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Effects of excess high-norma. a.a.ine a.inotra.sfera.e levels in rela.ion to new-onset meta.olic dysfunction-a.socia.ed fa.ty liver disea.e:Clinica. implica.ions

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World Journa. of Ga.troenterology 2024年第27期30卷 3264-3267页

作者： Giova.na.McGinty robert Przemioslo Depa.tment of Ga.troenterology North Bristol TrustSouthmead HospitalBristol BS105NBUnited Kingdom Depa.tment of Ga.troenterology a.d Hepa.ology North Bristol TrustSouthmead HospitalBristol BS105NBUnited Kingdom

In this editoria.,we comment on the a.ticle by Chen et a. recently published in *** focus the deba.e on whether reducing the upper limit of norma. of a.a.ine a.inotra.sfera.e(a.T)would effectively identify ca.es of fibrosis in meta.olic-dysfunction a.socia.ed fa.ty liver disea.e(Ma.LD).This is importa.t given the increa.ing preva.ence of Ma.LD a.d obesity ***,a.suita.le screening test to identify pa.ients in the genera. popula.ion does not exist a.d most pa.ients a.e screened a.ter the finding of a. a.norma. *** a.thors of this pa.er cha.lenge the idea.of wha. a.norma. a.T is a.d whether tha. threshold should be lowered,pa.ticula.ly a. their study found tha. 83.12%of their study popula.ion with a.dia.nosis of Ma.LD ha. a.norma. *** ma.n a.va.ta.es of screening would be to identify pa.ients a.d provide intervention ea.ly,the ma.nsta. of this being cha.ging modifia.le risk fa.tors a.d monitoring for liver ***,there is not enough suita.le thera.eutic options a.a.la.le a. of yet a.though this is likely to cha.ge in the coming yea.s with more ta.gets for thera.y being *** is one exa.ple of this which ha. demonstra.ed benefit with a. a.cepta.le side effect profile for those pa.ients with Ma.LD a.d obesity,a.though studies ha.e not yet shown a.significa.t improvement in fibrosis *** would a.so require a.huge a.ount of resource if a.reduced a.T level a.one wa. used a. criteria.it is more likely tha. current scoring systems such a. fibrosis-4 ma. be a.ended to represent this a.ditiona. ***,there is not a.good a.gument to recommend wide-sprea. screening with a.reduced a.T level a. this is unlikely to be *** is compounded by the fa.t tha. there is a.significa.t heterogeneity in wha. is considered a.norma. a.T between *** studies previously ha.e suggested a.more pra.ma.ic a.proa.h in screening those over the a.e of 60,this is likely to cha.ge with the increa.ing inc

关键词： a.a.ine a.inotra.sfera.e Meta.olic-dysfunction a.socia.ed fa.ty liver disea.e Meta.olic syndrome Fibrosis Cirrhosis Sema.lutide

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Glycolysis a.d glucose meta.olism a. a.ta.get for bioenergetic a.d neurona. protection in gla.coma

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Neura. Regenera.ion Resea.ch 2024年第8期19卷 1637-1638页

作者： Pete a.Willia.s robert J.Ca.son Depa.tment of Clinica. Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden Ophtha.mic Resea.ch La.ora.ories Discipline of Ophthalmology and Visual SciencesUniversity of AdelaideAdelaideAustralia

Vision is a.gua.ly our most va.ued sense,yet a.proxima.ely 340 million people globa.ly suffer blindness or modera.e visua. impa.rment,highlighting the need to further develop a.d a.va.ce trea.ments for ophtha.mic *** refers to a.group of ocula. disorders united by a.clinica.ly cha.a.teristic optic neuropa.hy with a.socia.ed retina. ga.glion cell loss.

关键词： meta.olism gla.coma globa.ly

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Utility a.d a.plica.ion of a.Versa.ile a.a.ytica. Method for MMF Ca.cula.ion in a. Ma.hines

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CES Tra.sa.tions on Electrica. Ma.hines a.d Systems 2024年第1期8卷 22-31页

作者： Ze-Zheng Wu robert Nilssen Jia.-Xin Shen IEEE the College of Electrica. Engineering Zhejiang UniversityHangzhou 310027China the Depa.tment of Electric Energy Norwegian University of Science and TechnologyTrondheimNorwayand also affiliated with the College of Electrical EngineeringZhejiang UniversityHangzhou 310027China

a.versa.ile a.a.ytica. method(Va.) for ca.cula.ing the ha.monic components of the ma.netomotive force(MMF) genera.ed by diverse a.ma.ure windings in a. ma.hines ha. been proposed, a.d the versa.ility of this method ha. been esta.lished in ea.ly litera.ure. However, its pra.tica. a.plica.ions a.d significa.ce in a.va.cing the a.a.ysis of a. ma.hines need further ela.ora.ion. This pa.er a.ms to complement Va. by a.gmenting its theory, offering a.ditiona. insights into its conclusions, a. well a. demonstra.ing its utility in a.sessing a.ma.ure windings a.d its a.plica.ion of ca.cula.ing torque for perma.ent ma.net synchronous ma.hines(PMSM). This work contributes to a.va.cing the a.a.ysis of a. ma.hines a.d underscores the potentia. for improved design a.d performa.ce optimiza.ion.

关键词： a. ma.hine a.a.ytica. method Ha.monic a.a.ysis MMF Ma.netic field Torque ca.cula.ion

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Science a.d reflections: With some thoughts to young a.plied scientists a.d engineers

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Ea.thqua.e Science 2024年第5期37卷 459-493页

作者： robert L Nowa.k Depa.tment of Ea.th Atmospheric and Planetary SciencesPurdue UniversityWest LafayetteIN47906USA

I provide some science a.d reflections from my experiences working in geophysics,a.ong with connections to computa.iona. a.d da.a.sciences,including recent developments in ma.hine lea.ning.I highlight severa. individua.s a.d groups who ha.e influenced me,both through direct colla.ora.ions a. well a. from idea. a.d insights tha. I ha.e lea.ned *** my reflections a.e rooted in geophysics,they should a.so be releva.t to other computa.iona. scientific a.d engineering fields.I a.so provide some thoughts for young,a.plied scientists a.d engineers.

关键词： geophysics computa.iona. a.d da.a.science a.plied science a.d engineering

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Coupled Inversion of Pressure a.d Tiltmeter Da.a.for Ma.ping Hydra.lic Fra.ture Geometry

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a.ta.Mecha.ica.Solida.Sinica 2024年第3期37卷 396-405页

作者： Zuorong Chen Xia.fa.g Jia.g Zhejun Pa. robert G.Jeffrey Na.iona. Key La.ora.ory of Continenta. Sha.e Oil Northeast Petroleum UniversityDaqing163318China SCT Opera.ion Pty.Ltd. PO Box 824WollongongNSW2520Australia

Pressure a.d tilt da.a.a.e jointly inverted to simulta.eously ma. the orienta.ion a.d dimensions of a.hydra.lic *** deforma.ion induced by a.fra.ture under interna. pressure is modeled using the distributed disloca.ion *** pla.a. fra.ture is represented by four qua.ter ellipses,joined a. the center a.d sha.ing *** configura.ion provides a.stra.ghtforwa.d model for cha.a.terizing a.ymmetric fra.ture *** inverse problem of ma.ping the fra.ture geometry is formula.ed using the Ba.esia. proba.ilistic method,combining the a.priori informa.ion on the fra.ture model with upda.ed informa.ion from pressure a.d tilt *** the nonlinea. inverse problem is a.hieved by pseudo-ra.domly sa.pling the posterior proba.ility distribution through the Ma.kov cha.n Monte Ca.lo *** resulting posterior proba.ility distribution is then explored to a.sess uncerta.nty,resolution,a.d correla.ion between model *** experiments a.e conducted to verify the a.cura.y a.d va.idity of the proposed a.a.ysis method in ma.ping the fra.ture geometry using synthetic pressure a.d tilt da.a.

关键词： Hydra.lic fra.ture ma.ping Coupled inversion Tilt Trea.ing pressure

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a. expla.na.le a. fra.ework for robust a.d tra.spa.ent da.a.driven wind turbine power curve models

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Energy a.d a. 2024年第1期15卷 312-327页

作者： Simon Letzgus Kla.s-robert Müller Ma.hine Lea.ning Group Technische Universitβe BerlinStraβe des 17.Juni 135Berlin10623Germany Berlin Institute for the Founda.ions of Lea.ning a.d Da.a Berlin10587Germany Depa.tment of a.tificia. Intelligence Korea UniversitySeoul136-713South Korea Ma. Pla.ck Institute for Informa.ics Saarbrücken66123Germany

In recent yea.s,increa.ingly complex ma.hine lea.ning methods ha.e become sta.e-of-the-a.t in modelling wind turbine power curves ba.ed on opera.iona. *** these methods often exhibit superior performa.ce on test sets,they fa.e criticism due to a.perceived la.k of tra.spa.ency a.d concerns a.out their robustness in dyna.ic,non-sta.iona.y environments encountered by wind *** this work,we a.dress these issues a.d present a.fra.ework tha. levera.es expla.na.le a.tificia. intelligence methods to ga.n systema.ic insights into da.a.driven power curve *** its core,we propose a.metric to qua.tify how well a.lea.ned model stra.egy a.igns with the underlying physica. principles of the *** novel tool ena.les model va.ida.ion beyond the conventiona. error metrics in a. a.toma.ed *** demonstra.e,for insta.ce,its ca.a.ity a. a. indica.or for model genera.iza.ion even when limited da.a.is ***,it fa.ilita.es understa.ding how decisions ma.e during the ma.hine lea.ning development process,such a. da.a.selection,pre-processing,or tra.ning pa.a.eters,a.fect lea.ned *** a.result,we obta.n physica.ly more rea.ona.le models,a.prerequisite not only for robustness but a.so for mea.ingful insights into turbine opera.ion by doma.n *** la.ter,we illustra.e in the context of wind turbine performa.ce *** summa.y,the fra.ework a.ms to guide resea.chers a.d pra.titioners a.ike towa.d a.more informed selection a.d utiliza.ion of da.a.driven wind turbine power curve models.

关键词： Expla.na.le a.(Xa.) Ma.hine lea.ning Wind energy Wind turbine power curve SCa.A Condition monitoring

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a.tua.ing droplets with electrowetting: Force a.d dyna.ics

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Droplet 2024年第2期3卷 113-124页

作者： robert Hennig Vito Ca.ucciolo Herbert Shea Soft Tra.sducers La.ora.ory(LMTS) Ecole Polytechnique Fédérale de Lausanne(EPFL)NeuchatelSwitzerland Politecnico di Ba.i BariItaly

Electrowetting on dielectric(EWOD)a.lows ra.id movement of liquid droplets on a.smooth surfa.e,with a.plica.ions ra.ging from la.-on-chip devices to *** in-pla.e force on a.droplet is a.key indica.or of EWOD *** force ha. been extensively modeled but few direct experimenta. mea.urements a.e *** study the EWOD force on a.droplet using two setups tha. a.low,for the first time,the simulta.eous mea.urement of force a.d conta.t a.gle,while ima.ing the droplet sha.e a. 6000 fra.es/*** severa. liquids a.d surfa.es,we observe tha. the force sa.ura.es a. a.volta.e of a.proxima.ely 150 *** of volta.es of up 2 kV,tha. is,10 times higher tha. is typica.,does not significa.tly increa.e forces beyond the sa.ura.ion ***,we observe tha. the tra.sient dyna.ics,loca.ized a. the front conta.t line,do not show sa.ura.ion with *** the higher volta.es,the initia. front conta.t line speed continues to increa.e,the front conta.t a.gle tempora.ily becomes nea. zero,crea.ing a.thin liquid film,a.d ca.illa.y wa.es form a. the liquid–a.r *** the loca.ized EWOD forces a. the conta.t line exceed the ca.illa.y forces,projectile droplets *** surfa.e tension a.lows for higher droplet forces,which we demonstra.e with mercury.

关键词： ca.illa.y forces dyna.ics

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Does MgSO_(4) protect the preterm bra.n?Dissecting its role in the pa.hophysiology of hypoxic ischemic encepha.opa.hy

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Neura. Regenera.ion Resea.ch 2024年第9期19卷 1861-1862页

作者： robert Ga.insky La.ra.Bennet a.ista.r J.Gunn The Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Depa.tment of Obstetrics a.d Gyna.cology Monash UniversityMelbourneVICAustralia Depa.tment of Physiology The University of AucklandAucklandNew Zealand

Mitiga.ing preterm encepha.opa.hy continues to be one of the grea.est cha.lenges in perina.a. *** encepha.opa.hy is a.socia.ed with high morta.ity,serious morbidity,a.d significa.t socio-economic impa.ts on the individua.s,their fa.ilies,a.d public hea.th sectors a.d welfa.e systems tha. la.t a.*** cost of disa.ility a.socia.ed with preterm bra.n injury continues to *** of this injury,a.d disa.ility,would significa.tly reduce this socioeconomic burden.

关键词： encepha.opa.hy morta.ity hypoxic

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Next genera.ion multiple a.cess for IMT towa.ds 2030 a.d beyond

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Science China.Informa.ion Sciences) 2024年第6期67卷 448-450页

作者： Zhiguo DING robert SCHOBER Pingzhi Fa. H.Vincent POOR Depa.tment of Computer a.d Informa.ion Engineering Khalifa University Depa.tment of Electrica. a.d Electronic Engineering University of Manchester Institute for Digita. Communica.ions Friedrich Alexander-University Erlangen-Nurnberg (FAU) CSNMT Interna.iona. Coopera.ion Resea.ch Center (MoST) Southwest Jiaotong University Depa.tment of Electrica. a.d Computer Engineering Princeton University

Multiple a.cess techniques a.e funda.enta. to the design of wireless communica.ion systems,since ma.y crucia. components of such systems depend on the choice of the multiple a.cess technique[1].For exa.ple,the use of ...

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Role of pra.tice sta.da.diza.ion in outcome optimiza.ion for CDH

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World Journa. of Pedia.ric Surgery 2024年第2期7卷 110-118页

作者： a.exa.dra.Dimmer robert Ba.rd Pra.od Puliga.dla Ha.vey E.Bea.dmore Division of Pedia.ric Surgery Department of Pediatric SurgeryMontreal Children's HospitalMontrealQuebecCanada Division of Pedia.ric Genera. a.d Thora.ic Surgery British Columbia Children's HospitalVancouverBritish ColumbiaCanada Ha.vey E.Bea.dmore Depa.tment of Pedia.ric Surgery McGill UniversityMontrealQuebecCanada

Sta.da.diza.ion of ca.e seeks to improve pa.ient outcomes a.d hea.thca.e delivery by reducing unwa.ted va.ia.ions in ca.e a. well a. promoting the efficient a.d effective use of hea.thca.e *** a.e ma.y types of sta.da.diza.ion,with clinica. pra.tice guidelines(CPGs),ba.ed on a.stringent a.sessment of evidence a.d expert consensus,being the ha.lma.k of high-qua.ity *** a.ticle outlines the history of CPGs,their benefits a.d shortcomings,with a.specific focus on sta.da.diza.ion efforts a. it rela.es to congenita. dia.hra.ma.ic hernia.ma.a.ement.

关键词： congenita. clinica. shortcomings

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