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Clinical pharmacology relevant to older adults with cardiovascular disease

Journal of Geriatric Cardiology 2015年第3期12卷 192-195页

作者： Jorge A Brenes-Salazar Laith Alshawabkeh Kenneth E Schmader Joseph t hanlon Daniel E Forman Department of Medicine Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA Department of Medicine Division of Cardiovascular Medicine University of lowa Iowa City IA USA Department of Medicine Division of Geriatrics Duke University School of Medicine Durham NC USA Departments of Medicine (Division of Geriatric Medicine) Pharmacy and Epidemiology University of Pittsburgh Geriatric Research Education and Clini- cal Center and Center for Health Equity Research and Promotion VA Pittsburgh Health System Pittsburgh PA USA Department of Medicine (Divisions of Geriatric Medicine and Cardiology) University of Pittsburgh Medical Center Geriatric Research Education and Clinical Center VA Pittsburgh Health System Pittsburgh PA USA

1 Introduction Although older adults are generally among the highest users of cardiovascular medications, they are typically underrepresented or excluded from most efficacy and safety trials. Drug developers are usually reluctant to include many senior adults in randomized controlled clinical trials in part due to their high prevalence of multiple comorbidities, frailty, and polypharmacy; and to age-related pharmacokinetic and pharmacodynamic complexities. Consequently, there is often insufficient high quality evidence-based data to inform pharmacologic management of common cardiovascular conditions on older adults. In the absence of data, clinicians often rely on conceptual principles regarding metabolism and drug-drug interactions to minimize adverse drug events, but this is often not well-substantiated or standardized. A related challenge is poor cardiovascular medication adherence among older adults, and its detrimental impact on their health outcomes. In this brief review we highlight some aspects of these topics.

关键词： Metabolism Pharmacokinetics Pharmacodynamics Polypharmacy

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Emergency department presentation changes due to the coronavirus disease pandemic in Nova Scotia,Canada

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World Journal of Emergency Medicine 2023年第1期14卷 62-64页

作者： tara Dahn Patrick t.Fok Hana Wiemer Daniel J.Dutton Valancy Cole David Lewis tong Liu Keith R.Brunt robe.t hanlon Jacqueline Fraser Chris Vaillancourt Paul Atkinson Department of Emergency Medicine Dalhousie UniversityHalifax B3H 3A7Canada Department of Community Health and Epidemiology Dalhousie UniversitySaint John E2K 5E2Canada Dalhousie Medicine New Brunswick Saint John E2L 4L5Canada Department of Emergency Medicine Level One Saint John Regional HospitalSaint John E2L 4L2Canada Department of Emergency Medicine Horizon Health NetworkSaint John E2L 4L2Canada

Multiple studies have reported decreased emergency department(ED)patient volumes during the coronavirus disease(COVID-19)pandemic,[1-6]including areas most affected by the virus.[7]Most existing studies have investigated general trends in ED presentations and have not examined the impact of COVID-19 on different types of EDs,specific ED patient groups,or illness presentations.

关键词： Canada department patient

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Awake Craniotomy and Coaching

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Open Journal of Medical Psychology 2014年第5期3卷 382-389页

作者： Carla Ruis Irene M. C. Huenges Wajer Pierre A. J. t. robe Martine J. E. van Zandvoort Department of Neurology & Neurosurgery Rudolf Magnus Institute of Neuroscience University Medical Center Utrecht Utrecht The Netherlands Department of Experimental Psychology Helmholtz Institute Utrecht University Utrecht The Netherlands

Background: the importance of monitoring cognition during awake craniotomy has been well described in previous studies. the relevance of being coached during such a procedure has received less attention and questions still remain unanswered about what factors are the most important herein. Objective: the aim of this study was to qualitatively analyze what factors were, according to our patients, important in being coaching during awake craniotomy. Methods: twenty-six patients who underwent awake craniotomy received a questionnaire about their experiences during the procedure. the questions concerned different aspects of the pre-operative part, the operation itself and coaching aspects. Answers were qualitatively analyzed by two investigators and per question, different answer categories were made. Results: two thirds of the 20 patients who responded to the questionnaire reported anxiety in the days before or during the operation, varying from general anxiety for being awake during surgery to anxiety for very specific aspects such as opening the skull. the constant presence of the neuropsychologist and a transparent communication during the procedure were most frequently (65% of all the answers) reported as helpful in staying calm. Conclusion: Results of this descriptive study show that patients experience different anxieties before and during an awake craniotomy and give more insight into what factors are important for patients in being coached during such an operation. this study gives directions for clinicians in improving their role as a coach.

关键词： Coaching Awake Craniotomy Anxiety Reassurance Cognition

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看海洋魔术师玩变身

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小哥白尼（野生动物） 2008年第6期 36-38页

作者：刘海儿 Roger t.hanlon

汉隆博士瞪大了眼睛,又瞪大了一点,紧紧地盯着它,他觉得自己的眼珠紧张得都快要掉出来了!尽管在水下人类就像棵可笑的水草一样,随着水流左摇右晃,一点儿也没有在陆地上那样灵巧,可汉隆博士还是没有游移开他的视线。因为这家伙实在太狡猾... 详细信息

汉隆博士瞪大了眼睛,又瞪大了一点,紧紧地盯着它,他觉得自己的眼珠紧张得都快要掉出来了!尽管在水下人类就像棵可笑的水草一样,随着水流左摇右晃,一点儿也没有在陆地上那样灵巧,可汉隆博士还是没有游移开他的视线。因为这家伙实在太狡猾了,稍不留神就会……

关键词：魔术师乌贼海洋实验室博士伪装水池水下色素细胞眼睛

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tACKLING PAIN WItH tCM the Battle Against Stagnation

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城市漫步（GBA版） 2017年第6期 54-54页

作者： Jonathan hanlon 不详

Pain affects everyone at some point in their *** yoifre lucky;it's rare and *** you aren't so lucky,then pain can be a daily problem that prevents you from living life to the *** you fall into the lat-ter category;acu... 详细信息

关键词： acupuncture everyone tCM

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淡水--生命最后的边界

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海外英语 2003年第3期 19-页

作者： Larry O'hanlon 吴雪梅

　　the final frontier for early animal life wasn't a crawl(爬行) onto dry land, but the plunge (跳入,投入) into freshwater streams and lakes, say paleontologists (古生物学者).……

关键词：淡水生命古生物学者爬行

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Verification of the MIKE11-NAM Model for Simulating Streamflow

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Journal of Environmental Protection 2020年第2期11卷 152-167页

作者： Fitsum t. teshome Haimanote K. Bayabil L. N. thakural Fikadu G. Welidehanna Department of Plant Science College of Agriculture and Natural Resources Madda Walabu University Bale-Robe Ethiopia Department of Agricultural and Biological Engineering Tropical Research and Education Center IFAS University of Florida Homestead FL USA Surface Water Hydrology Division National Institute of Hydrology Roorkee India

Modeling watershed hydrological processes are important for water resources planning, development, and management. In this study, the MIKE 11-NAM (Nedbor-Afstromings Model model) was evaluated for simulation of streamflow from the Bina basin located in the Madhya Pradesh State of India. the model was calibrated and validated on a daily basis using five years (1994-1998) observed hydrological data. In addition, a model sensitivity analysis was performed on nine MIKE 11-NAM parameters to identify sensitive model parameters. Statistical and graphical approaches were used to assess the performance of the model in simulating the streamflow of the basin. Results show that during daily model calibration, the model performed very well with a coefficient of determination (R2) and the percentage of water balance error (WBL) values 0.87% and -8.63%, respectively. In addition, the model performed good during the validation period with R2 and WBL values of 0.68% and -6.72%, respectively. Model sensitivity analysis results showed that Overland flow runoff coefficient (CQOF), time constant for routing overland flow (CK1,2) and Maximum water content in root zone storage (Lmax) were found as the most influential and sensitive model parameters for simulating streamflow. Overall, the model’s performance was satisfactory based on R2 and EI metrics.

关键词： Lumped Conceptual Model MIKE 11-NAM Sensitivity Analysis Rainfall-Runoff Modeling

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Modeling Stream Flow Using SWAt Model in the Bina River Basin, India

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Journal of Water Resource and Protection 2020年第3期12卷 203-222页

Understanding watershed runoff processes is critical for planning effective soil and water management practices and efficiently utilize available water resources. the main objective of this study was to investigate the performance of the Soil and Water Assessment tool (SWAt) to simulate streamflow from the Bina basin in the Madhya Pradesh state of India. the SWAt model was calibrated and validated on a daily and monthly basis using historical streamflow and weather data from the Bina basin. the Sequential Uncertainty Fitting (SUFI-2) technique in the SWAt? Calibration and Uncertainty Procedures (SWAt-CUP) program was used to assess model uncertainties. the SWAt model performed “satisfactory” and “very good” in simulating streamflow at daily and monthly time steps, respectively. Model calibration results showed that coefficients of determination (R2) values were 0.66 and 0.96;while Nash-Sutcliffe (NSE) values were 0.65 and 0.94 for daily and monthly simulations, respectively. the R2 values of daily and monthly simulations during model validation were 0.65 and 0.72, respectively while the respective NSE values were 0.58 and 0.72. this study demonstrated that the SWAt model could be effectively used to simulate streamflow in the Bina river basin.

关键词： Modeling Streamflow SWAt SWAt-CUP Bina River Basin

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Search for the doubly heavy baryons Ωbc0 and Ξbc0 decaying to Λc+π- and Ξc+π-

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Chinese Physics C 2021年第9期45卷 14-25页

作者： R.Aaij C.Abellán Beteta t.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.Bj?rn M.P.Blago t.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia t.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.t.Borsuk S.A.Bouchiba t.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins t.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovská M.Cruz torres R.Currie C.L.Da Silva E.Dall'Occo J.Dalseno C.D'Amb University of Edinburgh Horia Hulubei National Institute of Physics and Nuclear Engineering INFN Sezione di Bari Università di Bari Los Alamos National Laboratory (LANL) Van Swinderen Institute University of Groningen Universiteit Maastricht AGH-University of Science and technology Faculty of Physics and Applied Computer Science Université Clermont Auvergne Università di Cagliari Institute for Nuclear Research of the National Academy of Sciences (KINR) School of Physics University College Dublin NSC Kharkiv Institute of Physics and technology (NSC KIPt) INFN Sezione di Perugia StFC Rutherford Appleton Laboratory School of Physics and Astronomy Monash University Novosibirsk State University CNRS/IN2P3 Department of Physics and Astronomy Uppsala University Università di Genova School of Physics State Key Laboratory of Nuclear Physics and technology Peking University National Center for Nuclear Research (NCBJ) Università di Roma tor Vergata Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio) Universidade Federal do triangulo Mineiro (UFtM) Institute of Particle Physics LPC Central China Normal University Hangzhou Institute for Advanced Study UCAS Instituto de Fisica Corpuscular Centro Mixto Universidad de Valencia-CSIC Nikhef National Institute for Subatomic Physics and VU University Amsterdam National Research tomsk Polytechnic University AGH-University of Science and technology Faculty of Computer Science Electronics and telecommunications University of Michigan Università di Siena Università di Padova Scuola Normale Superiore National Research Centre Kurchatov Institute Università degli Studi di Milano MSU-Iligan Institute of technology (MSU-IIt) Università di Firenze INFN Sezione di Roma La Sapienza Institut für Physik Universit?t Rostock INFN Sezione di Milano Departamento de Fisica Universidad Nacional de Colombia Universit?t Bonn-Helmholtz-Institut für Strahlen und Kernphysik Hanoi University of Science Università di Pisa P.N. Lebedev Physical Institute Russian Academy of Science (LPI RAS) Università

the first search for the doubly heavy Ωbc0baryon and a search for the Ξbc0baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 teV,corresponding to an integrated luminosity of 5.2 *** baryons are reconstructed via their decays to ∧c+π-andΞc+π-.No significant excess is found for invariant masses between 6700 and 7300 MeV/c2,in a rapidity range from2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ωbc0andΞbc0production cross-section times the branching fraction to ∧c+π-（Ξc+π-） relative to that of the ∧b0（Ξb0） baryon,for different lifetime hypotheses,at 95% confidence *** upper limits range from 0.5×10-4to 2.5×10-4for theΩbc0→∧c+π-(Ξbc0→∧c+π-) decay,and from 1.4×10-3to 6.9×10-3for the Ωbc0→Ξc+π-(Ξbc0→Ξc+π-) decay,depending on the considered mass and lifetime of the Ωbc0(Ξbc0) baryon.

关键词： B physics quarkonium spectroscopy heavy quark production

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Search for the rare decay B^(0)→J/ψФ

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Chinese Physics C 2021年第4期45卷 47-60页

作者： R.Aaij C.Abellin Beteta t.Ackernley B.Adeva M.Adinolfi H.Afsharnial C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmaver J.J.Back S.Baker P.Baladron Rodriguez V.Balagura W.Baldinit J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschis I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Biorn M.P.Blago t.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia t.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.t.Borsuk S.A.Bouchiba t.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguezs M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Burschee A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbonel G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins t.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Centro Brasileiro de Pesquisas Fisicas(CBPF) Riode JaneiroBrazil Universidade Federal do Riode Janeiro(UFRJ) Riode JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universitq Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano Bicocca Milanolaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari Monserratoltaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and technology Faculty of Physics and Applied Computer Science

A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 teV,corresponding to an integrated luminosity of9 *** significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.

关键词： B physics flavour physics rare decay ω-Фmixing branching fraction

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