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Lipid droplets in the nervous system:involvement in cell meta.olic homeosta.is

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 740-750页

作者： Yuchen Zha.g Yiqing Chen Cheng Zhua.g Jingxua. Qi robert Chunhua.Zha. Jia. Wa.g School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Ba.ic Medica. Sciences Chinese a.a.emy of Medica. Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key La.ora.ory of New Drug Development a.d Clinica. Tria. of Stem Cell Thera.y BeijingChina

Lipid droplets serve a. prima.y stora.e orga.elles for neutra. lipids in neurons,glia. cells,a.d other cells in the nervous *** droplet forma.ion begins with the synthesis of neutra. lipids in the endopla.mic ***,lipid droplets were recognized for their role in ma.nta.ning lipid meta.olism a.d energy homeosta.is;however,recent resea.ch ha. shown tha. lipid droplets a.e highly a.a.tive orga.elles with diverse functions in the nervous *** a.dition to their role in regula.ing cell meta.olism,lipid droplets pla. a.protective role in va.ious cellula. stress ***,lipid droplets exhibit specific functions in neurons a.d glia. *** of lipid droplet forma.ion lea.s to cellula. dysfunction,meta.olic a.norma.ities,a.d nervous system *** review a.ms to provide a. overview of the role of lipid droplets in the nervous system,covering topics such a. biogenesis,cellula. specificity,a.d ***,it will explore the a.socia.ion between lipid droplets a.d neurodegenera.ive *** the involvement of lipid droplets in cell meta.olic homeosta.is rela.ed to the nervous system is crucia. to determine the underlying ca.ses a.d in exploring potentia. thera.eutic a.proa.hes for these disea.es.

关键词： a.zheimer's disea.e lipid droplet biogenesis lipid droplets lipid meta.olism nervous system neurodegenera.ive disorders oxida.ive stress Pa.kinson's disea.e

Public hea.th importa.ce of light intensity physica. a.tivity

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Journa. of Sport a.d Hea.th Science 2024年第5期13卷 674-675页

作者： robert Ross Ia. Ja.ssen Ma.k S.Trembla. School of Kinesiology a.d Hea.th Studies Queen’s UniversityKingstonON K7L 3N6Canada School of Medicine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada Hea.thy a.tive Living a.d Obesity Resea.ch Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Depa.tment of Pedia.rics University of OttawaOttawaON K1H 8L1Canada

*** intensity physica. a.tivity(Pa.benefits hea.th Pa.guidelines worldwide recommend tha. a.ults a.cumula.e 150 min of modera.e intensity or 75 min of vigorous intensity Pa.modera.e-to-vigorous Pa.MVPa.)weekly to a.hieve hea.th benefits.1-3 a.sent from these guidelines a.e recommenda.ions for light intensity Pa.LPa.e.g.,wa.king a. a.leisurely pa.e of 3 km/h or less,equiva.ent to 1.5-2.9 meta.olic equiva.ents).

关键词： intensity light benefits

Cha.a.teriza.ion of squa.h polysa.cha.ide a.d the a.ti-dia.etic effect on type 2 dia.etic ra. revea.ed by urine meta.olomics a.a.ysis

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Food Science a.d Huma. Wellness 2024年第5期13卷 2937-2946页

作者： Li Lia.g Fuming Zha.g Qua.hong Li Ba.guo Sun Yuyu Zha.g robert J.Linha.dt Beijing a.va.ced Innova.ion Center for Food Nutrition a.d Huma. Hea.th Beijing Key Laboratory of Flavor ChemistryBeijing Technology and Business University(BTBU)Beijing 100048China Depa.tments of Chemica. a.d Biologica. Engineering Chemistry and Chemical BiologyBiomedical Engineering and Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroy 12180USA College of Food Science a.d Nutritiona. Engineering China Agricultural UniversityBeijing 100083China China.Na.iona. Engineering Resea.ch Center for Fruit a.d Vegeta.le Processing Beijing 100083China

The present study reports the structura. cha.a.teristics of 3 polysa.cha.ide fra.tions(SPS-F1,SPS-F2 a.d SPS-F3)isola.ed a.d purified from ***-F1(molecula. weight(Mw)=12.30 kDa.a.d SPS-F2(Mw=19.40 kDa.were likely to conta.n HG a.d RG-I doma.n of pectic polysa.cha.ide,***-F2(Mw=270.4 kDa.wa. ma.nly composed of rha.nose,ga.a.tose a.d *** trea.ment with SPS decrea.ed body weight ga.n,glucose a.d TG levels in type 2 dia.etes ***,25 differentia. meta.olites were identified ba.ed on urina.y meta.olomics a.a.ysis,which a.e crucia. to the a.ti-dia.etic effect of *** regula.ion of nicotina.ide N-oxide,hista.ine,cis-a.onita.e,citra.e,L-ma.ic a.id,3-(3-hydroxyphenyl)propa.oic a.id a.d N-a.etyl-L-a.pa.tic a.id were ma.nly a.socia.ed with energy meta.olism,gut microbiota.a.d *** of surfa.e pla.mon resona.ce revea.ed the binding kinetics with ga.ectin-3(Ga.-3)a.d fibrobla.t growth fa.tor 2(FGF2).The K_(D)va.ues of SPS-F2 a.d SPS-F3 to Ga.-3 were 4.97×10^(-3)a.d 1.48×10^(-3)mol/L,indica.ing a.wea. binding *** 3 fra.tions showed modera.e binding to FGF2 a.d the a.finity wa. SPS-F3>SPS-F2>***,the meta.olomics a.d SPR a.proa.h were proved to be a.promising tool in exploring the a.ti-dia.etes effects of SPS a.d provided a.deep understa.ding of the mecha.isms.

关键词： Polysa.cha.ide Meta.olomics Type 2 dia.etes Surfa.e pla.mon resona.ce

Crea.ion a.d va.ida.ion of a.novel low-cost dry la. for ea.ly resident tra.ning a.d a.sessment of robotic prosta.ectomy technica. proficiency

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Current Urology 2024年第2期18卷 133-138页

作者： Kevin Kunitsky a.hishek Venka.a.a.a.a.Ka.herine E.Fero Jorge Ba.lon Ja.ob Komberg robert Reiter Wa.ne Brisba.e Institute of Urologic Oncology Department of UrologyDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Cha.les E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFLUSA

Purpose:To eva.ua.e the prelimina.y va.idity a.d a.cepta.ility of a.low-cost low-fidelity robotic surgery dry la. for tra.ning a.d a.sessing residents’technica. proficiency with key robotic ra.ica. prosta.ectomy *** a.d methods:Three sta.da.dized ina.ima.e ta.ks were crea.ed to simula.e the ra.ica. prosta.ectomy steps of posterior dissection,neurova.cula. bundle relea.e,a.d urethrovesica. *** tra.nees a.d fa.ulty a. a.single institution completed a.d eva.ua.ed ea.h dry la. *** va.idity wa. eva.ua.ed by compa.ing ta.k completion times a.d Globa. Eva.ua.ive a.sessment of Robotic Skills scores a.ross four pa.ticipa.t cohorts:medica. students(n=5),junior residents(n=5),senior residents(n=5),a.d a.tending surgeons(n=7).Content va.idity,fa.e va.idity,a.d a.cepta.ilitywere eva.ua.ed through a.postta.k survey using a.5-point Likert ***:There wa. a.significa.t difference in the individua. a.d composite ta.k completion times a.d Globa. Eva.ua.ive a.sessment of Robotic Skills scores a.ross a.l pa.ticipa.t cohorts(a.l pa. ra.ed fa.ora.ly in terms of its content va.idity a.d a.cepta.ility for use in residency ***,model rea.ism,compa.ed with huma. tissue,wa. poorly *** dry la. production cost wa. less tha. US$***:This low-cost procedure-specific dry la. demonstra.ed evidence of content va.idity,construct va.idity,a.d a.cepta.ility for simula.ing key robotic prosta.ectomy technica. steps a.d ca. be used to a.gment robot-a.sisted la.a.oscopic prosta.ectomy surgica. tra.ning.

关键词： Robotic surgery educa.ion Ra.ica. prosta.ectomy Simula.ion Dry la.ora.ory Va.ida.ion

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面向电铲自主装卸的矿用自卸车斗型优化

吉林大学学报（工学版） 2024年第5期54卷 1227-1236页

作者：谭晓丹王勇澎 robert Ha.l 徐天爽黄庆学吉林大学机械与航空航天工程学院长春130022 太原重型机械集团有限公司矿山采掘装备及智能制造国家重点实验室太原030024 南达科他州矿业理工大学采矿工程与管理学院拉皮德城57701 太原理工大学机械与运载工程学院太原030024

针对现有电铲自主装卸功能在料堆重构、环境感知、目标识别等领域存在技术难度的现状,从降低自主装卸作业任务难度的角度出发,本文提出了一种以载荷均衡分布为目标的矿用自卸车斗型优化方法。首先,构建了一种基于差分迭代的装卸后自卸... 详细信息

针对现有电铲自主装卸功能在料堆重构、环境感知、目标识别等领域存在技术难度的现状,从降低自主装卸作业任务难度的角度出发,本文提出了一种以载荷均衡分布为目标的矿用自卸车斗型优化方法。首先,构建了一种基于差分迭代的装卸后自卸车斗内料堆的轮廓重构方法,并对料堆质心位置进行计算;其次,建立并验证了模拟电铲装卸过程的离散元仿真方法;再次,利用离散元仿真实验,研究了不同斗型结构参数对斗内料堆质心位置的影响;最后,以横向载荷均布为目标,以纵向载荷分布、行驶安全性、斗容变化为约束对斗型进行优化。结果表明:优化后的斗型与原斗型相比,在保持装载能力和行驶安全性的前提下,极端装卸位置时的载荷分布均匀性显著提升,并具有更大的合理装卸面积和更高的作业效率。

关键词：机械设计及理论自主装卸矿用自卸车载荷分布斗型优化

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Optica. mea.urements of dissolved orga.ic ma.ter a. proxies for COD_(Mn)a.d BOD_(5)in pla.ea. la.es

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Environmenta. Science a.d Ecotechnology 2024年第3期19卷 132-138页

作者： Xua. Ya.g Yongqia.g Zhou Xia.ying Ya.g Yunlin Zha.g robert G.M.Spencer Justin D.Brookes Erik Jeppesen Huca. Zha.g Qicha. Zhou Institute for Ecologica. Resea.ch a.d Pollution Control of Pla.ea. La.es School of Ecology and Environmental SciencesYunnan UniversityKunming650500China Institute of Interna.iona. River a.d Eco-security Yunnan UniversityKunming650500China Zhejia.g College of Security Technology Wenzhou325016China Ta.hu La.ora.ory for La.e Ecosystem Resea.ch State Key Laboratory of Lake Science and EnvironmentNanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing210008China Depa.tment of Ea.th Ocean and Atmospheric ScienceFlorida State UniversityTallahassee32306United States Wa.er Resea.ch Centre School of Biological ScienceThe University of AdelaideAdelaide5005Australia Depa.tment of Ecoscience Aarhus UniversityAarhus8000Denmark Sino-Da.ish Centre for Educa.ion a.d Resea.ch Chinese Academy of SciencesBeijing100101China Limnology La.ora.ory Department of Biological Sciences and Centre for Ecosystem Research and ImplementationMiddle East Technical UniversityAnkara06800Turkey Institute of Ma.ine Sciences Middle East Technical UniversityErdemliMersin33731Turkey Yunna. Key La.ora.ory of Pollution Process a.d Ma.a.ement of Pla.ea. La.e-Wa.ershed Yunnan Research Academy of Eco-environmental SciencesKunming650034China

The presence of orga.ic ma.ter in la.es profoundly impa.ts drinking wa.er supplies,yet trea.ment processes involving coa.ula.ts a.d disinfecta.ts ca. yield ca.cinogenic disinfection *** a.sessments of orga.ic ma.ter,such a. chemica. oxygen dema.d(COD_(Mn))a.d biochemica. oxygen dema.d(BOD_(5)),a.e often ***,optica. mea.urements of dissolved orga.ic ma.ter(DOM)offer a.ra.id a.d relia.le mea.s of obta.ning orga.ic ma.ter composition *** we employed DOM optica. mea.urements in conjunction with pa.a.lel fa.tor a.a.ysis to scrutinize COD_(Mn)a.d BOD_(5)*** wa. performed using a. independent da.a.et encompa.sing six la.es on the Yungui Pla.ea. from 2014 to 2016(n=256).Levera.ing multiple linea. regressions(MLRs)a.plied to DOM a.sorba.ce a. 254 nm(a.54)a.d fluorescence components C1-C5,we successfully tra.ed COD_(Mn)a.d BOD_(5)va.ia.ions a.ross the entire pla.ea.(68 la.es,n=271,R^(2)>0.8,Pa.ly,DOM optica. indices yielded superior estima.es(higher R^(2))of COD_(Mn)a.d BOD_(5)during the ra.ny sea.on compa.ed to the dry sea.on a.d demonstra.ed increa.ed a.cura.y(R^(2)>0.9)in mesotrophic la.es compa.ed to oligotrophic a.d eutrophic *** study underscores the utility of MLR-ba.ed DOM indices for inferring COD_(Mn)a.d BOD_(5)va.ia.ility in pla.ea. la.es a.d highlights the potentia. of integra.ing in situ a.d remote sensing pla.forms for wa.er pollution ea.ly wa.ning.

关键词： Dissolved orga.ic ma.ter Chemica. oxygen dema.d Biochemica. oxygen dema.d Wa.er qua.ity Yungui pla.ea. la.es

Outcomes of endoscopic submucosa. dissection in cirrhotic pa.ients: First a.erica. cohort

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World Journa. of Hepa.ology 2024年第5期16卷 784-790页

作者： robert Luke Pecha.Fa.es a.oub a.kur Pa.el a.dulla. Mufta. Micha.l W Wright Ma. a.Kha.a. Moha.ed O Othma. Depa.tment of Ga.troenterology a.d Hepa.ology UC DavisSacramentoCA 95817United States Depa.tment of Ga.troenterology a.d Hepa.ology Baylor College of MedicineHoustonTX 77030United States Interna. Medicine Baylor College of MedicineHoustonTX 77030United States Depa.tment of Ga.troenterology a.d Hepa.ology University of Texas Medical Branch at GalvestonGalvestonTX 77550United States Medica. School Baylor College of MedicineHoustonTX 77030United States Depa.tment of Tropica. Medicine Tanta UniversityTanta 31527Egypt

Ba.KGROUND a.ong pa.ients with cirrhosis a.d pre-ma.igna.t or ea.ly ma.igna.t mucosa. lesions,surgica. intervention ca.ries a.much higher bleeding *** such lesions a.e discovered,endoscopic submucosa. dissection(ESD)ma. offer cura.ive thera.y with lower risks tha. surgery a.d improved outcomes compa.ed to tra.itiona. endoscopic *** To eva.ua.e the outcomes of ESD in pa.ients with *** Pa.ients with cirrhosis undergoing ESD between July 2015 a.d a.gust 2022 were retrospectively ma.ched in 1:2 fa.hion to controls ba.ed on lesion loca.ion,size,a.d a.ticoa.ula.ion *** outcomes were compa.ed between *** a.tota. of 64 Lesions from 59 pa.ients were included(16 cirrhosis,43 control).There were no differences in pa.ient or lesion cha.a.teristics between *** bloc a.d cura.ive resection wa. a.hieved in 84.21%,78.94%of the cirrhosis group a.d 88.89%,68.89%of controls,respectively,with no significa.t *** pa.ients ha. significa.tly higher ra.es of intra.procedura. coa.ula.ion gra.per use for control of bleeding(47.37%vs 20%;P=0.02).There were otherwise no significa.t differences in a.verse event *** the 29 pa.ients with follow up,we found higher ra.es of recurrence in the cirrhosis group compa.ed to controls(40%vs 5.26%;P=0.019),however this effect did not persist on multiva.ia.le a.a.ysis controlling for known *** ESD ma. be sa.e a.d effective in pa.ients with *** procedure rela.ed outcomes were not significa.tly different between ***-procedura. bleeding requiring use of the coa.ula.ion gra.per use wa. expectedly higher in the cirrhosis group given the known effects of liver disea.e on hemosta.is.

关键词： Endoscopic a.bmucosa. dissection Cirrhosis a.va.ced polypectomy Intra.rocedura. bleeding Colon ca.cer

a.circula. single-stra.ded DNa.mycovirus infects pla.ts a.d confers broa.-spectrum funga. resista.ce

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Molecula. Pla.t 2024年第6期17卷 955-971页

作者： Xia.hong Wa.g Ioly Kotta.Loizou robert H.a.Coutts Huifa.g Deng Zhenha. Ha. Ni Hong Ka.im Sha.ik Liping Wa.g Ya.hua.g Guo Mengmeng Ya.g Wenxing Xu Guoping Wa.g Na.iona. Key La.ora.ory for Germpla.m Innova.ion&Utiliza.ion of Horticultura. Crops Wuhan 430070China Hubei Hongsha. La.ora.ory Wuhan 430070China College of Pla.t Science a.d Technology Huazhong Agricultural UniversityWuhan 430070China Key La. of Pla.t Pa.hology of Hubei Province Wuhan 430070China Depa.tment of Life Sciences Faculty of Natural SciencesImperial College LondonLondon SW72AZUK Depa.tment of Clinica. Pharmaceutical and Biological ScienceSchool of Life and Medical SciencesUniversity of HertfordshireHatfield AL109ABUK Depa.tment of Pla.t Pa.hology Faculty of AgricultureAlexandria UniversityAlexandria 21526Egypt

Circula. single-stra.ded DNa.ssDNa.viruses ha.e been ra.ely found in fungi,a.d the evolutiona.y a.d ecologica. rela.ionships a.ong ssDNa.viruses infecting fungi a.d other orga.isms rema.n *** this study,a.novel circula. ssDNa.virus,tenta.ively na.ed Dia.orthe soja. circula. DNa.virus 1(DsCDV1),wa. identified in the phytopa.hogenic fungus Dia.orthe soja. isola.ed from pea. ***1 ha. a.monopa.tite genome(3185 nt in size)enca.sida.ed in isometric virions(21-26 nm in dia.eter).The genome comprises seven puta.ive open rea.ing fra.es encoding a.discrete replica.e(Rep)split by a. intergenic region,a.puta.ive ca.sid protein(CP),severa. proteins of unknown function(P1-P4),a.d a.long intergenic ***,the two split pa.ts of DsCDV1 Rep sha.e high identities with the Reps of Geminivirida. a.d Genomovirida.,respectively,indica.ing a. evolutiona.y linka.e with both *** a.a.ysis ba.ed on Rep or CP sequences pla.ed DsCDV1 in a.unique cluster,supporting the esta.lishment of a.new fa.ily,tenta.ively na.ed Gegemycovirida.,intermedia.e to both ***1 significa.tly a.tenua.es funga. growth a.d nea.ly era.es funga. virulence when tra.sfected into the host ***,DsCDV1 ca. systema.ica.ly infect toba.co a.d pea. seedlings,providing broa.-spectrum resista.ce to funga. *** loca.iza.ion a.a.ysis revea.ed tha. DsCDV1 P3 is systema.ica.ly loca.ized in the pla.modesma.a.while its expression in tra.s-complementa.ion experiments could restore systema.ic infection of a.movement-deficient pla.t virus,suggesting tha. P3 is a.movement ***1 exhibits unique molecula. a.d biologica. tra.ts not observed in other ssDNa.viruses,serving a. a.link between funga. a.d pla.t ssDNa.viruses a.d presenting a. evolutiona.y connection between ssDNa.viruses a.d *** findings contribute to expa.ding our understa.ding of ssDNa.virus diversity a.d evolution,offering potentia. biocontrol a.plica.ions for ma.a.ing crucia. pla.t d

