges the features extracted in different scales and makes the model learn the features more *** scales of filters with size 3×3 are used to extract *** three steps are compared with state-of-the-art *** proposed denoising architecture ensures a high-quality image with the highest peak signal-to-noise ratio(PSNR)value of *** proposed classification method is compared with the five different CNN models,and the proposed method ensures better classification with an accuracy of 96%,precision of 87%,sensitivity of 87%,specificity of 89%,and F1-score of 87%.To demonstrate the importance of preprocessing,the classification model was analyzed without denoising and attenuation correction.

关键词： SPECT-MPI CAD MSDC denoising attenuation correction classification

Three-Stage Transfer Learning with AlexNet50 for MRI Image Multi-Class Classification with Optimal Learning Rate

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 155-183页

作者： Suganya Athisayamani A.robert Singh Gyanendra Prasad Joshi Woong Cho School of Computing Sastra Deemed to be UniversityThanjavur613401India Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India Department of AI and Software Engineering Kangwon National UniversitySamcheok25913Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological *** is particularly effective for detecting soft tissue ***,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of *** address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI *** manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning *** are three stages for learning;in the first stage,the whole dataset is used to learn the *** the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented *** method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the School of Biomedical Engineering of Southern Medical University(SMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINS-dataset)for *** hyperparameter optimizers like Adam,stochastic gradient descent(SGD),Root mean square propagation(RMS prop),Adamax,and AdamW have been used to compare the performance of the learning ***-dataset registers maximum classification *** evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.

关键词： MRI tumors classification AlexNet50 transfer learning hyperparameter tuning optimizer

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen robert J.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis