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中国天文学会恒星分会2004年学术年会

作者： robert a.jacobson Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadenaCA 91109-8099

We have fitted numerically integrated orbits for the major Saturnian satellites to a large set of astrometric observations over the time interval 1966 September to 2003 December and to data obtained w

关键词： planets and satellites: general — planets and satellites: individual (Saturn) — solar system: general

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Effective teaching of endoscopy:a qualitative study of the perceptions of gastroenterology fellows and attending gastroenterologists

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Gastroenterology Report 2016年第2期4卷 125-130,I0002页

作者： Daniel J.Zanchetti Samuel A.Schueler Brian C.jacobson robert C.Lowe Boston University Medical Center BostonMAUSA

Background:There is little information describing the perceptions of gastroenterology fellows and attending gastroenterologists of what constitutes effective teaching of *** sought to identify common themes regarding endoscopy training methods and their impact among fellows and ***:Focus group exercises and surveys were conducted among fellows,about educational resources,teaching techniques and ways of improving the teaching of *** fellows identified the‘best’teachers of endoscopy,who were interviewed regarding their training in endoscopy,their teaching methods,key points of information,and opinions on endoscopy ***:Nineteen fellows(68%)had attended the American Society for Gastrointestinal Endoscopy First Year Fellows’Endoscopy course and found it very *** fellows(46%)had exposure to an endoscopy simulator,but their median duration of use was only 1 *** two out of five fellowship programs used a formal endoscopic skill assessment tool and none of the programs had an endoscopy curriculum of which the fellows were *** reported that they learned endoscopy best by performing *** also volunteered that attending gastroenterologists used variable teaching methods,and might benefit from instruction on how to teach *** attending gastroenterologists(77%)had received training in advanced procedures;none received formal training on teaching endoscopy:they all felt that such training would be ***:A standardized endoscopy curriculum may be beneficial to fellows,who prefer to learn endoscopy by performing procedures—but they want explicit and specific *** those attending and the fellows thought that formal instruction for attending gastroenterologists on how to teach endoscopy would be beneficial,indicating a role for a‘teachthe-teacher’curriculum.

关键词： endoscopy curriculum teaching endoscopy gastroenterology fellowship training

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麻疯病的治疗

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国外医药（抗生素分册） 1990年第3期11卷 213-216页

作者： robert R.jacobson 张荣富

正如大多数疾病的情况一样,在麻疯病方面所取得的进展不是很快而是很慢。如果以习惯为例,则氨苯砜(Dapson)或氯苯吩嗪(Clofazimine)的单一疗法,仍然广泛地用于治疗麻疯病,且通常奏效。由于含菌少的(不确定的、结核节样的以及边界的-结... 详细信息

正如大多数疾病的情况一样,在麻疯病方面所取得的进展不是很快而是很慢。如果以习惯为例,则氨苯砜(Dapson)或氯苯吩嗪(Clofazimine)的单一疗法,仍然广泛地用于治疗麻疯病,且通常奏效。由于含菌少的(不确定的、结核节样的以及边界的-结核节样的)患者需要治疗3～7年,而多种杆菌的(中央的-边界的、边界的-麻疯结节的和麻疯结节的)病人需要终身治疗,故病人的顺应性依然是一个难题。由于原发性和继发性氨苯砜耐药性已经发生,复发也就成为常见而严重的问题,因此,不可能再推荐单一疗法。

关键词：麻疯病

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Daclatasvir vs telaprevir plus peginterferon alfa/ribavirin for hepatitis C virus genotype 1

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World Journal of Gastroenterology 2016年第12期22卷 3418-3431页

作者： Ira.jacobson Stefan Zeuzem robert Flisiak Brygida Knysz Stefan Lueth Dorota Zarebska-Michaluk Ewa Janczewska Peter Ferenci Moises Diago Anna Linda Zignego Rifaat Safadi Yaacov Baruch Dzhamal Abdurakhmanov Stephen Shafran Dominique Thabut Rafael Bruck Adrian Gadano Alexander James Thompson Justin Kopit Fiona Mc Phee Tracy Michener Eric A Hughes Philip D Yin Stephanie Noviello Weill Cornell Medical College New YorkNY 10029United States Icahn School of Medicine at Mount Sinai New YorkNY 10029United States JW Goethe University Hospital 60323 FrankfurtGermany Uniwersytet Medyczny w Bialymstoku 15-089 BialystokPoland EMC and Medical University 50-220 WroclawPoland Universitatsklinikum Hamburg-Eppendorf 20246 HamburgGermany Wojewodzki Szpital Zespolony w Kielcach 25-736 KielcePoland ID Clinic 41-400 MyslowicePoland Medizinische Universitat Wien 1090 ViennaAustria Clinica Quiron 46010 ValenciaSpain Universita degli Studi di Firenze 50121 FlorenceItaly Holy Family Hospital Nazareth 6004Israel Rambam Medical Center Haifa 31096Israel 1st Moscow State Medical University N.A.I.M.Sechenov 119991 MoscowRussia University of Alberta Hospital EdmontonAlberta T6G 2B7Canada Groupe Hospitalier Pitie-Salpetriere 75013 ParisFrance Tel Aviv Sourasky Medical Center and Tel Aviv University Tel Aviv 64239Israel Hospital Italiano de Buenos Aires Buenos Aires C1181ACHArgentina St.Vincents Hospital and the University of Melbourne Melbourne 3065Australia Fiona McPhee Bristol-Myers Squibb Research and DevelopmentWallingfordCT 06492United States Bristol-Myers Squibb Research and Development PrincetonNJ 08450United States

AIM: To evaluate daclatasvir vs telaprevir, each combined with peginterferon alfa-2a/ribavirin(peg IFN/RBV), in treatment-naive hepatitis C virus(HCV) genotype(GT) 1-infected ***: In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned(2:1) to daclatasvir vs telaprevir, stratified by IL28 B rs12979860 host genotype(CC vs non-CC), cirrhosis status(compensated cirrhosis vs no cirrhosis), and HCV GT1 subtype(GT1a vs GT1b). Patients were selected by study inclusion criteria from a total of 793 enrolled patients. Patients received daclatasvir 60 mg once daily or telaprevir 750 mg 3 times daily plus peg IFN/RBV. Daclatasvir recipients received 24 wk of daclatasvir plus peg IFN/RBV; those without an extended rapid virologic response(e RVR; undetectable HCV-RNA at weeks 4 and 12) received an additional 24 wk of peg IFN/RBV. Telaprevir-treated patients received 12 wk of telaprevir plus peg IFN/RBV followed by 12(with e RVR) or 36(no e RVR) wk of peg IFN/RBV. The primary objective was to compare for noninferiority of sustained virologic response rates at posttreatment week 12(SVR12) in GT1b-infected patients. Key secondary objectives were to demonstrate that the rates of anemia(hemoglobin < 10 g/d L) and rashrelated events, through week 12, were lower with daclatasvir + peg IFN/RBV than with telaprevir + peg IFN/RBV among GT1b-infected patients. Resistance testing was performed using population-based sequencing of the NS5 A region for all patients at baseline, and for patients with virologic failure or relapse and HCV-RNA ≥ 1000 IU/m L, to investigate any link between NS5 A polymorphisms associated with daclatasvir resistance and virologic outcome. RESULTS: Patient demographics and disease characteristics were generally balanced across treatment arms; however, there was a higher proportion of black/African Americans in the daclatasvir groups(6.0% and 8.2% in the GT1 b and GT1 a groups, respectively) than in the telaprevi

关键词： Direct-acting antiviral Chronic hepatitis C Daclatasvir Genotype 1b NS5A inhibitor Liver disease

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使用直接作用抗病毒药物实现持续病毒学应答后的新发肝细胞癌的发生率和预测因素:来自吉利德Svr和肝硬化登记处的结果

使用直接作用抗病毒药物实现持续病毒学应答后的新发肝细胞癌的发...

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第十届全国疑难及重症肝病大会

作者： K.Rajender REDDY Ira M.jacobson Armand Abergel Barbara A.Leggett Charles S.Landis robert Hyland Frances Chen Liyun Ni Anu O.Osinusi Diana Brainard Jose Luis Calleja Eric J.Lawitz Andrew Joseph Muir Alessandra Mangia UniversityofPennsylvania QIMRBerghoferMedicalResearchInstitute UniversityofWashington CentroDeInvestigacionBiomedicaEnRedDeEnfermedadesHepaticasyDigestivas(CIBERehd) Irccs-OspedaleCasaSollievoDellaSofferenza CHUClermontFerrand GileadSciencesInc. DukeClinicalResearchInstitute NewYorkUniversity GileadSciences Inc. TexasLiverInstitute UniversityofTexasHealthSanAntonio

背景一些研究表明,使用直接作用抗病毒药物(DAA)实现持续病毒学应答(SVR)与肝细胞癌(HCC)发生的减少相关。本研究评估了在吉利德登记处的一支包括6700余名患者的特征良好的队列中的SVR后新发HCC的发生率和预测因素。方法本研究进行了一...

背景一些研究表明,使用直接作用抗病毒药物(DAA)实现持续病毒学应答(SVR)与肝细胞癌(HCC)发生的减少相关。本研究评估了在吉利德登记处的一支包括6700余名患者的特征良好的队列中的SVR后新发HCC的发生率和预测因素。方法本研究进行了一项汇总分析,评估了吉利德SVR和肝硬化登记处的患者中的新发HCC的

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