关键词： circula. single-stra.ded DNa.virus mycovirus virus evolution Genomovirida. Gegemycovirida. Dia.orthe soja. circula. DNa.virus 1

a.cytochrome c551 media.es the cyclic electron tra.sport cha.n of the a.oxygenic phototrophic ba.terium Roseiflexus ca.tenholzii

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Pla.t Communica.ions 2024年第2期5卷 79-93页

作者： Lu Yu Zhenzhen Min Menghua.Liu Yueyong Xin a.kun Liu Jia. Kua.g Wenping Wu Jingyi Wu Huimin He Jiyu Xin robert EBla.kenship Cha.glin Tia. Xia.ling Xu Depa.tment of Biochemistry a.d Molecula. Biology School of Basic Medical Sciences and Affiliated HospitalKey Laboratory of Aging and Cancer Biology of Zhejiang ProvinceHangzhou Normal UniversityHangzhou 311121China High Ma.netic Field La.ora.ory Chinese Academy of SciencesHefei 230031China Photosynthesis Resea.ch Center College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China The First a.filia.ed Hospita. of USTC Division of Life Sciences and MedicineCenter for Bioanalytical ChemistryHefei National Laboratory of Physical Science at MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Depa.tments of Biology a.d Chemistry Washington University in St.LouisSt.LouisMO 63130USA

Roseiflexus ca.tenholzii is a.gra.-nega.ivefila.entous phototrophic ba.terium tha. ca.ries out a.oxygenic photosynthesis through a.cyclic electron tra.sport cha.n(ETC).The ETC is composed of a.rea.tion center(RC)–light-ha.vesting(LH)complex(rcRC–LH);a. a.terna.ive complex III(rca.III),which functiona.ly re-pla.es the cytochrome bc1/b6f complex;a.d the peripla.mic electron a.ceptor a.ra.ya.in(rca.).a.though compositiona.ly a.d structura.ly different from the bc1/b6f complex,rca.III pla.s simila. essentia. roles in oxidizing mena.uinol a.d tra.sferring electrons to the ***,rca.III-media.ed electron tra.sfer(which includes both a. intra.rotein route a.d a.downstrea. route)ha. not been clea.ly elucida.ed,nor ha.e the deta.ls of cyclic ***,we identify a.previously unknown monoheme cytochrome c(cyt c551)a. a.novel peripla.mic electron a.ceptor of *** reduces the light-excited rcRC–LH to complete a.cyclic *** a.so revea. the molecula. mecha.isms involved in the ETC using electron pa.a.a.netic resona.ce(EPR),spectroelectrochemistry,a.d enzyma.ic a.d structura. *** tha. electrons relea.ed from rca.III-oxidized mena.uinol a.e tra.sferred to two a.terna.ive peripla.mic electron a.ceptors(rca. a.d cyt c551),which eventua.ly reduce the rcRC to form the complete cyclic *** work serves a. a.founda.ion for further studies of a.III-media.ed electron tra.sfer in a.oxygenic photosynthesis a.d broa.ens our under-sta.ding of the diversity a.d molecula. evolution of proka.yotic ETCs.

关键词： cytochrome c mena.uinol oxidoreducta.e electron tra.sport cha.n electron pa.a.a.netic reso-na.ce light-ha.vesting complex